Click here to switch to the map view.

The map label for this gene is htpX

Identifier: 18977507

GI number: 18977507

Start: 1084902

End: 1085771

Strand: Direct

Name: htpX

Synonym: PF1135

Alternate gene names: 18977507

Gene position: 1084902-1085771 (Clockwise)

Preceding gene: 18977506

Following gene: 18977508

Centisome position: 56.85

GC content: 44.48

Gene sequence:

>870_bases
GTGGGCATTGGATTATGGGTGAGAACTGGATTATTGATGGCATTTCTTACTGGCCTATTGGTGGGTATTGGATATCTAAT
AGGCGGTCAAGGTGGTATGATAATAGCCTTCACCATAGCCCTTTTCATGAACTTCTTCAGCTACTGGTTCAGTGACTCAA
TAGTCTTGAGTTGGTACAATGCCAGAATAGTTAGTGAAGAGGAAGCGCCAGAACTCCACAGGATAGTTGAAAAGCTTGCC
ATGCAGGCGGGAATTCCCAAGCCCAGAGTTGCTATAGTCCCAACATTAGTGCCAAATGCATTTGCAACCGGAAGAAGTCC
AGAGCATGCGGTAGTTGCCGTGACTGAGGGATTACTGAGAATTTTGAATAGGGATGAATTGGAAGGAGTTATTGCACACG
AGATAAGCCATATAAAGAACAGAGACACTCTAATTCAAACGATAGCAGCTGTTCTTGCGGGCGCAATAATGGTTCTCGTT
AACTTTGCGAGGTGGTCTTTATGGTTCGGGGCTTACGATGAAGATAGAGATGGTGGAAACATAGTAGCTCTAATCTTGGC
AATAATCCTTGCTCCAATTGCAGCAACACTAATTCAGCTCGCTATAAGCAGATCAAGGGAATACTTAGCTGATGAAACGG
GAGCCAAGATAAGCGGAAAGCCTCACGCTCTAGCGAGTGCGTTAATGAAGATCGAAGAAGCCGTGAGGTACAGGCCCCTA
AAGAATGGAAATCCAGCCACAGCCCACATGTTCATAGTAAACCCATTCAGAGGAGTGGACTTTGTAGAGCTATTTTCTAC
TCACCCACCAACTGAAAAGAGAATTGAAAGGCTAAGGAAGATAGCTATGGAGATGGGTATAATCTTTTGA

Upstream 100 bases:

>100_bases
ACCTTATAAACTCAGGGATTAAGAGGAGAGTTGGTATCGTGGATTGGACTAAAGTTTATGAAGAGATTATCCCATATTTA
AGGTTAGGGGGTGATTGAGA

Downstream 100 bases:

>100_bases
TCTTTTGATTTCTTCTTTCAGCTAAAATATTAAATACTTTTATTTCGTGATGATAATTTGTAGGGTGATTAAATGGGTAA
GTGGAGCGATGATATTTTAA

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MGIGLWVRTGLLMAFLTGLLVGIGYLIGGQGGMIIAFTIALFMNFFSYWFSDSIVLSWYNARIVSEEEAPELHRIVEKLA
MQAGIPKPRVAIVPTLVPNAFATGRSPEHAVVAVTEGLLRILNRDELEGVIAHEISHIKNRDTLIQTIAAVLAGAIMVLV
NFARWSLWFGAYDEDRDGGNIVALILAIILAPIAATLIQLAISRSREYLADETGAKISGKPHALASALMKIEEAVRYRPL
KNGNPATAHMFIVNPFRGVDFVELFSTHPPTEKRIERLRKIAMEMGIIF

Sequences:

>Translated_289_residues
MGIGLWVRTGLLMAFLTGLLVGIGYLIGGQGGMIIAFTIALFMNFFSYWFSDSIVLSWYNARIVSEEEAPELHRIVEKLA
MQAGIPKPRVAIVPTLVPNAFATGRSPEHAVVAVTEGLLRILNRDELEGVIAHEISHIKNRDTLIQTIAAVLAGAIMVLV
NFARWSLWFGAYDEDRDGGNIVALILAIILAPIAATLIQLAISRSREYLADETGAKISGKPHALASALMKIEEAVRYRPL
KNGNPATAHMFIVNPFRGVDFVELFSTHPPTEKRIERLRKIAMEMGIIF
>Mature_288_residues
GIGLWVRTGLLMAFLTGLLVGIGYLIGGQGGMIIAFTIALFMNFFSYWFSDSIVLSWYNARIVSEEEAPELHRIVEKLAM
QAGIPKPRVAIVPTLVPNAFATGRSPEHAVVAVTEGLLRILNRDELEGVIAHEISHIKNRDTLIQTIAAVLAGAIMVLVN
FARWSLWFGAYDEDRDGGNIVALILAIILAPIAATLIQLAISRSREYLADETGAKISGKPHALASALMKIEEAVRYRPLK
NGNPATAHMFIVNPFRGVDFVELFSTHPPTEKRIERLRKIAMEMGIIF

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=294, Percent_Identity=32.6530612244898, Blast_Score=114, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_PYRFU (Q8U1S0)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_578864.1
- ProteinModelPortal:   Q8U1S0
- SMR:   Q8U1S0
- MEROPS:   M48.004
- EnsemblBacteria:   EBPYRT00000004166
- GeneID:   1469004
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1135
- NMPDR:   fig|186497.1.peg.1175
- GeneTree:   EBGT00050000022867
- HOGENOM:   HBG739460
- OMA:   RRGAEIC
- ProtClustDB:   PRK03982
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 31803; Mature: 31672

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 134-134

Signals:

None

Transmembrane regions:

HASH(0xc0ff274)-; HASH(0xe0f0d78)-; HASH(0xdf52ba8)-; HASH(0xe0c3a0c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIGLWVRTGLLMAFLTGLLVGIGYLIGGQGGMIIAFTIALFMNFFSYWFSDSIVLSWYN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEC
ARIVSEEEAPELHRIVEKLAMQAGIPKPRVAIVPTLVPNAFATGRSPEHAVVAVTEGLLR
CEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHCCCCCCCHHHHHHHHHHH
ILNRDELEGVIAHEISHIKNRDTLIQTIAAVLAGAIMVLVNFARWSLWFGAYDEDRDGGN
HHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
IVALILAIILAPIAATLIQLAISRSREYLADETGAKISGKPHALASALMKIEEAVRYRPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
KNGNPATAHMFIVNPFRGVDFVELFSTHPPTEKRIERLRKIAMEMGIIF
CCCCCCEEEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
GIGLWVRTGLLMAFLTGLLVGIGYLIGGQGGMIIAFTIALFMNFFSYWFSDSIVLSWYN
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEC
ARIVSEEEAPELHRIVEKLAMQAGIPKPRVAIVPTLVPNAFATGRSPEHAVVAVTEGLLR
CEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHCCCCCCCHHHHHHHHHHH
ILNRDELEGVIAHEISHIKNRDTLIQTIAAVLAGAIMVLVNFARWSLWFGAYDEDRDGGN
HHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
IVALILAIILAPIAATLIQLAISRSREYLADETGAKISGKPHALASALMKIEEAVRYRPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
KNGNPATAHMFIVNPFRGVDFVELFSTHPPTEKRIERLRKIAMEMGIIF
CCCCCCEEEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA