BacMap

Definition	Pyrococcus furiosus DSM 3638, complete genome.
Accession	NC_003413
Length	1,908,256

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The map label for this gene is yeaE [H]

Identifier: 18978332

GI number: 18978332

Start: 1810244

End: 1811080

Strand: Direct

Name: yeaE [H]

Synonym: PF1960

Alternate gene names: 18978332

Gene position: 1810244-1811080 (Clockwise)

Preceding gene: 18978331

Following gene: 18978333

Centisome position: 94.86

GC content: 43.37

Gene sequence:

>837_bases
ATGAAAAGGGTAAATGCATTCAACGACCTTAAGCGTATAGGAGATGATAAGGTAACGGCAATTGGAATGGGAACATGGGG
AATAGGAGGGAGAGAGACCCCAGACTATTCTAGGGATAAGGAAAGCATAGAAGCAATAAGATATGGACTTGAATTAGGAA
TGAATTTAATCGACACAGCGGAATTCTATGGAGCTGGTCATGCTGAGGAAATAGTTGGAGAGGCCATTAAAGAATTCGAA
CGTGAGGACATCTTCATAGTGAGCAAGGTCTGGCCAACTCACTTTGGGTATGAGGAAGCAAAGAAGGCTGCTAGAGCAAG
TGCTAAAAGGTTAGGAACTTATATTGACCTTTATTTGTTGCACTGGCCCGTTGATGACTTCAAGAAGATAGAGGAGACAC
TTCACGCTTTGGAAGACCTCGTAGATGAGGGAGTGATAAGGTACATTGGAGTTAGCAACTTCAATCTGGAACTTCTCCAG
CGCTCCCAGGAGGTCATGAGGAAGTATGAGATTGTAGCAAATCAAGTTAAATACTCAGTGAAAGACCGCTGGCCCGAAAC
TACAGGACTTCTCGACTACATGAAGCGTGAAGGAATAGCATTAATGGCGTACACACCTCTAGAAAAGGGAACTCTTGCAA
GGAATGAATGTCTAGCTAAAATTGGAGAAAAATACGGAAAAACAGCTGCTCAAGTGGCTTTAAACTACCTGATTTGGGAG
GAAAATGTTGTAGCAATTCCAAAAGCAAGCAACAAGGAACACCTCAAAGAAAACTTTGGAGCTATGGGATGGAGGCTTTC
AGAGGAGGATAGAGAGATGGCAAGGAGGTGTGTGTGA

Upstream 100 bases:

>100_bases
TATTTCTCTTTCTACTGAAATTACCTTTTCGTTTCTTAACTTAGCGTTTTGGTAGAAACCTTAATTAAGGTGTATATCAA
AACTATTTTGGTGTGAAATT

Downstream 100 bases:

>100_bases
TGTTTGGGTATAAGGGAAAAATTGCAAGGGTTAACCTCACAACTGGGAAAGTTAAGTATGAAGACCTTCCAGAAGAGATA
ATCAGGAAGTTTATAGGTGG

Product: aldose reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MKRVNAFNDLKRIGDDKVTAIGMGTWGIGGRETPDYSRDKESIEAIRYGLELGMNLIDTAEFYGAGHAEEIVGEAIKEFE
REDIFIVSKVWPTHFGYEEAKKAARASAKRLGTYIDLYLLHWPVDDFKKIEETLHALEDLVDEGVIRYIGVSNFNLELLQ
RSQEVMRKYEIVANQVKYSVKDRWPETTGLLDYMKREGIALMAYTPLEKGTLARNECLAKIGEKYGKTAAQVALNYLIWE
ENVVAIPKASNKEHLKENFGAMGWRLSEEDREMARRCV

Sequences:

>Translated_278_residues
MKRVNAFNDLKRIGDDKVTAIGMGTWGIGGRETPDYSRDKESIEAIRYGLELGMNLIDTAEFYGAGHAEEIVGEAIKEFE
REDIFIVSKVWPTHFGYEEAKKAARASAKRLGTYIDLYLLHWPVDDFKKIEETLHALEDLVDEGVIRYIGVSNFNLELLQ
RSQEVMRKYEIVANQVKYSVKDRWPETTGLLDYMKREGIALMAYTPLEKGTLARNECLAKIGEKYGKTAAQVALNYLIWE
ENVVAIPKASNKEHLKENFGAMGWRLSEEDREMARRCV
>Mature_278_residues
MKRVNAFNDLKRIGDDKVTAIGMGTWGIGGRETPDYSRDKESIEAIRYGLELGMNLIDTAEFYGAGHAEEIVGEAIKEFE
REDIFIVSKVWPTHFGYEEAKKAARASAKRLGTYIDLYLLHWPVDDFKKIEETLHALEDLVDEGVIRYIGVSNFNLELLQ
RSQEVMRKYEIVANQVKYSVKDRWPETTGLLDYMKREGIALMAYTPLEKGTLARNECLAKIGEKYGKTAAQVALNYLIWE
ENVVAIPKASNKEHLKENFGAMGWRLSEEDREMARRCV

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI291291012, Length=270, Percent_Identity=34.8148148148148, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI223468663, Length=297, Percent_Identity=32.6599326599327, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI24497585, Length=287, Percent_Identity=29.616724738676, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI93277124, Length=309, Percent_Identity=27.5080906148867, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI310109922, Length=272, Percent_Identity=30.5147058823529, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI24497583, Length=287, Percent_Identity=29.616724738676, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4502049, Length=293, Percent_Identity=29.0102389078498, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI5174695, Length=295, Percent_Identity=29.4915254237288, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI45446745, Length=290, Percent_Identity=29.3103448275862, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4503285, Length=290, Percent_Identity=29.3103448275862, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI310109920, Length=290, Percent_Identity=29.3103448275862, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI24497577, Length=292, Percent_Identity=27.3972602739726, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI5174391, Length=292, Percent_Identity=27.3972602739726, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI5453543, Length=292, Percent_Identity=29.1095890410959, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI300116273, Length=284, Percent_Identity=29.5774647887324, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI27436969, Length=296, Percent_Identity=25, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4504825, Length=311, Percent_Identity=24.4372990353698, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI27436962, Length=306, Percent_Identity=25.8169934640523, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI27436966, Length=295, Percent_Identity=25.7627118644068, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI27436964, Length=295, Percent_Identity=25.7627118644068, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1788081, Length=266, Percent_Identity=38.7218045112782, Blast_Score=164, Evalue=4e-42,
Organism=Escherichia coli, GI1786400, Length=259, Percent_Identity=29.7297297297297, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1788070, Length=316, Percent_Identity=29.746835443038, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787674, Length=276, Percent_Identity=28.6231884057971, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87082198, Length=260, Percent_Identity=30, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1789375, Length=311, Percent_Identity=27.6527331189711, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI87081735, Length=293, Percent_Identity=30.0341296928328, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1789199, Length=324, Percent_Identity=28.0864197530864, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71998625, Length=262, Percent_Identity=34.7328244274809, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17564128, Length=295, Percent_Identity=28.4745762711864, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17561300, Length=277, Percent_Identity=29.6028880866426, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17566692, Length=286, Percent_Identity=29.020979020979, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17550248, Length=290, Percent_Identity=27.2413793103448, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17552492, Length=279, Percent_Identity=26.1648745519713, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17537077, Length=289, Percent_Identity=28.3737024221453, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17537075, Length=289, Percent_Identity=28.719723183391, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17561298, Length=275, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17538386, Length=276, Percent_Identity=26.4492753623188, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17537079, Length=299, Percent_Identity=24.7491638795987, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322556, Length=266, Percent_Identity=30.0751879699248, Blast_Score=104, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324694, Length=290, Percent_Identity=29.3103448275862, Blast_Score=92, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6321896, Length=295, Percent_Identity=28.8135593220339, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320576, Length=301, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319625, Length=274, Percent_Identity=30.2919708029197, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320079, Length=271, Percent_Identity=29.520295202952, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24663317, Length=290, Percent_Identity=34.1379310344828, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI20129731, Length=283, Percent_Identity=31.095406360424, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24657054, Length=290, Percent_Identity=30.6896551724138, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24662789, Length=276, Percent_Identity=30.7971014492754, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21356425, Length=295, Percent_Identity=31.5254237288136, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24644950, Length=300, Percent_Identity=30, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI45553081, Length=283, Percent_Identity=28.6219081272085, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281366140, Length=252, Percent_Identity=29.7619047619048, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24662781, Length=301, Percent_Identity=29.5681063122924, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24662785, Length=291, Percent_Identity=28.8659793814433, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24646159, Length=195, Percent_Identity=31.2820512820513, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24646155, Length=201, Percent_Identity=28.8557213930348, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 31796; Mature: 31796

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVNAFNDLKRIGDDKVTAIGMGTWGIGGRETPDYSRDKESIEAIRYGLELGMNLIDTA
CCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
EFYGAGHAEEIVGEAIKEFEREDIFIVSKVWPTHFGYEEAKKAARASAKRLGTYIDLYLL
HHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHE
HWPVDDFKKIEETLHALEDLVDEGVIRYIGVSNFNLELLQRSQEVMRKYEIVANQVKYSV
ECCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KDRWPETTGLLDYMKREGIALMAYTPLEKGTLARNECLAKIGEKYGKTAAQVALNYLIWE
HHCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
ENVVAIPKASNKEHLKENFGAMGWRLSEEDREMARRCV
CCEEECCCCCCHHHHHHHHHHCCCEECHHHHHHHHHCC
>Mature Secondary Structure
MKRVNAFNDLKRIGDDKVTAIGMGTWGIGGRETPDYSRDKESIEAIRYGLELGMNLIDTA
CCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
EFYGAGHAEEIVGEAIKEFEREDIFIVSKVWPTHFGYEEAKKAARASAKRLGTYIDLYLL
HHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHE
HWPVDDFKKIEETLHALEDLVDEGVIRYIGVSNFNLELLQRSQEVMRKYEIVANQVKYSV
ECCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KDRWPETTGLLDYMKREGIALMAYTPLEKGTLARNECLAKIGEKYGKTAAQVALNYLIWE
HHCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
ENVVAIPKASNKEHLKENFGAMGWRLSEEDREMARRCV
CCEEECCCCCCHHHHHHHHHHCCCEECHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]