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The map label for this gene is uppS [H]

Identifier: 190570532

GI number: 190570532

Start: 54403

End: 55098

Strand: Reverse

Name: uppS [H]

Synonym: WPa_0060

Alternate gene names: 190570532

Gene position: 55098-54403 (Counterclockwise)

Preceding gene: 190570533

Following gene: 190570531

Centisome position: 3.72

GC content: 32.18

Gene sequence:

>696_bases
ATGTTGAATCTAGAATCTCTGCCAAAACATCTAGCAATTATTATGGATGGTAATGGTAGGTGGGCAAACAATCAAGGAAG
GGTAAAAATTGATGGCTATAGAAAAGGCAGTGAGGTTGCATTTGATATTGCTAAGCATTGCACAGTCCTGGCCATACCTT
ACTTAACTTTGTATGCATTTTCCATGGAAAATTGGCTCAGATCTGAAAACGAAACAGACTACCTATTTAATTTATTTTAC
TACACTTTAACTAATGAAGATAAAATGAAATTCATTTACAATTGTAACATTAAGTTAAATTTTATTGGCAATTTAAGTCT
ATTGCCCAGTAAAATATTCGATCAAATCAAAAAAGCAGAAGAAGTGACACATAAGAACGATGGTCTATTACTCACTGTTG
CAGTTAGTTATGGAGCAAAGCAGGAAATTATACATGCTATCAACAACGTCATAAAAGGAAATATTGATTGCGTATTGGAA
GAGGAATTTGAAAAATTTCTGTATACTAAAGATTTGCCAAAATTGGATTTATTAATTCGCACTGGTGGCGAAAAAAGGTT
AAGCAATTTTTTATTATGGCAAGCAGCTTATGCTGAATTGTATTTTTGTGATACTTTGTGGCCCGATTTTTCTTGTCAAG
ATTTGACCAAAGCACTAGAAGATTATACAAAAAGAGAAAAAAAATATGGTAGATAA

Upstream 100 bases:

>100_bases
TATCAATGATTTTTCAGTAATAATATAGTTTTAGGTGGATATAGTGAACGTTTCATACAGAGATATAGACATTAAGCTAA
TTAGAACAGGTTGAATTCAA

Downstream 100 bases:

>100_bases
TAACTTTATGGTTAGAATATTGTCCTCAATAGTAATATTACTCATATTTTCTTTTGCTACATATTTCAGTGATTTATCAT
TTTATCTACTAATTTTTTCA

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MLNLESLPKHLAIIMDGNGRWANNQGRVKIDGYRKGSEVAFDIAKHCTVLAIPYLTLYAFSMENWLRSENETDYLFNLFY
YTLTNEDKMKFIYNCNIKLNFIGNLSLLPSKIFDQIKKAEEVTHKNDGLLLTVAVSYGAKQEIIHAINNVIKGNIDCVLE
EEFEKFLYTKDLPKLDLLIRTGGEKRLSNFLLWQAAYAELYFCDTLWPDFSCQDLTKALEDYTKREKKYGR

Sequences:

>Translated_231_residues
MLNLESLPKHLAIIMDGNGRWANNQGRVKIDGYRKGSEVAFDIAKHCTVLAIPYLTLYAFSMENWLRSENETDYLFNLFY
YTLTNEDKMKFIYNCNIKLNFIGNLSLLPSKIFDQIKKAEEVTHKNDGLLLTVAVSYGAKQEIIHAINNVIKGNIDCVLE
EEFEKFLYTKDLPKLDLLIRTGGEKRLSNFLLWQAAYAELYFCDTLWPDFSCQDLTKALEDYTKREKKYGR
>Mature_231_residues
MLNLESLPKHLAIIMDGNGRWANNQGRVKIDGYRKGSEVAFDIAKHCTVLAIPYLTLYAFSMENWLRSENETDYLFNLFY
YTLTNEDKMKFIYNCNIKLNFIGNLSLLPSKIFDQIKKAEEVTHKNDGLLLTVAVSYGAKQEIIHAINNVIKGNIDCVLE
EEFEKFLYTKDLPKLDLLIRTGGEKRLSNFLLWQAAYAELYFCDTLWPDFSCQDLTKALEDYTKREKKYGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=221, Percent_Identity=34.841628959276, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI45580738, Length=221, Percent_Identity=34.841628959276, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1786371, Length=236, Percent_Identity=41.9491525423729, Blast_Score=193, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI71993029, Length=229, Percent_Identity=35.8078602620087, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=34.7417840375587, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323748, Length=219, Percent_Identity=31.9634703196347, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI18857969, Length=214, Percent_Identity=35.981308411215, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 26841; Mature: 26841

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLESLPKHLAIIMDGNGRWANNQGRVKIDGYRKGSEVAFDIAKHCTVLAIPYLTLYAF
CCCHHHCCCEEEEEECCCCCEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SMENWLRSENETDYLFNLFYYTLTNEDKMKFIYNCNIKLNFIGNLSLLPSKIFDQIKKAE
HHHHHHCCCCCCCCEEEEEEEEECCCCCEEEEEECCEEEEEECCCCCCHHHHHHHHHHHH
EVTHKNDGLLLTVAVSYGAKQEIIHAINNVIKGNIDCVLEEEFEKFLYTKDLPKLDLLIR
HHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCEEEEEE
TGGEKRLSNFLLWQAAYAELYFCDTLWPDFSCQDLTKALEDYTKREKKYGR
CCCHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNLESLPKHLAIIMDGNGRWANNQGRVKIDGYRKGSEVAFDIAKHCTVLAIPYLTLYAF
CCCHHHCCCEEEEEECCCCCEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SMENWLRSENETDYLFNLFYYTLTNEDKMKFIYNCNIKLNFIGNLSLLPSKIFDQIKKAE
HHHHHHCCCCCCCCEEEEEEEEECCCCCEEEEEECCEEEEEECCCCCCHHHHHHHHHHHH
EVTHKNDGLLLTVAVSYGAKQEIIHAINNVIKGNIDCVLEEEFEKFLYTKDLPKLDLLIR
HHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCEEEEEE
TGGEKRLSNFLLWQAAYAELYFCDTLWPDFSCQDLTKALEDYTKREKKYGR
CCCHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA