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The map label for this gene is hmgA [H]

Identifier: 18978220

GI number: 18978220

Start: 1704745

End: 1705971

Strand: Reverse

Name: hmgA [H]

Synonym: PF1848

Alternate gene names: 18978220

Gene position: 1705971-1704745 (Counterclockwise)

Preceding gene: 18978221

Following gene: 18978219

Centisome position: 89.4

GC content: 43.52

Gene sequence:

>1227_bases
ATGGAAATAGAGGAGATTATAGAGAAAGTTGCTAGGGGAGAGATCAAGTTTCATCAAGTAGAAAACTATGTGAATGGGGA
TAAAAGGCTTGCAACTGAGATAAGAAGGAGAGCCTTGGAGAAAAAACTTGGAATACAGCTAAAGCACATTGGCCACTACT
CAATTGATCCAAACGAAGTTATTGGAAGGAACATTGAAAACATGATAGGTGTCGTTCAAATACCCATGGGTATTGCGGGT
CCTCTAAAGATTAATGGTGAATATGCAAAAGGTGAGTTTTACATTCCCCTAGCCACAACTGAAGGGGCCTTGGTTGCTTC
AGTAAACAGAGGTTGTTCTGCTCTAACAGAGGCTGGTGGAGTTTACACAACCCTAATAGATGACAAGATGACTAGAGCTC
CTCTATTGAAATGTCCAAACGCCAGAAGGGCGAGAGAAGTAGCTGAATGGGTCAAGAATAATCTGGATTACCTCCAAGAA
AAAGCTGTTAGTAAGGTTACTCGTCACGGAAAGCTTAGGGGGGTAAAGCCTTTTATCGTTGGGAGAAACTTATACTTAAG
ATTTGAATTCGAAACTGGAGATGCCATGGGAATGAACATGGTTACAATAGCGAGCGAAGAGATAATGAAAGTAATAGAAG
AAGAATTCCCCGATGTAAAATATTTGGCTCTTTCTGGTAATCTGTGCGTAGATAAGAAGCCAAACGCCTTAAACTTCATC
CTGGGAAGAGGAAAGACCATTATTGCTGAAGCTGTAGTTCCTAGAGAGATTGTTAAGAAAAAGCTAAAGACCACTCCAGA
GCTTATCGCTGAAGTAAACTACCTAAAGAACTTAGTGGGTTCGGCCCAAGCAGGTTCCTACGGTTTTAACGCTCACTTTG
CCAACATTGTAGGGGCGATATTCCTAGCCACAGGTCAGGATGAGGCTCAAATTACGGAAGGTGCACATGGAATAACCCTC
GCTGAAGTCACTGAAGATGGAGATCTATACATAAGCATAACAATGCCGAGCCTAGAAATAGGGACGGTTGGAGGTGGGAC
TAGAGTACCTCCTCAAAGAGAAGCTCTAGAAATTATGGGGGTTGCTGGAGGAGGAGATCCTCCAGGGATGAATGCTAAGA
AATTTGCGGAGATAGTTGCTGGTGCGGTTTTGGCTGGTGAGCTCTCTCTTCTGGCCGCAATTGCCGCCAAACATTTGGCT
AGGGCTCATAAAATGCTTGGGAGATGA

Upstream 100 bases:

>100_bases
CAGGAGTGAGGCCGCTATAGCTTTTAAAGAGTGTGGACAGATAACTGAAGAGTGGATTTTTGGATCATCTGAGTCTTCTC
CTTAGTTAGGGGGTGCTATG

Downstream 100 bases:

>100_bases
TTTCTTCTACCGTCAATTTTTTAATTTGCATATTTTAATAACAAAATGGAACAAAAATTCTGAGGAGGTGAGTAGATGCC
AGTAATAGAAGAGATTCCAA

Product: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MEIEEIIEKVARGEIKFHQVENYVNGDKRLATEIRRRALEKKLGIQLKHIGHYSIDPNEVIGRNIENMIGVVQIPMGIAG
PLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVYTTLIDDKMTRAPLLKCPNARRAREVAEWVKNNLDYLQE
KAVSKVTRHGKLRGVKPFIVGRNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVKYLALSGNLCVDKKPNALNFI
LGRGKTIIAEAVVPREIVKKKLKTTPELIAEVNYLKNLVGSAQAGSYGFNAHFANIVGAIFLATGQDEAQITEGAHGITL
AEVTEDGDLYISITMPSLEIGTVGGGTRVPPQREALEIMGVAGGGDPPGMNAKKFAEIVAGAVLAGELSLLAAIAAKHLA
RAHKMLGR

Sequences:

>Translated_408_residues
MEIEEIIEKVARGEIKFHQVENYVNGDKRLATEIRRRALEKKLGIQLKHIGHYSIDPNEVIGRNIENMIGVVQIPMGIAG
PLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVYTTLIDDKMTRAPLLKCPNARRAREVAEWVKNNLDYLQE
KAVSKVTRHGKLRGVKPFIVGRNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVKYLALSGNLCVDKKPNALNFI
LGRGKTIIAEAVVPREIVKKKLKTTPELIAEVNYLKNLVGSAQAGSYGFNAHFANIVGAIFLATGQDEAQITEGAHGITL
AEVTEDGDLYISITMPSLEIGTVGGGTRVPPQREALEIMGVAGGGDPPGMNAKKFAEIVAGAVLAGELSLLAAIAAKHLA
RAHKMLGR
>Mature_408_residues
MEIEEIIEKVARGEIKFHQVENYVNGDKRLATEIRRRALEKKLGIQLKHIGHYSIDPNEVIGRNIENMIGVVQIPMGIAG
PLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVYTTLIDDKMTRAPLLKCPNARRAREVAEWVKNNLDYLQE
KAVSKVTRHGKLRGVKPFIVGRNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVKYLALSGNLCVDKKPNALNFI
LGRGKTIIAEAVVPREIVKKKLKTTPELIAEVNYLKNLVGSAQAGSYGFNAHFANIVGAIFLATGQDEAQITEGAHGITL
AEVTEDGDLYISITMPSLEIGTVGGGTRVPPQREALEIMGVAGGGDPPGMNAKKFAEIVAGAVLAGELSLLAAIAAKHLA
RAHKMLGR

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=411, Percent_Identity=45.7420924574209, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI196049380, Length=295, Percent_Identity=48.4745762711864, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI25144592, Length=408, Percent_Identity=44.6078431372549, Blast_Score=336, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6323565, Length=417, Percent_Identity=42.6858513189448, Blast_Score=315, Evalue=8e-87,
Organism=Saccharomyces cerevisiae, GI6323483, Length=421, Percent_Identity=42.5178147268409, Blast_Score=308, Evalue=9e-85,
Organism=Drosophila melanogaster, GI281362379, Length=410, Percent_Identity=43.1707317073171, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI45553469, Length=410, Percent_Identity=43.1707317073171, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI24649399, Length=410, Percent_Identity=43.1707317073171, Blast_Score=295, Evalue=5e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 44227; Mature: 44227

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS00318 HMG_COA_REDUCTASE_2 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIEEIIEKVARGEIKFHQVENYVNGDKRLATEIRRRALEKKLGIQLKHIGHYSIDPNEV
CCHHHHHHHHHCCCEEEEHHHHHHCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHH
IGRNIENMIGVVQIPMGIAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGG
HHCCHHHHHEEEEECCCCCCCEEECCEEECCEEEEEEECCCCCEEEEHHCCHHHHHHCCC
VYTTLIDDKMTRAPLLKCPNARRAREVAEWVKNNLDYLQEKAVSKVTRHGKLRGVKPFIV
EEEEEECCCHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
GRNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVKYLALSGNLCVDKKPNALNFI
CCEEEEEEEECCCCCCCCEEEEECHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCEEEE
LGRGKTIIAEAVVPREIVKKKLKTTPELIAEVNYLKNLVGSAQAGSYGFNAHFANIVGAI
ECCCCEEEHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
FLATGQDEAQITEGAHGITLAEVTEDGDLYISITMPSLEIGTVGGGTRVPPQREALEIMG
HEECCCCHHHHHCCCCCEEEEEEECCCCEEEEEEECCEEEEECCCCCCCCCHHHHEEEEE
VAGGGDPPGMNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEIEEIIEKVARGEIKFHQVENYVNGDKRLATEIRRRALEKKLGIQLKHIGHYSIDPNEV
CCHHHHHHHHHCCCEEEEHHHHHHCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHH
IGRNIENMIGVVQIPMGIAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGG
HHCCHHHHHEEEEECCCCCCCEEECCEEECCEEEEEEECCCCCEEEEHHCCHHHHHHCCC
VYTTLIDDKMTRAPLLKCPNARRAREVAEWVKNNLDYLQEKAVSKVTRHGKLRGVKPFIV
EEEEEECCCHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
GRNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVKYLALSGNLCVDKKPNALNFI
CCEEEEEEEECCCCCCCCEEEEECHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCEEEE
LGRGKTIIAEAVVPREIVKKKLKTTPELIAEVNYLKNLVGSAQAGSYGFNAHFANIVGAI
ECCCCEEEHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
FLATGQDEAQITEGAHGITLAEVTEDGDLYISITMPSLEIGTVGGGTRVPPQREALEIMG
HEECCCCHHHHHCCCCCEEEEEEECCCCEEEEEEECCEEEEECCCCCCCCCHHHHEEEEE
VAGGGDPPGMNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]