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The map label for this gene is hisN [H]

Identifier: 190895134

GI number: 190895134

Start: 866278

End: 867063

Strand: Reverse

Name: hisN [H]

Synonym: RHECIAT_PC0000804

Alternate gene names: 190895134

Gene position: 867063-866278 (Counterclockwise)

Preceding gene: 190895135

Following gene: 190895133

Centisome position: 79.44

GC content: 57.63

Gene sequence:

>786_bases
ATGAAACTTCCTACGGCGGATTTTCTGCACAGATTAGCCGACGCTGCCGATCGCGAGACAGTGTCGCGATTTCGGAAAAA
GCTTGAGACGACAACGAAGCCAAAAGAGGGATACCGTTTTGATCCAGTGACGGAAGCGGATCGAGAGGCCGAATTGGCAA
TGCGAGCGCTGATCTCCCAGGAGTTTCCCGACCACAGCATTGTCGGTGAAGAGTACGGCGTCACGGGAGCTGGAGCATGC
CAGTGGGTCCTGGATCCGATTGATGGCACGCGCCCTTTTCTGCTTGGAATTCCGGTATGGGGAACCCTGATCGGCTTCTG
CGAGCAAGGGCGAGCGACCGCTGGATTGATGAGCCAACCGATCACGAGAGAGAGATTTTGGGCCCACAACGGCGAAAGCT
GGCTCAGGACGGACAACGCTACAACCCGCTTGACGACAAGTGCGTGCACGCAGCTCTCGGATGCCGTCTTGCATACGAAC
TCCCCTGAGGGCGTGCGCCGGAACCCGGACGTTCGATTTGATGTGCTCGACGCGACGGTCAAAATGACCCGCTATGGGGG
CGAGTGTTACGCTTTCGCCATGTTGGCGGCCGGCCACATTGATATCTGCGTCGAATTCAGTCTTCAGCCTTACGACATCG
TGCCGATGATTCCGCTTATCGAGGCTGCGGGGGGCGCAGTAACGACATTTGACGGGTCGCGTCCGGAAAACGGAGGCCGC
ATTATCGCTTCTGCCAACGAGGAACTCCACGCCGCTGCGATCAGTGTTTTGATGCGTGGACGATGA

Upstream 100 bases:

>100_bases
AACCGGGCGACATGGTGGCATCCTCATCGCAACAACCATACCGAAGTATAAAGCGACAGCGTTGCGGCGCTTCGAGACAC
CAACGAGACAGGAATAAACA

Downstream 100 bases:

>100_bases
AGCATAGCGCGTCGATCGCCAGGGGTTGAGCCTGTCGCGACGCGCCGTCACGAGCCGAGACGGTGGGCGCGCGACAGTGC
GTTCGCCGTCATCTGTTCCA

Product: putative inositol monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MKLPTADFLHRLADAADRETVSRFRKKLETTTKPKEGYRFDPVTEADREAELAMRALISQEFPDHSIVGEEYGVTGAGAC
QWVLDPIDGTRPFLLGIPVWGTLIGFCEQGRATAGLMSQPITRERFWAHNGESWLRTDNATTRLTTSACTQLSDAVLHTN
SPEGVRRNPDVRFDVLDATVKMTRYGGECYAFAMLAAGHIDICVEFSLQPYDIVPMIPLIEAAGGAVTTFDGSRPENGGR
IIASANEELHAAAISVLMRGR

Sequences:

>Translated_261_residues
MKLPTADFLHRLADAADRETVSRFRKKLETTTKPKEGYRFDPVTEADREAELAMRALISQEFPDHSIVGEEYGVTGAGAC
QWVLDPIDGTRPFLLGIPVWGTLIGFCEQGRATAGLMSQPITRERFWAHNGESWLRTDNATTRLTTSACTQLSDAVLHTN
SPEGVRRNPDVRFDVLDATVKMTRYGGECYAFAMLAAGHIDICVEFSLQPYDIVPMIPLIEAAGGAVTTFDGSRPENGGR
IIASANEELHAAAISVLMRGR
>Mature_261_residues
MKLPTADFLHRLADAADRETVSRFRKKLETTTKPKEGYRFDPVTEADREAELAMRALISQEFPDHSIVGEEYGVTGAGAC
QWVLDPIDGTRPFLLGIPVWGTLIGFCEQGRATAGLMSQPITRERFWAHNGESWLRTDNATTRLTTSACTQLSDAVLHTN
SPEGVRRNPDVRFDVLDATVKMTRYGGECYAFAMLAAGHIDICVEFSLQPYDIVPMIPLIEAAGGAVTTFDGSRPENGGR
IIASANEELHAAAISVLMRGR

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788882, Length=198, Percent_Identity=28.7878787878788, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193202570, Length=205, Percent_Identity=27.8048780487805, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193202572, Length=208, Percent_Identity=27.4038461538462, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357957, Length=275, Percent_Identity=24.7272727272727, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24664918, Length=262, Percent_Identity=25.5725190839695, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21357329, Length=234, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24664926, Length=252, Percent_Identity=23.4126984126984, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24664922, Length=248, Percent_Identity=26.2096774193548, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28645; Mature: 28645

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPTADFLHRLADAADRETVSRFRKKLETTTKPKEGYRFDPVTEADREAELAMRALISQ
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
EFPDHSIVGEEYGVTGAGACQWVLDPIDGTRPFLLGIPVWGTLIGFCEQGRATAGLMSQP
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHCCCCHHHHHCCC
ITRERFWAHNGESWLRTDNATTRLTTSACTQLSDAVLHTNSPEGVRRNPDVRFDVLDATV
CCHHHHHCCCCCCEEECCCCCEEEEHHHHHHHHHHHEECCCCCCCCCCCCCEEEEHHHHH
KMTRYGGECYAFAMLAAGHIDICVEFSLQPYDIVPMIPLIEAAGGAVTTFDGSRPENGGR
HHHHCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCE
IIASANEELHAAAISVLMRGR
EEEECCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLPTADFLHRLADAADRETVSRFRKKLETTTKPKEGYRFDPVTEADREAELAMRALISQ
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
EFPDHSIVGEEYGVTGAGACQWVLDPIDGTRPFLLGIPVWGTLIGFCEQGRATAGLMSQP
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHCCCCHHHHHCCC
ITRERFWAHNGESWLRTDNATTRLTTSACTQLSDAVLHTNSPEGVRRNPDVRFDVLDATV
CCHHHHHCCCCCCEEECCCCCEEEEHHHHHHHHHHHEECCCCCCCCCCCCCEEEEHHHHH
KMTRYGGECYAFAMLAAGHIDICVEFSLQPYDIVPMIPLIEAAGGAVTTFDGSRPENGGR
HHHHCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCE
IIASANEELHAAAISVLMRGR
EEEECCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]