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The map label for this gene is tsaA [H]

Identifier: 190570611

GI number: 190570611

Start: 158855

End: 159454

Strand: Reverse

Name: tsaA [H]

Synonym: WPa_0151

Alternate gene names: 190570611

Gene position: 159454-158855 (Counterclockwise)

Preceding gene: 190570612

Following gene: 190570610

Centisome position: 10.76

GC content: 34.33

Gene sequence:

>600_bases
ATGAATCTTGTAACAAAATCCGCTATCGATTTTACTGCTTCGGCTGTTCTTGCTAGTGGAAAAATAGTTGATGATTTCTG
TTTAAGTAAACATATAAAGGATAAGTATGCTGTCCTTTTTTTCTATCCACTTGATTTTACTTTTGTCTGTCCAACTGAGT
TGATATCATTTAGCAACAAAATAGAAGATTTTTCAAAACGTGATGTTGAAGTGATAGGAATAAGTATAGATTCAAAATTT
TCACACTATAAATGGCGAAACACTCCAGTTAATGATGGTGGTATTGGAGAGGTTAGCTACAATTTAGTGTCTGATATCAA
AAAGTCTATATCAAGAGACTATGGGGTCTTATATGATGACTCAATTGCACTAAGAGCAACTTTTGTTATTGATGATAAAT
TTGTTGTACGTCATCAATCGATAAATGATTTTCCTTTAGGGCGTAATATCGATGAATTCATTAGAATCATTGATGCAATA
AAACATAATGAAGAGCATGGTGAAGTATGTCCAGCAGGGTGGAAAAAAGGCAAGCCTGCGATGCAGGCAAGCGATGAAGG
AGTGGCTGATTATCTAAACTCACACAGTGCAGAATTATAA

Upstream 100 bases:

>100_bases
GCCATAAGAGGAAGTTTTTATAAGATTGGGGCTAAAGAAAACTTGCATGTAAATGTATCAAGGTATAAAATTATAAATAT
TAAGAATGAATAGGTTAGTT

Downstream 100 bases:

>100_bases
ATTGAGTACAAAAGTTCTTATTATTGGATCTGGAGCAGCGGGTTATGCTGCTGCTATATATGCAGCACGTGCAAATTTAG
AGCCAATTGTAGTAACAGGA

Product: antioxidant, AhpC/Tsa family

Products: NA

Alternate protein names: 26 kDa antigen; Thioredoxin reductase [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MNLVTKSAIDFTASAVLASGKIVDDFCLSKHIKDKYAVLFFYPLDFTFVCPTELISFSNKIEDFSKRDVEVIGISIDSKF
SHYKWRNTPVNDGGIGEVSYNLVSDIKKSISRDYGVLYDDSIALRATFVIDDKFVVRHQSINDFPLGRNIDEFIRIIDAI
KHNEEHGEVCPAGWKKGKPAMQASDEGVADYLNSHSAEL

Sequences:

>Translated_199_residues
MNLVTKSAIDFTASAVLASGKIVDDFCLSKHIKDKYAVLFFYPLDFTFVCPTELISFSNKIEDFSKRDVEVIGISIDSKF
SHYKWRNTPVNDGGIGEVSYNLVSDIKKSISRDYGVLYDDSIALRATFVIDDKFVVRHQSINDFPLGRNIDEFIRIIDAI
KHNEEHGEVCPAGWKKGKPAMQASDEGVADYLNSHSAEL
>Mature_199_residues
MNLVTKSAIDFTASAVLASGKIVDDFCLSKHIKDKYAVLFFYPLDFTFVCPTELISFSNKIEDFSKRDVEVIGISIDSKF
SHYKWRNTPVNDGGIGEVSYNLVSDIKKSISRDYGVLYDDSIALRATFVIDDKFVVRHQSINDFPLGRNIDEFIRIIDAI
KHNEEHGEVCPAGWKKGKPAMQASDEGVADYLNSHSAEL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=194, Percent_Identity=47.4226804123711, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI4505591, Length=188, Percent_Identity=49.468085106383, Blast_Score=192, Evalue=1e-49,
Organism=Homo sapiens, GI32455266, Length=188, Percent_Identity=49.468085106383, Blast_Score=192, Evalue=1e-49,
Organism=Homo sapiens, GI32455264, Length=188, Percent_Identity=49.468085106383, Blast_Score=192, Evalue=1e-49,
Organism=Homo sapiens, GI5802974, Length=195, Percent_Identity=46.1538461538462, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI32483377, Length=172, Percent_Identity=48.2558139534884, Blast_Score=184, Evalue=4e-47,
Organism=Homo sapiens, GI5453549, Length=162, Percent_Identity=46.9135802469136, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI33188454, Length=82, Percent_Identity=54.8780487804878, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI4758638, Length=161, Percent_Identity=27.9503105590062, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1786822, Length=157, Percent_Identity=33.7579617834395, Blast_Score=109, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193204376, Length=198, Percent_Identity=46.4646464646465, Blast_Score=172, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI32565831, Length=198, Percent_Identity=46.4646464646465, Blast_Score=172, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17554494, Length=162, Percent_Identity=43.2098765432099, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25153706, Length=161, Percent_Identity=26.7080745341615, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323613, Length=192, Percent_Identity=40.625, Blast_Score=159, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6320661, Length=188, Percent_Identity=40.9574468085106, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319407, Length=174, Percent_Identity=29.8850574712644, Blast_Score=85, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24656348, Length=191, Percent_Identity=46.0732984293194, Blast_Score=183, Evalue=7e-47,
Organism=Drosophila melanogaster, GI17864676, Length=191, Percent_Identity=46.0732984293194, Blast_Score=183, Evalue=7e-47,
Organism=Drosophila melanogaster, GI17157991, Length=197, Percent_Identity=43.6548223350254, Blast_Score=176, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24641739, Length=197, Percent_Identity=43.6548223350254, Blast_Score=176, Evalue=8e-45,
Organism=Drosophila melanogaster, GI17738015, Length=198, Percent_Identity=46.4646464646465, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=40.5263157894737, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24581278, Length=157, Percent_Identity=33.7579617834395, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI17975518, Length=162, Percent_Identity=29.6296296296296, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24652434, Length=162, Percent_Identity=29.6296296296296, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24652436, Length=162, Percent_Identity=29.6296296296296, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22350; Mature: 22350

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVTKSAIDFTASAVLASGKIVDDFCLSKHIKDKYAVLFFYPLDFTFVCPTELISFSNK
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHHH
IEDFSKRDVEVIGISIDSKFSHYKWRNTPVNDGGIGEVSYNLVSDIKKSISRDYGVLYDD
HHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEECC
SIALRATFVIDDKFVVRHQSINDFPLGRNIDEFIRIIDAIKHNEEHGEVCPAGWKKGKPA
CEEEEEEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
MQASDEGVADYLNSHSAEL
CCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MNLVTKSAIDFTASAVLASGKIVDDFCLSKHIKDKYAVLFFYPLDFTFVCPTELISFSNK
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHHH
IEDFSKRDVEVIGISIDSKFSHYKWRNTPVNDGGIGEVSYNLVSDIKKSISRDYGVLYDD
HHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEECC
SIALRATFVIDDKFVVRHQSINDFPLGRNIDEFIRIIDAIKHNEEHGEVCPAGWKKGKPA
CEEEEEEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
MQASDEGVADYLNSHSAEL
CCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 1987145 [H]