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The map label for this gene is groEL

Identifier: 190570503

GI number: 190570503

Start: 19890

End: 21548

Strand: Direct

Name: groEL

Synonym: WPa_0027

Alternate gene names: 190570503

Gene position: 19890-21548 (Clockwise)

Preceding gene: 190570502

Following gene: 190570504

Centisome position: 1.34

GC content: 38.22

Gene sequence:

>1659_bases
ATGGCTAACATAGTAGTATCAGGCGAACAGTTGCAAGAAGCCTTTCGTGAAGTTGCAGCAATGGTTGACTCAACGGTGGG
AGCAACTGCAGGGCCTAGGGGAAATACAATAGGAATTAGCAAGCCATATGGTGGACCAGAGGTCACAAAGGATGGCTATA
AGGTAATGAAAGGTATAAAGCCTGAAAAACCATTACACTCTGCGATAGTAAGCACCATTGCTCAAAGTGCTTCTCAGTGT
AATGACAAAGTTGGTGATGGTACCACAACATGCTCAATACTGACTAGCAATATGATAATGGAAGCTTCAAAGTCAATTGC
AGCTGGAAATGATCGTATTTGTATCAAAAATGGAATACAGAAGGCAAAAGATGTGATATTAAAGGAAATTACATCAATGT
CTCGCACAATTTCTTTAGAGAAAATGGATGAAGTTGCACAAGTTGCAATAATTTCTGCAAATGGTGATAAAGATATTGGT
AATAGCATTGCTGATGCTGTTAAAAAGGTTGGAAAAGAAGGCGTCATCACTGTTGAAGAGAGTAAGGGTTCAAAAGAATT
AGAAGTTGAACTTACAACTGGTATGCAGTTTGACCGTGGTTATCTCTCTCCATACTTTGTTACAAATAATGAAAAGATGA
GCGTGGAGCTTGATGATCCATATTTGCTGATTACAGAAAAAAAACTTAATATTATTCAACCTTTACTTCCTATTCTTGAG
GCTATTTTTAAGTCTGGTAAACCTTTGTTTATCATTGCAGAAGATGTTGAAGGTGAAGCATTAAGCACTTTAGTGATCAA
CAAATTACGTGGTCTAAAAGTTGCTGCAGTAAAAGCTCCAGGTTTTGGTGATAGGAGAAAGGAGATGCTCGAAGATATAG
CAGCTTTAACAGGTGCTAAGTATGTCATAAAAGATGAGCTTGGAATCAAGATGGAAGATTTGACTCTTGAAGATCTTGGT
ACTGCTAAAAATGTTAAAATCACTAAAGACAATACCACAATTGTTAGTGAAGACAGCGACTGTGACAAACAAAACAGAGT
AAATGCTAGAATTAACCAGATTAAATCTCAGATTGAAACTTCAACCTCTGATTATGACAAAGAAAAGCTAAGAGAGCGTT
TAGCAAAACTATCAGGCGGCGTTGCTGTACTCAAAGTTGGTGGAGCAACTGAAGTAGAGGTAAAAGAACGTAGAGATAGA
GTAGAAGATGCACTTCATGCAACAAGAGCTGCAATTGAAGAAGGGATAGTTCCAGGTGGAGGAGTTGCACTTCTTTACGC
TGCATCTGCTCTTGATAAGCTAAAAGCTTCAAGCGATGAAGAGCAAATAGGTATCAACATTGTCAAAAAAGTTCTCAGTG
CTCCAATCAAAAGATTGGTTAAAAATGCTGGTCTTGAATCTGCTGTTATAATTGACTATTTGATTAAGCAGAATGATAAA
GAGCTTATATACAACGTTGAGGCTATGAACTACGCTAATGCATCAACAGCTGGTGTAATTGATCCGGCAAAAGTAGTTCG
TATTGCTTTTGAAACGGCAGTGTCTGTAGCAAGCGCACTTATTACTACTGAATCTATGATAGTTGATCTACCAAACAAAG
AAGAAAATGCTTCATCACCTATGGGTGCAGGAGCAATGGGCGGAATGGGTGGATTCTAA

Upstream 100 bases:

>100_bases
TTATCAAGTAGGTATCCCTATTTTACTAAACTAATGCGCTATATAGTGCATTATGTATTTTAATATTCTAAATTTTTTAT
TAATTTAAGGAGTGATAAAA

Downstream 100 bases:

>100_bases
GTAAACAAGAGCCTTGGAGCAACTTGCTCCAAGGTATCTTTCTAGTTCTAAAAAGTCTTACATTTATAAAGGAAAGAAAT
TTGTGATTTTCTATGCAAAG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MANIVVSGEQLQEAFREVAAMVDSTVGATAGPRGNTIGISKPYGGPEVTKDGYKVMKGIKPEKPLHSAIVSTIAQSASQC
NDKVGDGTTTCSILTSNMIMEASKSIAAGNDRICIKNGIQKAKDVILKEITSMSRTISLEKMDEVAQVAIISANGDKDIG
NSIADAVKKVGKEGVITVEESKGSKELEVELTTGMQFDRGYLSPYFVTNNEKMSVELDDPYLLITEKKLNIIQPLLPILE
AIFKSGKPLFIIAEDVEGEALSTLVINKLRGLKVAAVKAPGFGDRRKEMLEDIAALTGAKYVIKDELGIKMEDLTLEDLG
TAKNVKITKDNTTIVSEDSDCDKQNRVNARINQIKSQIETSTSDYDKEKLRERLAKLSGGVAVLKVGGATEVEVKERRDR
VEDALHATRAAIEEGIVPGGGVALLYAASALDKLKASSDEEQIGINIVKKVLSAPIKRLVKNAGLESAVIIDYLIKQNDK
ELIYNVEAMNYANASTAGVIDPAKVVRIAFETAVSVASALITTESMIVDLPNKEENASSPMGAGAMGGMGGF

Sequences:

>Translated_552_residues
MANIVVSGEQLQEAFREVAAMVDSTVGATAGPRGNTIGISKPYGGPEVTKDGYKVMKGIKPEKPLHSAIVSTIAQSASQC
NDKVGDGTTTCSILTSNMIMEASKSIAAGNDRICIKNGIQKAKDVILKEITSMSRTISLEKMDEVAQVAIISANGDKDIG
NSIADAVKKVGKEGVITVEESKGSKELEVELTTGMQFDRGYLSPYFVTNNEKMSVELDDPYLLITEKKLNIIQPLLPILE
AIFKSGKPLFIIAEDVEGEALSTLVINKLRGLKVAAVKAPGFGDRRKEMLEDIAALTGAKYVIKDELGIKMEDLTLEDLG
TAKNVKITKDNTTIVSEDSDCDKQNRVNARINQIKSQIETSTSDYDKEKLRERLAKLSGGVAVLKVGGATEVEVKERRDR
VEDALHATRAAIEEGIVPGGGVALLYAASALDKLKASSDEEQIGINIVKKVLSAPIKRLVKNAGLESAVIIDYLIKQNDK
ELIYNVEAMNYANASTAGVIDPAKVVRIAFETAVSVASALITTESMIVDLPNKEENASSPMGAGAMGGMGGF
>Mature_551_residues
ANIVVSGEQLQEAFREVAAMVDSTVGATAGPRGNTIGISKPYGGPEVTKDGYKVMKGIKPEKPLHSAIVSTIAQSASQCN
DKVGDGTTTCSILTSNMIMEASKSIAAGNDRICIKNGIQKAKDVILKEITSMSRTISLEKMDEVAQVAIISANGDKDIGN
SIADAVKKVGKEGVITVEESKGSKELEVELTTGMQFDRGYLSPYFVTNNEKMSVELDDPYLLITEKKLNIIQPLLPILEA
IFKSGKPLFIIAEDVEGEALSTLVINKLRGLKVAAVKAPGFGDRRKEMLEDIAALTGAKYVIKDELGIKMEDLTLEDLGT
AKNVKITKDNTTIVSEDSDCDKQNRVNARINQIKSQIETSTSDYDKEKLRERLAKLSGGVAVLKVGGATEVEVKERRDRV
EDALHATRAAIEEGIVPGGGVALLYAASALDKLKASSDEEQIGINIVKKVLSAPIKRLVKNAGLESAVIIDYLIKQNDKE
LIYNVEAMNYANASTAGVIDPAKVVRIAFETAVSVASALITTESMIVDLPNKEENASSPMGAGAMGGMGGF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=512, Percent_Identity=44.921875, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI31542947, Length=512, Percent_Identity=44.921875, Blast_Score=422, Evalue=1e-118,
Organism=Escherichia coli, GI1790586, Length=521, Percent_Identity=48.9443378119002, Blast_Score=479, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17555558, Length=510, Percent_Identity=47.4509803921569, Blast_Score=440, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI193210679, Length=213, Percent_Identity=53.0516431924883, Blast_Score=210, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6323288, Length=508, Percent_Identity=45.2755905511811, Blast_Score=420, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24641193, Length=512, Percent_Identity=43.9453125, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24641191, Length=512, Percent_Identity=43.9453125, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI45550936, Length=511, Percent_Identity=42.2700587084149, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI45550132, Length=511, Percent_Identity=42.2700587084149, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI45550935, Length=511, Percent_Identity=42.2700587084149, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI17864606, Length=540, Percent_Identity=39.2592592592593, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI24584129, Length=536, Percent_Identity=31.7164179104478, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI19921262, Length=536, Percent_Identity=31.7164179104478, Blast_Score=246, Evalue=3e-65,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_WOLPP (B3CL71)

Other databases:

- EMBL:   AM999887
- RefSeq:   YP_001974861.1
- EnsemblBacteria:   EBWOLT00000000110
- GeneID:   6384426
- GenomeReviews:   AM999887_GR
- KEGG:   wpi:WPa_0027
- GeneTree:   EBGT00050000031456
- HOGENOM:   HBG625289
- OMA:   NKPETAT
- ProtClustDB:   PRK00013
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58983; Mature: 58852

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANIVVSGEQLQEAFREVAAMVDSTVGATAGPRGNTIGISKPYGGPEVTKDGYKVMKGIK
CCEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHCCC
PEKPLHSAIVSTIAQSASQCNDKVGDGTTTCSILTSNMIMEASKSIAAGNDRICIKNGIQ
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
KAKDVILKEITSMSRTISLEKMDEVAQVAIISANGDKDIGNSIADAVKKVGKEGVITVEE
HHHHHHHHHHHHHHHHCCHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEC
SKGSKELEVELTTGMQFDRGYLSPYFVTNNEKMSVELDDPYLLITEKKLNIIQPLLPILE
CCCCCEEEEEEECCCEECCCCCCCEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHHHH
AIFKSGKPLFIIAEDVEGEALSTLVINKLRGLKVAAVKAPGFGDRRKEMLEDIAALTGAK
HHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCC
YVIKDELGIKMEDLTLEDLGTAKNVKITKDNTTIVSEDSDCDKQNRVNARINQIKSQIET
EEEECCCCCEEECCCHHHCCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHC
STSDYDKEKLRERLAKLSGGVAVLKVGGATEVEVKERRDRVEDALHATRAAIEEGIVPGG
CCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GVALLYAASALDKLKASSDEEQIGINIVKKVLSAPIKRLVKNAGLESAVIIDYLIKQNDK
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCH
ELIYNVEAMNYANASTAGVIDPAKVVRIAFETAVSVASALITTESMIVDLPNKEENASSP
HEEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
MGAGAMGGMGGF
CCCCCCCCCCCC
>Mature Secondary Structure 
ANIVVSGEQLQEAFREVAAMVDSTVGATAGPRGNTIGISKPYGGPEVTKDGYKVMKGIK
CEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHCCC
PEKPLHSAIVSTIAQSASQCNDKVGDGTTTCSILTSNMIMEASKSIAAGNDRICIKNGIQ
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
KAKDVILKEITSMSRTISLEKMDEVAQVAIISANGDKDIGNSIADAVKKVGKEGVITVEE
HHHHHHHHHHHHHHHHCCHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEC
SKGSKELEVELTTGMQFDRGYLSPYFVTNNEKMSVELDDPYLLITEKKLNIIQPLLPILE
CCCCCEEEEEEECCCEECCCCCCCEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHHHH
AIFKSGKPLFIIAEDVEGEALSTLVINKLRGLKVAAVKAPGFGDRRKEMLEDIAALTGAK
HHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCC
YVIKDELGIKMEDLTLEDLGTAKNVKITKDNTTIVSEDSDCDKQNRVNARINQIKSQIET
EEEECCCCCEEECCCHHHCCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHC
STSDYDKEKLRERLAKLSGGVAVLKVGGATEVEVKERRDRVEDALHATRAAIEEGIVPGG
CCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GVALLYAASALDKLKASSDEEQIGINIVKKVLSAPIKRLVKNAGLESAVIIDYLIKQNDK
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCH
ELIYNVEAMNYANASTAGVIDPAKVVRIAFETAVSVASALITTESMIVDLPNKEENASSP
HEEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
MGAGAMGGMGGF
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA