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The map label for this gene is 18978268

Identifier: 18978268

GI number: 18978268

Start: 1746870

End: 1747631

Strand: Direct

Name: 18978268

Synonym: PF1896

Alternate gene names: NA

Gene position: 1746870-1747631 (Clockwise)

Preceding gene: 18978267

Following gene: 18978269

Centisome position: 91.54

GC content: 39.11

Gene sequence:

>762_bases
ATGATTAAAGAAGGGGAAAAAGTTCTCCTCGTTGATCCCAGGGGAAAGAAATACATTATTACTGTAGGAAAAAAGGATTT
CCACACAGATTTGGGCATACTAAAGCTCGAAGAGATAGTTGGCAAGAATTATGGGGAGAGCATAGTAAGTCATAAGGGAT
ATGAATTCAAGATCTTAAAGCCGAAAATTGTTGATTTAATTGAAAAAATGAAAAGAGGCCCTCAAATAGTTCATCCTAAG
GATGCTGCACTAATTGTGGCCTATGCAGGAATTTCCCCAGGAGATTTTATTGTAGAGGCTGGGGTTGGGAGCGGGGCACT
AACGCTCTTTTTAGCCAATATCATTGGCCCCACGGGAAGAATTGTTAGCTATGAGATCAGGGAAGATTTTGCAAAGCTCG
CTTGGGAAAACATAAAATGGGCTGGATTCGATGACAGAGTTGAAATCAAGATAAAAGATATCTATGAAGGAATAGACGAA
GAGAACGTTGATCATGTTATTCTTGACCTTCCTCAACCTGAGAGAGTTGTAGAGCATGCTGCAAAAGCTTTAAAGCCCGG
AGGTTATCTTGTTGCATATCTCCCCTGTGCGAACCAAGTAATAAGGCTTCATGAAAAACTAGCAGAATTTAGGGATGTAT
TTCTAAAACCTAAGACCATCGATGTTGTTGTCTTTGAACAAGAGGTTAAAAAGGAATGTATAAGACCTAGAACGACAATT
CTAGCTCATACTGGTTATATAACTTTTGCAAGAAAAAGGTAA

Upstream 100 bases:

>100_bases
TAAATACGGACGTAGCTCCTGAAAAAGCCGTCGCGGCATTAGAAGAGATTAGCCCAATAGTGATCCAAGTTAGAAACAAT
GAAATTCTGGTGAAGAAGAT

Downstream 100 bases:

>100_bases
TCAGACGAGAGGGGGCTCATCATCGTTTTTAGAACTCAGGGTACCGTGAAGTTCATCATCAAGCTATAATCTCTAAATAC
CCTCTTAACATTACCGAAAT

Product: l-isoaspartyl protein carboxyl methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MIKEGEKVLLVDPRGKKYIITVGKKDFHTDLGILKLEEIVGKNYGESIVSHKGYEFKILKPKIVDLIEKMKRGPQIVHPK
DAALIVAYAGISPGDFIVEAGVGSGALTLFLANIIGPTGRIVSYEIREDFAKLAWENIKWAGFDDRVEIKIKDIYEGIDE
ENVDHVILDLPQPERVVEHAAKALKPGGYLVAYLPCANQVIRLHEKLAEFRDVFLKPKTIDVVVFEQEVKKECIRPRTTI
LAHTGYITFARKR

Sequences:

>Translated_253_residues
MIKEGEKVLLVDPRGKKYIITVGKKDFHTDLGILKLEEIVGKNYGESIVSHKGYEFKILKPKIVDLIEKMKRGPQIVHPK
DAALIVAYAGISPGDFIVEAGVGSGALTLFLANIIGPTGRIVSYEIREDFAKLAWENIKWAGFDDRVEIKIKDIYEGIDE
ENVDHVILDLPQPERVVEHAAKALKPGGYLVAYLPCANQVIRLHEKLAEFRDVFLKPKTIDVVVFEQEVKKECIRPRTTI
LAHTGYITFARKR
>Mature_253_residues
MIKEGEKVLLVDPRGKKYIITVGKKDFHTDLGILKLEEIVGKNYGESIVSHKGYEFKILKPKIVDLIEKMKRGPQIVHPK
DAALIVAYAGISPGDFIVEAGVGSGALTLFLANIIGPTGRIVSYEIREDFAKLAWENIKWAGFDDRVEIKIKDIYEGIDE
ENVDHVILDLPQPERVVEHAAKALKPGGYLVAYLPCANQVIRLHEKLAEFRDVFLKPKTIDVVVFEQEVKKECIRPRTTI
LAHTGYITFARKR

Specific function: Unknown

COG id: COG2519

COG function: function code J; tRNA(1-methyladenosine) methyltransferase and related methyltransferases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TRM61 family [H]

Homologues:

Organism=Homo sapiens, GI222831587, Length=190, Percent_Identity=34.2105263157895, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI123173772, Length=278, Percent_Identity=26.978417266187, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17509459, Length=227, Percent_Identity=30.3964757709251, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24650257, Length=264, Percent_Identity=28.4090909090909, Blast_Score=101, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014816 [H]

Pfam domain/function: PF08704 GCD14 [H]

EC number: =2.1.1.36 [H]

Molecular weight: Translated: 28501; Mature: 28501

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKEGEKVLLVDPRGKKYIITVGKKDFHTDLGILKLEEIVGKNYGESIVSHKGYEFKILK
CCCCCCEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHCCCCEEEEEC
PKIVDLIEKMKRGPQIVHPKDAALIVAYAGISPGDFIVEAGVGSGALTLFLANIIGPTGR
HHHHHHHHHHHCCCCEECCCCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHCCCCCC
IVSYEIREDFAKLAWENIKWAGFDDRVEIKIKDIYEGIDEENVDHVILDLPQPERVVEHA
EEEEHHHHHHHHHHHHCCEECCCCCEEEEEEEHHHCCCCCCCCCEEEEECCCHHHHHHHH
AKALKPGGYLVAYLPCANQVIRLHEKLAEFRDVFLKPKTIDVVVFEQEVKKECIRPRTTI
HHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHCCCCCEE
LAHTGYITFARKR
EEECCEEEEEECC
>Mature Secondary Structure
MIKEGEKVLLVDPRGKKYIITVGKKDFHTDLGILKLEEIVGKNYGESIVSHKGYEFKILK
CCCCCCEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHCCCCEEEEEC
PKIVDLIEKMKRGPQIVHPKDAALIVAYAGISPGDFIVEAGVGSGALTLFLANIIGPTGR
HHHHHHHHHHHCCCCEECCCCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHCCCCCC
IVSYEIREDFAKLAWENIKWAGFDDRVEIKIKDIYEGIDEENVDHVILDLPQPERVVEHA
EEEEHHHHHHHHHHHHCCEECCCCCEEEEEEEHHHCCCCCCCCCEEEEECCCHHHHHHHH
AKALKPGGYLVAYLPCANQVIRLHEKLAEFRDVFLKPKTIDVVVFEQEVKKECIRPRTTI
HHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHCCCCCEE
LAHTGYITFARKR
EEECCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]