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The map label for this gene is srrA [H]

Identifier: 192290995

GI number: 192290995

Start: 2824640

End: 2825326

Strand: Reverse

Name: srrA [H]

Synonym: Rpal_2612

Alternate gene names: 192290995

Gene position: 2825326-2824640 (Counterclockwise)

Preceding gene: 192290996

Following gene: 192290994

Centisome position: 49.19

GC content: 61.43

Gene sequence:

>687_bases
ATGAACGAACTCATCCTCATCGCTGAAGACGAGCCGGAGATCGCCAAGATTCTCGACGCCTATCTGGTGCGGGAAGGATA
CCGCACCGTGAATGCGGCCGACGGGCAGACGGCGCTCGATCAGCACGCGATCCTGAAGCCGGATCTCGTTCTTCTCGATG
TGAAGATGCCGAAAATCGACGGCTGGGACGTCCTCGCAGAGTTGCGTCGTCGGGGTGAGACGCCGATCATCATGATCACG
GCGCTCGACCAGGATCTCGATCGTCTGCAGGGGCTCCGTCTTGGCGCGGACGACTATGTAGTCAAGCCCTTTAACCCGCT
CGAAGTCGTCGCCCGCGCCAAAGCAGTGCTGCGACGGTCGGGTTACGCCAATAATCGAACGCTTCTCCGCATCGAAAACC
TGGAGATCGACCTTGAGAGCCACCTCGCCAAGGTACATGGCGACGGCACCTCGATGTCATTGCAACTCACCCTGACGGAG
TTCCGACTTCTGGCTCACATGGCAAAAGCGCCGACGCGGGCTTTCGGCAGACACGAACTGATCGATGCCTGCCTACCGGG
TGGGGACGCGCTAGAGCGGACGGTCGACAGCCATGTCAGCAATCTGCGCCGCAAGCTCGACGAGGCGGGCGCGACCGGGA
TGATGTCGGTCGTGCGCGGGATCGGCTACCGGCTAACGGCCGCATGA

Upstream 100 bases:

>100_bases
GCCTACGACTGGTCATGGGACCATTGAACCGGGCGCACCGCGAGCCGGGGCCGATCCGGCAAGCCGTCTTGATCGGAACG
CCCCTGTTGGACGATGGACT

Downstream 100 bases:

>100_bases
GACGTCATCGCCTCAGCAGGCAGATCACACTGTCGATGAGCGTCGTCGTCGCCATCGCGGTGCTGATGGTGTTCGTCGGC
ACGTTCATCTTCTACAGCAT

Product: winged helix family two component transcriptional regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MNELILIAEDEPEIAKILDAYLVREGYRTVNAADGQTALDQHAILKPDLVLLDVKMPKIDGWDVLAELRRRGETPIIMIT
ALDQDLDRLQGLRLGADDYVVKPFNPLEVVARAKAVLRRSGYANNRTLLRIENLEIDLESHLAKVHGDGTSMSLQLTLTE
FRLLAHMAKAPTRAFGRHELIDACLPGGDALERTVDSHVSNLRRKLDEAGATGMMSVVRGIGYRLTAA

Sequences:

>Translated_228_residues
MNELILIAEDEPEIAKILDAYLVREGYRTVNAADGQTALDQHAILKPDLVLLDVKMPKIDGWDVLAELRRRGETPIIMIT
ALDQDLDRLQGLRLGADDYVVKPFNPLEVVARAKAVLRRSGYANNRTLLRIENLEIDLESHLAKVHGDGTSMSLQLTLTE
FRLLAHMAKAPTRAFGRHELIDACLPGGDALERTVDSHVSNLRRKLDEAGATGMMSVVRGIGYRLTAA
>Mature_228_residues
MNELILIAEDEPEIAKILDAYLVREGYRTVNAADGQTALDQHAILKPDLVLLDVKMPKIDGWDVLAELRRRGETPIIMIT
ALDQDLDRLQGLRLGADDYVVKPFNPLEVVARAKAVLRRSGYANNRTLLRIENLEIDLESHLAKVHGDGTSMSLQLTLTE
FRLLAHMAKAPTRAFGRHELIDACLPGGDALERTVDSHVSNLRRKLDEAGATGMMSVVRGIGYRLTAA

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=37.7777777777778, Blast_Score=143, Evalue=8e-36,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=35.4978354978355, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI1790860, Length=227, Percent_Identity=34.8017621145374, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI2367329, Length=237, Percent_Identity=39.2405063291139, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI87082012, Length=227, Percent_Identity=36.1233480176211, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=32.8888888888889, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=35.1111111111111, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1789809, Length=236, Percent_Identity=30.5084745762712, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=32.4444444444444, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1790863, Length=237, Percent_Identity=30.379746835443, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787229, Length=237, Percent_Identity=29.535864978903, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1788550, Length=102, Percent_Identity=40.1960784313725, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=32, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=31.063829787234, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787487, Length=104, Percent_Identity=39.4230769230769, Blast_Score=75, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25242; Mature: 25242

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELILIAEDEPEIAKILDAYLVREGYRTVNAADGQTALDQHAILKPDLVLLDVKMPKID
CCCEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCEEEEEEECCCCC
GWDVLAELRRRGETPIIMITALDQDLDRLQGLRLGADDYVVKPFNPLEVVARAKAVLRRS
CHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCEECCCCEEECCCCHHHHHHHHHHHHHHC
GYANNRTLLRIENLEIDLESHLAKVHGDGTSMSLQLTLTEFRLLAHMAKAPTRAFGRHEL
CCCCCCEEEEEECCEEEHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCHHHCCHHHH
IDACLPGGDALERTVDSHVSNLRRKLDEAGATGMMSVVRGIGYRLTAA
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECC
>Mature Secondary Structure
MNELILIAEDEPEIAKILDAYLVREGYRTVNAADGQTALDQHAILKPDLVLLDVKMPKID
CCCEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCEEEEEEECCCCC
GWDVLAELRRRGETPIIMITALDQDLDRLQGLRLGADDYVVKPFNPLEVVARAKAVLRRS
CHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCEECCCCEEECCCCHHHHHHHHHHHHHHC
GYANNRTLLRIENLEIDLESHLAKVHGDGTSMSLQLTLTEFRLLAHMAKAPTRAFGRHEL
CCCCCCEEEEEECCEEEHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCHHHCCHHHH
IDACLPGGDALERTVDSHVSNLRRKLDEAGATGMMSVVRGIGYRLTAA
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA