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The map label for this gene is rph [C]

Identifier: 18977939

GI number: 18977939

Start: 1464340

End: 1465173

Strand: Reverse

Name: rph [C]

Synonym: PF1567

Alternate gene names: 18977939

Gene position: 1465173-1464340 (Counterclockwise)

Preceding gene: 18977940

Following gene: 33359567

Centisome position: 76.78

GC content: 41.01

Gene sequence:

>834_bases
GTGAGCAATGACGAGATTGTTGCTGGAATAATGAGGGATTATATTCTAAATCTCCTTAAAGAGAAAAAAAGAATTGATGA
TAGAGGATTTGAAGATTATAGGCCTATAGAAGTTGAAGTTGGAGTAATAGAGAAGGCAGAAGGATCCGCACTTGTGAAAC
TTGGAAATACTCAAGTTTTAGTTGGGATAAAGGCAACGCTCGGAGAGCCTTTCCCAGATACCCCAAACATGGGTGTCATG
ACAACTAACGTGGAGCTAGTACCTCTTGCCTCTCCAACATTTGAGCCTGGGCCTCCTGATGAAAGGGCAATTGAACTTGC
AAGAGTTATTGACAGAGGGATAAGGGAAAGCAGAGCATTGAATTTGGAGAAAATGGTTATAGCTCCGGGCAAGATTGTGA
GAGTCGTCTTTATCGATGTCCATGTCCTAGACCACGACGGCAACCTTATGGATGCCATTGGAATCGGAGCTATAGCTGCT
TTGTTAAATGCAAGAGTTCCAAAAGTTTTGTATAATGAAGAAACTGGAGAAGTTGAGATCCTTGAGGAGAAAGAGCCCTT
GCCTGTAGAAAAAATACCAATTTCAGTGACCTTTGCTAAGATTGGAAACTACTTGGTTGTTGATCCAACTTTAGAGGAAG
AGCAGATTATGGATGGCAGACTTACAATAACCACTGACGAAACAGGCCACATATCTGCAGTCCAAAAAAGCGAGGGAGGA
GCCTTTAAATTAGAGGAAGTTATGTATGCTGTTGAAACAGCTTTCAAAAAGGCCGAAGAGATCAGAAAAATAATATTAAA
TGCTCTAGAGAAGGCAAATAACTCTGAGGAATAA

Upstream 100 bases:

>100_bases
GCAGTAAAATTAGCAATAAAGGGAGCAAAGGCTGTTTATCAAAAACAGAGGGAAGCTCTTAAAGAAAAATACCTTAAAAT
AGCCCAGGAGGTTGAGGGAA

Downstream 100 bases:

>100_bases
ATGGAAATATTTATAAACTTAACTTCTTCCTTTCATTTCGACCTTTAGAGCCCGGGTAGCCTAGCCTGGTGGGGCGGGGG
ACTTGTAATCCCCAGGTCGC

Product: exosome complex RNA-binding protein Rrp42

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MSNDEIVAGIMRDYILNLLKEKKRIDDRGFEDYRPIEVEVGVIEKAEGSALVKLGNTQVLVGIKATLGEPFPDTPNMGVM
TTNVELVPLASPTFEPGPPDERAIELARVIDRGIRESRALNLEKMVIAPGKIVRVVFIDVHVLDHDGNLMDAIGIGAIAA
LLNARVPKVLYNEETGEVEILEEKEPLPVEKIPISVTFAKIGNYLVVDPTLEEEQIMDGRLTITTDETGHISAVQKSEGG
AFKLEEVMYAVETAFKKAEEIRKIILNALEKANNSEE

Sequences:

>Translated_277_residues
MSNDEIVAGIMRDYILNLLKEKKRIDDRGFEDYRPIEVEVGVIEKAEGSALVKLGNTQVLVGIKATLGEPFPDTPNMGVM
TTNVELVPLASPTFEPGPPDERAIELARVIDRGIRESRALNLEKMVIAPGKIVRVVFIDVHVLDHDGNLMDAIGIGAIAA
LLNARVPKVLYNEETGEVEILEEKEPLPVEKIPISVTFAKIGNYLVVDPTLEEEQIMDGRLTITTDETGHISAVQKSEGG
AFKLEEVMYAVETAFKKAEEIRKIILNALEKANNSEE
>Mature_276_residues
SNDEIVAGIMRDYILNLLKEKKRIDDRGFEDYRPIEVEVGVIEKAEGSALVKLGNTQVLVGIKATLGEPFPDTPNMGVMT
TNVELVPLASPTFEPGPPDERAIELARVIDRGIRESRALNLEKMVIAPGKIVRVVFIDVHVLDHDGNLMDAIGIGAIAAL
LNARVPKVLYNEETGEVEILEEKEPLPVEKIPISVTFAKIGNYLVVDPTLEEEQIMDGRLTITTDETGHISAVQKSEGGA
FKLEEVMYAVETAFKKAEEIRKIILNALEKANNSEE

Specific function: Probably involved in the 3'->5' degradation of a variety of RNA species (Potential)

COG id: COG2123

COG function: function code J; RNase PH-related exoribonuclease

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase PH family

Homologues:

Organism=Homo sapiens, GI31415882, Length=255, Percent_Identity=38.0392156862745, Blast_Score=178, Evalue=4e-45,
Organism=Homo sapiens, GI189083688, Length=270, Percent_Identity=34.8148148148148, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI77812672, Length=268, Percent_Identity=34.7014925373134, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI77812670, Length=268, Percent_Identity=34.7014925373134, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25144570, Length=270, Percent_Identity=29.2592592592593, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI32566065, Length=293, Percent_Identity=29.3515358361775, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320486, Length=288, Percent_Identity=30.2083333333333, Blast_Score=136, Evalue=5e-33,
Organism=Drosophila melanogaster, GI28573444, Length=267, Percent_Identity=29.2134831460674, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24642649, Length=264, Percent_Identity=29.5454545454545, Blast_Score=121, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECX2_PYRFU (Q8U0M0)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579296.1
- ProteinModelPortal:   Q8U0M0
- SMR:   Q8U0M0
- EnsemblBacteria:   EBPYRT00000004424
- GeneID:   1469443
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1567
- NMPDR:   fig|186497.1.peg.1614
- GeneTree:   EBGT00050000022563
- HOGENOM:   HBG737187
- OMA:   IEMARVV
- ProtClustDB:   PRK04282
- GO:   GO:0005737
- HAMAP:   MF_00622
- InterPro:   IPR001247
- InterPro:   IPR015847
- InterPro:   IPR020869
- InterPro:   IPR020568

Pfam domain/function: PF01138 RNase_PH; PF03725 RNase_PH_C; SSF55666 3_ExoRNase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.1.13.-

Molecular weight: Translated: 30498; Mature: 30366

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDEIVAGIMRDYILNLLKEKKRIDDRGFEDYRPIEVEVGVIEKAEGSALVKLGNTQVL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCEEEEECCEEEE
VGIKATLGEPFPDTPNMGVMTTNVELVPLASPTFEPGPPDERAIELARVIDRGIRESRAL
EEEEHHCCCCCCCCCCCCEEEECEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
NLEKMVIAPGKIVRVVFIDVHVLDHDGNLMDAIGIGAIAALLNARVPKVLYNEETGEVEI
CCEEEEECCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEE
LEEKEPLPVEKIPISVTFAKIGNYLVVDPTLEEEQIMDGRLTITTDETGHISAVQKSEGG
EECCCCCCHHHCEEEEEHHHHCCEEEECCCCCHHHHCCCEEEEEECCCCCEEEEEECCCC
AFKLEEVMYAVETAFKKAEEIRKIILNALEKANNSEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SNDEIVAGIMRDYILNLLKEKKRIDDRGFEDYRPIEVEVGVIEKAEGSALVKLGNTQVL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCEEEEECCEEEE
VGIKATLGEPFPDTPNMGVMTTNVELVPLASPTFEPGPPDERAIELARVIDRGIRESRAL
EEEEHHCCCCCCCCCCCCEEEECEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
NLEKMVIAPGKIVRVVFIDVHVLDHDGNLMDAIGIGAIAALLNARVPKVLYNEETGEVEI
CCEEEEECCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEE
LEEKEPLPVEKIPISVTFAKIGNYLVVDPTLEEEQIMDGRLTITTDETGHISAVQKSEGG
EECCCCCCHHHCEEEEEHHHHCCEEEECCCCCHHHHCCCEEEEEECCCCCEEEEEECCCC
AFKLEEVMYAVETAFKKAEEIRKIILNALEKANNSEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA