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The map label for this gene is mscS [H]

Identifier: 193211885

GI number: 193211885

Start: 209549

End: 210364

Strand: Direct

Name: mscS [H]

Synonym: Cpar_0211

Alternate gene names: 193211885

Gene position: 209549-210364 (Clockwise)

Preceding gene: 193211884

Following gene: 193211886

Centisome position: 9.15

GC content: 55.88

Gene sequence:

>816_bases
ATGAATGAAGTGAATTTCAATCTTCTTGTGCATTACGTATCAACCTTCGGAATCAAGCTGCTGGTCGGCCTTGTCATTCT
TGTGGTCGGTATGAGACTTTCGACCTTCCTGAGTAATCGCCTTGTTGCGATGCTGAACCGGAAGGAGGGGCTCGACGAGA
TGCTGGTGCATTTCTTCGGAAGCCTTGCGCGCTACAGTATCATCGCCGTCACGGTGATCACCGTGCTCAACCAGATCGGC
GTGCAGACTGCGAGCCTTCTGGCGGTGCTGGCCTCCGCCGGTCTTGCCATCGGCCTGGCGTTGCAGGGAACGCTCTCTAA
CATTGCCTCCGGTGTCATGCTGATTTTCTTCAGGCCGTTCCGCACCGGCCAGTATATCGAAGTGGCCGGCAAGGCGGGCA
CGGTTAAAAACGTTTCGCTGTTCACCACGGAGCTTGCCACGCCGGACAACGTCCAGATCATTCTGCCGAACAGCGAGGTG
TGGAGCGGCTCGATCGTCAATTATTCGTATCACGAAACCCGGCGCGTCGATTTTCTGCTCGGCATTTCCTACAGCGACAA
CATCGACAAAGCCTTTTCGGTTATCAACGGCGTTATCGGTGGCGACAAGCGCATTCATGCGGAGCCTGCTCCGCAGGTCG
TGGTCAGCGAGCTTGCCAACAGTTCTGTCAACATCACGGTTCGCGTTTGGGTTGTGTCCGGAGACTACTGGGGCGTCAAG
TTCGATCTGACCAAACAGTTCAAGGAGGCGCTGGACGCTAACGGCCTCTCGATTCCCTTTCCCCAGCAGGACGTTCACCT
TATCCGGTCGGCGTAA

Upstream 100 bases:

>100_bases
GTTTATCAGATTTGTCAAATAGCATCTGGCGGCATTTCCCGGAGGCGGCTTCAAACCGCCTCTGAGCTTTCCTGATGCTT
TTCATTAAAAACTCATTGTA

Downstream 100 bases:

>100_bases
CCCGGCTGAGGCAATGGGCTTGGGCTGAGGGCCGCCTCGAATACCGACAATCCGATTCGCTTTCAAAGCCATCGGCAGCA
GGAGGACATGCAAAACGTGT

Product: mechanosensitive ion channel MscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MNEVNFNLLVHYVSTFGIKLLVGLVILVVGMRLSTFLSNRLVAMLNRKEGLDEMLVHFFGSLARYSIIAVTVITVLNQIG
VQTASLLAVLASAGLAIGLALQGTLSNIASGVMLIFFRPFRTGQYIEVAGKAGTVKNVSLFTTELATPDNVQIILPNSEV
WSGSIVNYSYHETRRVDFLLGISYSDNIDKAFSVINGVIGGDKRIHAEPAPQVVVSELANSSVNITVRVWVVSGDYWGVK
FDLTKQFKEALDANGLSIPFPQQDVHLIRSA

Sequences:

>Translated_271_residues
MNEVNFNLLVHYVSTFGIKLLVGLVILVVGMRLSTFLSNRLVAMLNRKEGLDEMLVHFFGSLARYSIIAVTVITVLNQIG
VQTASLLAVLASAGLAIGLALQGTLSNIASGVMLIFFRPFRTGQYIEVAGKAGTVKNVSLFTTELATPDNVQIILPNSEV
WSGSIVNYSYHETRRVDFLLGISYSDNIDKAFSVINGVIGGDKRIHAEPAPQVVVSELANSSVNITVRVWVVSGDYWGVK
FDLTKQFKEALDANGLSIPFPQQDVHLIRSA
>Mature_271_residues
MNEVNFNLLVHYVSTFGIKLLVGLVILVVGMRLSTFLSNRLVAMLNRKEGLDEMLVHFFGSLARYSIIAVTVITVLNQIG
VQTASLLAVLASAGLAIGLALQGTLSNIASGVMLIFFRPFRTGQYIEVAGKAGTVKNVSLFTTELATPDNVQIILPNSEV
WSGSIVNYSYHETRRVDFLLGISYSDNIDKAFSVINGVIGGDKRIHAEPAPQVVVSELANSSVNITVRVWVVSGDYWGVK
FDLTKQFKEALDANGLSIPFPQQDVHLIRSA

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=258, Percent_Identity=41.8604651162791, Blast_Score=220, Evalue=8e-59,
Organism=Escherichia coli, GI1786670, Length=205, Percent_Identity=27.3170731707317, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787591, Length=274, Percent_Identity=24.4525547445255, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI2367355, Length=203, Percent_Identity=20.1970443349754, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 29500; Mature: 29500

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEVNFNLLVHYVSTFGIKLLVGLVILVVGMRLSTFLSNRLVAMLNRKEGLDEMLVHFFG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SLARYSIIAVTVITVLNQIGVQTASLLAVLASAGLAIGLALQGTLSNIASGVMLIFFRPF
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHCEEEEEEECC
RTGQYIEVAGKAGTVKNVSLFTTELATPDNVQIILPNSEVWSGSIVNYSYHETRRVDFLL
CCCCEEEEECCCCCCCEEEEEEEECCCCCCCEEEECCCCCCCCCEEEECCCCCCEEEEEE
GISYSDNIDKAFSVINGVIGGDKRIHAEPAPQVVVSELANSSVNITVRVWVVSGDYWGVK
ECCCCCCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHCCCCEEEEEEEEEEECCEEEEE
FDLTKQFKEALDANGLSIPFPQQDVHLIRSA
EHHHHHHHHHHCCCCCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MNEVNFNLLVHYVSTFGIKLLVGLVILVVGMRLSTFLSNRLVAMLNRKEGLDEMLVHFFG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SLARYSIIAVTVITVLNQIGVQTASLLAVLASAGLAIGLALQGTLSNIASGVMLIFFRPF
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHCEEEEEEECC
RTGQYIEVAGKAGTVKNVSLFTTELATPDNVQIILPNSEVWSGSIVNYSYHETRRVDFLL
CCCCEEEEECCCCCCCEEEEEEEECCCCCCCEEEECCCCCCCCCEEEECCCCCCEEEEEE
GISYSDNIDKAFSVINGVIGGDKRIHAEPAPQVVVSELANSSVNITVRVWVVSGDYWGVK
ECCCCCCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHCCCCEEEEEEEEEEECCEEEEE
FDLTKQFKEALDANGLSIPFPQQDVHLIRSA
EHHHHHHHHHHCCCCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]