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The map label for this gene is nhaK [H]

Identifier: 192288951

GI number: 192288951

Start: 569246

End: 570898

Strand: Reverse

Name: nhaK [H]

Synonym: Rpal_0521

Alternate gene names: 192288951

Gene position: 570898-569246 (Counterclockwise)

Preceding gene: 192288954

Following gene: 192288947

Centisome position: 9.94

GC content: 66.3

Gene sequence:

>1653_bases
ATGCAGGCGGTCGCCGGCAGGTTCACTCAAAATCAGCGTGGTGACGTGGAAGCCAAATTCCAGATTTTTCTCACGCTGCT
TGCGGTGCTCGCCGGAACGGCGCTGCTGGCCCGACGGGTCAACATCGCACCCGCGATCCTGCTGCTGATTGCCGGCATCA
CCCTGGCCTTCATTCCTGGGATGCCGGCAATTGAACTGCCGCCGGATCTGATCCTGCTGTTGGTGCTGCCGCCGCTGATC
TACTCGGCGAGCGTGGCAATGAGCTGGCGCGAATTCTGCGCCAATCTGCGGGCGATCGGCCTGCTCGCGATCGGCTGTGT
GATCTTCACCGCATGCGCGGTGGCGGCGGCATCGCACTATCTGATCGGCCTGCCGTGGTCGGTCGGCTTCCTGCTCGGTG
CAATCGTCGCGCCCCCCGACGTGGTTGCCCCGCTGGCGATCGCCCGCAAGCTCGGCCTACCGCGGCGCATCGTGGTGGTG
CTGGAAGGCGAAGGGCTGGCCAATGATGCGACCGCGCTGATCCTGTACCGCTTCGCGGTGGCGGCGATCATGACCGGCGC
GTTCTCGCTGACCAAAGCCTCCGGCACCTTCGTGGCGATCATGGCGGGCGAACTCGCGTTCGGCGTCGCTGTCGGCTGGC
TCAGCCTGCGCGCGCGGCATTGGGTTCGCGACCCGCAGATCGAGATCACGCTGTCGCTGCTGACGCCTTACATCGCCTAT
TGGATTCCGGAGCATCATGGCGGCTCCGGCGTGATCGCCACCGTCGCCTGCGGTCTTTATATCTCATGGAACGGCCCGCT
GCTGATCTCGGCGGCGACGCGGCTGCAGGGCATCTTCTTCTGGGATCTGGTGATCTACCTGATCGAGGGGATGCTGTTTC
TGCTCACCGGCTTCCAACTGCGCGCCCTACTGGAGCGCTCGAAGGAATTTGCCTTCGGTGACATCCTGTCTGCCACGCTG
CTGGTCGCTGCGATCGTGATCGCCGCGCGCTTCATCTGGGTTTATCCGGCGTTCTATCTGCCCCGGTTTCTCAGCCGCCG
CTTGCGAGCGAGTGACCCCTACCCGTCGTGGCGCACCGTTTTCGTGATCGGCTTCACCGGCGTGCGCGGCGCGGTCTCGC
TCGCCGCGGCGCTGGCGCTGCCCTATGCGCTGCCGGGCGGCGAGACGTTCCCGTATCGCGACCTGATTCTGTTCGTCACT
TTTGGGGTGATCCTGATCACGCTGGTCGGCCTCGGCCTGACGCTGCCCGCCGTGGTGAAGCTGCTCGGCGTCACCCGCGT
CGGACACCGGGAGCAGATCGCCGAGCACGACGACGAGATCACCGCCCGCCGCGAAGCACTGGCTGCCGCGCAGGCATCGC
TGAAGAAGATCACCGACAATCGCGAACTGACTGACGAAGTGCTGAAGCTGCTGCACGCCCGGCACCAGACCCGCGCCAGC
CTGCTGCCCGATCCGATCGGCTCACCGGAGCACGAGGCCTCGGCGGTCGGCATCGCCCTGGTGCGCGAGCTGATCGCGGT
CGAGCGCAAGTTCATCCACGCCCAGCTCCGCGCCGGCAAGATCACCGACGAGGCGCGACGCCGGATCGAGCGCGACCTCG
ACCTGGAGGAGGCCAGCCTCGCGAACCGCGAAAGCGGCCCCGCGCCGCTTTAG

Upstream 100 bases:

>100_bases
GAACGGACGGCGTTTGAGACGAAAGTCGCACGTAGCTCTACGAGGGGCAGCGTCCTAGTGCGTAATTAGTTACCGCTTGA
CCGATCCAGACTTCCGGGCG

Downstream 100 bases:

>100_bases
AGCGCATCCATAGGAAGTGTGAACAGCGAGGTGTTCGTCATGGCCGACCTCGTCGGCCATCCACATTCTGCCCTGCAACG
AGCGCTCAAAAACGTGGATG

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MQAVAGRFTQNQRGDVEAKFQIFLTLLAVLAGTALLARRVNIAPAILLLIAGITLAFIPGMPAIELPPDLILLLVLPPLI
YSASVAMSWREFCANLRAIGLLAIGCVIFTACAVAAASHYLIGLPWSVGFLLGAIVAPPDVVAPLAIARKLGLPRRIVVV
LEGEGLANDATALILYRFAVAAIMTGAFSLTKASGTFVAIMAGELAFGVAVGWLSLRARHWVRDPQIEITLSLLTPYIAY
WIPEHHGGSGVIATVACGLYISWNGPLLISAATRLQGIFFWDLVIYLIEGMLFLLTGFQLRALLERSKEFAFGDILSATL
LVAAIVIAARFIWVYPAFYLPRFLSRRLRASDPYPSWRTVFVIGFTGVRGAVSLAAALALPYALPGGETFPYRDLILFVT
FGVILITLVGLGLTLPAVVKLLGVTRVGHREQIAEHDDEITARREALAAAQASLKKITDNRELTDEVLKLLHARHQTRAS
LLPDPIGSPEHEASAVGIALVRELIAVERKFIHAQLRAGKITDEARRRIERDLDLEEASLANRESGPAPL

Sequences:

>Translated_550_residues
MQAVAGRFTQNQRGDVEAKFQIFLTLLAVLAGTALLARRVNIAPAILLLIAGITLAFIPGMPAIELPPDLILLLVLPPLI
YSASVAMSWREFCANLRAIGLLAIGCVIFTACAVAAASHYLIGLPWSVGFLLGAIVAPPDVVAPLAIARKLGLPRRIVVV
LEGEGLANDATALILYRFAVAAIMTGAFSLTKASGTFVAIMAGELAFGVAVGWLSLRARHWVRDPQIEITLSLLTPYIAY
WIPEHHGGSGVIATVACGLYISWNGPLLISAATRLQGIFFWDLVIYLIEGMLFLLTGFQLRALLERSKEFAFGDILSATL
LVAAIVIAARFIWVYPAFYLPRFLSRRLRASDPYPSWRTVFVIGFTGVRGAVSLAAALALPYALPGGETFPYRDLILFVT
FGVILITLVGLGLTLPAVVKLLGVTRVGHREQIAEHDDEITARREALAAAQASLKKITDNRELTDEVLKLLHARHQTRAS
LLPDPIGSPEHEASAVGIALVRELIAVERKFIHAQLRAGKITDEARRRIERDLDLEEASLANRESGPAPL
>Mature_550_residues
MQAVAGRFTQNQRGDVEAKFQIFLTLLAVLAGTALLARRVNIAPAILLLIAGITLAFIPGMPAIELPPDLILLLVLPPLI
YSASVAMSWREFCANLRAIGLLAIGCVIFTACAVAAASHYLIGLPWSVGFLLGAIVAPPDVVAPLAIARKLGLPRRIVVV
LEGEGLANDATALILYRFAVAAIMTGAFSLTKASGTFVAIMAGELAFGVAVGWLSLRARHWVRDPQIEITLSLLTPYIAY
WIPEHHGGSGVIATVACGLYISWNGPLLISAATRLQGIFFWDLVIYLIEGMLFLLTGFQLRALLERSKEFAFGDILSATL
LVAAIVIAARFIWVYPAFYLPRFLSRRLRASDPYPSWRTVFVIGFTGVRGAVSLAAALALPYALPGGETFPYRDLILFVT
FGVILITLVGLGLTLPAVVKLLGVTRVGHREQIAEHDDEITARREALAAAQASLKKITDNRELTDEVLKLLHARHQTRAS
LLPDPIGSPEHEASAVGIALVRELIAVERKFIHAQLRAGKITDEARRRIERDLDLEEASLANRESGPAPL

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=453, Percent_Identity=24.7240618101545, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI148727259, Length=436, Percent_Identity=24.0825688073394, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI41872703, Length=432, Percent_Identity=22.2222222222222, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI294997330, Length=342, Percent_Identity=26.6081871345029, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI110227626, Length=393, Percent_Identity=25.9541984732824, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI5454070, Length=393, Percent_Identity=25.9541984732824, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI27734935, Length=367, Percent_Identity=22.8882833787466, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI14211919, Length=404, Percent_Identity=23.2673267326733, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI194239733, Length=385, Percent_Identity=25.1948051948052, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI27777632, Length=449, Percent_Identity=26.0579064587973, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4759144, Length=402, Percent_Identity=25.6218905472637, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790501, Length=519, Percent_Identity=31.0211946050096, Blast_Score=176, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI71987537, Length=462, Percent_Identity=22.7272727272727, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71987535, Length=462, Percent_Identity=22.5108225108225, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71980847, Length=395, Percent_Identity=24.3037974683544, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71999817, Length=510, Percent_Identity=21.1764705882353, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71999819, Length=510, Percent_Identity=20.9803921568627, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71999821, Length=510, Percent_Identity=20.9803921568627, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25147678, Length=439, Percent_Identity=23.0068337129841, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71992107, Length=337, Percent_Identity=22.2551928783383, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71992101, Length=337, Percent_Identity=22.2551928783383, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25150332, Length=370, Percent_Identity=21.6216216216216, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71990932, Length=387, Percent_Identity=24.031007751938, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71993590, Length=400, Percent_Identity=24.75, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71987545, Length=435, Percent_Identity=22.5287356321839, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71993582, Length=400, Percent_Identity=24.75, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71987559, Length=435, Percent_Identity=22.5287356321839, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71990924, Length=387, Percent_Identity=24.031007751938, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320663, Length=364, Percent_Identity=22.2527472527473, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281360447, Length=415, Percent_Identity=22.8915662650602, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI221473212, Length=341, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281364513, Length=341, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221473222, Length=341, Percent_Identity=25.8064516129032, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221473215, Length=341, Percent_Identity=25.8064516129032, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI221510738, Length=382, Percent_Identity=24.6073298429319, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221510734, Length=382, Percent_Identity=24.6073298429319, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221510732, Length=383, Percent_Identity=24.2819843342037, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI221510736, Length=383, Percent_Identity=24.2819843342037, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24585580, Length=383, Percent_Identity=24.2819843342037, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24585578, Length=383, Percent_Identity=24.2819843342037, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221510740, Length=383, Percent_Identity=24.2819843342037, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 59511; Mature: 59511

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAVAGRFTQNQRGDVEAKFQIFLTLLAVLAGTALLARRVNIAPAILLLIAGITLAFIPG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MPAIELPPDLILLLVLPPLIYSASVAMSWREFCANLRAIGLLAIGCVIFTACAVAAASHY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGLPWSVGFLLGAIVAPPDVVAPLAIARKLGLPRRIVVVLEGEGLANDATALILYRFAV
EEECCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHH
AAIMTGAFSLTKASGTFVAIMAGELAFGVAVGWLSLRARHWVRDPQIEITLSLLTPYIAY
HHHHHHHHHEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHH
WIPEHHGGSGVIATVACGLYISWNGPLLISAATRLQGIFFWDLVIYLIEGMLFLLTGFQL
HCCCCCCCCCHHHHHHCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RALLERSKEFAFGDILSATLLVAAIVIAARFIWVYPAFYLPRFLSRRLRASDPYPSWRTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
FVIGFTGVRGAVSLAAALALPYALPGGETFPYRDLILFVTFGVILITLVGLGLTLPAVVK
EEEEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGVTRVGHREQIAEHDDEITARREALAAAQASLKKITDNRELTDEVLKLLHARHQTRAS
HHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LLPDPIGSPEHEASAVGIALVRELIAVERKFIHAQLRAGKITDEARRRIERDLDLEEASL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHH
ANRESGPAPL
CCCCCCCCCC
>Mature Secondary Structure
MQAVAGRFTQNQRGDVEAKFQIFLTLLAVLAGTALLARRVNIAPAILLLIAGITLAFIPG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MPAIELPPDLILLLVLPPLIYSASVAMSWREFCANLRAIGLLAIGCVIFTACAVAAASHY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGLPWSVGFLLGAIVAPPDVVAPLAIARKLGLPRRIVVVLEGEGLANDATALILYRFAV
EEECCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHH
AAIMTGAFSLTKASGTFVAIMAGELAFGVAVGWLSLRARHWVRDPQIEITLSLLTPYIAY
HHHHHHHHHEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHH
WIPEHHGGSGVIATVACGLYISWNGPLLISAATRLQGIFFWDLVIYLIEGMLFLLTGFQL
HCCCCCCCCCHHHHHHCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RALLERSKEFAFGDILSATLLVAAIVIAARFIWVYPAFYLPRFLSRRLRASDPYPSWRTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
FVIGFTGVRGAVSLAAALALPYALPGGETFPYRDLILFVTFGVILITLVGLGLTLPAVVK
EEEEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGVTRVGHREQIAEHDDEITARREALAAAQASLKKITDNRELTDEVLKLLHARHQTRAS
HHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LLPDPIGSPEHEASAVGIALVRELIAVERKFIHAQLRAGKITDEARRRIERDLDLEEASL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHH
ANRESGPAPL
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA