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The map label for this gene is rhlB [C]

Identifier: 18978387

GI number: 18978387

Start: 1862800

End: 1865094

Strand: Direct

Name: rhlB [C]

Synonym: PF2015

Alternate gene names: 18978387

Gene position: 1862800-1865094 (Clockwise)

Preceding gene: 18978386

Following gene: 18978388

Centisome position: 97.62

GC content: 41.61

Gene sequence:

>2295_bases
GTGATGTTATTAAGGAGAGACTTAATACAGCCTAGGATATATCAAGAGGTAATATACGCCAAGTGCAAAGAAACAAACTG
CTTGATTGTTCTGCCCACAGGATTAGGTAAGACGCTGATAGCTATGATGATAGCAGAGTATAGATTAACGAAATATGGCG
GAAAAGTTCTAATGCTCGCCCCCACTAAGCCTCTCGTTCTTCAACATGCGGAAAGTTTTAGGAGGCTATTTAACCTCCCT
CCAGAAAAAATTGTAGCACTTACTGGAGAGAAGAGCCCAGAAGAGAGAAGTAAGGCCTGGGCGAGAGCAAAAGTAATTGT
AGCCACTCCTCAAACTATTGAAAATGACTTATTGGCGGGAAGAATATCTTTAGAAGACGTTTCGCTAATAGTATTCGATG
AAGCTCACAGAGCTGTGGGCAATTACGCTTACGTCTTTATAGCAAGAGAGTATAAAAGACAGGCCAAAAACCCACTTGTT
ATAGGGTTAACAGCCTCCCCTGGGAGCACTCCTGAAAAGATCATGGAGGTAATAAATAACTTGGGAATTGAGCATATTGA
ATACCGCTCCGAAAATTCTCCCGATGTTAGACCTTACGTTAAGGGAATAAGGTTTGAATGGGTTAGGGTTGATCTCCCAG
AAATATACAAGGAAGTAAGGAAACTTTTAAGAGAAATGCTTAGAGATGCCCTTAAACCGTTGGCAGAAACTGGACTTCTT
GAATCTTCTTCCCCAGACATTCCAAAGAAAGAAGTTCTTAGAGCTGGGCAAATAATAAACGAAGAAATGGCGAAAGGTAA
TCATGATCTCAGAGGCTTGCTTCTCTATCACGCAATGGCTCTTAAGCTACATCATGCAATTGAGCTGTTGGAAACCCAAG
GGTTATCCGCCCTGAGGGCTTATATAAAGAAGTTGTATGAGGAGGCAAAAGCGGGATCAACAAAGGCTAGCAAGGAAATA
TTCTCGGATAAGAGAATGAAAAAGGCAATCTCACTTTTAGTTCAAGCGAAGGAGATTGGGCTTGATCACCCCAAGATGGA
CAAGTTAAAAGAAATAATTAGGGAACAACTCCAAAGGAAACAAAATTCCAAAATCATAGTTTTCACTAACTACAGAGAAA
CTGCAAAAAAGATAGTCAATGAACTTGTGAAAGATGGAATAAAAGCTAAAAGGTTCGTTGGACAGGCCAGCAAAGAAAAT
GACCGTGGACTGAGTCAGAGAGAGCAGAAATTAATTCTTGACGAATTCGCTAGAGGAGAATTCAACGTTCTAGTGGCAAC
GAGTGTAGGAGAGGAAGGACTTGACGTGCCGGAAGTTGATTTGGTTGTGTTTTATGAGCCAGTACCATCTGCCATAAGGA
GCATCCAAAGAAGGGGTAGAACTGGCAGGCATATGCCGGGGAGAGTTATAATCCTAATGGCCAAGGGGACTAGAGATGAA
GCATACTACTGGAGTTCCAGGCAAAAGGAAAAGATAATGCAAGAGACAATAGCTAAGGTGAGTCAGGCAATTAAAAAGCA
GAAGCAAACTTCTCTAGTTGATTTTGTGAGAGAAAAAGAGAGCGAAAAGACCTCTCTAGACAAGTGGTTGAAAAAGGAAA
AAGAAGAAGCAACTGAAAAAGAGGAAAAGAAGGTAAAGGCTCAAGAGGGTGTAAAAGTCGTCGTAGATAGCAGAGAGCTT
AGGAGTGAGGTTGTGAAGAGACTTAAACTTCTTGGTGTAAAGTTAGAGGTTAAAACGCTCGATGTGGGAGATTATATAAT
TAGTGAGGACGTTGCAATTGAGAGGAAGTCAGCTAACGACTTCATTCAGTCAATTATTGATGGTAGACTTTTTGATCAAG
TTAAGAGGCTCAAAGAGGCATACTCAAGACCGATAATGATAGTCGAAGGTTCTTTATACGGAATTAGAAACGTCCATCCA
AATGCAATAAGGGGGGCAATAGCAGCGGTAACCGTAGACTTTGGGGTCCCAATAATATTTTCATCTACTCCAGAGGAAAC
CGCTCAATACATCTTTCTAATTGCAAAGAGGGAGCAAGAGGAGAGAGAAAAACCTGTGAGAATTAGAAGTGAGAAGAAGG
CCCTTACCCTTGCCGAGAGGCAGAGGTTAATAGTTGAGGGATTACCTCACGTCTCAGCAACTCTAGCTAGGAGATTGTTG
AAGCACTTTGGAAGTGTGGAAAGGGTATTCACTGCAAGCGTTGCTGAGTTAATGAAAGTTGAAGGCATAGGAGAGAAGAT
TGCTAAGGAGATTAGAAGGGTAATAACTGCCCCATATATAGAGGATGAGGAGTAG

Upstream 100 bases:

>100_bases
ATATAGATATTTCATTTAATGCAACTGATAGGCTTGATGTGATAGCCGTGAACAGCGAAGAGTTGCTAAAAACAATTTTA
AGCTTACTGGAGTAGATAGT

Downstream 100 bases:

>100_bases
TGTACCCCCGGGGAGCGAAGCGGGCTCACAGCTCGCCGCTCGCTCCCCCGCCGCGGTTTCCCGGGGGCAATGAAATTTCG
ACAAACATTTATAAATATCT

Product: Hef nuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 764; Mature: 764

Protein sequence:

>764_residues
MMLLRRDLIQPRIYQEVIYAKCKETNCLIVLPTGLGKTLIAMMIAEYRLTKYGGKVLMLAPTKPLVLQHAESFRRLFNLP
PEKIVALTGEKSPEERSKAWARAKVIVATPQTIENDLLAGRISLEDVSLIVFDEAHRAVGNYAYVFIAREYKRQAKNPLV
IGLTASPGSTPEKIMEVINNLGIEHIEYRSENSPDVRPYVKGIRFEWVRVDLPEIYKEVRKLLREMLRDALKPLAETGLL
ESSSPDIPKKEVLRAGQIINEEMAKGNHDLRGLLLYHAMALKLHHAIELLETQGLSALRAYIKKLYEEAKAGSTKASKEI
FSDKRMKKAISLLVQAKEIGLDHPKMDKLKEIIREQLQRKQNSKIIVFTNYRETAKKIVNELVKDGIKAKRFVGQASKEN
DRGLSQREQKLILDEFARGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSIQRRGRTGRHMPGRVIILMAKGTRDE
AYYWSSRQKEKIMQETIAKVSQAIKKQKQTSLVDFVREKESEKTSLDKWLKKEKEEATEKEEKKVKAQEGVKVVVDSREL
RSEVVKRLKLLGVKLEVKTLDVGDYIISEDVAIERKSANDFIQSIIDGRLFDQVKRLKEAYSRPIMIVEGSLYGIRNVHP
NAIRGAIAAVTVDFGVPIIFSSTPEETAQYIFLIAKREQEEREKPVRIRSEKKALTLAERQRLIVEGLPHVSATLARRLL
KHFGSVERVFTASVAELMKVEGIGEKIAKEIRRVITAPYIEDEE

Sequences:

>Translated_764_residues
MMLLRRDLIQPRIYQEVIYAKCKETNCLIVLPTGLGKTLIAMMIAEYRLTKYGGKVLMLAPTKPLVLQHAESFRRLFNLP
PEKIVALTGEKSPEERSKAWARAKVIVATPQTIENDLLAGRISLEDVSLIVFDEAHRAVGNYAYVFIAREYKRQAKNPLV
IGLTASPGSTPEKIMEVINNLGIEHIEYRSENSPDVRPYVKGIRFEWVRVDLPEIYKEVRKLLREMLRDALKPLAETGLL
ESSSPDIPKKEVLRAGQIINEEMAKGNHDLRGLLLYHAMALKLHHAIELLETQGLSALRAYIKKLYEEAKAGSTKASKEI
FSDKRMKKAISLLVQAKEIGLDHPKMDKLKEIIREQLQRKQNSKIIVFTNYRETAKKIVNELVKDGIKAKRFVGQASKEN
DRGLSQREQKLILDEFARGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSIQRRGRTGRHMPGRVIILMAKGTRDE
AYYWSSRQKEKIMQETIAKVSQAIKKQKQTSLVDFVREKESEKTSLDKWLKKEKEEATEKEEKKVKAQEGVKVVVDSREL
RSEVVKRLKLLGVKLEVKTLDVGDYIISEDVAIERKSANDFIQSIIDGRLFDQVKRLKEAYSRPIMIVEGSLYGIRNVHP
NAIRGAIAAVTVDFGVPIIFSSTPEETAQYIFLIAKREQEEREKPVRIRSEKKALTLAERQRLIVEGLPHVSATLARRLL
KHFGSVERVFTASVAELMKVEGIGEKIAKEIRRVITAPYIEDEE
>Mature_764_residues
MMLLRRDLIQPRIYQEVIYAKCKETNCLIVLPTGLGKTLIAMMIAEYRLTKYGGKVLMLAPTKPLVLQHAESFRRLFNLP
PEKIVALTGEKSPEERSKAWARAKVIVATPQTIENDLLAGRISLEDVSLIVFDEAHRAVGNYAYVFIAREYKRQAKNPLV
IGLTASPGSTPEKIMEVINNLGIEHIEYRSENSPDVRPYVKGIRFEWVRVDLPEIYKEVRKLLREMLRDALKPLAETGLL
ESSSPDIPKKEVLRAGQIINEEMAKGNHDLRGLLLYHAMALKLHHAIELLETQGLSALRAYIKKLYEEAKAGSTKASKEI
FSDKRMKKAISLLVQAKEIGLDHPKMDKLKEIIREQLQRKQNSKIIVFTNYRETAKKIVNELVKDGIKAKRFVGQASKEN
DRGLSQREQKLILDEFARGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSIQRRGRTGRHMPGRVIILMAKGTRDE
AYYWSSRQKEKIMQETIAKVSQAIKKQKQTSLVDFVREKESEKTSLDKWLKKEKEEATEKEEKKVKAQEGVKVVVDSREL
RSEVVKRLKLLGVKLEVKTLDVGDYIISEDVAIERKSANDFIQSIIDGRLFDQVKRLKEAYSRPIMIVEGSLYGIRNVHP
NAIRGAIAAVTVDFGVPIIFSSTPEETAQYIFLIAKREQEEREKPVRIRSEKKALTLAERQRLIVEGLPHVSATLARRLL
KHFGSVERVFTASVAELMKVEGIGEKIAKEIRRVITAPYIEDEE

Specific function: Can Carry Out ATP-Dependent Unwinding Of Double Stranded RNA. Has A Role In RNA Decay. Involved In The RNA Degradosome, A Multi-Enzyme Complex Important In RNA Processing And Messenger RNA Degradation. [C]

COG id: COG1111

COG function: function code L; ERCC4-like helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI74959747, Length=531, Percent_Identity=30.5084745762712, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI27881482, Length=539, Percent_Identity=25.7884972170686, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI149408122, Length=542, Percent_Identity=26.0147601476015, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI4885217, Length=347, Percent_Identity=25.9365994236311, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI27886568, Length=126, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71982860, Length=561, Percent_Identity=27.9857397504456, Blast_Score=115, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17539846, Length=247, Percent_Identity=30.3643724696356, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17532461, Length=133, Percent_Identity=27.8195488721804, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322192, Length=580, Percent_Identity=29.1379310344828, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6325235, Length=240, Percent_Identity=26.25, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI116008407, Length=577, Percent_Identity=29.6360485268631, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI17933560, Length=199, Percent_Identity=29.6482412060301, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR020819
- InterPro:   IPR006166
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR011335
- InterPro:   IPR010994 [H]

Pfam domain/function: PF00270 DEAD; PF02732 ERCC4; PF00271 Helicase_C; PF00633 HHH [H]

EC number: =3.6.4.13 [H]

Molecular weight: Translated: 86941; Mature: 86941

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS00690 DEAH_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLLRRDLIQPRIYQEVIYAKCKETNCLIVLPTGLGKTLIAMMIAEYRLTKYGGKVLMLA
CCCHHHHHHCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEE
PTKPLVLQHAESFRRLFNLPPEKIVALTGEKSPEERSKAWARAKVIVATPQTIENDLLAG
CCCHHHHHHHHHHHHHHCCCHHHEEEECCCCCHHHHHHHHHHEEEEEECCCHHHHHHHCC
RISLEDVSLIVFDEAHRAVGNYAYVFIAREYKRQAKNPLVIGLTASPGSTPEKIMEVINN
EEECCCEEEEEEECHHHHHCCEEEEEEEHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHH
LGIEHIEYRSENSPDVRPYVKGIRFEWVRVDLPEIYKEVRKLLREMLRDALKPLAETGLL
CCCCEEEECCCCCCCHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ESSSPDIPKKEVLRAGQIINEEMAKGNHDLRGLLLYHAMALKLHHAIELLETQGLSALRA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
YIKKLYEEAKAGSTKASKEIFSDKRMKKAISLLVQAKEIGLDHPKMDKLKEIIREQLQRK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
QNSKIIVFTNYRETAKKIVNELVKDGIKAKRFVGQASKENDRGLSQREQKLILDEFARGE
CCCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCC
FNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSIQRRGRTGRHMPGRVIILMAKGTRDE
EEEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCC
AYYWSSRQKEKIMQETIAKVSQAIKKQKQTSLVDFVREKESEKTSLDKWLKKEKEEATEK
CHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
EEKKVKAQEGVKVVVDSRELRSEVVKRLKLLGVKLEVKTLDVGDYIISEDVAIERKSAND
HHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCEEEEEEEECCCHHHCCCCCEECCCHHH
FIQSIIDGRLFDQVKRLKEAYSRPIMIVEGSLYGIRNVHPNAIRGAIAAVTVDFGVPIIF
HHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHEEEEECCCCEEE
SSTPEETAQYIFLIAKREQEEREKPVRIRSEKKALTLAERQRLIVEGLPHVSATLARRLL
CCCHHHHHHEEEEEECCCHHHCCCCCEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KHFGSVERVFTASVAELMKVEGIGEKIAKEIRRVITAPYIEDEE
HHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MMLLRRDLIQPRIYQEVIYAKCKETNCLIVLPTGLGKTLIAMMIAEYRLTKYGGKVLMLA
CCCHHHHHHCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEE
PTKPLVLQHAESFRRLFNLPPEKIVALTGEKSPEERSKAWARAKVIVATPQTIENDLLAG
CCCHHHHHHHHHHHHHHCCCHHHEEEECCCCCHHHHHHHHHHEEEEEECCCHHHHHHHCC
RISLEDVSLIVFDEAHRAVGNYAYVFIAREYKRQAKNPLVIGLTASPGSTPEKIMEVINN
EEECCCEEEEEEECHHHHHCCEEEEEEEHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHH
LGIEHIEYRSENSPDVRPYVKGIRFEWVRVDLPEIYKEVRKLLREMLRDALKPLAETGLL
CCCCEEEECCCCCCCHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ESSSPDIPKKEVLRAGQIINEEMAKGNHDLRGLLLYHAMALKLHHAIELLETQGLSALRA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
YIKKLYEEAKAGSTKASKEIFSDKRMKKAISLLVQAKEIGLDHPKMDKLKEIIREQLQRK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
QNSKIIVFTNYRETAKKIVNELVKDGIKAKRFVGQASKENDRGLSQREQKLILDEFARGE
CCCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCC
FNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSIQRRGRTGRHMPGRVIILMAKGTRDE
EEEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCC
AYYWSSRQKEKIMQETIAKVSQAIKKQKQTSLVDFVREKESEKTSLDKWLKKEKEEATEK
CHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
EEKKVKAQEGVKVVVDSRELRSEVVKRLKLLGVKLEVKTLDVGDYIISEDVAIERKSAND
HHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCEEEEEEEECCCHHHCCCCCEECCCHHH
FIQSIIDGRLFDQVKRLKEAYSRPIMIVEGSLYGIRNVHPNAIRGAIAAVTVDFGVPIIF
HHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHEEEEECCCCEEE
SSTPEETAQYIFLIAKREQEEREKPVRIRSEKKALTLAERQRLIVEGLPHVSATLARRLL
CCCHHHHHHEEEEEECCCHHHCCCCCEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KHFGSVERVFTASVAELMKVEGIGEKIAKEIRRVITAPYIEDEE
HHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]