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The map label for this gene is atpB [H]

Identifier: 192289342

GI number: 192289342

Start: 970283

End: 971029

Strand: Reverse

Name: atpB [H]

Synonym: Rpal_0914

Alternate gene names: 192289342

Gene position: 971029-970283 (Counterclockwise)

Preceding gene: 192289343

Following gene: 192289341

Centisome position: 16.9

GC content: 59.84

Gene sequence:

>747_bases
ATGGCCGCCGATCCGATCCATCAGTTCCAGATCACCAAGCTCTTCACCCTCGGTCACGTTGGCGGACAAGAAATCGCGTT
CACCAACTCGTCGGCCTACATGTTCGGCACGGTGGCGCTGATCGCCATCCTGATGCTGGTTCCGGGCCGCCAATTGGTGC
CGGGCAGGCTCCAGTCGATCGCAGAGCTGTCCTACGAATTCGTCGCCAACATGATACGGTCGACGGCCGGCAAGGAAGGC
CTGAAGTTCTTCCCGCTGGTGTTCTCGCTGTTCATGTTCATCGCCGTATCGAACCTGATCGGCATCGTGCCCTACACCTT
CACGGTGTCGAGCCACCTGATCGTCACCGTCGCGCTAGCGCTGCTGGTGTTCTTCACGGTGCTGATCTACGGGTTTTCCA
AGAACGGCCTGAAGTTCTTCAAGCTGTTCGTGCCCTCCGGCGTGCCGATCTACATCCTGCCGCTGGTCGTCTTCATCGAA
GTGATCTCGTTCTTCCTCAAGCCGGTTTCGCACTCGGTGCGTCTGTTCGCCAACATGCTGGCGGGCCACATCGCTCTGAA
GGTGTTCGCGAGCTTCGTGGCGATGCTCGGCGCACTGGGCGTCGTCGGCTGGTTCGGCGCCGTGCTGCCGCTCGGCCTGA
CCATCGCGCTGACCGCGCTGGAGCTGCTGGTCGCGTTCCTGCAGGCTTATGTGTTCGCCATTTTGACTTGCATCTATCTC
AACGATGCAATTCATCCGGGCCACTAA

Upstream 100 bases:

>100_bases
CGTCATGGCGAAACAGTCCGAGCGACTCTGAGCGGGATCCAAGGCGCACCGATCGTTCGAATCCCGCGCAAGCTCGCGAC
ACCGACAGACTGAGAGACGA

Downstream 100 bases:

>100_bases
AGACCCACTCGCAAACGACTACACCCAACCCCAACAGGAGTTCGTTACATGGATCCGATTGCCGCGAAGTACATTGGCGC
TGGTATTGCCTGCATTGGCA

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6 [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MAADPIHQFQITKLFTLGHVGGQEIAFTNSSAYMFGTVALIAILMLVPGRQLVPGRLQSIAELSYEFVANMIRSTAGKEG
LKFFPLVFSLFMFIAVSNLIGIVPYTFTVSSHLIVTVALALLVFFTVLIYGFSKNGLKFFKLFVPSGVPIYILPLVVFIE
VISFFLKPVSHSVRLFANMLAGHIALKVFASFVAMLGALGVVGWFGAVLPLGLTIALTALELLVAFLQAYVFAILTCIYL
NDAIHPGH

Sequences:

>Translated_248_residues
MAADPIHQFQITKLFTLGHVGGQEIAFTNSSAYMFGTVALIAILMLVPGRQLVPGRLQSIAELSYEFVANMIRSTAGKEG
LKFFPLVFSLFMFIAVSNLIGIVPYTFTVSSHLIVTVALALLVFFTVLIYGFSKNGLKFFKLFVPSGVPIYILPLVVFIE
VISFFLKPVSHSVRLFANMLAGHIALKVFASFVAMLGALGVVGWFGAVLPLGLTIALTALELLVAFLQAYVFAILTCIYL
NDAIHPGH
>Mature_247_residues
AADPIHQFQITKLFTLGHVGGQEIAFTNSSAYMFGTVALIAILMLVPGRQLVPGRLQSIAELSYEFVANMIRSTAGKEGL
KFFPLVFSLFMFIAVSNLIGIVPYTFTVSSHLIVTVALALLVFFTVLIYGFSKNGLKFFKLFVPSGVPIYILPLVVFIEV
ISFFLKPVSHSVRLFANMLAGHIALKVFASFVAMLGALGVVGWFGAVLPLGLTIALTALELLVAFLQAYVFAILTCIYLN
DAIHPGH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Homo sapiens, GI251831112, Length=199, Percent_Identity=30.1507537688442, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1790176, Length=209, Percent_Identity=25.8373205741627, Blast_Score=61, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6226527, Length=256, Percent_Identity=34.765625, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568
- InterPro:   IPR023011 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14

Molecular weight: Translated: 26952; Mature: 26821

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCCCCC
>Mature Secondary Structure 
AADPIHQFQITKLFTLGHVGGQEIAFTNSSAYMFGTVALIAILMLVPGRQLVPGRLQSI
CCCCHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AELSYEFVANMIRSTAGKEGLKFFPLVFSLFMFIAVSNLIGIVPYTFTVSSHLIVTVALA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLVFFTVLIYGFSKNGLKFFKLFVPSGVPIYILPLVVFIEVISFFLKPVSHSVRLFANML
HHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGHIALKVFASFVAMLGALGVVGWFGAVLPLGLTIALTALELLVAFLQAYVFAILTCIYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NDAIHPGH
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA