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The map label for this gene is virB6c [H]

Identifier: 190895232

GI number: 190895232

Start: 994896

End: 995828

Strand: Reverse

Name: virB6c [H]

Synonym: RHECIAT_PC0000905

Alternate gene names: 190895232

Gene position: 995828-994896 (Counterclockwise)

Preceding gene: 190895233

Following gene: 190895231

Centisome position: 91.23

GC content: 61.74

Gene sequence:

>933_bases
ATGTATCAGGTCTTCAGCTTCGTCGACGGACAATTCAAGACACCGCTGGAAAATTTCATTTCCTCCGGCACCTCGAATAT
CGCCAGCTGGGTCAGCGGCCCGCTGACGGCGGCACTCACGCTCTATGTCGTGCTCTACGGTTATCTCGTTCTACGCGGCT
CCGTCCAGGAGCCGATCCTCGAATTCGCCTTCCGGGCGATGAAGCTGGCGATCATCGTCATGCTGGTCAGGAACGCCAGC
GATTATCAGACCTATGTCACCAATATCTTCTTCGACGCGTTGCCCCGCGAGATATCGCAGGCGCTGAACTCCGGCACGGT
ACCGAGCGCCTCCACATTCGACAGCCTGCTCGACAAGGGCCAGAATTGCGCCCACGAGATATGGTCCCGCGCCTCCTGGC
CGGTCGACATCGTCACCGGCATCGGCGGCATGATGGTAATCGGCGCGAGCTTCGTCGTGGCGGCGATCGGCTATATCGTC
TCGCTCTATGCCCGGCTGGCGCTTGCCGTCGTGCTGGCGATCGGTCCGATCTTCATCGCGCTCGCAATGTTCCAGTCCAC
CCGACGCTTCACGGAATCCTGGATCGGCCAGCTTGTCAATTTCGTCATCCTGCAGGTGCTTGTCGTTGCCATCGGCTCGC
TGCTGATCACCTGCATCGATACAACGTTTACGGCGATCGAAAGCTATAGCGACGTGCTGATGCGTCCGGTCGCGCTCAGC
GCCATCTGCGTTGCCGCTCTCTACGTCTTCTACCAGCTGCCTGGCATCGCTTCAGCACTTGCGGCGGGTGGAGCGTCGCT
CACCTACGGCTATGGCGCTGCTCGCGATGCGCACGAAAGCACGCTCGCCTGGGCGACATCCCATACCGCCAGGGCGGTCG
GCCGCGGCGGGCGTTCCGTCGGCCGCCGCCTGACGCCCGGCAGGAGTGAATGA

Upstream 100 bases:

>100_bases
ATCCCGGAGAACTCCGCGACACGCCCAATTGCCGCAACGCCGAGGCTGCCGACGGCAAGCTGCGGCTGGAGCGGATGGGC
AAGGCGTTGGGAGGCTAACG

Downstream 100 bases:

>100_bases
CGGCCACAACGCTGAAGACAAGTGGACAGGTTACTTCCGAATGATCCGCATCGTTTTATCGCTTTTGCTGACTATTGGCC
TCGCAGGCTGCGGGTCAATT

Product: transport secretion system IV protein, VirB6

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MYQVFSFVDGQFKTPLENFISSGTSNIASWVSGPLTAALTLYVVLYGYLVLRGSVQEPILEFAFRAMKLAIIVMLVRNAS
DYQTYVTNIFFDALPREISQALNSGTVPSASTFDSLLDKGQNCAHEIWSRASWPVDIVTGIGGMMVIGASFVVAAIGYIV
SLYARLALAVVLAIGPIFIALAMFQSTRRFTESWIGQLVNFVILQVLVVAIGSLLITCIDTTFTAIESYSDVLMRPVALS
AICVAALYVFYQLPGIASALAAGGASLTYGYGAARDAHESTLAWATSHTARAVGRGGRSVGRRLTPGRSE

Sequences:

>Translated_310_residues
MYQVFSFVDGQFKTPLENFISSGTSNIASWVSGPLTAALTLYVVLYGYLVLRGSVQEPILEFAFRAMKLAIIVMLVRNAS
DYQTYVTNIFFDALPREISQALNSGTVPSASTFDSLLDKGQNCAHEIWSRASWPVDIVTGIGGMMVIGASFVVAAIGYIV
SLYARLALAVVLAIGPIFIALAMFQSTRRFTESWIGQLVNFVILQVLVVAIGSLLITCIDTTFTAIESYSDVLMRPVALS
AICVAALYVFYQLPGIASALAAGGASLTYGYGAARDAHESTLAWATSHTARAVGRGGRSVGRRLTPGRSE
>Mature_310_residues
MYQVFSFVDGQFKTPLENFISSGTSNIASWVSGPLTAALTLYVVLYGYLVLRGSVQEPILEFAFRAMKLAIIVMLVRNAS
DYQTYVTNIFFDALPREISQALNSGTVPSASTFDSLLDKGQNCAHEIWSRASWPVDIVTGIGGMMVIGASFVVAAIGYIV
SLYARLALAVVLAIGPIFIALAMFQSTRRFTESWIGQLVNFVILQVLVVAIGSLLITCIDTTFTAIESYSDVLMRPVALS
AICVAALYVFYQLPGIASALAAGGASLTYGYGAARDAHESTLAWATSHTARAVGRGGRSVGRRLTPGRSE

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG3704

COG function: function code U; Type IV secretory pathway, VirB6 components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbL/virB6 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007688 [H]

Pfam domain/function: PF04610 TrbL [H]

EC number: NA

Molecular weight: Translated: 33254; Mature: 33254

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCC
>Mature Secondary Structure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CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]