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The map label for this gene is gcp

Identifier: 190571188

GI number: 190571188

Start: 862378

End: 863388

Strand: Direct

Name: gcp

Synonym: WPa_0786

Alternate gene names: 190571188

Gene position: 862378-863388 (Clockwise)

Preceding gene: 190571187

Following gene: 190571189

Centisome position: 58.17

GC content: 37.49

Gene sequence:

>1011_bases
ATGAAAACCATTTTAGCGATTGAAACAAGTTGCGATGAAACTGCAGTTGCGATTGTAAATAGTGATAAGCAAGTGCTTGC
TAACGAAATTCTTTCTCAGGTAGAGCACAAAAAGTGCGGTGGAGTGATTCCTGAAATAGCATCACGTGCTCATATGAAGC
ATTTAAGTGGTTTAATAAAAAGTGCTATGGAAAAATCTAACCTTAACTTTTGTGATCTAGATGCAATTGCAGCAACATCA
GGACCAGGACTCATAGGTGGATTAATAATTGGTACAATGATGGCTAAAGCAATTGCACACGTAACACAAAAACCGTTTAT
TGCAGTTAATCACTTAGAAGCACATGCGTTAGTTGTTAGGCTACTATATGAGGTTGAATTTCCGTTTTTAGTCCTGCTGA
TATCAGGTGGTCACTGCCAATTTTTAATTGCACAGGATGTAGGTAAATACATCAAACTTGGAGAAACGCTTGATGACTCA
TTAGGAGAAGCATTTGACAAAGTCGCTAAAACGCTGGGTCTAAGCTATCCGGGAGGTCCATTAATTGAAGAGTTAGCTAA
AAAAGGTGATGGTATGAGATTTAAGCTGCCAAGAGCAATGATAAAACGTTCTGGATGTGACCTTTCATTTTCTGGAATTA
AAACAGCGGTAAAAAACTTAGCACGAGAATTTGTAATGAGTGAACAGGATGTGTGTGATATGTGTGCTTCGTTTCAAGAG
TGTATTAGCGACATATTACTCGATAGAGTCAGAAATGCTATTGGTATCGCTGTATCTTTAAATATTAAAATCAATGATTT
TGTAATTACTGGTGGAGTTGCAGCAAATAATTTCCTGAAAGAGAGATTAAAAAAGCACATAGACTTGAACGTGCTTTCTC
CTCCAAGCAATTTATGTACAGACAATGCAGTGATGGTTGGATGGACAGGAATTGAAAGGTTACAGAGAAGCTATGTAGAC
TCTCTTGACTTTGCACCAAGGCCAAAGTGGGAATTAGAAAAATATTACTAG

Upstream 100 bases:

>100_bases
TGGTTCTATATTTGAAGATGATAATTAGCTCAGCAGAACAAAGTTCACTTCTTCAACATTTCAAGTTATAGTTCTCGCAA
TTTAAAGAGTTCAAATATAT

Downstream 100 bases:

>100_bases
CACAAAAAATTATCTACTATATAATGCGGCCGCTGGTGAATTTTTGTAGGCTTAAAAATTACAGTGGTATCTACTAAAGC
CTTACCGGCATTATTATTTA

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKTILAIETSCDETAVAIVNSDKQVLANEILSQVEHKKCGGVIPEIASRAHMKHLSGLIKSAMEKSNLNFCDLDAIAATS
GPGLIGGLIIGTMMAKAIAHVTQKPFIAVNHLEAHALVVRLLYEVEFPFLVLLISGGHCQFLIAQDVGKYIKLGETLDDS
LGEAFDKVAKTLGLSYPGGPLIEELAKKGDGMRFKLPRAMIKRSGCDLSFSGIKTAVKNLAREFVMSEQDVCDMCASFQE
CISDILLDRVRNAIGIAVSLNIKINDFVITGGVAANNFLKERLKKHIDLNVLSPPSNLCTDNAVMVGWTGIERLQRSYVD
SLDFAPRPKWELEKYY

Sequences:

>Translated_336_residues
MKTILAIETSCDETAVAIVNSDKQVLANEILSQVEHKKCGGVIPEIASRAHMKHLSGLIKSAMEKSNLNFCDLDAIAATS
GPGLIGGLIIGTMMAKAIAHVTQKPFIAVNHLEAHALVVRLLYEVEFPFLVLLISGGHCQFLIAQDVGKYIKLGETLDDS
LGEAFDKVAKTLGLSYPGGPLIEELAKKGDGMRFKLPRAMIKRSGCDLSFSGIKTAVKNLAREFVMSEQDVCDMCASFQE
CISDILLDRVRNAIGIAVSLNIKINDFVITGGVAANNFLKERLKKHIDLNVLSPPSNLCTDNAVMVGWTGIERLQRSYVD
SLDFAPRPKWELEKYY
>Mature_336_residues
MKTILAIETSCDETAVAIVNSDKQVLANEILSQVEHKKCGGVIPEIASRAHMKHLSGLIKSAMEKSNLNFCDLDAIAATS
GPGLIGGLIIGTMMAKAIAHVTQKPFIAVNHLEAHALVVRLLYEVEFPFLVLLISGGHCQFLIAQDVGKYIKLGETLDDS
LGEAFDKVAKTLGLSYPGGPLIEELAKKGDGMRFKLPRAMIKRSGCDLSFSGIKTAVKNLAREFVMSEQDVCDMCASFQE
CISDILLDRVRNAIGIAVSLNIKINDFVITGGVAANNFLKERLKKHIDLNVLSPPSNLCTDNAVMVGWTGIERLQRSYVD
SLDFAPRPKWELEKYY

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=336, Percent_Identity=36.6071428571429, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI8923380, Length=328, Percent_Identity=29.8780487804878, Blast_Score=124, Evalue=8e-29,
Organism=Escherichia coli, GI1789445, Length=334, Percent_Identity=40.1197604790419, Blast_Score=265, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17557464, Length=325, Percent_Identity=32.6153846153846, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71995670, Length=319, Percent_Identity=29.153605015674, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320099, Length=362, Percent_Identity=28.4530386740331, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322891, Length=296, Percent_Identity=29.3918918918919, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI20129063, Length=341, Percent_Identity=34.6041055718475, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI21357207, Length=332, Percent_Identity=29.2168674698795, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_WOLPP (B3CLX6)

Other databases:

- EMBL:   AM999887
- RefSeq:   YP_001975546.1
- MEROPS:   M22.001
- EnsemblBacteria:   EBWOLT00000000725
- GeneID:   6384709
- GenomeReviews:   AM999887_GR
- KEGG:   wpi:WPa_0786
- GeneTree:   EBGT00050000031403
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36694; Mature: 36694

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTILAIETSCDETAVAIVNSDKQVLANEILSQVEHKKCGGVIPEIASRAHMKHLSGLIK
CCEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
SAMEKSNLNFCDLDAIAATSGPGLIGGLIIGTMMAKAIAHVTQKPFIAVNHLEAHALVVR
HHHHHCCCCEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHH
LLYEVEFPFLVLLISGGHCQFLIAQDVGKYIKLGETLDDSLGEAFDKVAKTLGLSYPGGP
HHHHHCCCEEEEEECCCCEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCH
LIEELAKKGDGMRFKLPRAMIKRSGCDLSFSGIKTAVKNLAREFVMSEQDVCDMCASFQE
HHHHHHHCCCCCEEECCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
CISDILLDRVRNAIGIAVSLNIKINDFVITGGVAANNFLKERLKKHIDLNVLSPPSNLCT
HHHHHHHHHHHHHHEEEEEEEEEEEEEEEECCHHHHHHHHHHHHHHCCCEEECCCCCCCC
DNAVMVGWTGIERLQRSYVDSLDFAPRPKWELEKYY
CCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKTILAIETSCDETAVAIVNSDKQVLANEILSQVEHKKCGGVIPEIASRAHMKHLSGLIK
CCEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
SAMEKSNLNFCDLDAIAATSGPGLIGGLIIGTMMAKAIAHVTQKPFIAVNHLEAHALVVR
HHHHHCCCCEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHH
LLYEVEFPFLVLLISGGHCQFLIAQDVGKYIKLGETLDDSLGEAFDKVAKTLGLSYPGGP
HHHHHCCCEEEEEECCCCEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCH
LIEELAKKGDGMRFKLPRAMIKRSGCDLSFSGIKTAVKNLAREFVMSEQDVCDMCASFQE
HHHHHHHCCCCCEEECCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
CISDILLDRVRNAIGIAVSLNIKINDFVITGGVAANNFLKERLKKHIDLNVLSPPSNLCT
HHHHHHHHHHHHHHEEEEEEEEEEEEEEEECCHHHHHHHHHHHHHHCCCEEECCCCCCCC
DNAVMVGWTGIERLQRSYVDSLDFAPRPKWELEKYY
CCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA