Click here to switch to the map view.

The map label for this gene is gmk [H]

Identifier: 190571084

GI number: 190571084

Start: 747366

End: 747974

Strand: Direct

Name: gmk [H]

Synonym: WPa_0679

Alternate gene names: 190571084

Gene position: 747366-747974 (Clockwise)

Preceding gene: 190571083

Following gene: 190571085

Centisome position: 50.41

GC content: 32.51

Gene sequence:

>609_bases
ATGACCGTAAAAAATGAGGGCATACTACTGATTCTATCCTCTCCTTCTGGAGCTGGAAAAACTACTATATCAGAAAAATT
ACTTGAGCAATCAACTGATTTAGTTATGTCTGTTTCTATGACTACACGCAAACCTCGTCCCGGTGAAGTAAACGGAAAAG
ACTATTTTTTCGTTACTGAAGAAAAGTTTCACGAACTATGTAAGGCTGGTCAAATGCTTGAATATGCCAAAGTTTTTGAG
AATTTTTACGGTATACCAAAAGATTTTATAGAACAAAACCTGAGCAGTGGAATAAGTGTTTTACTGAATATAGATTGGCA
AGGAGCATTTCATTTGTTTGAAATCTTAAGAGAAAAAGTTGTAAGTGTTTTTATACTACCTCCCTCAATGGAAGAGCTTA
GACTGCGTCTACAAAGGCGTAATAGTGATGATGAAATTGAAATAGAGCGTAGATTAGCCGAAGCGCAAAAAGAGATAAGT
AAAAGTAATAAATATGATTACGTAATAATTAATGATAATCTTGATAAAAGCGTAGAAGAGATAAAATCAATACTAAGTAA
AGGAATGCTTAAAAAATTAGAAGAAAAATCAAGTTTGAAAGATCTATAA

Upstream 100 bases:

>100_bases
TATCAAATTCTAATTTAGAGGGCTCTAGTCTTTTAAACTTTGATTTAAAAAATACAAAGTCTTAAAAAAGCTCTATAATG
TACTTGTTAAATAAAGAAAA

Downstream 100 bases:

>100_bases
AAATATTTGTTTATCTCTTTTAGCAGCATTCACGCTTCACAGTTTAGCCACATTTATTATTTTTTAAGATAAAATAGTTA
AAATAGTAGACAAGTGCTAA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MTVKNEGILLILSSPSGAGKTTISEKLLEQSTDLVMSVSMTTRKPRPGEVNGKDYFFVTEEKFHELCKAGQMLEYAKVFE
NFYGIPKDFIEQNLSSGISVLLNIDWQGAFHLFEILREKVVSVFILPPSMEELRLRLQRRNSDDEIEIERRLAEAQKEIS
KSNKYDYVIINDNLDKSVEEIKSILSKGMLKKLEEKSSLKDL

Sequences:

>Translated_202_residues
MTVKNEGILLILSSPSGAGKTTISEKLLEQSTDLVMSVSMTTRKPRPGEVNGKDYFFVTEEKFHELCKAGQMLEYAKVFE
NFYGIPKDFIEQNLSSGISVLLNIDWQGAFHLFEILREKVVSVFILPPSMEELRLRLQRRNSDDEIEIERRLAEAQKEIS
KSNKYDYVIINDNLDKSVEEIKSILSKGMLKKLEEKSSLKDL
>Mature_201_residues
TVKNEGILLILSSPSGAGKTTISEKLLEQSTDLVMSVSMTTRKPRPGEVNGKDYFFVTEEKFHELCKAGQMLEYAKVFEN
FYGIPKDFIEQNLSSGISVLLNIDWQGAFHLFEILREKVVSVFILPPSMEELRLRLQRRNSDDEIEIERRLAEAQKEISK
SNKYDYVIINDNLDKSVEEIKSILSKGMLKKLEEKSSLKDL

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=183, Percent_Identity=40.4371584699454, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI4504221, Length=183, Percent_Identity=40.4371584699454, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI226874831, Length=183, Percent_Identity=40.4371584699454, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI38570142, Length=184, Percent_Identity=30.9782608695652, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI21361598, Length=191, Percent_Identity=28.2722513089005, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI14780902, Length=197, Percent_Identity=26.3959390862944, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1790080, Length=196, Percent_Identity=43.8775510204082, Blast_Score=170, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI193203132, Length=183, Percent_Identity=34.4262295081967, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17508835, Length=183, Percent_Identity=34.4262295081967, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17557440, Length=187, Percent_Identity=28.3422459893048, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71988048, Length=183, Percent_Identity=25.6830601092896, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71988041, Length=183, Percent_Identity=25.6830601092896, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=179, Percent_Identity=39.6648044692737, Blast_Score=132, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=31.3186813186813, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45554489, Length=175, Percent_Identity=26.8571428571429, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45554481, Length=175, Percent_Identity=26.8571428571429, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161077626, Length=175, Percent_Identity=26.8571428571429, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24640542, Length=175, Percent_Identity=26.8571428571429, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI85724806, Length=175, Percent_Identity=26.8571428571429, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI116007136, Length=175, Percent_Identity=26.8571428571429, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23140; Mature: 23009

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKNEGILLILSSPSGAGKTTISEKLLEQSTDLVMSVSMTTRKPRPGEVNGKDYFFVTE
CCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHEEEEEHHCCCCCCCCCCCCEEEEECH
EKFHELCKAGQMLEYAKVFENFYGIPKDFIEQNLSSGISVLLNIDWQGAFHLFEILREKV
HHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHH
VSVFILPPSMEELRLRLQRRNSDDEIEIERRLAEAQKEISKSNKYDYVIINDNLDKSVEE
HEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
IKSILSKGMLKKLEEKSSLKDL
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TVKNEGILLILSSPSGAGKTTISEKLLEQSTDLVMSVSMTTRKPRPGEVNGKDYFFVTE
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHEEEEEHHCCCCCCCCCCCCEEEEECH
EKFHELCKAGQMLEYAKVFENFYGIPKDFIEQNLSSGISVLLNIDWQGAFHLFEILREKV
HHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHH
VSVFILPPSMEELRLRLQRRNSDDEIEIERRLAEAQKEISKSNKYDYVIINDNLDKSVEE
HEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
IKSILSKGMLKKLEEKSSLKDL
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA