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The map label for this gene is rsmB [H]

Identifier: 18977637

GI number: 18977637

Start: 1197174

End: 1198526

Strand: Reverse

Name: rsmB [H]

Synonym: PF1265

Alternate gene names: 18977637

Gene position: 1198526-1197174 (Counterclockwise)

Preceding gene: 33359555

Following gene: 18977633

Centisome position: 62.81

GC content: 38.06

Gene sequence:

>1353_bases
ATGGAGTTATTTTATCGAGTCACAATACATGAGATAGTCGCTGATGCTCTAATGTTGGTAGAGGAGAAAGAACTTTCATC
TAAGCATGCTCTGGAAAAAATTTTCAAAAAAGTTGAAGGCAAAGATAAGGAGAAGGCTAGAGGAATAGCTCATGCTTATG
TCTTCGAAATTGAAAAGTGGAGAGCCAAAATAGATTTTATCATAAACTCTGTTCTTAGGGGATCAAAAGTTGAAGATTTA
GATCCTTATCTAGCAAATCTCCTTCGAATTGGAGTTTTTGAAATGAAATTTAAAAAGATAAATCCAGCAATTGCGACTGA
TTCCATAGTTCGGGTTGTTAAGGAAAAGTTTGACTTAACTCGGGCTAAATTTGCAAACGCTATTCTCAGGGAAGTTGAGA
AGTTCAACGTTGAGAAGGCCTTAAAGCGGCTAAAAGAGAAGGACAGAATAGAATGGTTAGCCGTTAGGTTCTCCCATCCC
AGGTGGTATGTAGAGTATGTAATAGACCTACTTGGCTATGATGAGGCAGTTAGACTCCTCCTAAGCAATTTAAAGCCTCA
AAGGTATTATGTGAGGATAAATTCCCTAAAAGCTGATATTGAAAAAGTAAAGAAATACCTAGAAGAGAACGGGGTAAGAG
TAGCATATACTCCTGTAGATGATGTTCTCAAGGTTCTAGAATATGAAAAACCCATAACAAAGTTAGAAGGGTACAAGAAA
GGATACTTCGTCATTCAAGACTTAGCATCTGCATATGTAGCCCATGTTTTGAGTCCTGAACCTGGAGAAAGAGTGCTAGA
CTTAGCAGCAGCTCCTGGAAGCAAAACATTCCATGCTGCCGCTTTAATGGAGAACAAGGGGGAGATTGTGGCAGTGGACT
ATTCCTATGAAAGACTAGTTAGAATGAAGGAAAGAATGAAGAAGCTTGGAGTTAAAAATGTCAAGCTTGTTTATGCAGAT
GGGCAAAGTTATATTGACAAAGAAAAGTTTGATAAGATAATTCTCGATGCCCCCTGTTCTTCTTCTGGCACCTACAGGCA
GTTTCCAGAAGTAAAGTGGAGGTTTAATGAAGAAAAAATAAAAAGGATAATCAGTGTTCAAAGGAACATGCTCATAAATG
CTTTTAGAAACCTCAAAGAAGGTGGAGAAATGACGTATTCCACATGTTCGGTGAGAATAGACGAAAATGAGGAAAATGTA
ATGTTCGGCTTAGAAAGAGGTTTTGAAATAGTGGATTATCCCTTCTCCTGGGGAGATAAGGGATTTTTAGAAATCGGGGA
TAAAACGTTTAGAACTTGGACTCATAGACATGACTGCAACAGCTTTTTCATAGCAAAGCTAAGAAAACCTTGA

Upstream 100 bases:

>100_bases
TTTTCGACATAAAAATGACACATAAATATAACCACAAAGAATTAAACTTGCAAAAGTAACTGGGAAAGAGTTTATAAAGA
ACTCTTAAGACGTAGCGAAC

Downstream 100 bases:

>100_bases
AAAAGAGAAAGGAGAAAAATTCACTCCTCTTCTCCTTTAATCCTCATGATCTTAATCCTGCCAAGAGTTTCCCAGTATTC
GACGTTGATACCTTCCTTTA

Product: nol1-nop2-sun family nucleolar protein II

Products: NA

Alternate protein names: rRNA (cytosine-C(5)-)-methyltransferase rsmB [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MELFYRVTIHEIVADALMLVEEKELSSKHALEKIFKKVEGKDKEKARGIAHAYVFEIEKWRAKIDFIINSVLRGSKVEDL
DPYLANLLRIGVFEMKFKKINPAIATDSIVRVVKEKFDLTRAKFANAILREVEKFNVEKALKRLKEKDRIEWLAVRFSHP
RWYVEYVIDLLGYDEAVRLLLSNLKPQRYYVRINSLKADIEKVKKYLEENGVRVAYTPVDDVLKVLEYEKPITKLEGYKK
GYFVIQDLASAYVAHVLSPEPGERVLDLAAAPGSKTFHAAALMENKGEIVAVDYSYERLVRMKERMKKLGVKNVKLVYAD
GQSYIDKEKFDKIILDAPCSSSGTYRQFPEVKWRFNEEKIKRIISVQRNMLINAFRNLKEGGEMTYSTCSVRIDENEENV
MFGLERGFEIVDYPFSWGDKGFLEIGDKTFRTWTHRHDCNSFFIAKLRKP

Sequences:

>Translated_450_residues
MELFYRVTIHEIVADALMLVEEKELSSKHALEKIFKKVEGKDKEKARGIAHAYVFEIEKWRAKIDFIINSVLRGSKVEDL
DPYLANLLRIGVFEMKFKKINPAIATDSIVRVVKEKFDLTRAKFANAILREVEKFNVEKALKRLKEKDRIEWLAVRFSHP
RWYVEYVIDLLGYDEAVRLLLSNLKPQRYYVRINSLKADIEKVKKYLEENGVRVAYTPVDDVLKVLEYEKPITKLEGYKK
GYFVIQDLASAYVAHVLSPEPGERVLDLAAAPGSKTFHAAALMENKGEIVAVDYSYERLVRMKERMKKLGVKNVKLVYAD
GQSYIDKEKFDKIILDAPCSSSGTYRQFPEVKWRFNEEKIKRIISVQRNMLINAFRNLKEGGEMTYSTCSVRIDENEENV
MFGLERGFEIVDYPFSWGDKGFLEIGDKTFRTWTHRHDCNSFFIAKLRKP
>Mature_450_residues
MELFYRVTIHEIVADALMLVEEKELSSKHALEKIFKKVEGKDKEKARGIAHAYVFEIEKWRAKIDFIINSVLRGSKVEDL
DPYLANLLRIGVFEMKFKKINPAIATDSIVRVVKEKFDLTRAKFANAILREVEKFNVEKALKRLKEKDRIEWLAVRFSHP
RWYVEYVIDLLGYDEAVRLLLSNLKPQRYYVRINSLKADIEKVKKYLEENGVRVAYTPVDDVLKVLEYEKPITKLEGYKK
GYFVIQDLASAYVAHVLSPEPGERVLDLAAAPGSKTFHAAALMENKGEIVAVDYSYERLVRMKERMKKLGVKNVKLVYAD
GQSYIDKEKFDKIILDAPCSSSGTYRQFPEVKWRFNEEKIKRIISVQRNMLINAFRNLKEGGEMTYSTCSVRIDENEENV
MFGLERGFEIVDYPFSWGDKGFLEIGDKTFRTWTHRHDCNSFFIAKLRKP

Specific function: Unknown

COG id: COG0144

COG function: function code J; tRNA and rRNA cytosine-C5-methylases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmB/NOP family [H]

Homologues:

Organism=Homo sapiens, GI76150625, Length=327, Percent_Identity=32.1100917431193, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI76150623, Length=327, Percent_Identity=32.1100917431193, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI32698918, Length=179, Percent_Identity=36.3128491620112, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI8922322, Length=287, Percent_Identity=27.8745644599303, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI23199998, Length=287, Percent_Identity=27.8745644599303, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI270288816, Length=287, Percent_Identity=27.8745644599303, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI270288818, Length=287, Percent_Identity=27.8745644599303, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI39995082, Length=268, Percent_Identity=24.6268656716418, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI301336155, Length=185, Percent_Identity=27.027027027027, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI2367212, Length=408, Percent_Identity=26.4705882352941, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI87081985, Length=298, Percent_Identity=29.8657718120805, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17536757, Length=294, Percent_Identity=34.3537414965986, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71998419, Length=292, Percent_Identity=29.4520547945205, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI115534021, Length=279, Percent_Identity=29.3906810035842, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324268, Length=312, Percent_Identity=28.525641025641, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6319447, Length=197, Percent_Identity=31.9796954314721, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324306, Length=311, Percent_Identity=27.0096463022508, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI22024126, Length=315, Percent_Identity=28.5714285714286, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24668781, Length=235, Percent_Identity=33.1914893617021, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356513, Length=235, Percent_Identity=33.1914893617021, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356579, Length=219, Percent_Identity=27.3972602739726, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21355201, Length=197, Percent_Identity=30.4568527918782, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19920494, Length=175, Percent_Identity=29.7142857142857, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001678
- InterPro:   IPR018314
- InterPro:   IPR006027
- InterPro:   IPR004573 [H]

Pfam domain/function: PF01189 Nol1_Nop2_Fmu; PF01029 NusB [H]

EC number: NA

Molecular weight: Translated: 52445; Mature: 52445

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELFYRVTIHEIVADALMLVEEKELSSKHALEKIFKKVEGKDKEKARGIAHAYVFEIEKW
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RAKIDFIINSVLRGSKVEDLDPYLANLLRIGVFEMKFKKINPAIATDSIVRVVKEKFDLT
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RAKFANAILREVEKFNVEKALKRLKEKDRIEWLAVRFSHPRWYVEYVIDLLGYDEAVRLL
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHCHHHHHHHH
LSNLKPQRYYVRINSLKADIEKVKKYLEENGVRVAYTPVDDVLKVLEYEKPITKLEGYKK
HHHCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCHHHHCCCCC
GYFVIQDLASAYVAHVLSPEPGERVLDLAAAPGSKTFHAAALMENKGEIVAVDYSYERLV
CHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEECCHHHHH
RMKERMKKLGVKNVKLVYADGQSYIDKEKFDKIILDAPCSSSGTYRQFPEVKWRFNEEKI
HHHHHHHHCCCCCEEEEEECCCHHCCHHHHCEEEEECCCCCCCCCCCCCCHHEEECHHHH
KRIISVQRNMLINAFRNLKEGGEMTYSTCSVRIDENEENVMFGLERGFEIVDYPFSWGDK
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCEEEEHHCCCEEEECCCCCCCC
GFLEIGDKTFRTWTHRHDCNSFFIAKLRKP
CCEEECCHHHHHHHCCCCCCCHHHHEECCC
>Mature Secondary Structure
MELFYRVTIHEIVADALMLVEEKELSSKHALEKIFKKVEGKDKEKARGIAHAYVFEIEKW
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RAKIDFIINSVLRGSKVEDLDPYLANLLRIGVFEMKFKKINPAIATDSIVRVVKEKFDLT
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RAKFANAILREVEKFNVEKALKRLKEKDRIEWLAVRFSHPRWYVEYVIDLLGYDEAVRLL
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHCHHHHHHHH
LSNLKPQRYYVRINSLKADIEKVKKYLEENGVRVAYTPVDDVLKVLEYEKPITKLEGYKK
HHHCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCHHHHCCCCC
GYFVIQDLASAYVAHVLSPEPGERVLDLAAAPGSKTFHAAALMENKGEIVAVDYSYERLV
CHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEECCHHHHH
RMKERMKKLGVKNVKLVYADGQSYIDKEKFDKIILDAPCSSSGTYRQFPEVKWRFNEEKI
HHHHHHHHCCCCCEEEEEECCCHHCCHHHHCEEEEECCCCCCCCCCCCCCHHEEECHHHH
KRIISVQRNMLINAFRNLKEGGEMTYSTCSVRIDENEENVMFGLERGFEIVDYPFSWGDK
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCEEEEHHCCCEEEECCCCCCCC
GFLEIGDKTFRTWTHRHDCNSFFIAKLRKP
CCEEECCHHHHHHHCCCCCCCHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377; 9086272 [H]