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The map label for this gene is gltT [H]

Identifier: 18977841

GI number: 18977841

Start: 1374705

End: 1375985

Strand: Direct

Name: gltT [H]

Synonym: PF1469

Alternate gene names: 18977841

Gene position: 1374705-1375985 (Clockwise)

Preceding gene: 18977840

Following gene: 18977843

Centisome position: 72.04

GC content: 44.11

Gene sequence:

>1281_bases
GTGAGTTTATTAAAGAGATACCTGGAATATCCTGTTTTGCAAAAGATACTTATTGGCCTTATTTTGGGTGCAATATTTGG
TTTAATTATGGGCCACTTTGGATATGATGAAGCAGTAAAAACGTACATCAAGCCCTTTGGAGACCTCTTCGTCAGACTTC
TGAAAATGCTAGTTATGCCAATAGTCTTCGCATCGCTAGTGGTAGGTGCAGCCAGCATAAGTCCAGCAAGACTTGGAAGG
GTGGGAGTAAAAATAGTCCTCTACTATTTACTAACATCAGCATTTGCAGTTATGCTGGGAATTATAATGGCAAGAATCTT
CAACCCAGGAGCTGGAATTCAGCTTTCAGTTGGAGGGCAACAATTCCAGCCAAAAGAGGCACCACCCATTGTTCAAACAT
TACTTAACATAATTCCAACGAACCCCTTCGGAGCTCTTGCAAATGGCCAAGTCCTTCCAACGATATTCTTTGCTATCATA
TTGGGAATAGCAATAACATACCTAATGAACAGCAATGAAGAGAGAATAAGGAAGAGCGGAGAAACCTTGCTTCGTGCAAT
TGACGGTTTGGCTGAGGCGATGTACAAGATAGTTGGGGGAGTTATGCAATACGCTCCCATTGGTGTCTTTGCATTAATAG
CCCACGTAATGGCAACCCAAGGAGTCAAAGTTGTAGGTGAGTTGGCAAAGGTCACGGCAGCTGTTTACGTTGGATTATTC
GTTCATATCCTCCTAGTGTACTTTGTCCTTCTCAAGGTCTTCGGGATTGATCCCCTCAAGTTCATTAGTAAAGCTAAAGA
TGCCATGCTAACAGCATTCGTAACGAGGAGCTCAAGTGGAACACTTCCAGTAACCATGCGTGTTGCCAAGGAGATGGGAA
TCTCGGAGGGAATATACTCCTTCACCTTGCCCCTGGGAGCCACTATAAACATGGATGGAACCGCACTCTACCAGGGTGTC
TGTACATTCTTCATAGCAAACGCCCTAGGAACTCATCTAACAATTGGCCAACAGCTAACAATAGTCCTCACTGCTGTTCT
AGCCTCTATAGGAACAGCTGGAGTCCCAGGAGCTGGAGCAATAATGTTAGCTATGGTTCTTGAGAGCGTTGGGCTTCCGC
TAACCGATCCAAATGTGGCCGCAGCCTATGCAATGATCCTTGGAATAGATGCAATCCTCGGTTACTGGAGACCTAACTGG
TACTGCAATAGTTGCAAAGACAGAAGGGGAGCTAAAAGAAGGAATTATAGCCTGAATTACTTCTCTCTTTCCTTTTTATA
A

Upstream 100 bases:

>100_bases
AGATTTTGTCCATAACTAACCATCATCGTGTTTGGGTAAATATATAACTGCCTTGTCCAATATTATGCCTTGATATACAC
TTGTCGGGAGGTGTACAAAG

Downstream 100 bases:

>100_bases
AATACCCATTTTCGTATTTAATGCTGGGGGTGATTCTCTCCACTATATGAGGCTTTCTTAAAACGCTCTCCAATCTTTTT
TCATGGGCAATAAATCCCCT

Product: glutamate/aspartate transport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSLLKRYLEYPVLQKILIGLILGAIFGLIMGHFGYDEAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGR
VGVKIVLYYLLTSAFAVMLGIIMARIFNPGAGIQLSVGGQQFQPKEAPPIVQTLLNIIPTNPFGALANGQVLPTIFFAII
LGIAITYLMNSNEERIRKSGETLLRAIDGLAEAMYKIVGGVMQYAPIGVFALIAHVMATQGVKVVGELAKVTAAVYVGLF
VHILLVYFVLLKVFGIDPLKFISKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGV
CTFFIANALGTHLTIGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILGIDAILGYWRPNW
YCNSCKDRRGAKRRNYSLNYFSLSFL

Sequences:

