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The map label for this gene is nuoN [H]

Identifier: 18977519

GI number: 18977519

Start: 1099504

End: 1100967

Strand: Reverse

Name: nuoN [H]

Synonym: PF1147

Alternate gene names: 18977519

Gene position: 1100967-1099504 (Counterclockwise)

Preceding gene: 33359546

Following gene: 18977517

Centisome position: 57.69

GC content: 42.69

Gene sequence:

>1464_bases
ATGAACGCCTCAATACTCGCACTTCTTCCAGCCATATTCTCACTATTAATTTATCTATTTGGGAGCCTTAAGATAGAGGG
AAGTATAAGGGCAAGGTTCAAACTCCCCCTAACCCTTGAGGTAAAAGTCCTCTACTTACTTGGAGTCTTTCTCCCTGTAA
TACTATTACCCTTTTCCCAGGGGGGAGTTGTTGGAGGTTATTCTAGACTTTTAGGGATTGAAGTCGATCTAGACTCGATA
ACCTTCCTCTTCTTAATTGCAGAGCTGACCGTATTTTCCATGAGCTCCCTCTATGTTGTAACCTATGCGACTGAATGGAG
AAAGCTTTCCCTTCTCCTTTTAATGCATTCTGGATTAATAGGGGCTTTCATATCGAAGGACCTCTTCAACTTCTACGTGT
TTATGGAACTCTCGGCAATTTCATCTTTTGCACTAATAGCCTCCTCAAAGGAGAAAGGTAGCTATAAGGCCGCCTACAAC
TATCTCCTCCTTTCTATGACTGCCTCCTATCTCCTAGTTCTCTCGCTAGGCATGATTTACTTTTCCACCGGTACTCTAAA
TGTTAAGCTGGCTCAGGGGAGAGAAGTTCCCAGGATTGCAGTTCTGATTGCTTCTCTCGCCCTTTCATTGAAGAGTGGGA
TATTTCCCCTGCACATTTGGCTGCCTGATGCCCACTCGAAGGCCGACACATACTTAAGTGCAATTCTCTCTGGAATTGCA
GTTAAAGCCCCAGTATACGGGCTTGTTCTTCTCTCCTATCTTGCTGATCTGAGCTTTCTGAGACCGTTAGCTATGATGTC
AATGATTTTTGGTGTAGTTTTAGCGATGGTGCAAGTGAACGCAAAGAGAGTTCTCGCCTATCATACCGTTAGTCAAATGG
GCTATGTTCTTTTGGCCATTTCCTATAATAATCCCTATGCAGCGGCAATTTACTCTTTCGCTCACGCAATCTTTAAATCT
GGCCTCTTTCTCTCGATTGGAGCCCTAGTTGATGCGAGAAAGAGAAAAGAGCTAAATTATTTGGGTTGTAGAAACTGCTA
CATTCTTTTAATCACAGTAGCAATACTTAGCTTGTCGATAGCTGGATTTGGCATTACGGTGGGAGGTGTTGCAAAGGAAA
TCCTTTCTAAAGCTACCAAAGAAGAGGCACTTATCTACGGAGTCTCCCTGGGAACCGCATTTTCATTCGCAAAGCTCAAC
TATTATCTGTGGAAAGGCTATGGGCACAAACCTTCAGTAAAGAGAGTCATTCCTTCCCTTGTCTTGAGTTTAATCGCCCT
AGGCATGGGAATCATGTGGAATGGGACTCCCTCATATAAAGATGTTTTGATTCCCCTTGGATTTGTTTTATTCCTGCTGG
CAAAAGATTACGTTCCGAAAAGAGATTATATAATTAGAGTTGAGCCTAACTATGGGGTCGCTCTCTTGGTTCTGCTAATT
TCACTTTTTTCAATAATTACATAA

Upstream 100 bases:

>100_bases
CAGTTGATCCCCTTCCAACAGTTTTAATGTTGACAACAATAGTCGTTGATGTAGCCGTGACAGGTCTTGCTTTGGCCCTT
GTAATGGGGGGGAGGAAGGA

Downstream 100 bases:

>100_bases
TTAAATAATTAAAGCTCTTCAATCTTCTTCCTAGCTATCTTTTTTGAACCTATTCTAAGGTTCTTAAAGAAGTTTATGTG
ATCTTCAGGCAAAAACTCGT

Product: putative monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MNASILALLPAIFSLLIYLFGSLKIEGSIRARFKLPLTLEVKVLYLLGVFLPVILLPFSQGGVVGGYSRLLGIEVDLDSI
TFLFLIAELTVFSMSSLYVVTYATEWRKLSLLLLMHSGLIGAFISKDLFNFYVFMELSAISSFALIASSKEKGSYKAAYN
YLLLSMTASYLLVLSLGMIYFSTGTLNVKLAQGREVPRIAVLIASLALSLKSGIFPLHIWLPDAHSKADTYLSAILSGIA
VKAPVYGLVLLSYLADLSFLRPLAMMSMIFGVVLAMVQVNAKRVLAYHTVSQMGYVLLAISYNNPYAAAIYSFAHAIFKS
GLFLSIGALVDARKRKELNYLGCRNCYILLITVAILSLSIAGFGITVGGVAKEILSKATKEEALIYGVSLGTAFSFAKLN
YYLWKGYGHKPSVKRVIPSLVLSLIALGMGIMWNGTPSYKDVLIPLGFVLFLLAKDYVPKRDYIIRVEPNYGVALLVLLI
SLFSIIT

Sequences:

>Translated_487_residues
MNASILALLPAIFSLLIYLFGSLKIEGSIRARFKLPLTLEVKVLYLLGVFLPVILLPFSQGGVVGGYSRLLGIEVDLDSI
TFLFLIAELTVFSMSSLYVVTYATEWRKLSLLLLMHSGLIGAFISKDLFNFYVFMELSAISSFALIASSKEKGSYKAAYN
YLLLSMTASYLLVLSLGMIYFSTGTLNVKLAQGREVPRIAVLIASLALSLKSGIFPLHIWLPDAHSKADTYLSAILSGIA
VKAPVYGLVLLSYLADLSFLRPLAMMSMIFGVVLAMVQVNAKRVLAYHTVSQMGYVLLAISYNNPYAAAIYSFAHAIFKS
GLFLSIGALVDARKRKELNYLGCRNCYILLITVAILSLSIAGFGITVGGVAKEILSKATKEEALIYGVSLGTAFSFAKLN
YYLWKGYGHKPSVKRVIPSLVLSLIALGMGIMWNGTPSYKDVLIPLGFVLFLLAKDYVPKRDYIIRVEPNYGVALLVLLI
SLFSIIT
>Mature_487_residues
MNASILALLPAIFSLLIYLFGSLKIEGSIRARFKLPLTLEVKVLYLLGVFLPVILLPFSQGGVVGGYSRLLGIEVDLDSI
TFLFLIAELTVFSMSSLYVVTYATEWRKLSLLLLMHSGLIGAFISKDLFNFYVFMELSAISSFALIASSKEKGSYKAAYN
YLLLSMTASYLLVLSLGMIYFSTGTLNVKLAQGREVPRIAVLIASLALSLKSGIFPLHIWLPDAHSKADTYLSAILSGIA
VKAPVYGLVLLSYLADLSFLRPLAMMSMIFGVVLAMVQVNAKRVLAYHTVSQMGYVLLAISYNNPYAAAIYSFAHAIFKS
GLFLSIGALVDARKRKELNYLGCRNCYILLITVAILSLSIAGFGITVGGVAKEILSKATKEEALIYGVSLGTAFSFAKLN
YYLWKGYGHKPSVKRVIPSLVLSLIALGMGIMWNGTPSYKDVLIPLGFVLFLLAKDYVPKRDYIIRVEPNYGVALLVLLI
SLFSIIT

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=233, Percent_Identity=27.4678111587983, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788613, Length=258, Percent_Identity=29.8449612403101, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1788827, Length=303, Percent_Identity=24.7524752475248, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788831, Length=242, Percent_Identity=25.2066115702479, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI145693160, Length=233, Percent_Identity=27.8969957081545, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI2367154, Length=337, Percent_Identity=25.8160237388724, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788614, Length=234, Percent_Identity=28.2051282051282, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 53298; Mature: 53298

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASILALLPAIFSLLIYLFGSLKIEGSIRARFKLPLTLEVKVLYLLGVFLPVILLPFSQ
CCCHHHHHHHHHHHHHHHHHHCEEEECEEEEEEECCEEEHHHHHHHHHHHHHHHHCCCCC
GGVVGGYSRLLGIEVDLDSITFLFLIAELTVFSMSSLYVVTYATEWRKLSLLLLMHSGLI
CCEECCCHHHEEEEECHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHCCHH
GAFISKDLFNFYVFMELSAISSFALIASSKEKGSYKAAYNYLLLSMTASYLLVLSLGMIY
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FSTGTLNVKLAQGREVPRIAVLIASLALSLKSGIFPLHIWLPDAHSKADTYLSAILSGIA
EECCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHH
VKAPVYGLVLLSYLADLSFLRPLAMMSMIFGVVLAMVQVNAKRVLAYHTVSQMGYVLLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEEEEE
SYNNPYAAAIYSFAHAIFKSGLFLSIGALVDARKRKELNYLGCRNCYILLITVAILSLSI
ECCCCHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AGFGITVGGVAKEILSKATKEEALIYGVSLGTAFSFAKLNYYLWKGYGHKPSVKRVIPSL
HCCCEEHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHEEEEEEECCCCCCHHHHHHHHH
VLSLIALGMGIMWNGTPSYKDVLIPLGFVLFLLAKDYVPKRDYIIRVEPNYGVALLVLLI
HHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHH
SLFSIIT
HHHHHCC
>Mature Secondary Structure
MNASILALLPAIFSLLIYLFGSLKIEGSIRARFKLPLTLEVKVLYLLGVFLPVILLPFSQ
CCCHHHHHHHHHHHHHHHHHHCEEEECEEEEEEECCEEEHHHHHHHHHHHHHHHHCCCCC
GGVVGGYSRLLGIEVDLDSITFLFLIAELTVFSMSSLYVVTYATEWRKLSLLLLMHSGLI
CCEECCCHHHEEEEECHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHCCHH
GAFISKDLFNFYVFMELSAISSFALIASSKEKGSYKAAYNYLLLSMTASYLLVLSLGMIY
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FSTGTLNVKLAQGREVPRIAVLIASLALSLKSGIFPLHIWLPDAHSKADTYLSAILSGIA
EECCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHH
VKAPVYGLVLLSYLADLSFLRPLAMMSMIFGVVLAMVQVNAKRVLAYHTVSQMGYVLLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEEEEE
SYNNPYAAAIYSFAHAIFKSGLFLSIGALVDARKRKELNYLGCRNCYILLITVAILSLSI
ECCCCHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AGFGITVGGVAKEILSKATKEEALIYGVSLGTAFSFAKLNYYLWKGYGHKPSVKRVIPSL
HCCCEEHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHEEEEEEECCCCCCHHHHHHHHH
VLSLIALGMGIMWNGTPSYKDVLIPLGFVLFLLAKDYVPKRDYIIRVEPNYGVALLVLLI
HHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHH
SLFSIIT
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA