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The map label for this gene is virB3c [H]

Identifier: 190895236

GI number: 190895236

Start: 999118

End: 999456

Strand: Reverse

Name: virB3c [H]

Synonym: RHECIAT_PC0000909

Alternate gene names: 190895236

Gene position: 999456-999118 (Counterclockwise)

Preceding gene: 190895237

Following gene: 190895235

Centisome position: 91.57

GC content: 59.0

Gene sequence:

>339_bases
ATGGTGAGCATTCAGAGCCTTGAAGATGATACGCTGTTTCTCGCCTGCACCCGCCCGGCAATGATTGCCGGCGTGACGAT
GGAGGCGATGGGCGTCAACATCATGTTGACGACCATTCTCTATATCACGGCAGGATCGATTGCCTACGCCCTGGTCGGGA
TCGTTTTCCATGTCCTGTTTCGCGCCCTCGTCAAGCACGACCACAACAGGTTCCGCATCCTGATCGCGTGGATCGAGACC
CGCGGCCGCTCGCGCAATTCCGCTTACTGGGGCGGCTCCACACTCTCGCCCCTGACGCTCACCAGGCGCTATGACGAACG
GGATTTGAGCCTTGGCTAA

Upstream 100 bases:

>100_bases
GCTACATGGATTTGAGGCGCGCCGGCTTCTGGATCATCGGGATCGGCGGCATTTTCGGCGCCACCGAGCTGGTCAACACC
ATCGTCGGGAACTGAACGCT

Downstream 100 bases:

>100_bases
TATCGCGACGCTGCGGTCGCGCGAGCTCGGGCCGGAGACCTTCATCCCCTATGTCAGGCATGTCGACGAAACGACCATCG
CGCTCGAGTCCCGAGCGTTG

Product: transport secretion system IV protein, VirB3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 112; Mature: 112

Protein sequence:

>112_residues
MVSIQSLEDDTLFLACTRPAMIAGVTMEAMGVNIMLTTILYITAGSIAYALVGIVFHVLFRALVKHDHNRFRILIAWIET
RGRSRNSAYWGGSTLSPLTLTRRYDERDLSLG

Sequences:

>Translated_112_residues
MVSIQSLEDDTLFLACTRPAMIAGVTMEAMGVNIMLTTILYITAGSIAYALVGIVFHVLFRALVKHDHNRFRILIAWIET
RGRSRNSAYWGGSTLSPLTLTRRYDERDLSLG
>Mature_112_residues
MVSIQSLEDDTLFLACTRPAMIAGVTMEAMGVNIMLTTILYITAGSIAYALVGIVFHVLFRALVKHDHNRFRILIAWIET
RGRSRNSAYWGGSTLSPLTLTRRYDERDLSLG

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG3702

COG function: function code U; Type IV secretory pathway, VirB3 components

Gene ontology:

Cell location: Cell outer membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the virB3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007792 [H]

Pfam domain/function: PF05101 VirB3 [H]

EC number: NA

Molecular weight: Translated: 12534; Mature: 12534

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSIQSLEDDTLFLACTRPAMIAGVTMEAMGVNIMLTTILYITAGSIAYALVGIVFHVLF
CCCCCCCCCCEEEEEECCCHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RALVKHDHNRFRILIAWIETRGRSRNSAYWGGSTLSPLTLTRRYDERDLSLG
HHHHHCCCCCEEEEEEEEECCCCCCCCCEECCCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MVSIQSLEDDTLFLACTRPAMIAGVTMEAMGVNIMLTTILYITAGSIAYALVGIVFHVLF
CCCCCCCCCCEEEEEECCCHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RALVKHDHNRFRILIAWIETRGRSRNSAYWGGSTLSPLTLTRRYDERDLSLG
HHHHHCCCCCEEEEEEEEECCCCCCCCCEECCCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10749166; 10882236 [H]