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The map label for this gene is atpA2 [H]

Identifier: 192289475

GI number: 192289475

Start: 1120192

End: 1121745

Strand: Reverse

Name: atpA2 [H]

Synonym: Rpal_1050

Alternate gene names: 192289475

Gene position: 1121745-1120192 (Counterclockwise)

Preceding gene: 192289476

Following gene: 192289474

Centisome position: 19.53

GC content: 65.19

Gene sequence:

>1554_bases
ATGACGACAGATCCCGATAGCCCGGCCGACGCCTGGCTCAAACGCGCCAGCGCCAGGATCGACGCCACCACGCTCGGGCC
GCAGACCGAGCAGATCGGCGAGGTGGAAGCGGTCGGAGACGGCATCGCGCTCGTCGCGGGTCTGCCCAATGTCCGGCTCG
ATGAGTTGCTGCGTTTCGATAAGGGACAGTTCGGCTTCGCCCAGGTGCTTGAGCGCGATCATGTCGGCTGTGTGCTGCTT
GACGACGTGAATGCGATCGAGGCCGGTGACAGGGTGCGTGGCACGGGCGATGTCGTGCGCGTGCCGGTGGGACCGGCACT
GCTCGGCCGTATCGTCGACCCGCTCGGCCGCCCGCTCGACGGGAAAGGCCCGGTTGCCACCGACATGCTGGAGCCGATCG
ACGCCCCGGCACCCGCCATCGTCGATCGCGATCTGGTGACCCAGCCCGTTCAGACCGGCCTCGTGGTGGTCGATACCCTG
TTTGCTCTCGGCCGCGGTCAGCGCGAACTGATCATCGGCGACCGCGCCATCGGAAAGACCACGATCGCAATCGACACCAT
CGTCAATCAAAAAACGAGCGACATAATCTGCGTGTATGTCGCAGTCGGCCAGAAGACCGCGAGCGTCCGCCGCGCCATCG
ATGCGATCATGGCCTTTGGTGCGCCCGAGCGCTGCATCATCGTCGTGGCGGGGTCGTCGAGTTCACCCGGATTGCAGTGG
ATCGCACCTTTCGCGGCATTCAGCATGGCCGAATATTTTCGCGATCGCGGCCAACATGCCCTGATAGTGGTCGACGACCT
CAGCAAGCACGCGGCGAGCCACCGCGAGATCTCGCTGCTGACCCGCCAGTCGCCTGGTCGCGAGGCCTATCCGGGGGATA
TCTTCTATGTTCATGCGCGGCTGCTCGAACGGGCCGCCAAACTGTCCAAGGAAAAAGGCGGCGGCTCGCTGACGGCGCTA
CCGATCGCCGAGACCGACGCCGGCAACCTCAGCGCCTATATTCCGACCAATCTGATTTCAATCACCGACGGTCAGATCGT
CCTCGATGCCAGGCTGTTCCATGAAGGGCAGAAGCCGGCGGTCGACGTCGGCACCAGCGTCAGCCGGGTCGGCGGCAAGA
CCCAGGCACAGGCGCTCCGGGAGGCGGCGGAGACGGTGCGGCTCGATTACGCTCAGTTCCTCGAACTGGAGACTTTCACC
CGGTTTGGTGGAATGCCGGACAGCCGGGTTCGCGATCAACTGAGCCGGGGCGCGCGAATTCGCGCGATCCTCGGCCAACC
GCCGCACCTGCCCCTTCGGCTTGCCGACGAGGTGGCCCTGGTCCTGGCTGTGCAATCCGGGCTTTTGGATCCGTTGCCGT
TGCCGTCAGTGCCTGCGTTCCGGCATGGCCTGCGCGAGACCCTTGACCGCCACGTCCCGGGCGTCGTCCGTCGGATCCAA
GATACCGGCGCGCTCGACGAGCCCGGAAAGCAGGCGCTCCGCGAAACCCTCCGAAAATACCTTCAGACGCTGGCCACGGT
CGCGGATCCGTCGAAAGCACCGAGGCAATCATGA

Upstream 100 bases:

>100_bases
GATCCCGCGCTCATCGCCGGCCTGGAACTGCATGGCCCTCACCTCGTCATCACCAACAGCTGGCGCGCCGACCTTGCCAA
CACCCTTGCGGACCTCGCGC

Downstream 100 bases:

>100_bases
CCGATCGTCTTTCGGAGATTGGCGCGCGGATCGACGGGATCGGCCAGCTCGGCGCGGTCGTCAATGCCATGCGGGGCATC
GCCGCGGCACGCGCCCAGCA

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha 2; F-ATPase subunit alpha 2 [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MTTDPDSPADAWLKRASARIDATTLGPQTEQIGEVEAVGDGIALVAGLPNVRLDELLRFDKGQFGFAQVLERDHVGCVLL
DDVNAIEAGDRVRGTGDVVRVPVGPALLGRIVDPLGRPLDGKGPVATDMLEPIDAPAPAIVDRDLVTQPVQTGLVVVDTL
FALGRGQRELIIGDRAIGKTTIAIDTIVNQKTSDIICVYVAVGQKTASVRRAIDAIMAFGAPERCIIVVAGSSSSPGLQW
IAPFAAFSMAEYFRDRGQHALIVVDDLSKHAASHREISLLTRQSPGREAYPGDIFYVHARLLERAAKLSKEKGGGSLTAL
PIAETDAGNLSAYIPTNLISITDGQIVLDARLFHEGQKPAVDVGTSVSRVGGKTQAQALREAAETVRLDYAQFLELETFT
RFGGMPDSRVRDQLSRGARIRAILGQPPHLPLRLADEVALVLAVQSGLLDPLPLPSVPAFRHGLRETLDRHVPGVVRRIQ
DTGALDEPGKQALRETLRKYLQTLATVADPSKAPRQS

Sequences:

>Translated_517_residues
MTTDPDSPADAWLKRASARIDATTLGPQTEQIGEVEAVGDGIALVAGLPNVRLDELLRFDKGQFGFAQVLERDHVGCVLL
DDVNAIEAGDRVRGTGDVVRVPVGPALLGRIVDPLGRPLDGKGPVATDMLEPIDAPAPAIVDRDLVTQPVQTGLVVVDTL
FALGRGQRELIIGDRAIGKTTIAIDTIVNQKTSDIICVYVAVGQKTASVRRAIDAIMAFGAPERCIIVVAGSSSSPGLQW
IAPFAAFSMAEYFRDRGQHALIVVDDLSKHAASHREISLLTRQSPGREAYPGDIFYVHARLLERAAKLSKEKGGGSLTAL
PIAETDAGNLSAYIPTNLISITDGQIVLDARLFHEGQKPAVDVGTSVSRVGGKTQAQALREAAETVRLDYAQFLELETFT
RFGGMPDSRVRDQLSRGARIRAILGQPPHLPLRLADEVALVLAVQSGLLDPLPLPSVPAFRHGLRETLDRHVPGVVRRIQ
DTGALDEPGKQALRETLRKYLQTLATVADPSKAPRQS
>Mature_516_residues
TTDPDSPADAWLKRASARIDATTLGPQTEQIGEVEAVGDGIALVAGLPNVRLDELLRFDKGQFGFAQVLERDHVGCVLLD
DVNAIEAGDRVRGTGDVVRVPVGPALLGRIVDPLGRPLDGKGPVATDMLEPIDAPAPAIVDRDLVTQPVQTGLVVVDTLF
ALGRGQRELIIGDRAIGKTTIAIDTIVNQKTSDIICVYVAVGQKTASVRRAIDAIMAFGAPERCIIVVAGSSSSPGLQWI
APFAAFSMAEYFRDRGQHALIVVDDLSKHAASHREISLLTRQSPGREAYPGDIFYVHARLLERAAKLSKEKGGGSLTALP
IAETDAGNLSAYIPTNLISITDGQIVLDARLFHEGQKPAVDVGTSVSRVGGKTQAQALREAAETVRLDYAQFLELETFTR
FGGMPDSRVRDQLSRGARIRAILGQPPHLPLRLADEVALVLAVQSGLLDPLPLPSVPAFRHGLRETLDRHVPGVVRRIQD
TGALDEPGKQALRETLRKYLQTLATVADPSKAPRQS

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=480, Percent_Identity=45.625, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI4757810, Length=480, Percent_Identity=45.625, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI32189394, Length=459, Percent_Identity=25.7080610021786, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI19913428, Length=291, Percent_Identity=26.8041237113402, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI19913426, Length=295, Percent_Identity=27.4576271186441, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI1790172, Length=497, Percent_Identity=42.6559356136821, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1788251, Length=297, Percent_Identity=30.976430976431, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790170, Length=369, Percent_Identity=24.9322493224932, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71988063, Length=494, Percent_Identity=44.5344129554656, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI71988080, Length=494, Percent_Identity=44.5344129554656, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71988074, Length=494, Percent_Identity=41.0931174089069, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI25144756, Length=437, Percent_Identity=27.0022883295195, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17510931, Length=324, Percent_Identity=27.1604938271605, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17570191, Length=324, Percent_Identity=28.0864197530864, Blast_Score=104, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6319370, Length=494, Percent_Identity=46.1538461538462, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322581, Length=407, Percent_Identity=26.7813267813268, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6319603, Length=298, Percent_Identity=28.5234899328859, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24658560, Length=483, Percent_Identity=45.1345755693582, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24638766, Length=397, Percent_Identity=26.7002518891688, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281361666, Length=337, Percent_Identity=27.299703264095, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646341, Length=337, Percent_Identity=27.299703264095, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17136796, Length=337, Percent_Identity=27.299703264095, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28574560, Length=373, Percent_Identity=26.5415549597855, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 55418; Mature: 55287

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDPDSPADAWLKRASARIDATTLGPQTEQIGEVEAVGDGIALVAGLPNVRLDELLRFD
CCCCCCCHHHHHHHHHHCCCCEEECCCCHHHHCCHHHCCCCEEEEECCCCCCHHHHHHHC
KGQFGFAQVLERDHVGCVLLDDVNAIEAGDRVRGTGDVVRVPVGPALLGRIVDPLGRPLD
CCCCHHHHHHHCCCCCEEEECCCCHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCC
GKGPVATDMLEPIDAPAPAIVDRDLVTQPVQTGLVVVDTLFALGRGQRELIIGDRAIGKT
CCCCCHHHHHCCCCCCCCHHHCHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCCE
TIAIDTIVNQKTSDIICVYVAVGQKTASVRRAIDAIMAFGAPERCIIVVAGSSSSPGLQW
EEEEEHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHH
IAPFAAFSMAEYFRDRGQHALIVVDDLSKHAASHREISLLTRQSPGREAYPGDIFYVHAR
HHHHHHHHHHHHHHHCCCEEEEEEECCHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHH
LLERAAKLSKEKGGGSLTALPIAETDAGNLSAYIPTNLISITDGQIVLDARLFHEGQKPA
HHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEECCCCEEEECCCCEEEEEHHHCCCCCCC
VDVGTSVSRVGGKTQAQALREAAETVRLDYAQFLELETFTRFGGMPDSRVRDQLSRGARI
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEE
RAILGQPPHLPLRLADEVALVLAVQSGLLDPLPLPSVPAFRHGLRETLDRHVPGVVRRIQ
EEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DTGALDEPGKQALRETLRKYLQTLATVADPSKAPRQS
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TTDPDSPADAWLKRASARIDATTLGPQTEQIGEVEAVGDGIALVAGLPNVRLDELLRFD
CCCCCCHHHHHHHHHHCCCCEEECCCCHHHHCCHHHCCCCEEEEECCCCCCHHHHHHHC
KGQFGFAQVLERDHVGCVLLDDVNAIEAGDRVRGTGDVVRVPVGPALLGRIVDPLGRPLD
CCCCHHHHHHHCCCCCEEEECCCCHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCC
GKGPVATDMLEPIDAPAPAIVDRDLVTQPVQTGLVVVDTLFALGRGQRELIIGDRAIGKT
CCCCCHHHHHCCCCCCCCHHHCHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCCE
TIAIDTIVNQKTSDIICVYVAVGQKTASVRRAIDAIMAFGAPERCIIVVAGSSSSPGLQW
EEEEEHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHH
IAPFAAFSMAEYFRDRGQHALIVVDDLSKHAASHREISLLTRQSPGREAYPGDIFYVHAR
HHHHHHHHHHHHHHHCCCEEEEEEECCHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHH
LLERAAKLSKEKGGGSLTALPIAETDAGNLSAYIPTNLISITDGQIVLDARLFHEGQKPA
HHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEECCCCEEEECCCCEEEEEHHHCCCCCCC
VDVGTSVSRVGGKTQAQALREAAETVRLDYAQFLELETFTRFGGMPDSRVRDQLSRGARI
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEE
RAILGQPPHLPLRLADEVALVLAVQSGLLDPLPLPSVPAFRHGLRETLDRHVPGVVRRIQ
EEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DTGALDEPGKQALRETLRKYLQTLATVADPSKAPRQS
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA