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The map label for this gene is deoA [C]

Identifier: 18977979

GI number: 18977979

Start: 1497925

End: 1499436

Strand: Direct

Name: deoA [C]

Synonym: PF1607

Alternate gene names: 18977979

Gene position: 1497925-1499436 (Clockwise)

Preceding gene: 18977978

Following gene: 18977981

Centisome position: 78.5

GC content: 41.14

Gene sequence:

>1512_bases
ATGAGGGGAAAAATTAAAATTTTAGATATAGAAACAGGAAATCTTGCCATTTTTATAAATCCAGAAGACGCAGAACAATG
GCGAATCCATCCAAACGACCTTGTAAAAATTGAAAGCGGGAAGAGATACATTTATGGAAGTGCTTTTATAGGAAACATTG
TTGAAAAGGGAGAAATTGGAATATCAAAGGATGTTCTCTCAATTCATCAGTTTTCAAATGGAGAAATTGTTTCTTTAAGC
CCTGCAGGAACTCCTGAAAGTGTTAAGTATATAAAGAAAAAGATGAGAGGAGAGAAACTGAAAAAGGTAGAAATTGAGAC
AATTGTAAGAGATATCGTCGATAGAAAGCTTAGAAATACCGAAATCAGCGCGTTTGTTAGTGCAATAGAAATAAATGGTC
TTGACATGGAGGAAATTGCCGCTTTAACAATTGCAATGGCAGAAACTGGAGATATGTTGGACATAGAAAGGAAGCCAATA
ATGGATATCCACAGCATTGGCGGCGTACCTGGAAATAAGACCAATGTTATAGTTGTCCCCATAGTGGCGGCTGCAGGCCT
AACAATTCCCAAGACGAGTTCAAGAGCAATTACAAGTGCAGCAGGAACAGCCGATGTGGTGGAAGTTTTAACAAACGTTA
CACTGACTCTTGAAGAAATAAAGAGAATAGTGGAAAAAATTGGAGCCTGCCTAGTTTGGGGAGGTGCCCTAAATTTAGCC
CCAGCAGATGACTTGATGATACACGTAGAAAGGAGGCTAAGTTTGGATCCAAGGGGACTTATGCTTGCAAGTATAATGGC
TAAGAAATATGCTATCGGAAGTCAATACATACTCATTGACATCCCCACAGGAAAAGGAGCCAAAGTTGAGAGCATGGAGG
AGGCTAGATCACTTGCAAGAGATTTCATAGAGTTAGGGAAGAGATTAGGACAATACGTTGAAGTAGCAATTACTTACGGA
GGCCAGCCCATAGGTTATACAGTTGGTCCGGCTCTAGAAGCTAAAGAAGCCCTCGAAACACTAATGACAGGTAGAGGGCC
TGGAAGCTTAGTAGAAAAGGCCATAGGACTCGCTGGGCTACTTTTGGAAATGGGTGGAGCTGCTCCAAAAGGAAAGGGAA
AAATCATTGCGAGGGAAATTCTAGAGAAAGGAAAAGCATATCAAAAGATGAGAGAGATTATAGAAGAACAAGGTGGAGAT
CCTGACATAAAGCCAGAAGACATTCCAATAGGAGATAAAACATATACAATTCACGCCCAGACGAATGGTTATGTCACCGC
AATCGACAACAGAGGGATTACTGCAATAGCGAGAGAAGCTGGGGCCCCAGAAGATAAAGGGGCTGGAATTAGACTTCACG
TAAAAGTGGGAGACAAGGTAAAAGAAGGCGATCCACTATTCACAATACATGCAGAAAGTGAAAGTAGGCTAGACAAAGCT
ATCGTGCTTGCAAGAAGGCTTGAACCCATAAAGATAGAGGGAATGGTTTTGCAGGTTATTGAAAACCTCTAA

Upstream 100 bases:

>100_bases
TCTCAACTAGATATGACCTGAAAACAGGGAAATTTAGAGTTGAAGACATCATAAGATTTCTAATTGCCTTGATAAAGTCA
TAATTTGAGAGGTGAATTAC

Downstream 100 bases:

>100_bases
CACTAGTGTTTCCCATGTCTCTCATACCATCCCCACTCTTTTTTTGGTCCAAAAGCCCTAACCCCTTTATGAACTAAAGT
TACCCTTAATTCTTTGGCCA

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MRGKIKILDIETGNLAIFINPEDAEQWRIHPNDLVKIESGKRYIYGSAFIGNIVEKGEIGISKDVLSIHQFSNGEIVSLS
PAGTPESVKYIKKKMRGEKLKKVEIETIVRDIVDRKLRNTEISAFVSAIEINGLDMEEIAALTIAMAETGDMLDIERKPI
MDIHSIGGVPGNKTNVIVVPIVAAAGLTIPKTSSRAITSAAGTADVVEVLTNVTLTLEEIKRIVEKIGACLVWGGALNLA
PADDLMIHVERRLSLDPRGLMLASIMAKKYAIGSQYILIDIPTGKGAKVESMEEARSLARDFIELGKRLGQYVEVAITYG
GQPIGYTVGPALEAKEALETLMTGRGPGSLVEKAIGLAGLLLEMGGAAPKGKGKIIAREILEKGKAYQKMREIIEEQGGD
PDIKPEDIPIGDKTYTIHAQTNGYVTAIDNRGITAIAREAGAPEDKGAGIRLHVKVGDKVKEGDPLFTIHAESESRLDKA
IVLARRLEPIKIEGMVLQVIENL

Sequences:

>Translated_503_residues
MRGKIKILDIETGNLAIFINPEDAEQWRIHPNDLVKIESGKRYIYGSAFIGNIVEKGEIGISKDVLSIHQFSNGEIVSLS
PAGTPESVKYIKKKMRGEKLKKVEIETIVRDIVDRKLRNTEISAFVSAIEINGLDMEEIAALTIAMAETGDMLDIERKPI
MDIHSIGGVPGNKTNVIVVPIVAAAGLTIPKTSSRAITSAAGTADVVEVLTNVTLTLEEIKRIVEKIGACLVWGGALNLA
PADDLMIHVERRLSLDPRGLMLASIMAKKYAIGSQYILIDIPTGKGAKVESMEEARSLARDFIELGKRLGQYVEVAITYG
GQPIGYTVGPALEAKEALETLMTGRGPGSLVEKAIGLAGLLLEMGGAAPKGKGKIIAREILEKGKAYQKMREIIEEQGGD
PDIKPEDIPIGDKTYTIHAQTNGYVTAIDNRGITAIAREAGAPEDKGAGIRLHVKVGDKVKEGDPLFTIHAESESRLDKA
IVLARRLEPIKIEGMVLQVIENL
>Mature_503_residues
MRGKIKILDIETGNLAIFINPEDAEQWRIHPNDLVKIESGKRYIYGSAFIGNIVEKGEIGISKDVLSIHQFSNGEIVSLS
PAGTPESVKYIKKKMRGEKLKKVEIETIVRDIVDRKLRNTEISAFVSAIEINGLDMEEIAALTIAMAETGDMLDIERKPI
MDIHSIGGVPGNKTNVIVVPIVAAAGLTIPKTSSRAITSAAGTADVVEVLTNVTLTLEEIKRIVEKIGACLVWGGALNLA
PADDLMIHVERRLSLDPRGLMLASIMAKKYAIGSQYILIDIPTGKGAKVESMEEARSLARDFIELGKRLGQYVEVAITYG
GQPIGYTVGPALEAKEALETLMTGRGPGSLVEKAIGLAGLLLEMGGAAPKGKGKIIAREILEKGKAYQKMREIIEEQGGD
PDIKPEDIPIGDKTYTIHAQTNGYVTAIDNRGITAIAREAGAPEDKGAGIRLHVKVGDKVKEGDPLFTIHAESESRLDKA
IVLARRLEPIKIEGMVLQVIENL

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI166158925, Length=439, Percent_Identity=29.3849658314351, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4503445, Length=439, Percent_Identity=29.3849658314351, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI166158922, Length=439, Percent_Identity=29.3849658314351, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1790842, Length=406, Percent_Identity=28.8177339901478, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_PYRFU (Q8U0I2)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579336.1
- ProteinModelPortal:   Q8U0I2
- SMR:   Q8U0I2
- EnsemblBacteria:   EBPYRT00000005316
- GeneID:   1469483
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1607
- NMPDR:   fig|186497.1.peg.1654
- GeneTree:   EBGT00050000022435
- HOGENOM:   HBG460532
- OMA:   GGTADLM
- ProtClustDB:   PRK04350
- BRENDA:   2.4.2.4
- GO:   GO:0005488
- HAMAP:   MF_00703
- InterPro:   IPR017713
- InterPro:   IPR009010
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466
- Gene3D:   G3DSA:2.40.40.20
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR03327
- TIGRFAMs:   TIGR02645

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 54341; Mature: 54341

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGKIKILDIETGNLAIFINPEDAEQWRIHPNDLVKIESGKRYIYGSAFIGNIVEKGEIG
CCCEEEEEEEECCCEEEEECCCCCCCEEECCCCEEEEECCCEEEEECHHHHHHHHCCCCC
ISKDVLSIHQFSNGEIVSLSPAGTPESVKYIKKKMRGEKLKKVEIETIVRDIVDRKLRNT
CCHHHHHHEECCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
EISAFVSAIEINGLDMEEIAALTIAMAETGDMLDIERKPIMDIHSIGGVPGNKTNVIVVP
HHHHHHEEEEECCCCHHHHHHHHEEEECCCCEEECCCCCCCHHHHCCCCCCCCCCEEEEE
IVAAAGLTIPKTSSRAITSAAGTADVVEVLTNVTLTLEEIKRIVEKIGACLVWGGALNLA
EHHHCCCCCCCCCCCCHHCCCCHHHHHHHHHCCEEEHHHHHHHHHHCCCEEEECCCCCCC
PADDLMIHVERRLSLDPRGLMLASIMAKKYAIGSQYILIDIPTGKGAKVESMEEARSLAR
CCCCEEEEEEHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHH
DFIELGKRLGQYVEVAITYGGQPIGYTVGPALEAKEALETLMTGRGPGSLVEKAIGLAGL
HHHHHHHHHCCEEEEEEEECCCCCCEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LLEMGGAAPKGKGKIIAREILEKGKAYQKMREIIEEQGGDPDIKPEDIPIGDKTYTIHAQ
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEE
TNGYVTAIDNRGITAIAREAGAPEDKGAGIRLHVKVGDKVKEGDPLFTIHAESESRLDKA
CCCEEEEECCCCCEEEHHHCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCHHHHHHH
IVLARRLEPIKIEGMVLQVIENL
HHHHHCCCCEEECHHHHHHHHCC
>Mature Secondary Structure
MRGKIKILDIETGNLAIFINPEDAEQWRIHPNDLVKIESGKRYIYGSAFIGNIVEKGEIG
CCCEEEEEEEECCCEEEEECCCCCCCEEECCCCEEEEECCCEEEEECHHHHHHHHCCCCC
ISKDVLSIHQFSNGEIVSLSPAGTPESVKYIKKKMRGEKLKKVEIETIVRDIVDRKLRNT
CCHHHHHHEECCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
EISAFVSAIEINGLDMEEIAALTIAMAETGDMLDIERKPIMDIHSIGGVPGNKTNVIVVP
HHHHHHEEEEECCCCHHHHHHHHEEEECCCCEEECCCCCCCHHHHCCCCCCCCCCEEEEE
IVAAAGLTIPKTSSRAITSAAGTADVVEVLTNVTLTLEEIKRIVEKIGACLVWGGALNLA
EHHHCCCCCCCCCCCCHHCCCCHHHHHHHHHCCEEEHHHHHHHHHHCCCEEEECCCCCCC
PADDLMIHVERRLSLDPRGLMLASIMAKKYAIGSQYILIDIPTGKGAKVESMEEARSLAR
CCCCEEEEEEHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHH
DFIELGKRLGQYVEVAITYGGQPIGYTVGPALEAKEALETLMTGRGPGSLVEKAIGLAGL
HHHHHHHHHCCEEEEEEEECCCCCCEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LLEMGGAAPKGKGKIIAREILEKGKAYQKMREIIEEQGGDPDIKPEDIPIGDKTYTIHAQ
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEE
TNGYVTAIDNRGITAIAREAGAPEDKGAGIRLHVKVGDKVKEGDPLFTIHAESESRLDKA
CCCEEEEECCCCCEEEHHHCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCHHHHHHH
IVLARRLEPIKIEGMVLQVIENL
HHHHHCCCCEEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA