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The map label for this gene is glpA [C]

Identifier: 18978377

GI number: 18978377

Start: 1854402

End: 1855892

Strand: Direct

Name: glpA [C]

Synonym: PF2005

Alternate gene names: 18978377

Gene position: 1854402-1855892 (Clockwise)

Preceding gene: 18978376

Following gene: 18978378

Centisome position: 97.18

GC content: 43.8

Gene sequence:

>1491_bases
ATGATTAAGGTTGCGATAATTGGAGCGGGAATAACGGGAGCTAGTATAGCAAGAGTTCTAAGCAGATATGAAAACCTCGA
GGTTCATCTAATAGACAAAAATCCCGACGTTGGTTGGGGTGTTAGTAAAGCAAACACAGCTTTAATTCATGGTGGATACG
ATGACGATCCAGATAAATACCCAATGAGGGCAAAGCTCTGTGTAAGGGGAAATAGACTCTGGCATAGATGGGTTAAGGAA
CTAGAAATACCCCACATATGGAATGGTGCCCTTGTTGTGGCATTGGAGGAGGAAGATTTTGACGAACTCGAAAAGCTTCT
CGAGAGGGGTATAAGAAATGGAGTCCCCGAGATGAGAATCGTTGACAGAGAAGAGCTGTTTCATTTGGAGCCAGGGTTGA
ATCCAGAGGCAAAAGGAGCACTTTGGATACCAACGGTAGGTCAGATTGGCCCTATTCCTGCGGTAATAGCTATAGTTGAG
AATGCCGTTGCCAATGGAGTCAAGATCCATCTCAACACCAAAGTTAAAGGAATAAAAGTGCAGAACGGGGAGGTAAAAGG
AGTTGAGACAAACAACGGATTCATTGAGGCAGATGTTATAATAAATGCCGCCGGACTTTATGCAGATGAAATTTCTAGAA
TGGTTGGACTCGATTACTTCACTATTCATCCCAGGAAGGGTGAGTACTGGATATTTGACGATACCGTCCCAGGACCTAGG
AGAGTTCTTTTCCCAACACCGACTCCAATTAGTAAGGGAATTGTAGTTACAACAGAGATAAGCGGTCATCTAATGATTGG
GCCCAATGCCCAGGACTTGCCACCTGAAGAAAAGGAAAACCTGGCAACTACAAGGGAAGGACTAGAGGAGGTATGGGAGG
GTGCAAAGAAGTTGTGGCCAAACCTTCCTCCAAGGAGCAAGGTAATAAGGACATTTGCAGGGTTAAGACCAGAGCCCACA
GGTGGAGACTTTATAATTAAGGCTGAAGAAGAAGTCTTTGGTTTCATAAACGTTGCTGGAATCCGTTCTCCTGGACTTAC
TAGTGCCCCAGCAATTGCTTATGAAGTTGCAGAGATAATCCAGAGGGATCTCGGTATTAAGCTCATAGAAAAAGAAAAGT
GGAACCCATATAGGAAGGATATAACAAGATTCTCAATGCTCTCTCCAGAGGAAGCAAACAGATTGATTAGAGAGAACCCT
GCTTACGGAAAGATTGTATGCAGGTGTAACCTAGTAACTGAAGGTGAGATTCTAGAGGCAATAGAGAGAATGAAGTTCAT
AGGCGTTAAAATTCCAAGCATAGACTCAATAAAGTTTAGGACTAAAGCTACCTCAGGAACCTGCCAGGGAAGCTTTTGTA
GGGTTAGGATAATTCAACTTCTCTCAAAGGCATACAACGTTCCACCCTGGGAAATTACTCTTAAGGGAGAGGGAAGCGAG
ATTGGTATAGGAGATGTTAAGGCATTGCTAAGAGGTGAGAACAGTGCTTGA

Upstream 100 bases:

>100_bases
GATGGATGAAAAAACTAGAGAAAAACTATATAGGGGATGGAAAGAGGCCGTTAAGAGAGCTTTAGGTTGGGCCAAAGTTG
TGAGTTGAGGAGGGGGATAA

Downstream 100 bases:

>100_bases
GAGTTATGACGTCGTTGTCATTGGAGGAGGACCAGCTGGAATGGGTGCAGCAATTAAGGCCAAAGAGCTTGGCCTGAAGG
TATTATTGCTCGATGACAAC

Product: glycerol-3-phosphate dehydrogenase

Products: glycerone phosphate; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MIKVAIIGAGITGASIARVLSRYENLEVHLIDKNPDVGWGVSKANTALIHGGYDDDPDKYPMRAKLCVRGNRLWHRWVKE
LEIPHIWNGALVVALEEEDFDELEKLLERGIRNGVPEMRIVDREELFHLEPGLNPEAKGALWIPTVGQIGPIPAVIAIVE
NAVANGVKIHLNTKVKGIKVQNGEVKGVETNNGFIEADVIINAAGLYADEISRMVGLDYFTIHPRKGEYWIFDDTVPGPR
RVLFPTPTPISKGIVVTTEISGHLMIGPNAQDLPPEEKENLATTREGLEEVWEGAKKLWPNLPPRSKVIRTFAGLRPEPT
GGDFIIKAEEEVFGFINVAGIRSPGLTSAPAIAYEVAEIIQRDLGIKLIEKEKWNPYRKDITRFSMLSPEEANRLIRENP
AYGKIVCRCNLVTEGEILEAIERMKFIGVKIPSIDSIKFRTKATSGTCQGSFCRVRIIQLLSKAYNVPPWEITLKGEGSE
IGIGDVKALLRGENSA

Sequences:

>Translated_496_residues
MIKVAIIGAGITGASIARVLSRYENLEVHLIDKNPDVGWGVSKANTALIHGGYDDDPDKYPMRAKLCVRGNRLWHRWVKE
LEIPHIWNGALVVALEEEDFDELEKLLERGIRNGVPEMRIVDREELFHLEPGLNPEAKGALWIPTVGQIGPIPAVIAIVE
NAVANGVKIHLNTKVKGIKVQNGEVKGVETNNGFIEADVIINAAGLYADEISRMVGLDYFTIHPRKGEYWIFDDTVPGPR
RVLFPTPTPISKGIVVTTEISGHLMIGPNAQDLPPEEKENLATTREGLEEVWEGAKKLWPNLPPRSKVIRTFAGLRPEPT
GGDFIIKAEEEVFGFINVAGIRSPGLTSAPAIAYEVAEIIQRDLGIKLIEKEKWNPYRKDITRFSMLSPEEANRLIRENP
AYGKIVCRCNLVTEGEILEAIERMKFIGVKIPSIDSIKFRTKATSGTCQGSFCRVRIIQLLSKAYNVPPWEITLKGEGSE
IGIGDVKALLRGENSA
>Mature_496_residues
MIKVAIIGAGITGASIARVLSRYENLEVHLIDKNPDVGWGVSKANTALIHGGYDDDPDKYPMRAKLCVRGNRLWHRWVKE
LEIPHIWNGALVVALEEEDFDELEKLLERGIRNGVPEMRIVDREELFHLEPGLNPEAKGALWIPTVGQIGPIPAVIAIVE
NAVANGVKIHLNTKVKGIKVQNGEVKGVETNNGFIEADVIINAAGLYADEISRMVGLDYFTIHPRKGEYWIFDDTVPGPR
RVLFPTPTPISKGIVVTTEISGHLMIGPNAQDLPPEEKENLATTREGLEEVWEGAKKLWPNLPPRSKVIRTFAGLRPEPT
GGDFIIKAEEEVFGFINVAGIRSPGLTSAPAIAYEVAEIIQRDLGIKLIEKEKWNPYRKDITRFSMLSPEEANRLIRENP
AYGKIVCRCNLVTEGEILEAIERMKFIGVKIPSIDSIKFRTKATSGTCQGSFCRVRIIQLLSKAYNVPPWEITLKGEGSE
IGIGDVKALLRGENSA

