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The map label for this gene is folP [H]

Identifier: 18977668

GI number: 18977668

Start: 1222581

End: 1223405

Strand: Direct

Name: folP [H]

Synonym: PF1296

Alternate gene names: 18977668

Gene position: 1222581-1223405 (Clockwise)

Preceding gene: 18977667

Following gene: 18977680

Centisome position: 64.07

GC content: 41.82

Gene sequence:

>825_bases
ATGAAGTTTGCTGGAGTTTCGTTAGATACTCCCAAAGTAATGGGAGTCATAAACGTTTCCCCTGAAAGCTTCTTCAAGGG
GAGTGTGAAGAGAGGAGAAGAGCTTATAGAAACAGCGGTAAGAATGGTTGAAGAGGGGGCGGCGTTTATAGATATTGGCG
CAAAATCAACTGCTCCCTACTTAGAAACTGAGATACCAGTTGAAGAGGAAATTAGAAGGGCCGTTGAAGCTATAAGAGCT
ATTAGAGATGCTGTAGATGTCCCGATAAGTATTGACACAACTAATGCTAAGGTTGCTGAGGAAGCAATAAAAGCTGGGGC
AGACATTGTGAACGATGTAACTGGGCTTAAGGGAGACCCAGAGATGGTTAAAGTTGTTAAAGAATATGATGTCCCCGTCG
TTATATGTGCACATCAAGAAAATGTAAGGAACTTTTCAGATCCAGTTCATGAAGTGATAGACTCCTTGAAGGAAAGTCTT
CAGATAGCATACAAAAACGGGATAGAGAAAGAGAACATAGCAATAGACCCAGCCATAGGATTTTTCAGGCCCGAATATCC
TCCCTGGTATGTTTGGGATTCGAAGGTAATAGCGAATTTAAAGTTACTGAAAGTCTTTGGACTTCCAATTTTAGTTGGAA
TATCAAGGAAGTCATTCATTGGAGCTATAACGGGAAGGGAGGATCCAAGTGAAAGGCTTGAAGGAAGCTTGGCCGCTACG
GCGATAGCTGTGTTAAATGGAGCAAACATAATAAGAGCTCATGACGTCAAAGAAACCCTAGATGTAATAAAGGTTGCAGA
CTTCATTCGGAGATTCACTCTATAG

Upstream 100 bases:

>100_bases
GCAAAGAGTGAAGCAGATGCCTGGGAGGCAGTGAGAAAGCTGTTGAGAGAATTGGATAAGTATGGACTGCTAGAGGAAGA
AGAGGAGGAGCTTTGATTTC

Downstream 100 bases:

>100_bases
GAACTCCGTCCTTAGTCCTTGGAGCTAGCCATTTCATTAGCTTTTGCGGCTCCTTCGTTCTTATTATTATTGTTATCGGA
CCTAGAGGTGATTCTTCGTT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MKFAGVSLDTPKVMGVINVSPESFFKGSVKRGEELIETAVRMVEEGAAFIDIGAKSTAPYLETEIPVEEEIRRAVEAIRA
IRDAVDVPISIDTTNAKVAEEAIKAGADIVNDVTGLKGDPEMVKVVKEYDVPVVICAHQENVRNFSDPVHEVIDSLKESL
QIAYKNGIEKENIAIDPAIGFFRPEYPPWYVWDSKVIANLKLLKVFGLPILVGISRKSFIGAITGREDPSERLEGSLAAT
AIAVLNGANIIRAHDVKETLDVIKVADFIRRFTL

Sequences:

>Translated_274_residues
MKFAGVSLDTPKVMGVINVSPESFFKGSVKRGEELIETAVRMVEEGAAFIDIGAKSTAPYLETEIPVEEEIRRAVEAIRA
IRDAVDVPISIDTTNAKVAEEAIKAGADIVNDVTGLKGDPEMVKVVKEYDVPVVICAHQENVRNFSDPVHEVIDSLKESL
QIAYKNGIEKENIAIDPAIGFFRPEYPPWYVWDSKVIANLKLLKVFGLPILVGISRKSFIGAITGREDPSERLEGSLAAT
AIAVLNGANIIRAHDVKETLDVIKVADFIRRFTL
>Mature_274_residues
MKFAGVSLDTPKVMGVINVSPESFFKGSVKRGEELIETAVRMVEEGAAFIDIGAKSTAPYLETEIPVEEEIRRAVEAIRA
IRDAVDVPISIDTTNAKVAEEAIKAGADIVNDVTGLKGDPEMVKVVKEYDVPVVICAHQENVRNFSDPVHEVIDSLKESL
QIAYKNGIEKENIAIDPAIGFFRPEYPPWYVWDSKVIANLKLLKVFGLPILVGISRKSFIGAITGREDPSERLEGSLAAT
AIAVLNGANIIRAHDVKETLDVIKVADFIRRFTL

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=272, Percent_Identity=37.1323529411765, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324073, Length=322, Percent_Identity=28.2608695652174, Blast_Score=112, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30014; Mature: 30014

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50972 PTERIN_BINDING ; PS01319 RBFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFAGVSLDTPKVMGVINVSPESFFKGSVKRGEELIETAVRMVEEGAAFIDIGAKSTAPY
CCCCCCCCCCCCEEEEEECCHHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
LETEIPVEEEIRRAVEAIRAIRDAVDVPISIDTTNAKVAEEAIKAGADIVNDVTGLKGDP
CCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCH
EMVKVVKEYDVPVVICAHQENVRNFSDPVHEVIDSLKESLQIAYKNGIEKENIAIDPAIG
HHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHH
FFRPEYPPWYVWDSKVIANLKLLKVFGLPILVGISRKSFIGAITGREDPSERLEGSLAAT
CCCCCCCCEEEECCHHHHHHHHHHHHCCHHEEECCCHHHEEEECCCCCHHHHHCCHHHHH
AIAVLNGANIIRAHDVKETLDVIKVADFIRRFTL
HHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFAGVSLDTPKVMGVINVSPESFFKGSVKRGEELIETAVRMVEEGAAFIDIGAKSTAPY
CCCCCCCCCCCCEEEEEECCHHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
LETEIPVEEEIRRAVEAIRAIRDAVDVPISIDTTNAKVAEEAIKAGADIVNDVTGLKGDP
CCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCH
EMVKVVKEYDVPVVICAHQENVRNFSDPVHEVIDSLKESLQIAYKNGIEKENIAIDPAIG
HHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHH
FFRPEYPPWYVWDSKVIANLKLLKVFGLPILVGISRKSFIGAITGREDPSERLEGSLAAT
CCCCCCCCEEEECCHHHHHHHHHHHHCCHHEEECCCHHHEEEECCCCCHHHHHCCHHHHH
AIAVLNGANIIRAHDVKETLDVIKVADFIRRFTL
HHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]