>Translated_426_residues
MSLLKRYLEYPVLQKILIGLILGAIFGLIMGHFGYDEAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGR
VGVKIVLYYLLTSAFAVMLGIIMARIFNPGAGIQLSVGGQQFQPKEAPPIVQTLLNIIPTNPFGALANGQVLPTIFFAII
LGIAITYLMNSNEERIRKSGETLLRAIDGLAEAMYKIVGGVMQYAPIGVFALIAHVMATQGVKVVGELAKVTAAVYVGLF
VHILLVYFVLLKVFGIDPLKFISKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGV
CTFFIANALGTHLTIGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILGIDAILGYWRPNW
YCNSCKDRRGAKRRNYSLNYFSLSFL
>Mature_425_residues
SLLKRYLEYPVLQKILIGLILGAIFGLIMGHFGYDEAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRV
GVKIVLYYLLTSAFAVMLGIIMARIFNPGAGIQLSVGGQQFQPKEAPPIVQTLLNIIPTNPFGALANGQVLPTIFFAIIL
GIAITYLMNSNEERIRKSGETLLRAIDGLAEAMYKIVGGVMQYAPIGVFALIAHVMATQGVKVVGELAKVTAAVYVGLFV
HILLVYFVLLKVFGIDPLKFISKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVC
TFFIANALGTHLTIGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILGIDAILGYWRPNWY
CNSCKDRRGAKRRNYSLNYFSLSFL

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=449, Percent_Identity=32.739420935412, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI194239697, Length=459, Percent_Identity=32.0261437908497, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI21314632, Length=400, Percent_Identity=32.25, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI66773030, Length=455, Percent_Identity=30.5494505494506, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI40254478, Length=438, Percent_Identity=28.7671232876712, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI4827012, Length=289, Percent_Identity=36.6782006920415, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI5032093, Length=396, Percent_Identity=32.5757575757576, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI262359914, Length=379, Percent_Identity=31.6622691292876, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI223468566, Length=257, Percent_Identity=33.852140077821, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI223468564, Length=248, Percent_Identity=33.8709677419355, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI301601644, Length=156, Percent_Identity=37.1794871794872, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1790514, Length=406, Percent_Identity=34.2364532019704, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1789947, Length=404, Percent_Identity=30.4455445544554, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1788024, Length=348, Percent_Identity=30.1724137931034, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1789473, Length=334, Percent_Identity=27.5449101796407, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71996953, Length=412, Percent_Identity=31.5533980582524, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71983099, Length=445, Percent_Identity=30.1123595505618, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71983106, Length=445, Percent_Identity=30.1123595505618, Blast_Score=168, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17537407, Length=417, Percent_Identity=30.4556354916067, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI193206505, Length=436, Percent_Identity=27.9816513761468, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI193206654, Length=418, Percent_Identity=27.511961722488, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17541374, Length=390, Percent_Identity=27.9487179487179, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24583025, Length=449, Percent_Identity=28.2850779510022, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI17137668, Length=449, Percent_Identity=28.2850779510022, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24583023, Length=449, Percent_Identity=28.2850779510022, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI281360483, Length=404, Percent_Identity=28.4653465346535, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI17137666, Length=404, Percent_Identity=28.4653465346535, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI281360481, Length=404, Percent_Identity=28.4653465346535, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45806; Mature: 45674

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLKRYLEYPVLQKILIGLILGAIFGLIMGHFGYDEAVKTYIKPFGDLFVRLLKMLVMP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IVFASLVVGAASISPARLGRVGVKIVLYYLLTSAFAVMLGIIMARIFNPGAGIQLSVGGQ
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
QFQPKEAPPIVQTLLNIIPTNPFGALANGQVLPTIFFAIILGIAITYLMNSNEERIRKSG
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ETLLRAIDGLAEAMYKIVGGVMQYAPIGVFALIAHVMATQGVKVVGELAKVTAAVYVGLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VHILLVYFVLLKVFGIDPLKFISKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYS
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHH
FTLPLGATINMDGTALYQGVCTFFIANALGTHLTIGQQLTIVLTAVLASIGTAGVPGAGA
EEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHH
IMLAMVLESVGLPLTDPNVAAAYAMILGIDAILGYWRPNWYCNSCKDRRGAKRRNYSLNY
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHCCCCCCE
FSLSFL
EEEECC
>Mature Secondary Structure 
SLLKRYLEYPVLQKILIGLILGAIFGLIMGHFGYDEAVKTYIKPFGDLFVRLLKMLVMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IVFASLVVGAASISPARLGRVGVKIVLYYLLTSAFAVMLGIIMARIFNPGAGIQLSVGGQ
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
QFQPKEAPPIVQTLLNIIPTNPFGALANGQVLPTIFFAIILGIAITYLMNSNEERIRKSG
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ETLLRAIDGLAEAMYKIVGGVMQYAPIGVFALIAHVMATQGVKVVGELAKVTAAVYVGLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VHILLVYFVLLKVFGIDPLKFISKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYS
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHH
FTLPLGATINMDGTALYQGVCTFFIANALGTHLTIGQQLTIVLTAVLASIGTAGVPGAGA
EEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHH
IMLAMVLESVGLPLTDPNVAAAYAMILGIDAILGYWRPNWYCNSCKDRRGAKRRNYSLNY
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHCCCCCCE
FSLSFL
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]