Click here to switch to the map view.

The map label for this gene is ldc [H]

Identifier: 192289366

GI number: 192289366

Start: 996477

End: 997619

Strand: Reverse

Name: ldc [H]

Synonym: Rpal_0938

Alternate gene names: 192289366

Gene position: 997619-996477 (Counterclockwise)

Preceding gene: 192289367

Following gene: 192289365

Centisome position: 17.37

GC content: 65.0

Gene sequence:

>1143_bases
ATGACCGAACGTATCCGTGAATTCCTGCGCGACCGCCGCGCCAAGGGTCTGGACGTCGAGCCGTGCCTGGTCGTTGACCT
CGAAGTGGTCCGCGACAACTTCATGCATTTCGCCAAGGCGCTGCCGGACAGCCGCGTGTTCTATGCGATCAAGGCCAACC
CGGCGCCGGAAGTGCTGTCGCTGCTGGCCTCGCTCGGCTCGTGCTTCGACTGCGCCTCGGTGCAGGAAATCCAGATGGCG
CTGGCCGCGGGAGCGACCCCGGACCGCATCTCGTTTGGTAACACCATCAAGAAGGAGCGCGACATCGCGCGCGCCTACGA
GCTCGGCATCCGCCTGTTCTCGGTCGACTGCACTCCCGAGGTGGAGAAGGTCGCGCGTGCGGCTCCCGGCTCCAAGGTGT
TCTGCCGCATCCTGTACGATTGCGCCGGCGCCGAGTGGCCGCTGTCGCGCAAGTTCGGCTGCGATCCGGAGATGGCGGTG
GACGTGCTCGACAACGCCAAGCGTCTCGGCCTGGAAGCCTATGGCATTTCGTTCCATGTCGGCTCGCAGCAGCGCAAGGT
GAAGGCGTGGGACCGTGCGCTGGCGATGGCCGCGCAGGTGTTCCGCGACTGCGCCGAACGCGGCATCTCGCTGTCGATGG
TCAACATGGGTGGCGGCTTCCCGACCAAGTATCTGAAGGAAGTCCCGCCGGTGGTGCAGTACGGCCGCTCGATCTTCCGG
GCGCTGCGCAAGCACTTCGGCAACCAGATCCCGGAGACCATCATCGAGCCGGGCCGCGGCATGGTCGGAAACGCCGGCGT
GATCGAGACCGAAGTCGTTCTGATCTCGAAGAAGAGCGACGAGGACGACGTGCGCTGGGTCTATCTCGACATCGGCAAGT
TCGGCGGTCTCGCCGAGACGATGGACGAGTCGATCCGCTACGCGATCAAGTCGCGTCATGACGGCGCCGAGATGACGCCC
TGCGTGCTCGCCGGCCCGACCTGCGATTCGGCCGACGTGCTGTACGAGAAGATGCCGTATCCGCTGCCGGTGACGCTCGA
GATTGGCGACAAGCTGCTGATCGAAGGCACCGGCGCCTATACGTCGACTTACTCGTCCGTGGCGTTCAACGGCTTCCCGC
CGCTGGCGACCTACCACATCTGA

Upstream 100 bases:

>100_bases
GCTGATCGCTCGTCGCGCCTCCATCGCGCGACGGCGCTGAAGCCGTCGGATCAGCGCCATCGTTGGTAAGCGCCCGTCGC
TGGGCGCGTGGGAGAGTGCC

Downstream 100 bases:

>100_bases
GGGTCTCCCTCTGGATCCTCCGCCACGCGCGGAGACGTCAATAAAGTCGAGGCCGGCTTGCCGGCCTCTCCCTGTCACAT
GTGAAGTTGCTGACAACACG

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTERIREFLRDRRAKGLDVEPCLVVDLEVVRDNFMHFAKALPDSRVFYAIKANPAPEVLSLLASLGSCFDCASVQEIQMA
LAAGATPDRISFGNTIKKERDIARAYELGIRLFSVDCTPEVEKVARAAPGSKVFCRILYDCAGAEWPLSRKFGCDPEMAV
DVLDNAKRLGLEAYGISFHVGSQQRKVKAWDRALAMAAQVFRDCAERGISLSMVNMGGGFPTKYLKEVPPVVQYGRSIFR
ALRKHFGNQIPETIIEPGRGMVGNAGVIETEVVLISKKSDEDDVRWVYLDIGKFGGLAETMDESIRYAIKSRHDGAEMTP
CVLAGPTCDSADVLYEKMPYPLPVTLEIGDKLLIEGTGAYTSTYSSVAFNGFPPLATYHI

Sequences:

>Translated_380_residues
MTERIREFLRDRRAKGLDVEPCLVVDLEVVRDNFMHFAKALPDSRVFYAIKANPAPEVLSLLASLGSCFDCASVQEIQMA
LAAGATPDRISFGNTIKKERDIARAYELGIRLFSVDCTPEVEKVARAAPGSKVFCRILYDCAGAEWPLSRKFGCDPEMAV
DVLDNAKRLGLEAYGISFHVGSQQRKVKAWDRALAMAAQVFRDCAERGISLSMVNMGGGFPTKYLKEVPPVVQYGRSIFR
ALRKHFGNQIPETIIEPGRGMVGNAGVIETEVVLISKKSDEDDVRWVYLDIGKFGGLAETMDESIRYAIKSRHDGAEMTP
CVLAGPTCDSADVLYEKMPYPLPVTLEIGDKLLIEGTGAYTSTYSSVAFNGFPPLATYHI
>Mature_379_residues
TERIREFLRDRRAKGLDVEPCLVVDLEVVRDNFMHFAKALPDSRVFYAIKANPAPEVLSLLASLGSCFDCASVQEIQMAL
AAGATPDRISFGNTIKKERDIARAYELGIRLFSVDCTPEVEKVARAAPGSKVFCRILYDCAGAEWPLSRKFGCDPEMAVD
VLDNAKRLGLEAYGISFHVGSQQRKVKAWDRALAMAAQVFRDCAERGISLSMVNMGGGFPTKYLKEVPPVVQYGRSIFRA
LRKHFGNQIPETIIEPGRGMVGNAGVIETEVVLISKKSDEDDVRWVYLDIGKFGGLAETMDESIRYAIKSRHDGAEMTPC
VLAGPTCDSADVLYEKMPYPLPVTLEIGDKLLIEGTGAYTSTYSSVAFNGFPPLATYHI

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=383, Percent_Identity=31.331592689295, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI22538418, Length=378, Percent_Identity=29.1005291005291, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI21361583, Length=378, Percent_Identity=29.1005291005291, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI16506287, Length=360, Percent_Identity=30.8333333333333, Blast_Score=125, Evalue=8e-29,
Organism=Escherichia coli, GI1789203, Length=381, Percent_Identity=25.9842519685039, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17562780, Length=371, Percent_Identity=30.4582210242588, Blast_Score=147, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6322664, Length=382, Percent_Identity=32.7225130890052, Blast_Score=153, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24586472, Length=356, Percent_Identity=32.0224719101124, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24586474, Length=376, Percent_Identity=31.1170212765957, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 41869; Mature: 41737

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERIREFLRDRRAKGLDVEPCLVVDLEVVRDNFMHFAKALPDSRVFYAIKANPAPEVLS
CCHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHH
LLASLGSCFDCASVQEIQMALAAGATPDRISFGNTIKKERDIARAYELGIRLFSVDCTPE
HHHHHCCHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCH
VEKVARAAPGSKVFCRILYDCAGAEWPLSRKFGCDPEMAVDVLDNAKRLGLEAYGISFHV
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEEE
GSQQRKVKAWDRALAMAAQVFRDCAERGISLSMVNMGGGFPTKYLKEVPPVVQYGRSIFR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCCHHHHHHHHHHH
ALRKHFGNQIPETIIEPGRGMVGNAGVIETEVVLISKKSDEDDVRWVYLDIGKFGGLAET
HHHHHHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEECCCCCCHHHH
MDESIRYAIKSRHDGAEMTPCVLAGPTCDSADVLYEKMPYPLPVTLEIGDKLLIEGTGAY
HHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCEEEEECCCEEEEEECCCC
TSTYSSVAFNGFPPLATYHI
HHCCCCCEECCCCCCEECCC
>Mature Secondary Structure 
TERIREFLRDRRAKGLDVEPCLVVDLEVVRDNFMHFAKALPDSRVFYAIKANPAPEVLS
CHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHH
LLASLGSCFDCASVQEIQMALAAGATPDRISFGNTIKKERDIARAYELGIRLFSVDCTPE
HHHHHCCHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCH
VEKVARAAPGSKVFCRILYDCAGAEWPLSRKFGCDPEMAVDVLDNAKRLGLEAYGISFHV
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEEE
GSQQRKVKAWDRALAMAAQVFRDCAERGISLSMVNMGGGFPTKYLKEVPPVVQYGRSIFR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCCHHHHHHHHHHH
ALRKHFGNQIPETIIEPGRGMVGNAGVIETEVVLISKKSDEDDVRWVYLDIGKFGGLAET
HHHHHHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEECCCCCCHHHH
MDESIRYAIKSRHDGAEMTPCVLAGPTCDSADVLYEKMPYPLPVTLEIGDKLLIEGTGAY
HHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCEEEEECCCEEEEEECCCC
TSTYSSVAFNGFPPLATYHI
HHCCCCCEECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]