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The map label for this gene is virB8c [H]

Identifier: 190895230

GI number: 190895230

Start: 993903

End: 994574

Strand: Reverse

Name: virB8c [H]

Synonym: RHECIAT_PC0000903

Alternate gene names: 190895230

Gene position: 994574-993903 (Counterclockwise)

Preceding gene: 190895231

Following gene: 190895229

Centisome position: 91.12

GC content: 60.12

Gene sequence:

>672_bases
ATGGTGACCACGGACAGCCTCAAAAGTTACTTCGAAAAGGCCCGCCGGTTCGATCAGGAACGGATGATGCAGGTTGAACG
TTCCGCCCGCATTGCCTGGTTCGTCGCCGTTTCCGCCGGCGCCCTTGCTGCTGCCTCCGTCTTTGCCATTGCCGGCCTCA
CGCCTCTGAAAACTGTCGAACCCTTCGTCGTGCGGGTCGACAATTCAACAGGCATCGTCGACGTGGTCTCGGCGCTGACA
TCCACCGCCGGCACCTACGACGAGGCCGTCACCAAATATTTTGCGGCCAAATACGTCCGCGCCCGCGAAGGTTACGTCTG
GAGCGAGGGCGAGGAGAATTTCCGGACGGTGGCATTGCTGTCGACGCAGCCGGAGCAAACGCGGTTTTCAGCACTCTATC
GCGGCAGCAATCCGGATTCGCCGCAGAACATTTATGGCCGCAGCGCGACCTCGCGGATCAACATCGTTTCCATCTCGCTG
ATCAACGCCAACGTTGCATCCGTCCGCTATATGAGGACCGTGACCCGTGGTGACGAGGTGCGCACCACGCACTGGGTTGC
GACCCTGACCTTTTCCTACGCCAACGCGCCGATGTCCTCAACCGATCGGCTGATCAATCCGCTCGGCTTCGTCGTCAGCG
AATATCGCGCCGATCCGGAGGCCATCAATTGA

Upstream 100 bases:

>100_bases
GCCTTGCCGCCTCCTATGTGCCGGCCCCTTCCGCCCCCGCGCCGGCCGCCTTCGGACATTTCGATGTCGCGGGTTCCTAC
CGTCCATGCGAGGGCGTGAC

Downstream 100 bases:

>100_bases
GATCGCACGTTTTCCTTCCGCTTATCCTTGCCGGCAGCCTCTCCTCGCCGGTGCTCGCCCTCGAAACGCCACGCGGTGCG
GCGCAGGATAGCCGCATTCG

Product: transport secretion system IV protein, VirB8

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MVTTDSLKSYFEKARRFDQERMMQVERSARIAWFVAVSAGALAAASVFAIAGLTPLKTVEPFVVRVDNSTGIVDVVSALT
STAGTYDEAVTKYFAAKYVRAREGYVWSEGEENFRTVALLSTQPEQTRFSALYRGSNPDSPQNIYGRSATSRINIVSISL
INANVASVRYMRTVTRGDEVRTTHWVATLTFSYANAPMSSTDRLINPLGFVVSEYRADPEAIN

Sequences:

>Translated_223_residues
MVTTDSLKSYFEKARRFDQERMMQVERSARIAWFVAVSAGALAAASVFAIAGLTPLKTVEPFVVRVDNSTGIVDVVSALT
STAGTYDEAVTKYFAAKYVRAREGYVWSEGEENFRTVALLSTQPEQTRFSALYRGSNPDSPQNIYGRSATSRINIVSISL
INANVASVRYMRTVTRGDEVRTTHWVATLTFSYANAPMSSTDRLINPLGFVVSEYRADPEAIN
>Mature_223_residues
MVTTDSLKSYFEKARRFDQERMMQVERSARIAWFVAVSAGALAAASVFAIAGLTPLKTVEPFVVRVDNSTGIVDVVSALT
STAGTYDEAVTKYFAAKYVRAREGYVWSEGEENFRTVALLSTQPEQTRFSALYRGSNPDSPQNIYGRSATSRINIVSISL
INANVASVRYMRTVTRGDEVRTTHWVATLTFSYANAPMSSTDRLINPLGFVVSEYRADPEAIN

Specific function: Component of the type IV secretion system virB/virD4 which could be a major virulence determinant for subversion of human endothelial cell (HEC) function [H]

COG id: COG3736

COG function: function code U; Type IV secretory pathway, component VirB8

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the virB8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007430 [H]

Pfam domain/function: PF04335 VirB8 [H]

EC number: NA

Molecular weight: Translated: 24651; Mature: 24651

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTTDSLKSYFEKARRFDQERMMQVERSARIAWFVAVSAGALAAASVFAIAGLTPLKTVE
CCCHHHHHHHHHHHHHCCHHHHHHHHHHCEEEEEEEEHHCHHHHHHHHHHHCCCCCCCCC
PFVVRVDNSTGIVDVVSALTSTAGTYDEAVTKYFAAKYVRAREGYVWSEGEENFRTVALL
CEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEEE
STQPEQTRFSALYRGSNPDSPQNIYGRSATSRINIVSISLINANVASVRYMRTVTRGDEV
ECCCCHHHHHHHCCCCCCCCCHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHCCCCC
RTTHWVATLTFSYANAPMSSTDRLINPLGFVVSEYRADPEAIN
EEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVTTDSLKSYFEKARRFDQERMMQVERSARIAWFVAVSAGALAAASVFAIAGLTPLKTVE
CCCHHHHHHHHHHHHHCCHHHHHHHHHHCEEEEEEEEHHCHHHHHHHHHHHCCCCCCCCC
PFVVRVDNSTGIVDVVSALTSTAGTYDEAVTKYFAAKYVRAREGYVWSEGEENFRTVALL
CEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEEE
STQPEQTRFSALYRGSNPDSPQNIYGRSATSRINIVSISLINANVASVRYMRTVTRGDEV
ECCCCHHHHHHHCCCCCCCCCHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHCCCCC
RTTHWVATLTFSYANAPMSSTDRLINPLGFVVSEYRADPEAIN
EEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA