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The map label for this gene is trxA [H]

Identifier: 192288509

GI number: 192288509

Start: 79508

End: 79828

Strand: Reverse

Name: trxA [H]

Synonym: Rpal_0076

Alternate gene names: 192288509

Gene position: 79828-79508 (Counterclockwise)

Preceding gene: 192288510

Following gene: 192288498

Centisome position: 1.39

GC content: 63.24

Gene sequence:

>321_bases
ATGGCCGTTGGTAAGGTGTCAGACGCCGATTTCGAAAACGAGGTTCTCAACGCTCAGGGGCCTGTGGTGGTGGACTTCTG
GGCCGAGTGGTGCGGCCCGTGCCGCATGATCGCGCCGGCGCTCGATGAAATCGCCGGAGCGATGGGCGACAAGGTCAAGA
TCGTGAAGCTCAACGTCGACGAGAGCCCGGTCACCGCCTCGAAGTACGGCGTGATGTCGATCCCGACCCTGATGATCTTC
AAGGGCGGCGAGATGGCTTCGCGCCAGGTCGGCGCCGCGCCGAAGGCTAAGCTTCAGCAGTGGATCAGCGCAGCGGTCTG
A

Upstream 100 bases:

>100_bases
GTGAGCCGTGCTTGACCGCACCGCGGTGCGTTCCTACGTTCACCCGTCATCACGGCGCGATTCCCGCCGCCGCTCTTCAT
CCGGTTTCACGAGGTATCCC

Downstream 100 bases:

>100_bases
ACTCCGACGCTCGATGAACGTTCTGAAACGGCCGGCATTCGCCGGCCGTTTTGCTTTTCCGGCCTCTCGTCATTGCGAGG
AACGAAGCGGCGAAGCAATC

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MAVGKVSDADFENEVLNAQGPVVVDFWAEWCGPCRMIAPALDEIAGAMGDKVKIVKLNVDESPVTASKYGVMSIPTLMIF
KGGEMASRQVGAAPKAKLQQWISAAV

Sequences:

>Translated_106_residues
MAVGKVSDADFENEVLNAQGPVVVDFWAEWCGPCRMIAPALDEIAGAMGDKVKIVKLNVDESPVTASKYGVMSIPTLMIF
KGGEMASRQVGAAPKAKLQQWISAAV
>Mature_105_residues
AVGKVSDADFENEVLNAQGPVVVDFWAEWCGPCRMIAPALDEIAGAMGDKVKIVKLNVDESPVTASKYGVMSIPTLMIFK
GGEMASRQVGAAPKAKLQQWISAAV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=32.9896907216495, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87082331, Length=102, Percent_Identity=50.9803921568627, Blast_Score=122, Evalue=6e-30,
Organism=Escherichia coli, GI1788936, Length=114, Percent_Identity=39.4736842105263, Blast_Score=97, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=38.7096774193548, Blast_Score=78, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17509965, Length=86, Percent_Identity=34.8837209302326, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=90, Percent_Identity=40, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=80, Percent_Identity=37.5, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=80, Percent_Identity=37.5, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71998175, Length=86, Percent_Identity=39.5348837209302, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17544108, Length=94, Percent_Identity=35.1063829787234, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=100, Percent_Identity=32, Blast_Score=61, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6321648, Length=100, Percent_Identity=42, Blast_Score=79, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319925, Length=96, Percent_Identity=36.4583333333333, Blast_Score=72, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=83, Percent_Identity=44.578313253012, Blast_Score=70, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=37.1134020618557, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24639826, Length=83, Percent_Identity=43.3734939759036, Blast_Score=82, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21358065, Length=100, Percent_Identity=37, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17648013, Length=106, Percent_Identity=38.6792452830189, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24583090, Length=106, Percent_Identity=38.6792452830189, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11253; Mature: 11122

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVGKVSDADFENEVLNAQGPVVVDFWAEWCGPCRMIAPALDEIAGAMGDKVKIVKLNVD
CCCCCCCCCCCCCCEECCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEECC
ESPVTASKYGVMSIPTLMIFKGGEMASRQVGAAPKAKLQQWISAAV
CCCCCCCCCCCEECCEEEEEECCCCCCHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AVGKVSDADFENEVLNAQGPVVVDFWAEWCGPCRMIAPALDEIAGAMGDKVKIVKLNVD
CCCCCCCCCCCCCEECCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEECC
ESPVTASKYGVMSIPTLMIFKGGEMASRQVGAAPKAKLQQWISAAV
CCCCCCCCCCCEECCEEEEEECCCCCCHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3129411 [H]