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The map label for this gene is panE [C]

Identifier: 18977768

GI number: 18977768

Start: 1309734

End: 1310660

Strand: Reverse

Name: panE [C]

Synonym: PF1396

Alternate gene names: 18977768

Gene position: 1310660-1309734 (Counterclockwise)

Preceding gene: 18977787

Following gene: 18977767

Centisome position: 68.68

GC content: 39.91

Gene sequence:

>927_bases
ATGAAAATTTATGTTCTGGGTGCTGGGGCTATAGGCTCGCTTTTTGGAGGGCTACTTTTCGCTGCAGGTGAGGATGTTGT
TCTTATTGGCAGAAAGCCCCATGTAGATGCAATAAATAAGAGAGGGCTTAGGATAACTGGGATTATAGAAGAGGTGATAA
AAGTTCCTGCTACAATCTCTCCTCCCGAAGAAAAACCAGATCTAATAATACTCGCAACAAAATCGTACTCTACAGTAGAA
GCCCTTAGAGCCTCTAAAGCGATTGTGGAGGACACTTGGATATTAAGTATTCAAAATGGAATAGGAAATGAAGATGAAAT
AAGAAAGTTCGGGGGAAAGCCTATAGGAGGAATAACTACAAATGGAGCTATCTTAGTGAGCTCAGGGGTTGTGAAGTGGA
CGGGAAAAGGAATAACTGTAGTTGGTTTATACCCTAAAGGGCGTCACACATTTGTTGACAAAATTTCCGAAATTTTCAAT
AGAGCGGGATTAGAAACTATTGTAAGTGAGAACATTGAAGGGTGGATATGGGCAAAGGCAATTGTTAATTCTGCTATTAA
CCCCATTGGCACTCTGTTACGGGTTAAAAATGGGGCAATTCTAGACAATGAGGAATTGCTTTCTGTAGCAGTAGAAGTTG
TGAAAGAGGGGTGTAAGGTTGCGACGCAAAATGGAGTAAAATTAGAGGTTCATCCAATAGATTTGCTATTCCAGACATTG
AAAAAAACTAGGGAGAATTACAATTCCATGCTCCAGGATATATTAAAGGGGAGAAAGACTGAAATTGACTACATAAACGG
AAAAATAGTTGAGTATGCCAAATCTGTTGGGCTTGAAGCTCCCCTTAATTTTCTTCTGTGGGGGTTAATTAAGGGAATGG
AAAAGTTACATGGAGGAGTGGAAAATGTTTGGGGCAAAAGAGAATGA

Upstream 100 bases:

>100_bases
CATCCTCTAGGGGCTCCCAATATAGTGCTGTTCTCATCACTACCTTATGAGCAAAGGGCATTTATATATCTACCCCCAAA
CTAATATGAGGAGATGTGGA

Downstream 100 bases:

>100_bases
TGTGTTTAAACTAATAAGGGATCATTTGACAATGGTCGGAGATACATTAAAATACACCAAGGAGATGTTTGTTCAGTATT
TGCAGGGAAACATAGGAAAT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MKIYVLGAGAIGSLFGGLLFAAGEDVVLIGRKPHVDAINKRGLRITGIIEEVIKVPATISPPEEKPDLIILATKSYSTVE
ALRASKAIVEDTWILSIQNGIGNEDEIRKFGGKPIGGITTNGAILVSSGVVKWTGKGITVVGLYPKGRHTFVDKISEIFN
RAGLETIVSENIEGWIWAKAIVNSAINPIGTLLRVKNGAILDNEELLSVAVEVVKEGCKVATQNGVKLEVHPIDLLFQTL
KKTRENYNSMLQDILKGRKTEIDYINGKIVEYAKSVGLEAPLNFLLWGLIKGMEKLHGGVENVWGKRE

Sequences:

>Translated_308_residues
MKIYVLGAGAIGSLFGGLLFAAGEDVVLIGRKPHVDAINKRGLRITGIIEEVIKVPATISPPEEKPDLIILATKSYSTVE
ALRASKAIVEDTWILSIQNGIGNEDEIRKFGGKPIGGITTNGAILVSSGVVKWTGKGITVVGLYPKGRHTFVDKISEIFN
RAGLETIVSENIEGWIWAKAIVNSAINPIGTLLRVKNGAILDNEELLSVAVEVVKEGCKVATQNGVKLEVHPIDLLFQTL
KKTRENYNSMLQDILKGRKTEIDYINGKIVEYAKSVGLEAPLNFLLWGLIKGMEKLHGGVENVWGKRE
>Mature_308_residues
MKIYVLGAGAIGSLFGGLLFAAGEDVVLIGRKPHVDAINKRGLRITGIIEEVIKVPATISPPEEKPDLIILATKSYSTVE
ALRASKAIVEDTWILSIQNGIGNEDEIRKFGGKPIGGITTNGAILVSSGVVKWTGKGITVVGLYPKGRHTFVDKISEIFN
RAGLETIVSENIEGWIWAKAIVNSAINPIGTLLRVKNGAILDNEELLSVAVEVVKEGCKVATQNGVKLEVHPIDLLFQTL
KKTRENYNSMLQDILKGRKTEIDYINGKIVEYAKSVGLEAPLNFLLWGLIKGMEKLHGGVENVWGKRE

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=309, Percent_Identity=28.1553398058252, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33443; Mature: 33443

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIYVLGAGAIGSLFGGLLFAAGEDVVLIGRKPHVDAINKRGLRITGIIEEVIKVPATIS
CEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHCCCCEEHHHHHHHHHCCCCCC
PPEEKPDLIILATKSYSTVEALRASKAIVEDTWILSIQNGIGNEDEIRKFGGKPIGGITT
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHCCCCCCCEEC
NGAILVSSGVVKWTGKGITVVGLYPKGRHTFVDKISEIFNRAGLETIVSENIEGWIWAKA
CCEEEEECCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHH
IVNSAINPIGTLLRVKNGAILDNEELLSVAVEVVKEGCKVATQNGVKLEVHPIDLLFQTL
HHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHEECCCCCEEEEEHHHHHHHHH
KKTRENYNSMLQDILKGRKTEIDYINGKIVEYAKSVGLEAPLNFLLWGLIKGMEKLHGGV
HHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCH
ENVWGKRE
HHHCCCCC
>Mature Secondary Structure
MKIYVLGAGAIGSLFGGLLFAAGEDVVLIGRKPHVDAINKRGLRITGIIEEVIKVPATIS
CEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHCCCCEEHHHHHHHHHCCCCCC
PPEEKPDLIILATKSYSTVEALRASKAIVEDTWILSIQNGIGNEDEIRKFGGKPIGGITT
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHCCCCCCCEEC
NGAILVSSGVVKWTGKGITVVGLYPKGRHTFVDKISEIFNRAGLETIVSENIEGWIWAKA
CCEEEEECCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHH
IVNSAINPIGTLLRVKNGAILDNEELLSVAVEVVKEGCKVATQNGVKLEVHPIDLLFQTL
HHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHEECCCCCEEEEEHHHHHHHHH
KKTRENYNSMLQDILKGRKTEIDYINGKIVEYAKSVGLEAPLNFLLWGLIKGMEKLHGGV
HHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCH
ENVWGKRE
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]