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The map label for this gene is pyrF

Identifier: 18977486

GI number: 18977486

Start: 1062504

End: 1063139

Strand: Direct

Name: pyrF

Synonym: PF1114

Alternate gene names: 18977486

Gene position: 1062504-1063139 (Clockwise)

Preceding gene: 18977485

Following gene: 18977487

Centisome position: 55.68

GC content: 44.34

Gene sequence:

>636_bases
ATGATTGTACTAGCGTTGGACGTGTATGAGAGAGAAAAGGCCTTAAGCATAGCGGAAGATGTTAAAGATTACATTTCAAT
GATAAAGGTGAACTGGCCCCTGATAATTGGAAGTGGTCTTGGAGTTATTTCAGAGCTAAAGAAGAAAACAGGCCTCCCGA
TAATAGCGGATCTAAAGCTGGCAGACATCCCAAACACAAATAGGTTGATAGCAAAGAAAGTTTATGATGCTGGGGCGGAT
TATATAATACTCCATTCCTTTGTAGGGAGGGACAGCGTAAAGGCAGTGAAGGAGCTAGGAGAAATTATAATGATAGTTGA
GATGAGCCATCCTGGGGCCTTAGAATTCATAAACCCACTCACCGACAAGTTCATAGACATGGCCAATGAAATAAAGCCTT
TCGGCGTCATAGCGCCAGGAACCAGGCCAGAGAGAATTAGATACATTAGAGAGAGGCTGAGTAAAGACATAAAAGTGCTT
ACCCCAGGAATTGGAGCCCAAGGAGGATCGCCAGTGGAGGCGTTGAAAGCTGGAGCAGATTACATCATCATTGGAAGGGC
CATATACAATGCTGAAAGGCCCAGGGAAGCCGCTAAGAAGATTTTCGAGGAGGTGAAAGAATGGAGCTCAAGATAA

Upstream 100 bases:

>100_bases
TACTTGGGCAGATAAAATTGGAAGGCGCTTAAAGCAGCCTTCACGTTGCAGTCGTCTTAAAGGGAGACCAACTCCCCAGG
GAAATATTGGAGGTGGCTGA

Downstream 100 bases:

>100_bases
AGCACCCCCTAAGCAAGAAGGATGTTAAAGAGATAATCAACGTCCTCTCTCAGATGTTTGGAGAGGAAATTGCAAGCAAG
ATGCTCACAAAGAAAGATGA

Product: orotidine 5'-phosphate decarboxylase

Products: NA

Alternate protein names: OMP decarboxylase; OMPDCase; OMPdecase

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MIVLALDVYEREKALSIAEDVKDYISMIKVNWPLIIGSGLGVISELKKKTGLPIIADLKLADIPNTNRLIAKKVYDAGAD
YIILHSFVGRDSVKAVKELGEIIMIVEMSHPGALEFINPLTDKFIDMANEIKPFGVIAPGTRPERIRYIRERLSKDIKVL
TPGIGAQGGSPVEALKAGADYIIIGRAIYNAERPREAAKKIFEEVKEWSSR

Sequences:

>Translated_211_residues
MIVLALDVYEREKALSIAEDVKDYISMIKVNWPLIIGSGLGVISELKKKTGLPIIADLKLADIPNTNRLIAKKVYDAGAD
YIILHSFVGRDSVKAVKELGEIIMIVEMSHPGALEFINPLTDKFIDMANEIKPFGVIAPGTRPERIRYIRERLSKDIKVL
TPGIGAQGGSPVEALKAGADYIIIGRAIYNAERPREAAKKIFEEVKEWSSR
>Mature_211_residues
MIVLALDVYEREKALSIAEDVKDYISMIKVNWPLIIGSGLGVISELKKKTGLPIIADLKLADIPNTNRLIAKKVYDAGAD
YIILHSFVGRDSVKAVKELGEIIMIVEMSHPGALEFINPLTDKFIDMANEIKPFGVIAPGTRPERIRYIRERLSKDIKVL
TPGIGAQGGSPVEALKAGADYIIIGRAIYNAERPREAAKKIFEEVKEWSSR

Specific function: Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the OMP decarboxylase family. Type 1 subfamily

Homologues:

None

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PYRF_PYRFU (Q8U1U1)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_578843.1
- ProteinModelPortal:   Q8U1U1
- SMR:   Q8U1U1
- EnsemblBacteria:   EBPYRT00000005945
- GeneID:   1468983
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1114
- NMPDR:   fig|186497.1.peg.1154
- GeneTree:   EBGT00050000022429
- HOGENOM:   HBG625253
- OMA:   TEMSHPG
- ProtClustDB:   PRK13813
- BRENDA:   4.1.1.23
- HAMAP:   MF_01200_A
- InterPro:   IPR013785
- InterPro:   IPR014732
- InterPro:   IPR018089
- InterPro:   IPR001754
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00934
- TIGRFAMs:   TIGR01740

Pfam domain/function: PF00215 OMPdecase; SSF51366 RibP_bind_barrel

EC number: =4.1.1.23

Molecular weight: Translated: 23357; Mature: 23357

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00156 OMPDECASE

Important sites: ACT_SITE 59-59 BINDING 7-7 BINDING 29-29 BINDING 109-109 BINDING 185-185 BINDING 186-186

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVLALDVYEREKALSIAEDVKDYISMIKVNWPLIIGSGLGVISELKKKTGLPIIADLKL
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCEEECCEE
ADIPNTNRLIAKKVYDAGADYIILHSFVGRDSVKAVKELGEIIMIVEMSHPGALEFINPL
ECCCCCCHHHHHHHHHCCCCEEEEEHHHCCHHHHHHHHHCCEEEEEEECCCCHHHHHHHH
TDKFIDMANEIKPFGVIAPGTRPERIRYIRERLSKDIKVLTPGIGAQGGSPVEALKAGAD
HHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHCCCC
YIIIGRAIYNAERPREAAKKIFEEVKEWSSR
EEEEEHHHHCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIVLALDVYEREKALSIAEDVKDYISMIKVNWPLIIGSGLGVISELKKKTGLPIIADLKL
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCEEECCEE
ADIPNTNRLIAKKVYDAGADYIILHSFVGRDSVKAVKELGEIIMIVEMSHPGALEFINPL
ECCCCCCHHHHHHHHHCCCCEEEEEHHHCCHHHHHHHHHCCEEEEEEECCCCHHHHHHHH
TDKFIDMANEIKPFGVIAPGTRPERIRYIRERLSKDIKVLTPGIGAQGGSPVEALKAGAD
HHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHCCCC
YIIIGRAIYNAERPREAAKKIFEEVKEWSSR
EEEEEHHHHCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA