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The map label for this gene is hisN [H]

Identifier: 192289400

GI number: 192289400

Start: 1039357

End: 1040139

Strand: Reverse

Name: hisN [H]

Synonym: Rpal_0973

Alternate gene names: 192289400

Gene position: 1040139-1039357 (Counterclockwise)

Preceding gene: 192289401

Following gene: 192289398

Centisome position: 18.11

GC content: 64.88

Gene sequence:

>783_bases
GTGACGGTCATCGATTTCGCCGCCTTTATCGGCCGCCTTGCGACCTCGTCGGGCGACACCATCCTGCCGTTCTTCCGCAC
ATCGCTCACGATCGACAACAAGCAGCCCGGCCGTGATTTCGACCCAGTGACCGAGGCCGATCGCGCCGCCGAGGCGGTGA
TGCGCCGGCTGATCAAGGCGAGCTTTCCCCAGCACGGCATCATCGGTGAAGAGTTCGGCAACGAGCGCGAGGACGCCGAT
TACGTCTGGGTGCTGGATCCGATCGACGGCACCAAATCCTTCATCGCCGGCTTTCCAGTGTGGGGTACGCTGATCGCGCT
GCTGCACAAGGGCGCGCCGGTGTTCGGCATGATGCATCAGCCCTTCATTGGCGAACGCTTCTCCGGCGACAATGGTTCGG
CGACGTACAAAGGCCCGTCCGGCGAGCGCAAGCTCGGCGTGCGCCGCTGCGCCGCCATCAAGGACGCCACGCTGTTCACC
ACCTCGCCGCTGCTGATGAATGACGGTGATCGCGGCATCTTCGAGAAGGTGCAGGCCGAGGCGCGGCTGACCCGCTACGG
CGGCGACTGCTATTCCTATTGTATGCTGGCCGCCGGTCAGCTCGATCTGGTGATCGAGACCGAGCTGAAGCCCTACGACG
TCGCGGCGCTGATCCCGATCATCACCGGCGCCGGCGGCATCATCACCACCTGGGACGGCAAGCCAGCGCAGAATGGCGGC
CGCATCGTCGCAGCCGGCGACAAGCGCGTGCACGAAGCCGCGATGAAGATCCTCAACGCCTGA

Upstream 100 bases:

>100_bases
AGTCACCCGCCATAATAAAGGAGCAAGGGTTCGGCCGCTCCCGTCTAAGATGATGGTGCGGTTCCATGTCCCGCCCGCAA
TGCTCGCAAAGGATCGCTCC

Downstream 100 bases:

>100_bases
ACCACGCCTTAGCCGTCATCGCCGCAGCCCTTCGATCAGGGCCCGCAGCACAGCAAGGCAACTCTCGCGATCGCCGCCGT
GCGCGATCTCCAGCGCGGCA

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTVIDFAAFIGRLATSSGDTILPFFRTSLTIDNKQPGRDFDPVTEADRAAEAVMRRLIKASFPQHGIIGEEFGNEREDAD
YVWVLDPIDGTKSFIAGFPVWGTLIALLHKGAPVFGMMHQPFIGERFSGDNGSATYKGPSGERKLGVRRCAAIKDATLFT
TSPLLMNDGDRGIFEKVQAEARLTRYGGDCYSYCMLAAGQLDLVIETELKPYDVAALIPIITGAGGIITTWDGKPAQNGG
RIVAAGDKRVHEAAMKILNA

Sequences:

>Translated_260_residues
MTVIDFAAFIGRLATSSGDTILPFFRTSLTIDNKQPGRDFDPVTEADRAAEAVMRRLIKASFPQHGIIGEEFGNEREDAD
YVWVLDPIDGTKSFIAGFPVWGTLIALLHKGAPVFGMMHQPFIGERFSGDNGSATYKGPSGERKLGVRRCAAIKDATLFT
TSPLLMNDGDRGIFEKVQAEARLTRYGGDCYSYCMLAAGQLDLVIETELKPYDVAALIPIITGAGGIITTWDGKPAQNGG
RIVAAGDKRVHEAAMKILNA
>Mature_259_residues
TVIDFAAFIGRLATSSGDTILPFFRTSLTIDNKQPGRDFDPVTEADRAAEAVMRRLIKASFPQHGIIGEEFGNEREDADY
VWVLDPIDGTKSFIAGFPVWGTLIALLHKGAPVFGMMHQPFIGERFSGDNGSATYKGPSGERKLGVRRCAAIKDATLFTT
SPLLMNDGDRGIFEKVQAEARLTRYGGDCYSYCMLAAGQLDLVIETELKPYDVAALIPIITGAGGIITTWDGKPAQNGGR
IVAAGDKRVHEAAMKILNA

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=260, Percent_Identity=24.2307692307692, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI221625487, Length=260, Percent_Identity=24.2307692307692, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1788882, Length=246, Percent_Identity=31.7073170731707, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790659, Length=208, Percent_Identity=27.4038461538462, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193202570, Length=216, Percent_Identity=26.8518518518519, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320493, Length=215, Percent_Identity=26.5116279069767, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24664918, Length=238, Percent_Identity=27.3109243697479, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21357957, Length=238, Percent_Identity=27.3109243697479, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24664922, Length=205, Percent_Identity=31.7073170731707, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357329, Length=201, Percent_Identity=28.8557213930348, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24664926, Length=197, Percent_Identity=27.9187817258883, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28131; Mature: 28000

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIDFAAFIGRLATSSGDTILPFFRTSLTIDNKQPGRDFDPVTEADRAAEAVMRRLIKA
CCHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SFPQHGIIGEEFGNEREDADYVWVLDPIDGTKSFIAGFPVWGTLIALLHKGAPVFGMMHQ
CCCCCCCCHHHHCCCCCCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHCCCCEECCCCC
PFIGERFSGDNGSATYKGPSGERKLGVRRCAAIKDATLFTTSPLLMNDGDRGIFEKVQAE
CCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCEEEECCCCEECCCCCHHHHHHHHH
ARLTRYGGDCYSYCMLAAGQLDLVIETELKPYDVAALIPIITGAGGIITTWDGKPAQNGG
HHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCC
RIVAAGDKRVHEAAMKILNA
EEEEECCHHHHHHHHHHHCC
>Mature Secondary Structure 
TVIDFAAFIGRLATSSGDTILPFFRTSLTIDNKQPGRDFDPVTEADRAAEAVMRRLIKA
CHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SFPQHGIIGEEFGNEREDADYVWVLDPIDGTKSFIAGFPVWGTLIALLHKGAPVFGMMHQ
CCCCCCCCHHHHCCCCCCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHCCCCEECCCCC
PFIGERFSGDNGSATYKGPSGERKLGVRRCAAIKDATLFTTSPLLMNDGDRGIFEKVQAE
CCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCEEEECCCCEECCCCCHHHHHHHHH
ARLTRYGGDCYSYCMLAAGQLDLVIETELKPYDVAALIPIITGAGGIITTWDGKPAQNGG
HHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCC
RIVAAGDKRVHEAAMKILNA
EEEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]