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The map label for this gene is nuoN [H]

Identifier: 18977802

GI number: 18977802

Start: 1339867

End: 1341399

Strand: Direct

Name: nuoN [H]

Synonym: PF1430

Alternate gene names: 18977802

Gene position: 1339867-1341399 (Clockwise)

Preceding gene: 18977801

Following gene: 33359564

Centisome position: 70.21

GC content: 43.05

Gene sequence:

>1533_bases
ATGACCTGGTTACCATTCATCATTATCATTCCCCTCTTAGGGGCATTTTCAATGCCTATAGTGAGCCTACTAAAGGGCAA
AGCAAAGGAAATTTGGGCGTCTATGATAAGTTTTGCAACCCTCATTGTCGGAATACAAGTCTTTAGAGAAGTCTGGAGCA
AAGGGACAATAGTCTATACGTTAGGAGCACCAAATCCCTTTGGAAAAGCAACGTTCCCAATTAGAATAGTCTGGGAAGTT
GACAAGTTTGGGGCCCTAATGGTTCTAATAGTGACTTTCGTTAGTTTCCTAGCGGTCATATACTCTATTGAGTATATGAA
GCACGACACTGGACTAGAGAAGTTCTACACCCTAATCTTAATACTAGAGCTTGGGATGCTCGGAATAGCGATAACTGGAG
ATATATTCAACTTCTATGTCTTCCTAGAGATAATGAGCATCGCAAGCTATGCACTTGTTGCATTCAGGAATGACACATGG
GAAGGAATTGAAGCCGGCATAAAGTACATGTTTGCAGGGTCATTGGCAAGTAGCTTTGTTCTTCTGGGGATAGCCCTTCT
CTATGGGCAATATGGAACACTTACCATGGGTTATCTTGCTGTAAAGATTGCGGAAAACCCAACAATAGTAGCGAAAGTTG
CCCTTGCCCTCTTCATAGGTGGATTACTCTTCAAGAGTGGTGCTGCTCCAGTTCACATGTGGCTAGCAGATGCACACCCA
GCCGCTCCAAGCTCAATCTCAGCAATGCTTTCAGGTCTCGTAATTAAGATAGGAGGAATTTACGCAATAGCAAGGATAGT
GTTCAGCATATTCTCTCCAACGATAAATCTTGGGACAATAGGGTGGATAATAATAATCTTCGCATGCATTACTCTAATAG
TTGGAAACGCAATGGCAGTTGTGCAAGAAGACTTGAAGAGACTGCTCGCATATTCTTCAGTGGGACAGATTGGCTACATT
CTCCTGGGACTCGGAATAGGAATGGTGGCTTATGGAACTAGAGTAGGTGAAATAGCATTGGCAGGTGCAATATACCACAC
TGTAAATCATGCGCTAATGAAGGCACTCCTCTTCCTTGTTGCAGGTGCTGTCATTCACGAAATTGGAACTAGAAACATGA
ACGAGCTGAGCGGATTGGCAAAGACGATGCCAAAAACAACCTTTGCCTTTCTGATTGGAGCAGCTGCAATTGTTGGTCTA
CCTCCTCTAAATGGATTTGCAAGTAAGTGGCTTATCTACGAAAGCTCAGCTCTGTTCAATCCAATATTAGGTGCAATTGC
TGTCATTGGGACAGTGTTTTGTACAGCAGCCTATGTAAGGGCATTATTCACATTCTTCGGAAGGCCAAGTGAAAAGGTCA
CGAATGCAAGAGACCCAGGAATAGCTATGATGCTTCCAATGATAATTCTTGTAGTGACAATAATAGTCATGGGCTTCTTC
CCATGGCAAATAAGTGACAGAATAATGGTTCCAACAGCGAGAGCCCTTTGGGATGTAATTGACTATATTTCATCCTTAAT
GGGAGGTGGATGA

Upstream 100 bases:

>100_bases
TTATTGGAGTATGTGTGCTATCCTTAGCTATTGCCCTTACTGTCAACGCATACAGGCATTATGGAACTTTGGATGTAACA
AAGCTTAGGAGGTTGAGAGG

Downstream 100 bases:

>100_bases
AATGTTTGGATACTGGGATCCCCTCTATTTTATCATCGTATTTATCATTGGCCTAATACTTGCATATCTATTGAACTTAT
GGGCCAAGAAGAGTGGAATG

Product: putative monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MTWLPFIIIIPLLGAFSMPIVSLLKGKAKEIWASMISFATLIVGIQVFREVWSKGTIVYTLGAPNPFGKATFPIRIVWEV
DKFGALMVLIVTFVSFLAVIYSIEYMKHDTGLEKFYTLILILELGMLGIAITGDIFNFYVFLEIMSIASYALVAFRNDTW
EGIEAGIKYMFAGSLASSFVLLGIALLYGQYGTLTMGYLAVKIAENPTIVAKVALALFIGGLLFKSGAAPVHMWLADAHP
AAPSSISAMLSGLVIKIGGIYAIARIVFSIFSPTINLGTIGWIIIIFACITLIVGNAMAVVQEDLKRLLAYSSVGQIGYI
LLGLGIGMVAYGTRVGEIALAGAIYHTVNHALMKALLFLVAGAVIHEIGTRNMNELSGLAKTMPKTTFAFLIGAAAIVGL
PPLNGFASKWLIYESSALFNPILGAIAVIGTVFCTAAYVRALFTFFGRPSEKVTNARDPGIAMMLPMIILVVTIIVMGFF
PWQISDRIMVPTARALWDVIDYISSLMGGG

Sequences:

>Translated_510_residues
MTWLPFIIIIPLLGAFSMPIVSLLKGKAKEIWASMISFATLIVGIQVFREVWSKGTIVYTLGAPNPFGKATFPIRIVWEV
DKFGALMVLIVTFVSFLAVIYSIEYMKHDTGLEKFYTLILILELGMLGIAITGDIFNFYVFLEIMSIASYALVAFRNDTW
EGIEAGIKYMFAGSLASSFVLLGIALLYGQYGTLTMGYLAVKIAENPTIVAKVALALFIGGLLFKSGAAPVHMWLADAHP
AAPSSISAMLSGLVIKIGGIYAIARIVFSIFSPTINLGTIGWIIIIFACITLIVGNAMAVVQEDLKRLLAYSSVGQIGYI
LLGLGIGMVAYGTRVGEIALAGAIYHTVNHALMKALLFLVAGAVIHEIGTRNMNELSGLAKTMPKTTFAFLIGAAAIVGL
PPLNGFASKWLIYESSALFNPILGAIAVIGTVFCTAAYVRALFTFFGRPSEKVTNARDPGIAMMLPMIILVVTIIVMGFF
PWQISDRIMVPTARALWDVIDYISSLMGGG
>Mature_509_residues
TWLPFIIIIPLLGAFSMPIVSLLKGKAKEIWASMISFATLIVGIQVFREVWSKGTIVYTLGAPNPFGKATFPIRIVWEVD
KFGALMVLIVTFVSFLAVIYSIEYMKHDTGLEKFYTLILILELGMLGIAITGDIFNFYVFLEIMSIASYALVAFRNDTWE
GIEAGIKYMFAGSLASSFVLLGIALLYGQYGTLTMGYLAVKIAENPTIVAKVALALFIGGLLFKSGAAPVHMWLADAHPA
APSSISAMLSGLVIKIGGIYAIARIVFSIFSPTINLGTIGWIIIIFACITLIVGNAMAVVQEDLKRLLAYSSVGQIGYIL
LGLGIGMVAYGTRVGEIALAGAIYHTVNHALMKALLFLVAGAVIHEIGTRNMNELSGLAKTMPKTTFAFLIGAAAIVGLP
PLNGFASKWLIYESSALFNPILGAIAVIGTVFCTAAYVRALFTFFGRPSEKVTNARDPGIAMMLPMIILVVTIIVMGFFP
WQISDRIMVPTARALWDVIDYISSLMGGG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=415, Percent_Identity=25.0602409638554, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI251831116, Length=292, Percent_Identity=23.972602739726, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788827, Length=357, Percent_Identity=35.0140056022409, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1788829, Length=490, Percent_Identity=28.9795918367347, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788831, Length=459, Percent_Identity=28.7581699346405, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1788614, Length=491, Percent_Identity=27.6985743380855, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI2367154, Length=423, Percent_Identity=28.8416075650118, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1788613, Length=506, Percent_Identity=27.6679841897233, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI145693160, Length=251, Percent_Identity=30.6772908366534, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54981; Mature: 54850

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWLPFIIIIPLLGAFSMPIVSLLKGKAKEIWASMISFATLIVGIQVFREVWSKGTIVYT
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
LGAPNPFGKATFPIRIVWEVDKFGALMVLIVTFVSFLAVIYSIEYMKHDTGLEKFYTLIL
ECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ILELGMLGIAITGDIFNFYVFLEIMSIASYALVAFRNDTWEGIEAGIKYMFAGSLASSFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LLGIALLYGQYGTLTMGYLAVKIAENPTIVAKVALALFIGGLLFKSGAAPVHMWLADAHP
HHHHHHHHCCCCHHEEHHEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
AAPSSISAMLSGLVIKIGGIYAIARIVFSIFSPTINLGTIGWIIIIFACITLIVGNAMAV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHH
VQEDLKRLLAYSSVGQIGYILLGLGIGMVAYGTRVGEIALAGAIYHTVNHALMKALLFLV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGAVIHEIGTRNMNELSGLAKTMPKTTFAFLIGAAAIVGLPPLNGFASKWLIYESSALFN
HHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHEEECHHHHH
PILGAIAVIGTVFCTAAYVRALFTFFGRPSEKVTNARDPGIAMMLPMIILVVTIIVMGFF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
PWQISDRIMVPTARALWDVIDYISSLMGGG
CCCCCCEEECCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TWLPFIIIIPLLGAFSMPIVSLLKGKAKEIWASMISFATLIVGIQVFREVWSKGTIVYT
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
LGAPNPFGKATFPIRIVWEVDKFGALMVLIVTFVSFLAVIYSIEYMKHDTGLEKFYTLIL
ECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ILELGMLGIAITGDIFNFYVFLEIMSIASYALVAFRNDTWEGIEAGIKYMFAGSLASSFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LLGIALLYGQYGTLTMGYLAVKIAENPTIVAKVALALFIGGLLFKSGAAPVHMWLADAHP
HHHHHHHHCCCCHHEEHHEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
AAPSSISAMLSGLVIKIGGIYAIARIVFSIFSPTINLGTIGWIIIIFACITLIVGNAMAV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHH
VQEDLKRLLAYSSVGQIGYILLGLGIGMVAYGTRVGEIALAGAIYHTVNHALMKALLFLV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGAVIHEIGTRNMNELSGLAKTMPKTTFAFLIGAAAIVGLPPLNGFASKWLIYESSALFN
HHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHEEECHHHHH
PILGAIAVIGTVFCTAAYVRALFTFFGRPSEKVTNARDPGIAMMLPMIILVVTIIVMGFF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
PWQISDRIMVPTARALWDVIDYISSLMGGG
CCCCCCEEECCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA