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The map label for this gene is pccB [H]

Identifier: 190571286

GI number: 190571286

Start: 956182

End: 957708

Strand: Reverse

Name: pccB [H]

Synonym: WPa_0889

Alternate gene names: 190571286

Gene position: 957708-956182 (Counterclockwise)

Preceding gene: 190571287

Following gene: 190571285

Centisome position: 64.6

GC content: 37.0

Gene sequence:

>1527_bases
ATGCAAGACTCTGAAATACTAGAAACTCTAAAGATCAAAACATTAGAAGCCGAAAAAGGAGGAGGTCCTGATAGAGTTAA
CAAGCAACATGAAAAAGGAAAGCTAACCGCTAGAGAAAGGCTGAGTATATTGCTCGATGAAAATTCATTTCAAGAGTATG
ATAAGTTTGTGAAGCATCACGCAACTGATTTTGGCATGCAAAATGCTGATTTTTTAGGTGATGGAGTTGTAATTGGCCAT
GGTACTATTCATGGCAGAAAAGTTTTTGTTTATTCTCAGGATTTCACTGTCTTTGGTGGATCACTTGGTGCATCACATGC
AAAAAAAATATGCAAAATTATGGATATGGCAATTAATGCCAGGATTCCAATTATCGGACTAAACGACTCTGGTGGAGCTA
GAATTCAAGAGGGAGTAAATTCCCTTGCTGGTTACGGAGAAATTTTTCAAAGGAATGTAAATGCATCAGGCGTTATACCA
CAAATCTCTCTAATCATGGGCCCATGTGCTGGCGGTGCAGTTTACTCTCCAGCGCTAACCGATTTTATTTTCATGGTAAA
AAATAGCTCATACATGTTTATAACCGGACCAGATGTAGTGAAAAAAGTTACCTATGAAGATGTAAGCCACGAAGATCTTG
GTGGAGCAAAAATTCATACAAGCAAAACAGGAGTAGCAGATTTTGCGTTCAATAACGATGTTGAAATGCTGCTGAGAATC
CGTGAATTCCTTACCTTTTTACCAGTAAATAATCAAGAGTCAACGAAATCTGTACCAATCTGCAACTTAATTGATGATGT
TGATGAATCTTTGAACACTCTAGTTCCTAGTAATCCTAATACTCCTTATGATATGTATGAACTTATTGAAAAGGTGTGTG
ATGAAAGGAAATTTTTTGCACTAAAACCCGATTTTGCCCGTAACATCATAATTGGCTTTGGCAGAATTGGAGGAAATACT
ATTGGTGTTGTTGCAAATCAACCTATGCACCTTGCAGGATGCTTGGATATTGACTCTTCAAGAAAAGCTGCGAGGTTTGT
AAGATTTTGTGACGCATTTAACATTCCCATCATCACACTTATTGATGTTCCAGGTTTCCTGCCAGGTACAAATCAAGAAT
ACAATAATATAATACAACACGGAGCGAAACTGCTTTACGCTTATGCTGAAGCGACCGTGCCGAAAATTAGCCTTATCACT
AGAAAAGCGTATGGTGGTGCATATATTGTTATGAACTCAAAGCATTTAAAAGGTGATATAAATTATGCTTGGCCAACTGC
TGAAATAGCTGTAATGGGCCCTGAAAGTGCAGTTGAAATTATATTTAGGCATGAAAAAGACCAGCAAACGTTAATCAAAG
AATATAAAGAGAAATTTGCTAATCCATTTTTTGCTGCATCACATGGATACATTGATGACATTATAGTGCCAAGTAAAACA
AGGCATCACTTTCACAAAGCACTAGAGCTACTTAAAAACAAGAAAGTAGAAAGAATATGGAAGAAGCATGATAATCTTCC
TTTGTAA

Upstream 100 bases:

>100_bases
TACACATACACCGTTGCATGCAGTAACGGTGTATGTGTATAATCAATAGGATTTGTAAGCTCAATAAAGTTTACAACCAA
TTTGAAAGTTATTTTACTAC

Downstream 100 bases:

>100_bases
CTTTCCTCTCAGTCTTTATTGTAAGGTCTACAGTGCCGTTACACCAAGTTGGATTACCAATAACGCTAACTTTTGGGTTC
CTTTTTTCTATAATATATTC

Product: propionyl-CoA carboxylase, beta subunit

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MQDSEILETLKIKTLEAEKGGGPDRVNKQHEKGKLTARERLSILLDENSFQEYDKFVKHHATDFGMQNADFLGDGVVIGH
GTIHGRKVFVYSQDFTVFGGSLGASHAKKICKIMDMAINARIPIIGLNDSGGARIQEGVNSLAGYGEIFQRNVNASGVIP
QISLIMGPCAGGAVYSPALTDFIFMVKNSSYMFITGPDVVKKVTYEDVSHEDLGGAKIHTSKTGVADFAFNNDVEMLLRI
REFLTFLPVNNQESTKSVPICNLIDDVDESLNTLVPSNPNTPYDMYELIEKVCDERKFFALKPDFARNIIIGFGRIGGNT
IGVVANQPMHLAGCLDIDSSRKAARFVRFCDAFNIPIITLIDVPGFLPGTNQEYNNIIQHGAKLLYAYAEATVPKISLIT
RKAYGGAYIVMNSKHLKGDINYAWPTAEIAVMGPESAVEIIFRHEKDQQTLIKEYKEKFANPFFAASHGYIDDIIVPSKT
RHHFHKALELLKNKKVERIWKKHDNLPL

Sequences:

>Translated_508_residues
MQDSEILETLKIKTLEAEKGGGPDRVNKQHEKGKLTARERLSILLDENSFQEYDKFVKHHATDFGMQNADFLGDGVVIGH
GTIHGRKVFVYSQDFTVFGGSLGASHAKKICKIMDMAINARIPIIGLNDSGGARIQEGVNSLAGYGEIFQRNVNASGVIP
QISLIMGPCAGGAVYSPALTDFIFMVKNSSYMFITGPDVVKKVTYEDVSHEDLGGAKIHTSKTGVADFAFNNDVEMLLRI
REFLTFLPVNNQESTKSVPICNLIDDVDESLNTLVPSNPNTPYDMYELIEKVCDERKFFALKPDFARNIIIGFGRIGGNT
IGVVANQPMHLAGCLDIDSSRKAARFVRFCDAFNIPIITLIDVPGFLPGTNQEYNNIIQHGAKLLYAYAEATVPKISLIT
RKAYGGAYIVMNSKHLKGDINYAWPTAEIAVMGPESAVEIIFRHEKDQQTLIKEYKEKFANPFFAASHGYIDDIIVPSKT
RHHFHKALELLKNKKVERIWKKHDNLPL
>Mature_508_residues
MQDSEILETLKIKTLEAEKGGGPDRVNKQHEKGKLTARERLSILLDENSFQEYDKFVKHHATDFGMQNADFLGDGVVIGH
GTIHGRKVFVYSQDFTVFGGSLGASHAKKICKIMDMAINARIPIIGLNDSGGARIQEGVNSLAGYGEIFQRNVNASGVIP
QISLIMGPCAGGAVYSPALTDFIFMVKNSSYMFITGPDVVKKVTYEDVSHEDLGGAKIHTSKTGVADFAFNNDVEMLLRI
REFLTFLPVNNQESTKSVPICNLIDDVDESLNTLVPSNPNTPYDMYELIEKVCDERKFFALKPDFARNIIIGFGRIGGNT
IGVVANQPMHLAGCLDIDSSRKAARFVRFCDAFNIPIITLIDVPGFLPGTNQEYNNIIQHGAKLLYAYAEATVPKISLIT
RKAYGGAYIVMNSKHLKGDINYAWPTAEIAVMGPESAVEIIFRHEKDQQTLIKEYKEKFANPFFAASHGYIDDIIVPSKT
RHHFHKALELLKNKKVERIWKKHDNLPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=510, Percent_Identity=61.7647058823529, Blast_Score=647, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=530, Percent_Identity=59.4339622641509, Blast_Score=635, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=509, Percent_Identity=30.8447937131631, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI134142062, Length=411, Percent_Identity=25.5474452554745, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788655, Length=197, Percent_Identity=25.8883248730964, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=515, Percent_Identity=60.5825242718447, Blast_Score=635, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=515, Percent_Identity=60.5825242718447, Blast_Score=635, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=498, Percent_Identity=31.1244979919679, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI71997163, Length=365, Percent_Identity=24.6575342465753, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323863, Length=357, Percent_Identity=24.0896358543417, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24586065, Length=528, Percent_Identity=30.8712121212121, Blast_Score=236, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56443; Mature: 56443

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDSEILETLKIKTLEAEKGGGPDRVNKQHEKGKLTARERLSILLDENSFQEYDKFVKHH
CCHHHHHHHHHHEEEECCCCCCCCCCCCCHHHCCCCHHHHEEEEECCCCHHHHHHHHHHH
ATDFGMQNADFLGDGVVIGHGTIHGRKVFVYSQDFTVFGGSLGASHAKKICKIMDMAINA
HHHCCCCCCCCCCCCEEEECCEECCEEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHCC
RIPIIGLNDSGGARIQEGVNSLAGYGEIFQRNVNASGVIPQISLIMGPCAGGAVYSPALT
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
DFIFMVKNSSYMFITGPDVVKKVTYEDVSHEDLGGAKIHTSKTGVADFAFNNDVEMLLRI
HEEEEEECCCEEEEECHHHHHHHHHCCCCCCCCCCCEEECCCCCCEEEECCCCHHHHHHH
REFLTFLPVNNQESTKSVPICNLIDDVDESLNTLVPSNPNTPYDMYELIEKVCDERKFFA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEE
LKPDFARNIIIGFGRIGGNTIGVVANQPMHLAGCLDIDSSRKAARFVRFCDAFNIPIITL
ECCCCCCEEEEEEECCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEE
IDVPGFLPGTNQEYNNIIQHGAKLLYAYAEATVPKISLITRKAYGGAYIVMNSKHLKGDI
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCCCCC
NYAWPTAEIAVMGPESAVEIIFRHEKDQQTLIKEYKEKFANPFFAASHGYIDDIIVPSKT
EEECCCEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCCEECCCCH
RHHFHKALELLKNKKVERIWKKHDNLPL
HHHHHHHHHHHHCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MQDSEILETLKIKTLEAEKGGGPDRVNKQHEKGKLTARERLSILLDENSFQEYDKFVKHH
CCHHHHHHHHHHEEEECCCCCCCCCCCCCHHHCCCCHHHHEEEEECCCCHHHHHHHHHHH
ATDFGMQNADFLGDGVVIGHGTIHGRKVFVYSQDFTVFGGSLGASHAKKICKIMDMAINA
HHHCCCCCCCCCCCCEEEECCEECCEEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHCC
RIPIIGLNDSGGARIQEGVNSLAGYGEIFQRNVNASGVIPQISLIMGPCAGGAVYSPALT
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
DFIFMVKNSSYMFITGPDVVKKVTYEDVSHEDLGGAKIHTSKTGVADFAFNNDVEMLLRI
HEEEEEECCCEEEEECHHHHHHHHHCCCCCCCCCCCEEECCCCCCEEEECCCCHHHHHHH
REFLTFLPVNNQESTKSVPICNLIDDVDESLNTLVPSNPNTPYDMYELIEKVCDERKFFA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEE
LKPDFARNIIIGFGRIGGNTIGVVANQPMHLAGCLDIDSSRKAARFVRFCDAFNIPIITL
ECCCCCCEEEEEEECCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEE
IDVPGFLPGTNQEYNNIIQHGAKLLYAYAEATVPKISLITRKAYGGAYIVMNSKHLKGDI
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCCCCC
NYAWPTAEIAVMGPESAVEIIFRHEKDQQTLIKEYKEKFANPFFAASHGYIDDIIVPSKT
EEECCCEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCCEECCCCH
RHHFHKALELLKNKKVERIWKKHDNLPL
HHHHHHHHHHHHCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]