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The map label for this gene is gltX [H]

Identifier: 18978125

GI number: 18978125

Start: 1630248

End: 1631990

Strand: Direct

Name: gltX [H]

Synonym: PF1753

Alternate gene names: 18978125

Gene position: 1630248-1631990 (Clockwise)

Preceding gene: 18978124

Following gene: 18978128

Centisome position: 85.43

GC content: 40.79

Gene sequence:

>1743_bases
ATGTCATTTTTCCAGGGGAGAAAGATGGAAGTAGAAAAGCTTGCACTCAAGTACGCTCTAATAAATGCAATAGAGCACGA
CGGTAAAGCTAATCCAAAGGCAGTCATAGGGAAAATACTCGGAGAAAACCCCGAGCTCAGAAAGAAGGCCAGAGAAATTG
TTCCAATAGTTAATAAAATTGTAGAGGAAGTTAATACCCTCTCACTGGAAGAGCAGAAAAAGAAACTTGAAGAAATTTAT
CCAGAGTACTTCATGGAAGGCACTAAAAAAGAAAAAGAGGAGAAAAAGCAACTCCCCCCACTACCTAAAGCAGAAAAGGG
TAAGGTTGTAACAAGATTTGCTCCAAATCCAGACGGTGCTTTTCACCTGGGGAATGCTAGAGCAGCAATATTAAGCTATG
AGTATGCCAAAATGTACGATGGAAAGTTTATTCTAAGGTTCGATGACACGGATCCAAAGGTAAAGAGGCCAGAGCTAATA
TTCTACGACATGATAATAGAAGACTTAGAATGGTTAGGGATAAAACCAGACGAAATTGTTTATGCAAGTGATAGGCTTGA
AATTTATTACAAATACGCAGAAGAGCTCATAAAAATGGGAAAGGCATATGTATGTACTTGCCCACCAGATGAGTTTAGGA
AGTTAAGGGATCAAGGAATTGCTTGCCCCCATAGAGATGAACCCGTAGAGGTGCAACTGGAAAGATGGAAAAAAATGCTA
AATGGAGAATATAGAGAGGGAGAGGCCGTAGTTAGAATTAAAACTGATTTAAACCACCCAAATCCAGCGGTTAGAGATTG
GCCCGCTCTTAGAATTGTTGATGAGCCAAATCACCCAAGGACTGGAAATAAGTATAGGGTATGGCCTCTCTACAACTTTG
CTTCGGCAATAGATGACCACGAATTAGGAGTTACTCACATCTTCAGAGGGCAAGAACACTCAGAAAATGAGACGAGGCAA
AGGTATATCTACGAGTATTTTGGATGGGAATATCCAGTAACAGTTCATCACGGAAGACTGTCAATTGAAGGAGTAATTCT
CAGCAAGTCAAAGACTAGAAAGGGGATAGAGGAAGGGAAATATCTAGGATGGGATGATCCCAGGTTGGGAACCATAAGGG
CCTTAAGAAGGAGAGGAATCTTGCCGGAAGCAATAAGAGAGCTAATCCTGGAGGTTGGACTTAAAAAGAGCGACGCAACC
GTAAGCTGGGATAACCTAGCTGCAATAAATAGAAAACTCGTTGATCCAATAGCAAATAGATACTTCTTTGTTGCAGACCC
GATTCCCATGTATATAGAGGAGGCCGAAGAGTTTGAGGCAAAGATACCTCTTCACCCAGATCATCCAGAAAGGGGATACA
GAGTGCTAAAATTCGAACCGGGAAAGCCAATTTATGTCTCAAAAGACGATCTAAGCTTGTTAAAGCCAGGAGGATTTATT
AGACTAAAGGACTTATTTAACGTCGAAATTTTAGAGGTAGGGGATACAATAAAGGCGAGATTCCACAGCCATGAATATGA
AGTCGCGAGGAAAAACAAGTGGAGAATGATTCACTGGGTTCCAGAGGGTAAAGAGTGTGAGGTAATAATTCCAGAAGGAG
AAGAGCTAATAATCAGAAAGGGCCTACTGGAAAAGAATGCCAACGTAAAAGAAGGAGAAATAGTGCAGTTTGAAAGATTT
GGATTTGTAAGGATTGACAAAATAGAAAACGACAAAGTTATCGCAATATATGCCCACAAATGA

Upstream 100 bases:

>100_bases
GTGATCCGCCTGGTGATGTTACTGAATGGCTTCAGGAGGTGATGCCCCAGTTATCCTAACAGTATCCAGGAGGATTAGGT
AACGTTTATATCTTTTTTGA

Downstream 100 bases:

>100_bases
TTTTTCTCCCTTTAATTTTTTCTGTATAGGGATCTTCCCTTTGAATCTATAGAGACTAGTAGAGGCATGTCTCTCACTTC
TAATTCCCAAACTGCATCAG

Product: glutamyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamate--tRNA ligase; GluRS [H]

Number of amino acids: Translated: 580; Mature: 579

Protein sequence:

>580_residues
MSFFQGRKMEVEKLALKYALINAIEHDGKANPKAVIGKILGENPELRKKAREIVPIVNKIVEEVNTLSLEEQKKKLEEIY
PEYFMEGTKKEKEEKKQLPPLPKAEKGKVVTRFAPNPDGAFHLGNARAAILSYEYAKMYDGKFILRFDDTDPKVKRPELI
FYDMIIEDLEWLGIKPDEIVYASDRLEIYYKYAEELIKMGKAYVCTCPPDEFRKLRDQGIACPHRDEPVEVQLERWKKML
NGEYREGEAVVRIKTDLNHPNPAVRDWPALRIVDEPNHPRTGNKYRVWPLYNFASAIDDHELGVTHIFRGQEHSENETRQ
RYIYEYFGWEYPVTVHHGRLSIEGVILSKSKTRKGIEEGKYLGWDDPRLGTIRALRRRGILPEAIRELILEVGLKKSDAT
VSWDNLAAINRKLVDPIANRYFFVADPIPMYIEEAEEFEAKIPLHPDHPERGYRVLKFEPGKPIYVSKDDLSLLKPGGFI
RLKDLFNVEILEVGDTIKARFHSHEYEVARKNKWRMIHWVPEGKECEVIIPEGEELIIRKGLLEKNANVKEGEIVQFERF
GFVRIDKIENDKVIAIYAHK

Sequences:

>Translated_580_residues
MSFFQGRKMEVEKLALKYALINAIEHDGKANPKAVIGKILGENPELRKKAREIVPIVNKIVEEVNTLSLEEQKKKLEEIY
PEYFMEGTKKEKEEKKQLPPLPKAEKGKVVTRFAPNPDGAFHLGNARAAILSYEYAKMYDGKFILRFDDTDPKVKRPELI
FYDMIIEDLEWLGIKPDEIVYASDRLEIYYKYAEELIKMGKAYVCTCPPDEFRKLRDQGIACPHRDEPVEVQLERWKKML
NGEYREGEAVVRIKTDLNHPNPAVRDWPALRIVDEPNHPRTGNKYRVWPLYNFASAIDDHELGVTHIFRGQEHSENETRQ
RYIYEYFGWEYPVTVHHGRLSIEGVILSKSKTRKGIEEGKYLGWDDPRLGTIRALRRRGILPEAIRELILEVGLKKSDAT
VSWDNLAAINRKLVDPIANRYFFVADPIPMYIEEAEEFEAKIPLHPDHPERGYRVLKFEPGKPIYVSKDDLSLLKPGGFI
RLKDLFNVEILEVGDTIKARFHSHEYEVARKNKWRMIHWVPEGKECEVIIPEGEELIIRKGLLEKNANVKEGEIVQFERF
GFVRIDKIENDKVIAIYAHK
>Mature_579_residues
SFFQGRKMEVEKLALKYALINAIEHDGKANPKAVIGKILGENPELRKKAREIVPIVNKIVEEVNTLSLEEQKKKLEEIYP
EYFMEGTKKEKEEKKQLPPLPKAEKGKVVTRFAPNPDGAFHLGNARAAILSYEYAKMYDGKFILRFDDTDPKVKRPELIF
YDMIIEDLEWLGIKPDEIVYASDRLEIYYKYAEELIKMGKAYVCTCPPDEFRKLRDQGIACPHRDEPVEVQLERWKKMLN
GEYREGEAVVRIKTDLNHPNPAVRDWPALRIVDEPNHPRTGNKYRVWPLYNFASAIDDHELGVTHIFRGQEHSENETRQR
YIYEYFGWEYPVTVHHGRLSIEGVILSKSKTRKGIEEGKYLGWDDPRLGTIRALRRRGILPEAIRELILEVGLKKSDATV
SWDNLAAINRKLVDPIANRYFFVADPIPMYIEEAEEFEAKIPLHPDHPERGYRVLKFEPGKPIYVSKDDLSLLKPGGFIR
LKDLFNVEILEVGDTIKARFHSHEYEVARKNKWRMIHWVPEGKECEVIIPEGEELIIRKGLLEKNANVKEGEIVQFERFG
FVRIDKIENDKVIAIYAHK

Specific function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) [H]

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI62241042, Length=498, Percent_Identity=33.1325301204819, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI4826960, Length=438, Percent_Identity=30.365296803653, Blast_Score=195, Evalue=9e-50,
Organism=Homo sapiens, GI134288884, Length=408, Percent_Identity=28.1862745098039, Blast_Score=116, Evalue=7e-26,
Organism=Escherichia coli, GI1786895, Length=520, Percent_Identity=30.1923076923077, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI1788743, Length=315, Percent_Identity=27.9365079365079, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17511007, Length=507, Percent_Identity=30.7692307692308, Blast_Score=245, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI17543332, Length=510, Percent_Identity=30.3921568627451, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71993394, Length=320, Percent_Identity=28.75, Blast_Score=102, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324742, Length=456, Percent_Identity=35.0877192982456, Blast_Score=260, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6321192, Length=515, Percent_Identity=32.4271844660194, Blast_Score=240, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6324540, Length=304, Percent_Identity=31.25, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24649466, Length=547, Percent_Identity=30.8957952468007, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI17864488, Length=395, Percent_Identity=32.4050632911392, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24665321, Length=304, Percent_Identity=30.2631578947368, Blast_Score=117, Evalue=3e-26,

