Click here to switch to the map view.

The map label for this gene is serS [H]

Identifier: 18977576

GI number: 18977576

Start: 1145476

End: 1146843

Strand: Direct

Name: serS [H]

Synonym: PF1204

Alternate gene names: 18977576

Gene position: 1145476-1146843 (Clockwise)

Preceding gene: 18977575

Following gene: 18977577

Centisome position: 60.03

GC content: 45.91

Gene sequence:

>1368_bases
ATGCTCGACATAAATTTAATCAGAAATAATCCAGAGCTCGTCAAGAACGATCTTAAGAAGAGGGGAGAGCTAGACAAAAT
TGCATGGATTGACGAGATACTTAGGTTAGATGAAGAGTGGAGGAAGAAGCTAAAAGAGATAAACAGGCTTAGGCACGAGA
GAAATAAAATCGCAATAGAGATAGGGAAGAGGAAGAAGGCTGGAGAGCCAGTAGAGGATCTTCTGGCAAAAAGCAAAGAG
ATAGTTAAGAGGATAGAAGAATTAGAGAAGGAAGTTGAGGAGTTAAGAAAGAGAATAGACTACTACCTATGGAGGCTTCC
AAACATAACCCATCCAAGCGTTCCCGTTGGGAAGGATGAGAATGACAACGTCCCCATAAGGTTCTGGGGGAAGGCTAAGG
TTTGGAAAGGACACTTAGAGAGCTTCCTTGAGCAGAGCCAAGGAAAGATGGAGTATGAAGTTCTAGAGTGGAGACCAAAA
CTTCACGTCGACCTTTTGGAGATCCTCGGTGGGGCTGACTTTGCTAGAGCAGCAAAGGTTAGCGGTTCTAGATTCTATTA
CCTCCTAAACGAAATAGTCATACTTGACTTGGCATTGATAAGGTTTGCTTTGGATAGGCTAATAGAGAAGGGCTTCACCC
CAGTTATCCCTCCCTACATGGTTAGAAGATTTGTCGAAGAAGGGTCGACTACATTCGAGGACTTTGAAGATGTTATATAC
AAGGTTGAAGGGGAAGACCTCTACTTAATCCCCACGGCCGAGCACCCATTGGCTGGCATGCACGCAAACGAGATTCTCGA
TGGAAAGGATTTACCTTTACTATATGTAGCTTTCAGCCCGTGCTTTAGAAAAGAGGCAGGGACCGCCGGAAAGGATACCA
AGGGAATCTTTAGGGTTCACCAGTTCCACAAGGTTGAGCAGTTCGTCTATTCTAGACCTGAAGAGAGCTGGGAGTGGCAT
GAAAGGCTAGTTAGGAACGCTGAAGAGCTCTTCCAAGAGCTTGAGATTCCCTACAGAGTAGTTAACATCTGTACTGGAGA
TCTGGGTTACGTAGCCGCAAAGAAGTACGACATAGAGGCTTGGATGCCTGGGCAGGGGAGGTTTAGAGAAGTTGTTTCGG
CAAGCAACTGTACAGACTGGCAGGCTAGGAGGTTGAACATTAGGTTTAGAGATAGAACTGACGAAAAGCCCAGGTACGTG
CACACTTTAAACTCCACTGCAATAGCAACTTCTAGAGCAATAGTGGCAATTCTAGAGAACCACCAGCAGGAGGATGGAAC
TGTAAAGATACCCAGGGCGCTCTGGAAGTACACTGGATTCAAGGAGATAGTCCCGGTTGAGAAGAAGGAAGGGTGCTGCA
AGGCATGA

Upstream 100 bases:

>100_bases
GCTGGAGAAGGTTACAAACCTTGAGTGATTCCTTTTTCTCTTCTTTTCCTCGAACAATAAATATTTTAATGGTTTTGCTT
CATTAGGGTAAGGGGTAAAA

Downstream 100 bases:

>100_bases
AGCTTGTCCTTGACTCTTCTGTTTTTATTCAGGGTGTTGAGGTGGAAGGTTACACAACGCCAAGTGTTGTTGAGGAGATT
AAAGATAGAGAATCCAAGTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MLDINLIRNNPELVKNDLKKRGELDKIAWIDEILRLDEEWRKKLKEINRLRHERNKIAIEIGKRKKAGEPVEDLLAKSKE
IVKRIEELEKEVEELRKRIDYYLWRLPNITHPSVPVGKDENDNVPIRFWGKAKVWKGHLESFLEQSQGKMEYEVLEWRPK
LHVDLLEILGGADFARAAKVSGSRFYYLLNEIVILDLALIRFALDRLIEKGFTPVIPPYMVRRFVEEGSTTFEDFEDVIY
KVEGEDLYLIPTAEHPLAGMHANEILDGKDLPLLYVAFSPCFRKEAGTAGKDTKGIFRVHQFHKVEQFVYSRPEESWEWH
ERLVRNAEELFQELEIPYRVVNICTGDLGYVAAKKYDIEAWMPGQGRFREVVSASNCTDWQARRLNIRFRDRTDEKPRYV
HTLNSTAIATSRAIVAILENHQQEDGTVKIPRALWKYTGFKEIVPVEKKEGCCKA

Sequences:

>Translated_455_residues
MLDINLIRNNPELVKNDLKKRGELDKIAWIDEILRLDEEWRKKLKEINRLRHERNKIAIEIGKRKKAGEPVEDLLAKSKE
IVKRIEELEKEVEELRKRIDYYLWRLPNITHPSVPVGKDENDNVPIRFWGKAKVWKGHLESFLEQSQGKMEYEVLEWRPK
LHVDLLEILGGADFARAAKVSGSRFYYLLNEIVILDLALIRFALDRLIEKGFTPVIPPYMVRRFVEEGSTTFEDFEDVIY
KVEGEDLYLIPTAEHPLAGMHANEILDGKDLPLLYVAFSPCFRKEAGTAGKDTKGIFRVHQFHKVEQFVYSRPEESWEWH
ERLVRNAEELFQELEIPYRVVNICTGDLGYVAAKKYDIEAWMPGQGRFREVVSASNCTDWQARRLNIRFRDRTDEKPRYV
HTLNSTAIATSRAIVAILENHQQEDGTVKIPRALWKYTGFKEIVPVEKKEGCCKA
>Mature_455_residues
MLDINLIRNNPELVKNDLKKRGELDKIAWIDEILRLDEEWRKKLKEINRLRHERNKIAIEIGKRKKAGEPVEDLLAKSKE
IVKRIEELEKEVEELRKRIDYYLWRLPNITHPSVPVGKDENDNVPIRFWGKAKVWKGHLESFLEQSQGKMEYEVLEWRPK
LHVDLLEILGGADFARAAKVSGSRFYYLLNEIVILDLALIRFALDRLIEKGFTPVIPPYMVRRFVEEGSTTFEDFEDVIY
KVEGEDLYLIPTAEHPLAGMHANEILDGKDLPLLYVAFSPCFRKEAGTAGKDTKGIFRVHQFHKVEQFVYSRPEESWEWH
ERLVRNAEELFQELEIPYRVVNICTGDLGYVAAKKYDIEAWMPGQGRFREVVSASNCTDWQARRLNIRFRDRTDEKPRYV
HTLNSTAIATSRAIVAILENHQQEDGTVKIPRALWKYTGFKEIVPVEKKEGCCKA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=496, Percent_Identity=36.6935483870968, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI8923421, Length=458, Percent_Identity=34.4978165938865, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI225579074, Length=365, Percent_Identity=37.5342465753425, Blast_Score=221, Evalue=1e-57,
Organism=Escherichia coli, GI1787120, Length=456, Percent_Identity=37.0614035087719, Blast_Score=298, Evalue=7e-82,
Organism=Caenorhabditis elegans, GI17539260, Length=499, Percent_Identity=36.0721442885772, Blast_Score=301, Evalue=5e-82,
Organism=Caenorhabditis elegans, GI17542084, Length=335, Percent_Identity=33.4328358208955, Blast_Score=175, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6320226, Length=456, Percent_Identity=38.1578947368421, Blast_Score=298, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6321799, Length=414, Percent_Identity=36.231884057971, Blast_Score=239, Evalue=9e-64,
Organism=Drosophila melanogaster, GI24581334, Length=497, Percent_Identity=36.4185110663984, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI17737985, Length=367, Percent_Identity=32.6975476839237, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 53201; Mature: 53201

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDINLIRNNPELVKNDLKKRGELDKIAWIDEILRLDEEWRKKLKEINRLRHERNKIAIE
CEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEE
IGKRKKAGEPVEDLLAKSKEIVKRIEELEKEVEELRKRIDYYLWRLPNITHPSVPVGKDE
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
NDNVPIRFWGKAKVWKGHLESFLEQSQGKMEYEVLEWRPKLHVDLLEILGGADFARAAKV
CCCCCEEECCCCHHHHHHHHHHHHHHCCCCEEHHHHCCCCHHHHHHHHHCCCCHHHHHHC
SGSRFYYLLNEIVILDLALIRFALDRLIEKGFTPVIPPYMVRRFVEEGSTTFEDFEDVIY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHE
KVEGEDLYLIPTAEHPLAGMHANEILDGKDLPLLYVAFSPCFRKEAGTAGKDTKGIFRVH
EECCCEEEEEECCCCCCCCCCHHHCCCCCCCCEEEEECCHHHHHHCCCCCCCCHHHHHHH
QFHKVEQFVYSRPEESWEWHERLVRNAEELFQELEIPYRVVNICTGDLGYVAAKKYDIEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHEEHHHCCCCCHHEEEEECCEE
WMPGQGRFREVVSASNCTDWQARRLNIRFRDRTDEKPRYVHTLNSTAIATSRAIVAILEN
ECCCCCHHHHHHHCCCCCCCHHHEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHH
HQQEDGTVKIPRALWKYTGFKEIVPVEKKEGCCKA
CCCCCCCEEHHHHHHHHCCCHHCCCCCCCCCCCCC
>Mature Secondary Structure
MLDINLIRNNPELVKNDLKKRGELDKIAWIDEILRLDEEWRKKLKEINRLRHERNKIAIE
CEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEE
IGKRKKAGEPVEDLLAKSKEIVKRIEELEKEVEELRKRIDYYLWRLPNITHPSVPVGKDE
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
NDNVPIRFWGKAKVWKGHLESFLEQSQGKMEYEVLEWRPKLHVDLLEILGGADFARAAKV
CCCCCEEECCCCHHHHHHHHHHHHHHCCCCEEHHHHCCCCHHHHHHHHHCCCCHHHHHHC
SGSRFYYLLNEIVILDLALIRFALDRLIEKGFTPVIPPYMVRRFVEEGSTTFEDFEDVIY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHE
KVEGEDLYLIPTAEHPLAGMHANEILDGKDLPLLYVAFSPCFRKEAGTAGKDTKGIFRVH
EECCCEEEEEECCCCCCCCCCHHHCCCCCCCCEEEEECCHHHHHHCCCCCCCCHHHHHHH
QFHKVEQFVYSRPEESWEWHERLVRNAEELFQELEIPYRVVNICTGDLGYVAAKKYDIEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHEEHHHCCCCCHHEEEEECCEE
WMPGQGRFREVVSASNCTDWQARRLNIRFRDRTDEKPRYVHTLNSTAIATSRAIVAILEN
ECCCCCHHHHHHHCCCCCCCHHHEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHH
HQQEDGTVKIPRALWKYTGFKEIVPVEKKEGCCKA
CCCCCCCEEHHHHHHHHCCCHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]