Specific function: Conversion Of Glycerol 3-Phosphate To Dihydroxyacetone. Uses Fumarate Or Nitrate As Electron Acceptor. [C]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Loosely Bound To The Cytoplasm Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI13376331, Length=281, Percent_Identity=26.3345195729537, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI197927446, Length=138, Percent_Identity=31.1594202898551, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI21361378, Length=138, Percent_Identity=31.1594202898551, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788574, Length=488, Percent_Identity=23.5655737704918, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI87082148, Length=261, Percent_Identity=25.2873563218391, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17565764, Length=296, Percent_Identity=27.7027027027027, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24585081, Length=287, Percent_Identity=26.1324041811847, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: 1.1.99.5

Molecular weight: Translated: 54946; Mature: 54946

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVAIIGAGITGASIARVLSRYENLEVHLIDKNPDVGWGVSKANTALIHGGYDDDPDKY
CEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCC
PMRAKLCVRGNRLWHRWVKELEIPHIWNGALVVALEEEDFDELEKLLERGIRNGVPEMRI
CCEEEEEECCCHHHHHHHHHCCCCEEECCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEE
VDREELFHLEPGLNPEAKGALWIPTVGQIGPIPAVIAIVENAVANGVKIHLNTKVKGIKV
ECHHHHEEECCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECEEEEEEE
QNGEVKGVETNNGFIEADVIINAAGLYADEISRMVGLDYFTIHPRKGEYWIFDDTVPGPR
ECCEEEEEECCCCEEEEEEEEEECHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCC
RVLFPTPTPISKGIVVTTEISGHLMIGPNAQDLPPEEKENLATTREGLEEVWEGAKKLWP
EEEECCCCCCCCCEEEEEECCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
NLPPRSKVIRTFAGLRPEPTGGDFIIKAEEEVFGFINVAGIRSPGLTSAPAIAYEVAEII
CCCCHHHHHHHHHCCCCCCCCCCEEEEECHHHEEEEEEEECCCCCCCCCCHHHHHHHHHH
QRDLGIKLIEKEKWNPYRKDITRFSMLSPEEANRLIRENPAYGKIVCRCNLVTEGEILEA
HHHCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHH
IERMKFIGVKIPSIDSIKFRTKATSGTCQGSFCRVRIIQLLSKAYNVPPWEITLKGEGSE
HHHHHHHEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCE
IGIGDVKALLRGENSA
ECHHHHHHHHCCCCCC
>Mature Secondary Structure
MIKVAIIGAGITGASIARVLSRYENLEVHLIDKNPDVGWGVSKANTALIHGGYDDDPDKY
CEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCC
PMRAKLCVRGNRLWHRWVKELEIPHIWNGALVVALEEEDFDELEKLLERGIRNGVPEMRI
CCEEEEEECCCHHHHHHHHHCCCCEEECCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEE
VDREELFHLEPGLNPEAKGALWIPTVGQIGPIPAVIAIVENAVANGVKIHLNTKVKGIKV
ECHHHHEEECCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECEEEEEEE
QNGEVKGVETNNGFIEADVIINAAGLYADEISRMVGLDYFTIHPRKGEYWIFDDTVPGPR
ECCEEEEEECCCCEEEEEEEEEECHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCC
RVLFPTPTPISKGIVVTTEISGHLMIGPNAQDLPPEEKENLATTREGLEEVWEGAKKLWP
EEEECCCCCCCCCEEEEEECCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
NLPPRSKVIRTFAGLRPEPTGGDFIIKAEEEVFGFINVAGIRSPGLTSAPAIAYEVAEII
CCCCHHHHHHHHHCCCCCCCCCCEEEEECHHHEEEEEEEECCCCCCCCCCHHHHHHHHHH
QRDLGIKLIEKEKWNPYRKDITRFSMLSPEEANRLIRENPAYGKIVCRCNLVTEGEILEA
HHHCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHH
IERMKFIGVKIPSIDSIKFRTKATSGTCQGSFCRVRIIQLLSKAYNVPPWEITLKGEGSE
HHHHHHHEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCE
IGIGDVKALLRGENSA
ECHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: sn-glycerol 3-phosphate; acceptor

Specific reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7569993 [H]