Paralogues:

None

Copy number: 520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004526
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR020059
- InterPro:   IPR022888
- InterPro:   IPR020056
- InterPro:   IPR011035
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c; PF03950 tRNA-synt_1c_C [H]

EC number: =6.1.1.17 [H]

Molecular weight: Translated: 67546; Mature: 67414

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFFQGRKMEVEKLALKYALINAIEHDGKANPKAVIGKILGENPELRKKAREIVPIVNKI
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VEEVNTLSLEEQKKKLEEIYPEYFMEGTKKEKEEKKQLPPLPKAEKGKVVTRFAPNPDGA
HHHHHHCCHHHHHHHHHHHCHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCC
FHLGNARAAILSYEYAKMYDGKFILRFDDTDPKVKRPELIFYDMIIEDLEWLGIKPDEIV
EEECCCEEEEEEEHHHHHCCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCEE
YASDRLEIYYKYAEELIKMGKAYVCTCPPDEFRKLRDQGIACPHRDEPVEVQLERWKKML
EECCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
NGEYREGEAVVRIKTDLNHPNPAVRDWPALRIVDEPNHPRTGNKYRVWPLYNFASAIDDH
CCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEHHHHHHCCCC
ELGVTHIFRGQEHSENETRQRYIYEYFGWEYPVTVHHGRLSIEGVILSKSKTRKGIEEGK
CCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCEEEEEEEEEECCHHHCCHHHCC
YLGWDDPRLGTIRALRRRGILPEAIRELILEVGLKKSDATVSWDNLAAINRKLVDPIANR
CCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHCC
YFFVADPIPMYIEEAEEFEAKIPLHPDHPERGYRVLKFEPGKPIYVSKDDLSLLKPGGFI
EEEEECCCCHHHHHHHHCCEECCCCCCCCCCCCEEEEECCCCEEEEECCCCHHCCCCCEE
RLKDLFNVEILEVGDTIKARFHSHEYEVARKNKWRMIHWVPEGKECEVIIPEGEELIIRK
EEECCCCEEEEECCCHHHHHHCCCHHHHHHCCCCEEEEECCCCCCEEEECCCCCEEEEEH
GLLEKNANVKEGEIVQFERFGFVRIDKIENDKVIAIYAHK
HHHHCCCCCCCCCEEEEECCCCEEEEEECCCCEEEEEECC
>Mature Secondary Structure 
SFFQGRKMEVEKLALKYALINAIEHDGKANPKAVIGKILGENPELRKKAREIVPIVNKI
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VEEVNTLSLEEQKKKLEEIYPEYFMEGTKKEKEEKKQLPPLPKAEKGKVVTRFAPNPDGA
HHHHHHCCHHHHHHHHHHHCHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCC
FHLGNARAAILSYEYAKMYDGKFILRFDDTDPKVKRPELIFYDMIIEDLEWLGIKPDEIV
EEECCCEEEEEEEHHHHHCCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCEE
YASDRLEIYYKYAEELIKMGKAYVCTCPPDEFRKLRDQGIACPHRDEPVEVQLERWKKML
EECCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
NGEYREGEAVVRIKTDLNHPNPAVRDWPALRIVDEPNHPRTGNKYRVWPLYNFASAIDDH
CCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEHHHHHHCCCC
ELGVTHIFRGQEHSENETRQRYIYEYFGWEYPVTVHHGRLSIEGVILSKSKTRKGIEEGK
CCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCEEEEEEEEEECCHHHCCHHHCC
YLGWDDPRLGTIRALRRRGILPEAIRELILEVGLKKSDATVSWDNLAAINRKLVDPIANR
CCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHCC
YFFVADPIPMYIEEAEEFEAKIPLHPDHPERGYRVLKFEPGKPIYVSKDDLSLLKPGGFI
EEEEECCCCHHHHHHHHCCEECCCCCCCCCCCCEEEEECCCCEEEEECCCCHHCCCCCEE
RLKDLFNVEILEVGDTIKARFHSHEYEVARKNKWRMIHWVPEGKECEVIIPEGEELIIRK
EEECCCCEEEEECCCHHHHHHCCCHHHHHHCCCCEEEEECCCCCCEEEECCCCCEEEEEH
GLLEKNANVKEGEIVQFERFGFVRIDKIENDKVIAIYAHK
HHHHCCCCCCCCCEEEEECCCCEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA