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The map label for this gene is napA [H]

Identifier: 18977975

GI number: 18977975

Start: 1495219

End: 1496502

Strand: Reverse

Name: napA [H]

Synonym: PF1603

Alternate gene names: 18977975

Gene position: 1496502-1495219 (Counterclockwise)

Preceding gene: 18977976

Following gene: 18977974

Centisome position: 78.42

GC content: 39.49

Gene sequence:

>1284_bases
ATGGAAGCAGCAACATGGATATTATTTACATTGGGTGTATCTCTTATTCTAGCTAAAATAGGAGACTCCCTAGTTGAAAG
ATTTGAACTCCCAGGAGTACTGGGAGAGTTATTGGTAGGAATTATTCTCGGAAATTTGGTGTATTTTGGGGTTATTAGTA
GTGAATATTTACCAATAACAGCTGGTTCAAGTGAAGTTATAGATTTCATGGCAAAACTTGGAGTAGTGTTTCTGTTATTT
TTGGGGGCTCTTGACACGGATCTTAACTTAATAAAAAGAACTGGAATAACGGCTGTTGTATCTACTATTCTGGGAGTTTT
CGTTCCACTAATTCTTGGATACCTAGGACTTAGGTGGTTGGGATATGATAATAAAGAAGCATTTGCTGGGGGAGTCCTTC
TTACCGCCACTAGTATAGGGTTAACGGTTAGGGTCATGATGGATCTAGGAGTTTTAAGAAGTGAAGTTGGGGCTGCATCA
TTAAGTGCGAGTGTTATTGATGATTTTCTAGGTATTGCTCTAATAATATTTGCCGTGGGCTCAGGTTCACTCCTGGGACT
TGGGATAAAAATCATCATTTTCTTCTTAATTACGGGAGTTGTTGGGTGGTATTTTATTGACCACTATCTAAAATTTGCGG
AAAGACTAGGAGTTGAAAAGGGCGTTTTAGGATTTGTTTTGGGAATGATGTTAATATTCTCAGCTTTGGCTGAGGGATGG
TTTGCAGCTGCAATTGAAGGAGCATTTATGATGGGGTTAATACTCTCTAAGACTGCTGAAGGTAAGAGGCTTCTAGAGGA
AGTGAGAAGCATTGGTTACGGATTCCTTATTCCAATATTCTTCGTCCATACTGGAGCAATGCTGAACTTTAAGGTTTTTG
AGAATCTCGAAGCAATTAAGCTGGCTGTGGTTCTTAGTGTAATTGCAATAGTAGGGAAGGTGGCTGGAAGGGGGTTTGGA
GCCTGGATAACTGCCTGGGGAAGAGGTAAGGATTTTCTCTTCACTAGGGAAAACTTCAGAATGTCTTTTCAAATGGGAAT
TGGATCTATTCCAAGAACTGAAGTTGCGTTAGTCGCTCTAATGGTAGCCATTCATGGTGGTGCAATTTCCCCTGATGATG
CTCCAAAGTTTATAGCAGCAACTTTGATCTTCATAACAATTTCAGTCCTCATAACTCCTCCATTATTAAAGTGGGCATTC
CGAGAAGAAATTTTAGCACAGAAAAAGTTATTACTTGAAAATAGAAAGGAGAAAATAGAGAGTAAAAAGAGAGGAACCCG
ATGA

Upstream 100 bases:

>100_bases
TTTTAGCCTTAATTGATGAAGAGGGGAAACTTAAGGGAGAAATTAGCTTAAGGATTCTAATAAATGAATTTCTCAGGCTA
ATAAGGGTAGGTGGTGGATA

Downstream 100 bases:

>100_bases
TTGAAAATGGAGTGAGCTGAGTTAATGATGACCGACTTCCCACTGAGGGCCTCTAGAATGTTCAACACTATGGCTCTATT
ATGTGCATTGATGTATGTAA

Product: Na antiporter

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MEAATWILFTLGVSLILAKIGDSLVERFELPGVLGELLVGIILGNLVYFGVISSEYLPITAGSSEVIDFMAKLGVVFLLF
LGALDTDLNLIKRTGITAVVSTILGVFVPLILGYLGLRWLGYDNKEAFAGGVLLTATSIGLTVRVMMDLGVLRSEVGAAS
LSASVIDDFLGIALIIFAVGSGSLLGLGIKIIIFFLITGVVGWYFIDHYLKFAERLGVEKGVLGFVLGMMLIFSALAEGW
FAAAIEGAFMMGLILSKTAEGKRLLEEVRSIGYGFLIPIFFVHTGAMLNFKVFENLEAIKLAVVLSVIAIVGKVAGRGFG
AWITAWGRGKDFLFTRENFRMSFQMGIGSIPRTEVALVALMVAIHGGAISPDDAPKFIAATLIFITISVLITPPLLKWAF
REEILAQKKLLLENRKEKIESKKRGTR

Sequences:

>Translated_427_residues
MEAATWILFTLGVSLILAKIGDSLVERFELPGVLGELLVGIILGNLVYFGVISSEYLPITAGSSEVIDFMAKLGVVFLLF
LGALDTDLNLIKRTGITAVVSTILGVFVPLILGYLGLRWLGYDNKEAFAGGVLLTATSIGLTVRVMMDLGVLRSEVGAAS
LSASVIDDFLGIALIIFAVGSGSLLGLGIKIIIFFLITGVVGWYFIDHYLKFAERLGVEKGVLGFVLGMMLIFSALAEGW
FAAAIEGAFMMGLILSKTAEGKRLLEEVRSIGYGFLIPIFFVHTGAMLNFKVFENLEAIKLAVVLSVIAIVGKVAGRGFG
AWITAWGRGKDFLFTRENFRMSFQMGIGSIPRTEVALVALMVAIHGGAISPDDAPKFIAATLIFITISVLITPPLLKWAF
REEILAQKKLLLENRKEKIESKKRGTR
>Mature_427_residues
MEAATWILFTLGVSLILAKIGDSLVERFELPGVLGELLVGIILGNLVYFGVISSEYLPITAGSSEVIDFMAKLGVVFLLF
LGALDTDLNLIKRTGITAVVSTILGVFVPLILGYLGLRWLGYDNKEAFAGGVLLTATSIGLTVRVMMDLGVLRSEVGAAS
LSASVIDDFLGIALIIFAVGSGSLLGLGIKIIIFFLITGVVGWYFIDHYLKFAERLGVEKGVLGFVLGMMLIFSALAEGW
FAAAIEGAFMMGLILSKTAEGKRLLEEVRSIGYGFLIPIFFVHTGAMLNFKVFENLEAIKLAVVLSVIAIVGKVAGRGFG
AWITAWGRGKDFLFTRENFRMSFQMGIGSIPRTEVALVALMVAIHGGAISPDDAPKFIAATLIFITISVLITPPLLKWAF
REEILAQKKLLLENRKEKIESKKRGTR

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 46137; Mature: 46137

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCC
>Mature Secondary Structure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HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]