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The map label for this gene is mtaD

Identifier: 18977910

GI number: 18977910

Start: 1436914

End: 1438173

Strand: Reverse

Name: mtaD

Synonym: PF1538

Alternate gene names: 18977910

Gene position: 1438173-1436914 (Counterclockwise)

Preceding gene: 33359566

Following gene: 18977909

Centisome position: 75.37

GC content: 39.68

Gene sequence:

>1260_bases
GTGATAATTAAAAATGGAATGATCATTTATGGTGATGAGTTTACAATTGTGAGATCTGATGTACTTATTGAAGATGGTGT
GATAAAGGAAGTGGGGAAAAACATTAGAGCTCCGGCTGATATGGTTATCGACGCTTCTTCTCATCTAGTAATTCCTGGGT
TAATTAATGCTCATACTCATGTGTCAATGGTTTTACTCAGAGGTTTGGCAGAGGATGTCCCACTCCAAGAATGGCTTCAA
AATTATATATGGCCCAGGGAAAGAGAGCTTAAGAGGAAGGATATATACTGGGGAACTCTTCTTGGATTAGTTGAAATGGC
TCGTTCTGGAGTAACCACGTTTGTTGACATGTACTTTCACATAGAGGAGGTAGCAAAAGCGACAATAGAAGTTGGTCTGA
GGGGGTTCTTGGGATACGGAATGGTTGATTTGGAAAACAGAGAGAAGCTTGAAGTTGAGATTAAGGAGACTGAGAAATTT
TATGAGTATGTAACAAAAATAAATTCTCCGCTTGTAAACTTTGTCTTAGCTCCTCATGCTCCCTATACTTGCTCTCTAGA
GTGTTTAAAGTGGGTTTCTAAAAAAGCCAATCAATGGAACGTTCCAGTGACAATTCATCTTTCTGAAACCAAGAAAGAAG
TGGAGGAAATAAGGAAGAAATATGGAATGACCCCTACCCAATTGTTGGATGAAGTTGGTCTGCTCAATGAAAAATTAATA
GCTGCACATGGAGTTTGGTTAAGTGAGGAAGAGTTGAGGATGCTTTCTTCTGCAAATGCCACTGTAGTTCACTGCCCAGC
AAGCAATATGAAACTTGGAAGTGGTGTCTTTCCATTGAGAAAAGCTCTCGACCTTGGAGTGAATGTGGCCCTCGGAACGG
ATGGAGCTGCAAGTAACAATACTCTTGATATGCTGAGAGAAATGAGATTGGCCAGCCTTCTTCAAAAAGTTGCCCATTTA
AATCCAGCAATAGTAAAGTCAGAAGAAATTTTGAAAATGGCGACAGTGAATCCAGCAAAGGCATTAGGACTCAAGAGTGG
AGTGATAAAAGAGGGGTATATTGCAGATTTAGCGCTGATAAACCTAAGAAGGCCGCACTTATTACCTCTCAATTCTCCAA
CATCTCTGCTGATCTATTCGGCAAGAGGAGGGGACGTTGATACACTCTTTGTAAATGGAGAGATAGTGATATTAGATGGA
GAGTTTTTAACGGTAAATGAAGAAAAAATATTAGATAAGTTTTTGAAGGTGATCGAATAA

Upstream 100 bases:

>100_bases
GCTCTATTTTTATGCTCATTAATTATCCCCTCATGAAAAAACTGGGCAAGGTTTTTATATTTGTCCGCTTAATTCTTAAG
TAGGTGATGTATCATTGTCA

Downstream 100 bases:

>100_bases
TGTGGATCTTCCAGCCAAACTTCATTATAGGGCTCTCTTTCCTATTTCTCTATGCCATGTTTTTCTACTTCTACTATACA
CGGAATAAGTTAGAGATGCT

Product: N-ethylammeline chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MIIKNGMIIYGDEFTIVRSDVLIEDGVIKEVGKNIRAPADMVIDASSHLVIPGLINAHTHVSMVLLRGLAEDVPLQEWLQ
NYIWPRERELKRKDIYWGTLLGLVEMARSGVTTFVDMYFHIEEVAKATIEVGLRGFLGYGMVDLENREKLEVEIKETEKF
YEYVTKINSPLVNFVLAPHAPYTCSLECLKWVSKKANQWNVPVTIHLSETKKEVEEIRKKYGMTPTQLLDEVGLLNEKLI
AAHGVWLSEEELRMLSSANATVVHCPASNMKLGSGVFPLRKALDLGVNVALGTDGAASNNTLDMLREMRLASLLQKVAHL
NPAIVKSEEILKMATVNPAKALGLKSGVIKEGYIADLALINLRRPHLLPLNSPTSLLIYSARGGDVDTLFVNGEIVILDG
EFLTVNEEKILDKFLKVIE

Sequences:

>Translated_419_residues
MIIKNGMIIYGDEFTIVRSDVLIEDGVIKEVGKNIRAPADMVIDASSHLVIPGLINAHTHVSMVLLRGLAEDVPLQEWLQ
NYIWPRERELKRKDIYWGTLLGLVEMARSGVTTFVDMYFHIEEVAKATIEVGLRGFLGYGMVDLENREKLEVEIKETEKF
YEYVTKINSPLVNFVLAPHAPYTCSLECLKWVSKKANQWNVPVTIHLSETKKEVEEIRKKYGMTPTQLLDEVGLLNEKLI
AAHGVWLSEEELRMLSSANATVVHCPASNMKLGSGVFPLRKALDLGVNVALGTDGAASNNTLDMLREMRLASLLQKVAHL
NPAIVKSEEILKMATVNPAKALGLKSGVIKEGYIADLALINLRRPHLLPLNSPTSLLIYSARGGDVDTLFVNGEIVILDG
EFLTVNEEKILDKFLKVIE
>Mature_419_residues
MIIKNGMIIYGDEFTIVRSDVLIEDGVIKEVGKNIRAPADMVIDASSHLVIPGLINAHTHVSMVLLRGLAEDVPLQEWLQ
NYIWPRERELKRKDIYWGTLLGLVEMARSGVTTFVDMYFHIEEVAKATIEVGLRGFLGYGMVDLENREKLEVEIKETEKF
YEYVTKINSPLVNFVLAPHAPYTCSLECLKWVSKKANQWNVPVTIHLSETKKEVEEIRKKYGMTPTQLLDEVGLLNEKLI
AAHGVWLSEEELRMLSSANATVVHCPASNMKLGSGVFPLRKALDLGVNVALGTDGAASNNTLDMLREMRLASLLQKVAHL
NPAIVKSEEILKMATVNPAKALGLKSGVIKEGYIADLALINLRRPHLLPLNSPTSLLIYSARGGDVDTLFVNGEIVILDG
EFLTVNEEKILDKFLKVIE

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family

Homologues:

Organism=Homo sapiens, GI4758426, Length=356, Percent_Identity=30.3370786516854, Blast_Score=145, Evalue=5e-35,
Organism=Escherichia coli, GI87082177, Length=409, Percent_Identity=25.6723716381418, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1789249, Length=392, Percent_Identity=27.5510204081633, Blast_Score=101, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17540282, Length=403, Percent_Identity=26.5508684863524, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319963, Length=385, Percent_Identity=27.012987012987, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24643849, Length=383, Percent_Identity=27.154046997389, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAD_PYRFU (Q8U0P7)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579267.1
- ProteinModelPortal:   Q8U0P7
- SMR:   Q8U0P7
- EnsemblBacteria:   EBPYRT00000005360
- GeneID:   1469414
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1538
- NMPDR:   fig|186497.1.peg.1585
- GeneTree:   EBGT00050000022604
- HOGENOM:   HBG668170
- OMA:   KENIESH
- ProtClustDB:   PRK08393
- BRENDA:   3.5.4.28
- HAMAP:   MF_01281
- InterPro:   IPR006680
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.28

Molecular weight: Translated: 46708; Mature: 46708

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: BINDING 87-87 BINDING 179-179 BINDING 209-209 BINDING 294-294

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIKNGMIIYGDEFTIVRSDVLIEDGVIKEVGKNIRAPADMVIDASSHLVIPGLINAHTH
CEEECCEEEECCCEEEEECCEEECCCHHHHHCCCCCCCCCEEEECCCCEEECCHHCCHHH
VSMVLLRGLAEDVPLQEWLQNYIWPRERELKRKDIYWGTLLGLVEMARSGVTTFVDMYFH
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IEEVAKATIEVGLRGFLGYGMVDLENREKLEVEIKETEKFYEYVTKINSPLVNFVLAPHA
HHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCC
PYTCSLECLKWVSKKANQWNVPVTIHLSETKKEVEEIRKKYGMTPTQLLDEVGLLNEKLI
CCEEHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHH
AAHGVWLSEEELRMLSSANATVVHCPASNMKLGSGVFPLRKALDLGVNVALGTDGAASNN
HHCCCEECHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCC
TLDMLREMRLASLLQKVAHLNPAIVKSEEILKMATVNPAKALGLKSGVIKEGYIADLALI
HHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHEEEE
NLRRPHLLPLNSPTSLLIYSARGGDVDTLFVNGEIVILDGEFLTVNEEKILDKFLKVIE
ECCCCCEEECCCCCEEEEEECCCCCEEEEEECCEEEEECCCEEEECHHHHHHHHHHHCC
>Mature Secondary Structure
MIIKNGMIIYGDEFTIVRSDVLIEDGVIKEVGKNIRAPADMVIDASSHLVIPGLINAHTH
CEEECCEEEECCCEEEEECCEEECCCHHHHHCCCCCCCCCEEEECCCCEEECCHHCCHHH
VSMVLLRGLAEDVPLQEWLQNYIWPRERELKRKDIYWGTLLGLVEMARSGVTTFVDMYFH
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IEEVAKATIEVGLRGFLGYGMVDLENREKLEVEIKETEKFYEYVTKINSPLVNFVLAPHA
HHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCC
PYTCSLECLKWVSKKANQWNVPVTIHLSETKKEVEEIRKKYGMTPTQLLDEVGLLNEKLI
CCEEHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHH
AAHGVWLSEEELRMLSSANATVVHCPASNMKLGSGVFPLRKALDLGVNVALGTDGAASNN
HHCCCEECHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCC
TLDMLREMRLASLLQKVAHLNPAIVKSEEILKMATVNPAKALGLKSGVIKEGYIADLALI
HHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHEEEE
NLRRPHLLPLNSPTSLLIYSARGGDVDTLFVNGEIVILDGEFLTVNEEKILDKFLKVIE
ECCCCCEEECCCCCEEEEEECCCCCEEEEEECCEEEEECCCEEEECHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA