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The map label for this gene is iscS [H]

Identifier: 190571221

GI number: 190571221

Start: 899190

End: 900362

Strand: Reverse

Name: iscS [H]

Synonym: WPa_0821

Alternate gene names: 190571221

Gene position: 900362-899190 (Counterclockwise)

Preceding gene: 190571224

Following gene: 190571220

Centisome position: 60.73

GC content: 36.66

Gene sequence:

>1173_bases
GTGAGTTTATTCTCTCTGGAAGAAAGTAGTTGCGTGTATGCTGATTATAATGCAACTGCTCCAGTGAGTAAAAATGTAAA
AAAAAGTATACTTGAGATTTTGTCAAAACAAACACTAAATCCATCATCTCTGCATAAAAGAGGACAAGAAGCGAGGAAGA
TTCTTAAAGAGGTAAGAGATAACGTACGTGATGCTCTTAGCATTCCAGATGATAAAGAAATAGTTTTTACGTCTGGTGCA
ACTGAAGCAAACAACCTCGTCATGAGAGGAATGAAAGGCTATCTGCATGTAATTTCAGCTACAGAGCATCCTTCAATTCT
TAATTCTGCATGTAATCCACATATAATACCCGTTAATCAAGAGGGTATTGTTGACTTTTTAGAGCTAGAGAAAATTCTAA
GCGAACTTGAAGGGAATAAAGTAATAATTTCAGTGATGATGGCTAATAACGAAACTGGAGTTATCCAGCCTGTTAAGGAA
ATAGCTAAAATAGCACATAAATTCGGGGCAATCTGTCACACTGACGCTGCTCAAAGTGTTGGGAAAATCAAAGTAAATAT
GGAAGATTTAGGAGTGGATTTACTTACTTTATCTGCTCACAAATTTGGTGGTATAGCAGGTAGTGGAGTTTTAATATTTG
ACAAAAAGCTTGTAATAGAACCTACTATAATAGGTGGTGGGCAAGAAAGAGGATTGCGTGGTGGTACAGAAAACATTGTT
GCAATTGCAGGTCTTTCTGCTGCATTGCAAAACATTCCAGATCTTCTATCAAAAATGAATGAAGTGGAGAAGCTGCGTGA
TCAATTGGAGTGTGAATTATTAAGTCTTGTCAGTGATATCAAGATCTTTGGCAGAAATTCTGAAAGATTGCCAAATACAA
GTTTTATTTATATGCCGAGGGTAAAGAATGATCTGCAGCTCATGCATTTTGACTTAAATAATATTGCAGTCAGCAATGGT
TCTGCATGCTCTTCTGGAAAAGTTGGGCCTTCTCATGTTTTGCTTGCAATGGGAGCAACAAAAGAGCAAGCAGAATGTTC
AATTAGAATCAGTATAGGTCCGGAGGTTAAACCGCGAGACATAGAAAAAATAGTGGATTGTTGGTATAGTATCTATAAGA
AGAATGCTTTAGTAAATGCAAAAACTACTTTCACCATTCCCCTTAAATCATGA

Upstream 100 bases:

>100_bases
TTTATTAATTATGTATTAATTTCACTGTTTTTGCAATAAATTTTTTATCGTGTTAAAGTTAACATACATAATTGGTTAAT
GGTAAGTGACAAATAAGCCT

Downstream 100 bases:

>100_bases
TAGAGGGAATGGTGAAAGTAATTTCTATTGCCAGAGGTTGTTATAATAGTTAAATGCTGCTGAAAACCGATTTGCTTATA
GTTATGGAAGAAATTCTCTA

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSLFSLEESSCVYADYNATAPVSKNVKKSILEILSKQTLNPSSLHKRGQEARKILKEVRDNVRDALSIPDDKEIVFTSGA
TEANNLVMRGMKGYLHVISATEHPSILNSACNPHIIPVNQEGIVDFLELEKILSELEGNKVIISVMMANNETGVIQPVKE
IAKIAHKFGAICHTDAAQSVGKIKVNMEDLGVDLLTLSAHKFGGIAGSGVLIFDKKLVIEPTIIGGGQERGLRGGTENIV
AIAGLSAALQNIPDLLSKMNEVEKLRDQLECELLSLVSDIKIFGRNSERLPNTSFIYMPRVKNDLQLMHFDLNNIAVSNG
SACSSGKVGPSHVLLAMGATKEQAECSIRISIGPEVKPRDIEKIVDCWYSIYKKNALVNAKTTFTIPLKS

Sequences:

>Translated_390_residues
MSLFSLEESSCVYADYNATAPVSKNVKKSILEILSKQTLNPSSLHKRGQEARKILKEVRDNVRDALSIPDDKEIVFTSGA
TEANNLVMRGMKGYLHVISATEHPSILNSACNPHIIPVNQEGIVDFLELEKILSELEGNKVIISVMMANNETGVIQPVKE
IAKIAHKFGAICHTDAAQSVGKIKVNMEDLGVDLLTLSAHKFGGIAGSGVLIFDKKLVIEPTIIGGGQERGLRGGTENIV
AIAGLSAALQNIPDLLSKMNEVEKLRDQLECELLSLVSDIKIFGRNSERLPNTSFIYMPRVKNDLQLMHFDLNNIAVSNG
SACSSGKVGPSHVLLAMGATKEQAECSIRISIGPEVKPRDIEKIVDCWYSIYKKNALVNAKTTFTIPLKS
>Mature_389_residues
SLFSLEESSCVYADYNATAPVSKNVKKSILEILSKQTLNPSSLHKRGQEARKILKEVRDNVRDALSIPDDKEIVFTSGAT
EANNLVMRGMKGYLHVISATEHPSILNSACNPHIIPVNQEGIVDFLELEKILSELEGNKVIISVMMANNETGVIQPVKEI
AKIAHKFGAICHTDAAQSVGKIKVNMEDLGVDLLTLSAHKFGGIAGSGVLIFDKKLVIEPTIIGGGQERGLRGGTENIVA
IAGLSAALQNIPDLLSKMNEVEKLRDQLECELLSLVSDIKIFGRNSERLPNTSFIYMPRVKNDLQLMHFDLNNIAVSNGS
ACSSGKVGPSHVLLAMGATKEQAECSIRISIGPEVKPRDIEKIVDCWYSIYKKNALVNAKTTFTIPLKS

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=363, Percent_Identity=34.435261707989, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI156713448, Length=405, Percent_Identity=32.0987654320988, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI48994898, Length=381, Percent_Identity=33.5958005249344, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1789175, Length=400, Percent_Identity=24, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787970, Length=313, Percent_Identity=25.5591054313099, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25143064, Length=377, Percent_Identity=33.6870026525199, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17533177, Length=321, Percent_Identity=35.5140186915888, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319831, Length=374, Percent_Identity=35.0267379679144, Blast_Score=190, Evalue=4e-49,
Organism=Drosophila melanogaster, GI20129463, Length=383, Percent_Identity=34.4647519582245, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42459; Mature: 42327

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFSLEESSCVYADYNATAPVSKNVKKSILEILSKQTLNPSSLHKRGQEARKILKEVRD
CCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
NVRDALSIPDDKEIVFTSGATEANNLVMRGMKGYLHVISATEHPSILNSACNPHIIPVNQ
HHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCEEECCC
EGIVDFLELEKILSELEGNKVIISVMMANNETGVIQPVKEIAKIAHKFGAICHTDAAQSV
CCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCC
GKIKVNMEDLGVDLLTLSAHKFGGIAGSGVLIFDKKLVIEPTIIGGGQERGLRGGTENIV
CEEEEEHHHCCEEEEEECHHHCCCCCCCCEEEEECEEEEEEEEECCCCCCCCCCCCCCEE
AIAGLSAALQNIPDLLSKMNEVEKLRDQLECELLSLVSDIKIFGRNSERLPNTSFIYMPR
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC
VKNDLQLMHFDLNNIAVSNGSACSSGKVGPSHVLLAMGATKEQAECSIRISIGPEVKPRD
CCCCEEEEEEECCCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCHHH
IEKIVDCWYSIYKKNALVNAKTTFTIPLKS
HHHHHHHHHHHHHCCCEEECCEEEEEEECC
>Mature Secondary Structure 
SLFSLEESSCVYADYNATAPVSKNVKKSILEILSKQTLNPSSLHKRGQEARKILKEVRD
CCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
NVRDALSIPDDKEIVFTSGATEANNLVMRGMKGYLHVISATEHPSILNSACNPHIIPVNQ
HHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCEEECCC
EGIVDFLELEKILSELEGNKVIISVMMANNETGVIQPVKEIAKIAHKFGAICHTDAAQSV
CCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCC
GKIKVNMEDLGVDLLTLSAHKFGGIAGSGVLIFDKKLVIEPTIIGGGQERGLRGGTENIV
CEEEEEHHHCCEEEEEECHHHCCCCCCCCEEEEECEEEEEEEEECCCCCCCCCCCCCCEE
AIAGLSAALQNIPDLLSKMNEVEKLRDQLECELLSLVSDIKIFGRNSERLPNTSFIYMPR
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC
VKNDLQLMHFDLNNIAVSNGSACSSGKVGPSHVLLAMGATKEQAECSIRISIGPEVKPRD
CCCCEEEEEEECCCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCHHH
IEKIVDCWYSIYKKNALVNAKTTFTIPLKS
HHHHHHHHHHHHHCCCEEECCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA