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The map label for this gene is lon1 [H]

Identifier: 192290663

GI number: 192290663

Start: 2459573

End: 2461594

Strand: Reverse

Name: lon1 [H]

Synonym: Rpal_2272

Alternate gene names: 192290663

Gene position: 2461594-2459573 (Counterclockwise)

Preceding gene: 192290671

Following gene: 192290662

Centisome position: 42.85

GC content: 68.4

Gene sequence:

>2022_bases
ATGTCGGACAGCGATTCGAGAAGCAAGACGGAAGAATACTGGCTGACAACCGTTGAGGAGGACCGCGCAGAGTCCGCGCC
GGCGCCGGCTGATCCGGCTGATCTCGACATCCTCGAGCTCCCCACCGCGGCCATCGACGCCATGCTGTGCCCGACGGAGC
GCGAGGCGGTCGACTGCGCCATCGTGCGCGCCGAGGTCGCGCTGCGCGGCCGGACGGATCGCCTGCAGGTCGACTTAGCC
AAGATGCGGACGCCAAAGGCCGATGCCATCGATCGCCTGCGGTGGTCGTCCGAGTGCCGCGCGATAGCCTCTGAACTCGA
AGCGATCGGCGGCGCCGCAGCTAACGAAGCCGCCCTCCTCTGGTGGATGCTGTCGTCATCGCCGCGAGACCCCGGGACGT
GCGCGGTCGCTGTCGACCTGGCGAAGATCGCCCCGCGGATCCGGTGGCCGGAGAAGGCCGACGAGATCAAGGCGCGACTC
AGTGTCTGGAGGCGCGCCTACGCCGGCAAGTACGTGGACGACAACCGCGACCTTTTCGCCATCGCCGAGGAAGAGATTAT
GAGATCGAAGAATCCGACGATGCGGAAGAACTACGGGTCAGTTCCGCTCTCGGTGCTACTCTGCGACGACGAGAAGTCTG
CCGTCGCGCTGGTCGTCAAATACACGCGGAAGATCTCGGGACCACCGTACGTCGATGTTCCTGACTTCCTGGTGAGCACG
CCGCCGAAGGACGGGGATCGGCGCATCTGGTGGCGCACTGAGTGCCGCCGGATGTCGTCCCGGCTATCCGAGCGCGCCGA
CGATGGCCTCGCCGGAGCGACCGCGCTCGCGTGGCGGATGCTCGCCGCCGACCCGGCCGATACGCGGACATTTTTGCCGG
TCCTGCCGGCTCTGAGGCATCTCGCGGACCGGTGCACATGGTCGGATGACCAGAAGTCCAAGCTGACGGCGCGCCTAGCT
ATATGGACCCTGGCAGCCTCCGGCGAGTACGGCCGCGATCCGCGCGACATGTTCGTGATCGCCGCGCAGCAGTCCGAGTC
CCTGCACGCCGACGAGGGTCATGACGATCCGGCGGTCGAAGAGCTCTGCAATCGCGCCCATGCAGCGCTGAGTCGCCGGA
AAGTGCGCCTCCCGTCGTCGCCGGCCAGGCCGAGGCCGGCGCCGGATGGCCCTGCTGTCGTCGTGATGACCGAGGCGCCG
GTCGAGAAGAAGCACATGCCGGACGTCTGGAAGCGCCTGGAAGGCGCCGACGTGCCGCTGGTAGTCTGCCGCGACGCTGC
CGTCGTCCGGCAGGCACTGGAGGCCGAGTACCCGCACGCGCGCGCTGCCGTGGCGATGCTGACGCAGGATCTGCGGGACG
GCGAGCCGGTCCGGATGCGGCCGACCCTCCTCGTTGGTCCCCCAGGCTCCGGCAAGTCGCGCCTGGTGCGCCGGATCGGG
GAACTACTCGGCGTCTATGTTTACAGGCTCGACGCAACCGCCAGCGCCGACGGATTTTTCGCCGGCACCAACCGCGCATG
GCACTCGTCGGCCCCCTCCGTGCCCGCGCGCGCGATCGCGGCGGCGATGCGCGCAAACCCAATCGTGATGATTGACGAGA
TCGAGAAGGCCGCCGAGAGCACTATGAACGGAAACCTATGGTCGGCGATGGCGCCTCTTCTGGAGCGCGAGACCTCGCGT
AGCTACAGAGACTGCGGCCTCGACGCCCAGCTCGATCTCTCGCACGTCAACCATGTCGCCACCGCGAACACGACAGAGCG
GTTGCCGTCGTTCCTGCGCGACCGCTTCAGGCTGATCCGCGTCCCGTCCCCCACGCTGGCGCACCTGCCGGCGTTGGCGG
CGCTGGTCCTGCAGGACATCGCGCGGGACGACGACGCGCGCGCCGGGGCACCACCACTGGCGCCCGACGAGCTCGACGTG
ATCGGCCGGGCGTGGGCCCGGGAGAAATTCTCGATGCGCAAGCTGGCGCGCCTGGTCGAGGCGACCCTCGAGGCGCGCGA
CGCCTGCGCGCCGCGGCACTGA

Upstream 100 bases:

>100_bases
TTTCGAATCCTTAACCATGCAGTTCCCGAGTCCTTGAAAAACGTGGTCTCGTTGTCATACATTTCCGGTCAATGATGGCA
ACGTCGTACGGACAAATAGC

Downstream 100 bases:

>100_bases
CGGAGGCCGGCATGGACGAGGTGATGGCGAAGCTGCTCGACGACGATTTCGACGGCTATCTGCGCAACGTGCCGCCTTCC
GAGGTCGAGATGCAGATCGC

Product: ATPase AAA

Products: NA

Alternate protein names: ATP-dependent protease La 1 [H]

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MSDSDSRSKTEEYWLTTVEEDRAESAPAPADPADLDILELPTAAIDAMLCPTEREAVDCAIVRAEVALRGRTDRLQVDLA
KMRTPKADAIDRLRWSSECRAIASELEAIGGAAANEAALLWWMLSSSPRDPGTCAVAVDLAKIAPRIRWPEKADEIKARL
SVWRRAYAGKYVDDNRDLFAIAEEEIMRSKNPTMRKNYGSVPLSVLLCDDEKSAVALVVKYTRKISGPPYVDVPDFLVST
PPKDGDRRIWWRTECRRMSSRLSERADDGLAGATALAWRMLAADPADTRTFLPVLPALRHLADRCTWSDDQKSKLTARLA
IWTLAASGEYGRDPRDMFVIAAQQSESLHADEGHDDPAVEELCNRAHAALSRRKVRLPSSPARPRPAPDGPAVVVMTEAP
VEKKHMPDVWKRLEGADVPLVVCRDAAVVRQALEAEYPHARAAVAMLTQDLRDGEPVRMRPTLLVGPPGSGKSRLVRRIG
ELLGVYVYRLDATASADGFFAGTNRAWHSSAPSVPARAIAAAMRANPIVMIDEIEKAAESTMNGNLWSAMAPLLERETSR
SYRDCGLDAQLDLSHVNHVATANTTERLPSFLRDRFRLIRVPSPTLAHLPALAALVLQDIARDDDARAGAPPLAPDELDV
IGRAWAREKFSMRKLARLVEATLEARDACAPRH

Sequences:

>Translated_673_residues
MSDSDSRSKTEEYWLTTVEEDRAESAPAPADPADLDILELPTAAIDAMLCPTEREAVDCAIVRAEVALRGRTDRLQVDLA
KMRTPKADAIDRLRWSSECRAIASELEAIGGAAANEAALLWWMLSSSPRDPGTCAVAVDLAKIAPRIRWPEKADEIKARL
SVWRRAYAGKYVDDNRDLFAIAEEEIMRSKNPTMRKNYGSVPLSVLLCDDEKSAVALVVKYTRKISGPPYVDVPDFLVST
PPKDGDRRIWWRTECRRMSSRLSERADDGLAGATALAWRMLAADPADTRTFLPVLPALRHLADRCTWSDDQKSKLTARLA
IWTLAASGEYGRDPRDMFVIAAQQSESLHADEGHDDPAVEELCNRAHAALSRRKVRLPSSPARPRPAPDGPAVVVMTEAP
VEKKHMPDVWKRLEGADVPLVVCRDAAVVRQALEAEYPHARAAVAMLTQDLRDGEPVRMRPTLLVGPPGSGKSRLVRRIG
ELLGVYVYRLDATASADGFFAGTNRAWHSSAPSVPARAIAAAMRANPIVMIDEIEKAAESTMNGNLWSAMAPLLERETSR
SYRDCGLDAQLDLSHVNHVATANTTERLPSFLRDRFRLIRVPSPTLAHLPALAALVLQDIARDDDARAGAPPLAPDELDV
IGRAWAREKFSMRKLARLVEATLEARDACAPRH
>Mature_672_residues
SDSDSRSKTEEYWLTTVEEDRAESAPAPADPADLDILELPTAAIDAMLCPTEREAVDCAIVRAEVALRGRTDRLQVDLAK
MRTPKADAIDRLRWSSECRAIASELEAIGGAAANEAALLWWMLSSSPRDPGTCAVAVDLAKIAPRIRWPEKADEIKARLS
VWRRAYAGKYVDDNRDLFAIAEEEIMRSKNPTMRKNYGSVPLSVLLCDDEKSAVALVVKYTRKISGPPYVDVPDFLVSTP
PKDGDRRIWWRTECRRMSSRLSERADDGLAGATALAWRMLAADPADTRTFLPVLPALRHLADRCTWSDDQKSKLTARLAI
WTLAASGEYGRDPRDMFVIAAQQSESLHADEGHDDPAVEELCNRAHAALSRRKVRLPSSPARPRPAPDGPAVVVMTEAPV
EKKHMPDVWKRLEGADVPLVVCRDAAVVRQALEAEYPHARAAVAMLTQDLRDGEPVRMRPTLLVGPPGSGKSRLVRRIGE
LLGVYVYRLDATASADGFFAGTNRAWHSSAPSVPARAIAAAMRANPIVMIDEIEKAAESTMNGNLWSAMAPLLERETSRS
YRDCGLDAQLDLSHVNHVATANTTERLPSFLRDRFRLIRVPSPTLAHLPALAALVLQDIARDDDARAGAPPLAPDELDVI
GRAWAREKFSMRKLARLVEATLEARDACAPRH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=205, Percent_Identity=29.7560975609756, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI31377667, Length=143, Percent_Identity=32.1678321678322, Blast_Score=81, Evalue=4e-15,
Organism=Escherichia coli, GI1786643, Length=143, Percent_Identity=33.5664335664336, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17505831, Length=137, Percent_Identity=31.3868613138686, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17556486, Length=144, Percent_Identity=29.1666666666667, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319449, Length=139, Percent_Identity=31.6546762589928, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666867, Length=200, Percent_Identity=28, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221513036, Length=200, Percent_Identity=28, Blast_Score=77, Evalue=5e-14,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 74154; Mature: 74023

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSDSRSKTEEYWLTTVEEDRAESAPAPADPADLDILELPTAAIDAMLCPTEREAVDCA
CCCCCCCCCCHHHHEEECHHHHHCCCCCCCCCCCCCHHHCCHHHHHHHCCCCCHHHHHHH
IVRAEVALRGRTDRLQVDLAKMRTPKADAIDRLRWSSECRAIASELEAIGGAAANEAALL
HHHHHHHHCCCCCHHEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
WWMLSSSPRDPGTCAVAVDLAKIAPRIRWPEKADEIKARLSVWRRAYAGKYVDDNRDLFA
EEEECCCCCCCCCEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
IAEEEIMRSKNPTMRKNYGSVPLSVLLCDDEKSAVALVVKYTRKISGPPYVDVPDFLVST
EEHHHHHHCCCCCHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCC
PPKDGDRRIWWRTECRRMSSRLSERADDGLAGATALAWRMLAADPADTRTFLPVLPALRH
CCCCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LADRCTWSDDQKSKLTARLAIWTLAASGEYGRDPRDMFVIAAQQSESLHADEGHDDPAVE
HHHHCCCCCCHHHHHHHHEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHH
ELCNRAHAALSRRKVRLPSSPARPRPAPDGPAVVVMTEAPVEKKHMPDVWKRLEGADVPL
HHHHHHHHHHHHCCEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCE
VVCRDAAVVRQALEAEYPHARAAVAMLTQDLRDGEPVRMRPTLLVGPPGSGKSRLVRRIG
EEECCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCEEEECCCCCCHHHHHHHHH
ELLGVYVYRLDATASADGFFAGTNRAWHSSAPSVPARAIAAAMRANPIVMIDEIEKAAES
HHHHHHHHEEECCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHH
TMNGNLWSAMAPLLERETSRSYRDCGLDAQLDLSHVNHVATANTTERLPSFLRDRFRLIR
HCCCCHHHHHHHHHHHHHCCHHHHCCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHEEEE
VPSPTLAHLPALAALVLQDIARDDDARAGAPPLAPDELDVIGRAWAREKFSMRKLARLVE
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ATLEARDACAPRH
HHHHHHHCCCCCC
>Mature Secondary Structure 
SDSDSRSKTEEYWLTTVEEDRAESAPAPADPADLDILELPTAAIDAMLCPTEREAVDCA
CCCCCCCCCHHHHEEECHHHHHCCCCCCCCCCCCCHHHCCHHHHHHHCCCCCHHHHHHH
IVRAEVALRGRTDRLQVDLAKMRTPKADAIDRLRWSSECRAIASELEAIGGAAANEAALL
HHHHHHHHCCCCCHHEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
WWMLSSSPRDPGTCAVAVDLAKIAPRIRWPEKADEIKARLSVWRRAYAGKYVDDNRDLFA
EEEECCCCCCCCCEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
IAEEEIMRSKNPTMRKNYGSVPLSVLLCDDEKSAVALVVKYTRKISGPPYVDVPDFLVST
EEHHHHHHCCCCCHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCC
PPKDGDRRIWWRTECRRMSSRLSERADDGLAGATALAWRMLAADPADTRTFLPVLPALRH
CCCCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LADRCTWSDDQKSKLTARLAIWTLAASGEYGRDPRDMFVIAAQQSESLHADEGHDDPAVE
HHHHCCCCCCHHHHHHHHEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHH
ELCNRAHAALSRRKVRLPSSPARPRPAPDGPAVVVMTEAPVEKKHMPDVWKRLEGADVPL
HHHHHHHHHHHHCCEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCE
VVCRDAAVVRQALEAEYPHARAAVAMLTQDLRDGEPVRMRPTLLVGPPGSGKSRLVRRIG
EEECCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCEEEECCCCCCHHHHHHHHH
ELLGVYVYRLDATASADGFFAGTNRAWHSSAPSVPARAIAAAMRANPIVMIDEIEKAAES
HHHHHHHHEEECCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHH
TMNGNLWSAMAPLLERETSRSYRDCGLDAQLDLSHVNHVATANTTERLPSFLRDRFRLIR
HCCCCHHHHHHHHHHHHHCCHHHHCCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHEEEE
VPSPTLAHLPALAALVLQDIARDDDARAGAPPLAPDELDVIGRAWAREKFSMRKLARLVE
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ATLEARDACAPRH
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA