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The map label for this gene is ggt [H]

Identifier: 192288459

GI number: 192288459

Start: 26926

End: 28659

Strand: Reverse

Name: ggt [H]

Synonym: Rpal_0026

Alternate gene names: 192288459

Gene position: 28659-26926 (Counterclockwise)

Preceding gene: 192288462

Following gene: 192288458

Centisome position: 0.5

GC content: 67.07

Gene sequence:

>1734_bases
ATGATCACACTGCGCGTCCCGCAACGCATTTTGATGACGCTGGCCGCGCTGGTGCTGGTGGTGATCCCGCTCGCCGCGCC
GGCGCAGGATATGCGCAGCGGCATGGCGCGCGGGCCGACCCAAGCGGTGGTCGCCAAACACGGCATGGTAGTGGCGCAGG
AACGGTTGGCTGCGAAAATCGGCGCCGGCTTCCTGTCCCGCGGCGGCAATGCGATCGATGCCGCGGTGGCGACCGGCTTC
GCCATGGCGGTCACCTATCCGCGTGCCGGCAATCTCGGCGGCGGCGGCTTCATGGTGATCCATTCCGCGGTAAAGAATGA
GGATGTGGCGATCGACTATCGCGAAACCGCGCCGCAGGCCGCCACTCAGGACATGTTTCTGACCGACGGCAAACCCGACC
CGGACAAATCGCGCAAATCCGCGCTCGGCATCGGTGTGCCCGGCACTGTGGCTGGATTGGCGCTGGCGCTCGAGAAATAC
GGCTCCGGCAAGTTCAAGCTAGCGGATGTGATCGCGCCGGCGATCGCGCTCGCCCGCGATGGGATCACCGTCGCCGACGA
CACCGCCGACACGCTACCGGATTGGCACGCCTGGCTGTCGCGCTGGCCTTCCACCCGCAAGGTGTTCGCTCGTCCCGACG
GCTCGCCGCTGCAGGCCGGCGACAGGCTGGTGCAGCCCGATCTGGCGGCGACGCTCGAAGCCATCGCCAAGCAGGGGCCG
GACGGTTTCTACCGCGGCCCGATCGCCGAGAAGTTGTCACGCGGCATTCGCGACGCCGGCGGGTTGATCACGCCCGAGGA
TCTCGCCGGCTATCAGCCAATGCTGCGATCGCCGCTACGCGGTAACTATCGCGGCTACGATATCGTGGCGATGCCGCAGC
CGTCGTCCGGCGGCGTCGTGCTGATCGAAAGCCTGAACATCCTCGAAGGCTATGCGATGCGCGACCTCGGGCAGGGCACG
CCGCCGTCGCTGCATCTGCTGATCGAAGCGATGAAGCGCGCCTATGCGGATCGCGCCCGCTATCTCGGCGATCCTGCCTT
CAGCGAGGCGCCGATGACAAAGCTGCTGTCGAAGGACTACGCAGCGAGCCTGCGGGCCGGCATCGATCCGCAGCGCGCCA
CTCCGGTCGCTGAGCCACTGCCGCAGCCGCGCGAAGGCCAGAACACCACGCACTTCTCGGTCGCCGATGCCGAGGGCAAT
GCGGTCAGCAACACCTACACGCTCAACTTCTCTTACGGCGTCGGACTGGTAGCGGATGGCACCGGCGTGCTGCTCAACAA
CGAACTCGACGATTTCACAGCGGCTCCCGGTGCCTCCAACGCCTACGGCCTGGTCGGCTTCGCCGCCAATCTGCCGGCGC
CCGGCAAACGGCCGCTGTCATCGATGTCGCCGACGATTCTGCTGAAGGACGGCAAACCGGTGCTCGTCACCGGCTCGCCC
GGCGGCAGCCGCATCATTTCCGCAGTGCTGCAGGTGATCGTCGATGTGATCGATTACCGGATGAACGTCGCGGACGCCGT
GGCGGCGCCGCGGCTGCATCATCAATGGCTGCCGGACGAGGTGCGGGTCGAAGGCGGATTTCCCGAAGCGACCTTGGACA
CGCTCCGCGCGATGGGCCACCGCATCGTCACCCCGCTCGGCCAGACCTCGGCGAATTCCATCCTGATCGACGCTGACGGC
TTCCATGGCGCCCCCGATCCCCGCACGCGGGGCGCGACGGCGGCGGGGAATTGA

Upstream 100 bases:

>100_bases
TCCTTCCGCCGGCCGGACCGCGTTTTGCCCCGCGGCTTCGATTGCCTATAGGATTCGTCCGGCGCGTGGCAGCCTGCGCC
GCAGAAATCGGAGCCGCTTG

Downstream 100 bases:

>100_bases
TACCTGGCGTCGTTGCCGGGCTTGACCCGGCAACCCATCGACTTTGAAGCATGGGCTTTTCCGAAGATGATGGATGCGCG
GGCCTTCGCCGCGCCGAAGG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MITLRVPQRILMTLAALVLVVIPLAAPAQDMRSGMARGPTQAVVAKHGMVVAQERLAAKIGAGFLSRGGNAIDAAVATGF
AMAVTYPRAGNLGGGGFMVIHSAVKNEDVAIDYRETAPQAATQDMFLTDGKPDPDKSRKSALGIGVPGTVAGLALALEKY
GSGKFKLADVIAPAIALARDGITVADDTADTLPDWHAWLSRWPSTRKVFARPDGSPLQAGDRLVQPDLAATLEAIAKQGP
DGFYRGPIAEKLSRGIRDAGGLITPEDLAGYQPMLRSPLRGNYRGYDIVAMPQPSSGGVVLIESLNILEGYAMRDLGQGT
PPSLHLLIEAMKRAYADRARYLGDPAFSEAPMTKLLSKDYAASLRAGIDPQRATPVAEPLPQPREGQNTTHFSVADAEGN
AVSNTYTLNFSYGVGLVADGTGVLLNNELDDFTAAPGASNAYGLVGFAANLPAPGKRPLSSMSPTILLKDGKPVLVTGSP
GGSRIISAVLQVIVDVIDYRMNVADAVAAPRLHHQWLPDEVRVEGGFPEATLDTLRAMGHRIVTPLGQTSANSILIDADG
FHGAPDPRTRGATAAGN

Sequences:

>Translated_577_residues
MITLRVPQRILMTLAALVLVVIPLAAPAQDMRSGMARGPTQAVVAKHGMVVAQERLAAKIGAGFLSRGGNAIDAAVATGF
AMAVTYPRAGNLGGGGFMVIHSAVKNEDVAIDYRETAPQAATQDMFLTDGKPDPDKSRKSALGIGVPGTVAGLALALEKY
GSGKFKLADVIAPAIALARDGITVADDTADTLPDWHAWLSRWPSTRKVFARPDGSPLQAGDRLVQPDLAATLEAIAKQGP
DGFYRGPIAEKLSRGIRDAGGLITPEDLAGYQPMLRSPLRGNYRGYDIVAMPQPSSGGVVLIESLNILEGYAMRDLGQGT
PPSLHLLIEAMKRAYADRARYLGDPAFSEAPMTKLLSKDYAASLRAGIDPQRATPVAEPLPQPREGQNTTHFSVADAEGN
AVSNTYTLNFSYGVGLVADGTGVLLNNELDDFTAAPGASNAYGLVGFAANLPAPGKRPLSSMSPTILLKDGKPVLVTGSP
GGSRIISAVLQVIVDVIDYRMNVADAVAAPRLHHQWLPDEVRVEGGFPEATLDTLRAMGHRIVTPLGQTSANSILIDADG
FHGAPDPRTRGATAAGN
>Mature_577_residues
MITLRVPQRILMTLAALVLVVIPLAAPAQDMRSGMARGPTQAVVAKHGMVVAQERLAAKIGAGFLSRGGNAIDAAVATGF
AMAVTYPRAGNLGGGGFMVIHSAVKNEDVAIDYRETAPQAATQDMFLTDGKPDPDKSRKSALGIGVPGTVAGLALALEKY
GSGKFKLADVIAPAIALARDGITVADDTADTLPDWHAWLSRWPSTRKVFARPDGSPLQAGDRLVQPDLAATLEAIAKQGP
DGFYRGPIAEKLSRGIRDAGGLITPEDLAGYQPMLRSPLRGNYRGYDIVAMPQPSSGGVVLIESLNILEGYAMRDLGQGT
PPSLHLLIEAMKRAYADRARYLGDPAFSEAPMTKLLSKDYAASLRAGIDPQRATPVAEPLPQPREGQNTTHFSVADAEGN
AVSNTYTLNFSYGVGLVADGTGVLLNNELDDFTAAPGASNAYGLVGFAANLPAPGKRPLSSMSPTILLKDGKPVLVTGSP
GGSRIISAVLQVIVDVIDYRMNVADAVAAPRLHHQWLPDEVRVEGGFPEATLDTLRAMGHRIVTPLGQTSANSILIDADG
FHGAPDPRTRGATAAGN

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=539, Percent_Identity=33.7662337662338, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI73915090, Length=539, Percent_Identity=33.7662337662338, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI73915096, Length=539, Percent_Identity=33.7662337662338, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI73915094, Length=539, Percent_Identity=33.7662337662338, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI113429324, Length=550, Percent_Identity=31.8181818181818, Blast_Score=233, Evalue=5e-61,
Organism=Homo sapiens, GI113429326, Length=558, Percent_Identity=31.7204301075269, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI109148539, Length=522, Percent_Identity=31.4176245210728, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI153266885, Length=486, Percent_Identity=31.4814814814815, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI153266901, Length=487, Percent_Identity=31.6221765913758, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI153266907, Length=486, Percent_Identity=30.6584362139918, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI30581157, Length=222, Percent_Identity=34.6846846846847, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI30581155, Length=222, Percent_Identity=34.6846846846847, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI218505805, Length=227, Percent_Identity=33.4801762114537, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI310124095, Length=227, Percent_Identity=31.7180616740088, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1789856, Length=540, Percent_Identity=51.8518518518518, Blast_Score=531, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI212646519, Length=492, Percent_Identity=34.349593495935, Blast_Score=249, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI72000294, Length=492, Percent_Identity=34.349593495935, Blast_Score=249, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17506189, Length=528, Percent_Identity=32.7651515151515, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI193208247, Length=562, Percent_Identity=32.2064056939502, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI193208245, Length=566, Percent_Identity=32.3321554770318, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17542894, Length=550, Percent_Identity=32.5454545454545, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17564448, Length=420, Percent_Identity=25.7142857142857, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI72001497, Length=243, Percent_Identity=25.9259259259259, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI72001495, Length=243, Percent_Identity=25.9259259259259, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323330, Length=541, Percent_Identity=31.2384473197782, Blast_Score=204, Evalue=3e-53,
Organism=Drosophila melanogaster, GI161077880, Length=547, Percent_Identity=31.8098720292505, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI161077878, Length=547, Percent_Identity=31.8098720292505, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI45551474, Length=547, Percent_Identity=31.8098720292505, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24642670, Length=547, Percent_Identity=31.8098720292505, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24642666, Length=547, Percent_Identity=31.8098720292505, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI161077496, Length=499, Percent_Identity=33.2665330661323, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI18859741, Length=505, Percent_Identity=31.0891089108911, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI18859893, Length=521, Percent_Identity=32.2456813819578, Blast_Score=203, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 60493; Mature: 60493

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLRVPQRILMTLAALVLVVIPLAAPAQDMRSGMARGPTQAVVAKHGMVVAQERLAAKI
CEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHH
GAGFLSRGGNAIDAAVATGFAMAVTYPRAGNLGGGGFMVIHSAVKNEDVAIDYRETAPQA
CCHHHHCCCCHHHHHHHHCEEEEEECCCCCCCCCCCEEEEEHHHCCCCEEEEEHHCCCCH
ATQDMFLTDGKPDPDKSRKSALGIGVPGTVAGLALALEKYGSGKFKLADVIAPAIALARD
HCCCEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHC
GITVADDTADTLPDWHAWLSRWPSTRKVFARPDGSPLQAGDRLVQPDLAATLEAIAKQGP
CCEEECCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
DGFYRGPIAEKLSRGIRDAGGLITPEDLAGYQPMLRSPLRGNYRGYDIVAMPQPSSGGVV
CCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCHHHCCCCCCCCCCEEEEEECCCCCCCEE
LIESLNILEGYAMRDLGQGTPPSLHLLIEAMKRAYADRARYLGDPAFSEAPMTKLLSKDY
EEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
AASLRAGIDPQRATPVAEPLPQPREGQNTTHFSVADAEGNAVSNTYTLNFSYGVGLVADG
HHHHHCCCCHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEECCEEEEEEECCCEEEECC
TGVLLNNELDDFTAAPGASNAYGLVGFAANLPAPGKRPLSSMSPTILLKDGKPVLVTGSP
CEEEECCCCCHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCEEEEECCC
GGSRIISAVLQVIVDVIDYRMNVADAVAAPRLHHQWLPDEVRVEGGFPEATLDTLRAMGH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEECCCCCHHHHHHHHHHHH
RIVTPLGQTSANSILIDADGFHGAPDPRTRGATAAGN
HHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MITLRVPQRILMTLAALVLVVIPLAAPAQDMRSGMARGPTQAVVAKHGMVVAQERLAAKI
CEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHH
GAGFLSRGGNAIDAAVATGFAMAVTYPRAGNLGGGGFMVIHSAVKNEDVAIDYRETAPQA
CCHHHHCCCCHHHHHHHHCEEEEEECCCCCCCCCCCEEEEEHHHCCCCEEEEEHHCCCCH
ATQDMFLTDGKPDPDKSRKSALGIGVPGTVAGLALALEKYGSGKFKLADVIAPAIALARD
HCCCEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHC
GITVADDTADTLPDWHAWLSRWPSTRKVFARPDGSPLQAGDRLVQPDLAATLEAIAKQGP
CCEEECCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
DGFYRGPIAEKLSRGIRDAGGLITPEDLAGYQPMLRSPLRGNYRGYDIVAMPQPSSGGVV
CCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCHHHCCCCCCCCCCEEEEEECCCCCCCEE
LIESLNILEGYAMRDLGQGTPPSLHLLIEAMKRAYADRARYLGDPAFSEAPMTKLLSKDY
EEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
AASLRAGIDPQRATPVAEPLPQPREGQNTTHFSVADAEGNAVSNTYTLNFSYGVGLVADG
HHHHHCCCCHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEECCEEEEEEECCCEEEECC
TGVLLNNELDDFTAAPGASNAYGLVGFAANLPAPGKRPLSSMSPTILLKDGKPVLVTGSP
CEEEECCCCCHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCEEEEECCC
GGSRIISAVLQVIVDVIDYRMNVADAVAAPRLHHQWLPDEVRVEGGFPEATLDTLRAMGH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEECCCCCHHHHHHHHHHHH
RIVTPLGQTSANSILIDADGFHGAPDPRTRGATAAGN
HHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]