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The map label for this gene is 18977511

Identifier: 18977511

GI number: 18977511

Start: 1093579

End: 1094745

Strand: Reverse

Name: 18977511

Synonym: PF1139

Alternate gene names: NA

Gene position: 1094745-1093579 (Counterclockwise)

Preceding gene: 18977516

Following gene: 18977510

Centisome position: 57.37

GC content: 41.73

Gene sequence:

>1167_bases
ATGATACTTGAAAAAGCCAGAGAGATATTGGAGGAGCATCAACTCTGCAACCACTGCTTGGGTAGGTTATTTGGAAAACT
CGGGAAGGGAACGAACGAAGAAAGGGGTAGAGCCATTAGGCTTCTTCTTTCAATGGAAACTGGAAAGGAGTATAAGGAGC
CTGAAAAATGTGAGCTTTGTGGAGGTGTTTTTAATAACCTCGATAAGTTTGCTGAACTCTGCATAAAAGCTGCTGAAGGA
ATAGAATTTGAAACCTTCTGGGTGGGTTCGAGGTTCCCAGAAGAAATTGAAAAAAAGGAGGAGGAAATTTGGAGGAAATT
CAGAGTAGTGAGTGGAGAAAAGATTACAAAAGAGTTCAACAGGGAGCTTGGGAAAGTTATTGCAGTTAGATATGGAAAGA
CACCAGTAAAAGAGAGGCCCGACGTTGTCTTCATAGTTGAGCCCTTCTCGGAAAAGGTTGAACTTCAGGTAAATCCAATA
TATGTAGCTGGGAGGTATAGAAAGCTCATTAGAGGAATACCCCAAACTCCAGCCCCTGGGTTTAAGGAGAGCATAGCAAC
GATAATCTGCAGAGCTTTTAAGAAGCACTTCCATGGAAAGTGCATATTCAAAGGAGCTGGGAGAGAAGACGTCGACGTTA
GAATGCTGGGCAATGGAAGGCCCTTCGTAGTTGAGATAAAGAGACCCAGGAAGAGAAAAGTAAATCTAAAGGACATTGAA
GAAGAGATAAACCAAAGTGGAAAGGTGGAGGTTCTTAATTTAAGGTTCATAACGCCAGAGGAAGCCGAGAGAATTTTAAC
CACAAGACATAGAAAAGTGTACGAGGCCATTGTTTACGTTAAGGATGGAATAACAAAGGAAGAAGTTGAAAAGGTAGTTA
AGTCCTTAAAGAATGCGGAAATTAAACAGAGAACCCCCAGGAGAGTGCTCAATAGTAGAGCTGATTTAGTTAGAGTTAGA
AAGGTTTACGATGTGAAGGGAGAGTTAATTGATGACAAGCACTTCAAACTCAGGTTAGTCACCGATGGAGGTTTATACAT
AAAAGAGCTGATATCTGGGGATAGGGGAAGGACCACCCCTTCAGTGTCTGAAATTTTGGGAAAGGAAGCTTGGTGTGAAA
TCTTAGATGTTTTAGAGGTGTTGGACGATGTTGAGGGAGATAATTGA

Upstream 100 bases:

>100_bases
CCCTCTTCGGGATACTCCCTTGCTCTCCTGGGCATGCTTCCACCTCCAAGAAGGCTCTTTAATACTCATCCTTTTAAAGT
TGCCCCTTTAAATAATTGCG

Downstream 100 bases:

>100_bases
GAAGTTTGATGATACCGTAATAGTTGATAAGCCCGTGAAAAAGGAATACGAGATAACTAAATACCTGCTTAAGTATAAGG
ACAGGCCCGTCTTATTCAAA

Product: putative pseudouridylate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MILEKAREILEEHQLCNHCLGRLFGKLGKGTNEERGRAIRLLLSMETGKEYKEPEKCELCGGVFNNLDKFAELCIKAAEG
IEFETFWVGSRFPEEIEKKEEEIWRKFRVVSGEKITKEFNRELGKVIAVRYGKTPVKERPDVVFIVEPFSEKVELQVNPI
YVAGRYRKLIRGIPQTPAPGFKESIATIICRAFKKHFHGKCIFKGAGREDVDVRMLGNGRPFVVEIKRPRKRKVNLKDIE
EEINQSGKVEVLNLRFITPEEAERILTTRHRKVYEAIVYVKDGITKEEVEKVVKSLKNAEIKQRTPRRVLNSRADLVRVR
KVYDVKGELIDDKHFKLRLVTDGGLYIKELISGDRGRTTPSVSEILGKEAWCEILDVLEVLDDVEGDN

Sequences:

>Translated_388_residues
MILEKAREILEEHQLCNHCLGRLFGKLGKGTNEERGRAIRLLLSMETGKEYKEPEKCELCGGVFNNLDKFAELCIKAAEG
IEFETFWVGSRFPEEIEKKEEEIWRKFRVVSGEKITKEFNRELGKVIAVRYGKTPVKERPDVVFIVEPFSEKVELQVNPI
YVAGRYRKLIRGIPQTPAPGFKESIATIICRAFKKHFHGKCIFKGAGREDVDVRMLGNGRPFVVEIKRPRKRKVNLKDIE
EEINQSGKVEVLNLRFITPEEAERILTTRHRKVYEAIVYVKDGITKEEVEKVVKSLKNAEIKQRTPRRVLNSRADLVRVR
KVYDVKGELIDDKHFKLRLVTDGGLYIKELISGDRGRTTPSVSEILGKEAWCEILDVLEVLDDVEGDN
>Mature_388_residues
MILEKAREILEEHQLCNHCLGRLFGKLGKGTNEERGRAIRLLLSMETGKEYKEPEKCELCGGVFNNLDKFAELCIKAAEG
IEFETFWVGSRFPEEIEKKEEEIWRKFRVVSGEKITKEFNRELGKVIAVRYGKTPVKERPDVVFIVEPFSEKVELQVNPI
YVAGRYRKLIRGIPQTPAPGFKESIATIICRAFKKHFHGKCIFKGAGREDVDVRMLGNGRPFVVEIKRPRKRKVNLKDIE
EEINQSGKVEVLNLRFITPEEAERILTTRHRKVYEAIVYVKDGITKEEVEKVVKSLKNAEIKQRTPRRVLNSRADLVRVR
KVYDVKGELIDDKHFKLRLVTDGGLYIKELISGDRGRTTPSVSEILGKEAWCEILDVLEVLDDVEGDN

Specific function: Unknown

COG id: COG1258

COG function: function code J; Predicted pseudouridylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 THUMP domain [H]

Homologues:

Organism=Homo sapiens, GI207113130, Length=250, Percent_Identity=34, Blast_Score=138, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17537241, Length=254, Percent_Identity=37.007874015748, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI19920442, Length=244, Percent_Identity=38.5245901639344, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005912
- InterPro:   IPR020103
- InterPro:   IPR004114 [H]

Pfam domain/function: PF02926 THUMP [H]

EC number: NA

Molecular weight: Translated: 44680; Mature: 44680

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS51165 THUMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILEKAREILEEHQLCNHCLGRLFGKLGKGTNEERGRAIRLLLSMETGKEYKEPEKCELC
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHH
GGVFNNLDKFAELCIKAAEGIEFETFWVGSRFPEEIEKKEEEIWRKFRVVSGEKITKEFN
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
RELGKVIAVRYGKTPVKERPDVVFIVEPFSEKVELQVNPIYVAGRYRKLIRGIPQTPAPG
HHHHHEEEEECCCCCCCCCCCEEEEECCCCCCEEEEEEEEEECHHHHHHHCCCCCCCCCC
FKESIATIICRAFKKHFHGKCIFKGAGREDVDVRMLGNGRPFVVEIKRPRKRKVNLKDIE
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCEEEEECCCCCCCCCHHHHH
EEINQSGKVEVLNLRFITPEEAERILTTRHRKVYEAIVYVKDGITKEEVEKVVKSLKNAE
HHHCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCH
IKQRTPRRVLNSRADLVRVRKVYDVKGELIDDKHFKLRLVTDGGLYIKELISGDRGRTTP
HHHCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEECCCHHHHHHHCCCCCCCCC
SVSEILGKEAWCEILDVLEVLDDVEGDN
HHHHHHCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MILEKAREILEEHQLCNHCLGRLFGKLGKGTNEERGRAIRLLLSMETGKEYKEPEKCELC
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHH
GGVFNNLDKFAELCIKAAEGIEFETFWVGSRFPEEIEKKEEEIWRKFRVVSGEKITKEFN
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
RELGKVIAVRYGKTPVKERPDVVFIVEPFSEKVELQVNPIYVAGRYRKLIRGIPQTPAPG
HHHHHEEEEECCCCCCCCCCCEEEEECCCCCCEEEEEEEEEECHHHHHHHCCCCCCCCCC
FKESIATIICRAFKKHFHGKCIFKGAGREDVDVRMLGNGRPFVVEIKRPRKRKVNLKDIE
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCEEEEECCCCCCCCCHHHHH
EEINQSGKVEVLNLRFITPEEAERILTTRHRKVYEAIVYVKDGITKEEVEKVVKSLKNAE
HHHCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCH
IKQRTPRRVLNSRADLVRVRKVYDVKGELIDDKHFKLRLVTDGGLYIKELISGDRGRTTP
HHHCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEECCCHHHHHHHCCCCCCCCC
SVSEILGKEAWCEILDVLEVLDDVEGDN
HHHHHHCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]