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The map label for this gene is mltB [H]

Identifier: 192291169

GI number: 192291169

Start: 3033898

End: 3035127

Strand: Reverse

Name: mltB [H]

Synonym: Rpal_2790

Alternate gene names: 192291169

Gene position: 3035127-3033898 (Counterclockwise)

Preceding gene: 192291171

Following gene: 192291168

Centisome position: 52.84

GC content: 67.32

Gene sequence:

>1230_bases
ATGGTCGATCGCGATTCCCCAACCTCTCTCACCCGTCGCCGCCTGCTGCAGACGGCCGTCGGCGCCGCCATGATGCTGCC
GGCCGCAGCTTCCGCCGCGGCGCCGGCCGGCTTCGATGAATGGCGCGACGCGTTCCGGGCGAAGGCGCTCGCCAAAGGCG
TCTCGCCCCGCACCTGGGATCGGGTGATGGGATCGCTCGAACCCGACATGAGCGTGTTCAAGAACTTCCAGAAGCAACCG
GAATTCAACGAGCAGCTCTGGCAGTACATCAACCGTCGGGTGTCGGACTGGCGGATCACCGCCGGCCGCGAGGCGCTGCG
CAAGAACGAAGCGTTGTTCGCGCGGATCGAGCGCGACTTCGGCGTCGAGCGCGGCACACTGCTGGCGCTGTGGGGCGTCG
AGAGCGCCTATGGCGATCCGCTGGTGCAGCAGAACCATATGCGTCCGGTCTTCCCCTCCCTCGCAGCGCTGGCTTGGCGC
GAGCCGCGGCGGCGTCCGTATTGGGAGACCGAGCTGATCAATGCGCTGCGGATCGTCGACAAGGGCTGGTCGACGCCGGA
GGAAATGCGCGGCTCCTGGGCCGGCGCGATGGGCCACAGCCAATGGATGCCCGAGGTTTGGCTGAACGTCGGCATCGACT
ATGACGGCGACGGACGCGTATCGCCGTTCGGCCGGCCCGACGACGCGCTCGGATCGACTGCGAAGTATCTGGTCCGGCGC
GGCAACTATCACCGCGGCGAGCATTGGGGCTACGAGGTCGAAGGCCCCGGCGGCGCGGTCAGCGGCAGCCGCAGCTATCT
GGCGTGGTCGCGCTCCGGCGTCTCCCGCGCCGACGGCCAGCCGTTTCCTGATTCCTCTGCCAGCGCAACCATGTGGGTGC
CGGTCGACGGAGGTCCGAAATTCCTGATCGGGCCGAATTTCTACGCGGTGAAGAGCTACAACCCGTCGATGAACTACGCG
CTCGCGATCTGCCATCTCGGTGATCGCATTCTCGGCGGCAGCCCGTTCATCCATCCGTTCCCCGGATCGGAGCGCGCGCT
GACGCTCGCCGAGGTGCAGGAGATGCAGACGCGGCTGACAAGCGCCGGCTTCGACACCGGCGGCACCGACGGCCGGGTCG
GCAACGACACCATGAAGGCGATCCGGGACTTCCAAATCAAATCCGGCCTTCGGCCTGCCGACGGCTATGGCGGACTGAAG
GTGCTGGCGCGACTGCGGCAGGGTGGATAG

Upstream 100 bases:

>100_bases
GTCGCTGCGGCTTGGTGGAACAATCCGCGCCTTGCCTGCGCAGCTGCTATCGAGCCGCAGCAGCTTTGGGGACGCCCGCA
ATGCCGCTACACTGCCGGCT

Downstream 100 bases:

>100_bases
AGGCCGCAGGCTTTTCGATGATGCGACATCACTGGACGTGGCACCGAATCAAGGCGCTGGCGCACGAAGAGTGGCGCGAG
CTCGTCACCTTTAATCCGAG

Product: lytic murein transglycosylase

Products: Muramic Acid Residue [C]

Alternate protein names: 35 kDa soluble lytic transglycosylase; Murein hydrolase B; Slt35 [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MVDRDSPTSLTRRRLLQTAVGAAMMLPAAASAAAPAGFDEWRDAFRAKALAKGVSPRTWDRVMGSLEPDMSVFKNFQKQP
EFNEQLWQYINRRVSDWRITAGREALRKNEALFARIERDFGVERGTLLALWGVESAYGDPLVQQNHMRPVFPSLAALAWR
EPRRRPYWETELINALRIVDKGWSTPEEMRGSWAGAMGHSQWMPEVWLNVGIDYDGDGRVSPFGRPDDALGSTAKYLVRR
GNYHRGEHWGYEVEGPGGAVSGSRSYLAWSRSGVSRADGQPFPDSSASATMWVPVDGGPKFLIGPNFYAVKSYNPSMNYA
LAICHLGDRILGGSPFIHPFPGSERALTLAEVQEMQTRLTSAGFDTGGTDGRVGNDTMKAIRDFQIKSGLRPADGYGGLK
VLARLRQGG

Sequences:

>Translated_409_residues
MVDRDSPTSLTRRRLLQTAVGAAMMLPAAASAAAPAGFDEWRDAFRAKALAKGVSPRTWDRVMGSLEPDMSVFKNFQKQP
EFNEQLWQYINRRVSDWRITAGREALRKNEALFARIERDFGVERGTLLALWGVESAYGDPLVQQNHMRPVFPSLAALAWR
EPRRRPYWETELINALRIVDKGWSTPEEMRGSWAGAMGHSQWMPEVWLNVGIDYDGDGRVSPFGRPDDALGSTAKYLVRR
GNYHRGEHWGYEVEGPGGAVSGSRSYLAWSRSGVSRADGQPFPDSSASATMWVPVDGGPKFLIGPNFYAVKSYNPSMNYA
LAICHLGDRILGGSPFIHPFPGSERALTLAEVQEMQTRLTSAGFDTGGTDGRVGNDTMKAIRDFQIKSGLRPADGYGGLK
VLARLRQGG
>Mature_409_residues
MVDRDSPTSLTRRRLLQTAVGAAMMLPAAASAAAPAGFDEWRDAFRAKALAKGVSPRTWDRVMGSLEPDMSVFKNFQKQP
EFNEQLWQYINRRVSDWRITAGREALRKNEALFARIERDFGVERGTLLALWGVESAYGDPLVQQNHMRPVFPSLAALAWR
EPRRRPYWETELINALRIVDKGWSTPEEMRGSWAGAMGHSQWMPEVWLNVGIDYDGDGRVSPFGRPDDALGSTAKYLVRR
GNYHRGEHWGYEVEGPGGAVSGSRSYLAWSRSGVSRADGQPFPDSSASATMWVPVDGGPKFLIGPNFYAVKSYNPSMNYA
LAICHLGDRILGGSPFIHPFPGSERALTLAEVQEMQTRLTSAGFDTGGTDGRVGNDTMKAIRDFQIKSGLRPADGYGGLK
VLARLRQGG

Specific function: Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG2951

COG function: function code M; Membrane-bound lytic murein transglycosylase B

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor; Periplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789053, Length=274, Percent_Identity=26.6423357664234, Blast_Score=90, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011757 [H]

Pfam domain/function: NA

EC number: 3.2.1.- [C]

Molecular weight: Translated: 45287; Mature: 45287

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDRDSPTSLTRRRLLQTAVGAAMMLPAAASAAAPAGFDEWRDAFRAKALAKGVSPRTWD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHH
RVMGSLEPDMSVFKNFQKQPEFNEQLWQYINRRVSDWRITAGREALRKNEALFARIERDF
HHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHC
GVERGTLLALWGVESAYGDPLVQQNHMRPVFPSLAALAWREPRRRPYWETELINALRIVD
CCCCCCEEEEECCCHHHCCCCHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
KGWSTPEEMRGSWAGAMGHSQWMPEVWLNVGIDYDGDGRVSPFGRPDDALGSTAKYLVRR
CCCCCHHHHCCCHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GNYHRGEHWGYEVEGPGGAVSGSRSYLAWSRSGVSRADGQPFPDSSASATMWVPVDGGPK
CCCCCCCCCCEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCE
FLIGPNFYAVKSYNPSMNYALAICHLGDRILGGSPFIHPFPGSERALTLAEVQEMQTRLT
EEECCCEEEEECCCCCCCCEEEEEHHCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SAGFDTGGTDGRVGNDTMKAIRDFQIKSGLRPADGYGGLKVLARLRQGG
HCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MVDRDSPTSLTRRRLLQTAVGAAMMLPAAASAAAPAGFDEWRDAFRAKALAKGVSPRTWD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHH
RVMGSLEPDMSVFKNFQKQPEFNEQLWQYINRRVSDWRITAGREALRKNEALFARIERDF
HHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHC
GVERGTLLALWGVESAYGDPLVQQNHMRPVFPSLAALAWREPRRRPYWETELINALRIVD
CCCCCCEEEEECCCHHHCCCCHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
KGWSTPEEMRGSWAGAMGHSQWMPEVWLNVGIDYDGDGRVSPFGRPDDALGSTAKYLVRR
CCCCCHHHHCCCHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GNYHRGEHWGYEVEGPGGAVSGSRSYLAWSRSGVSRADGQPFPDSSASATMWVPVDGGPK
CCCCCCCCCCEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCE
FLIGPNFYAVKSYNPSMNYALAICHLGDRILGGSPFIHPFPGSERALTLAEVQEMQTRLT
EEECCCEEEEECCCCCCCCEEEEEHHCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SAGFDTGGTDGRVGNDTMKAIRDFQIKSGLRPADGYGGLKVLARLRQGG
HCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7476170; 7789526; 9205837; 9278503; 3553176; 9761817; 10570954; 10545329; 10684641 [H]