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The map label for this gene is ileS [H]

Identifier: 18977468

GI number: 18977468

Start: 1040727

End: 1043927

Strand: Reverse

Name: ileS [H]

Synonym: PF1096

Alternate gene names: 18977468

Gene position: 1043927-1040727 (Counterclockwise)

Preceding gene: 18977469

Following gene: 18977466

Centisome position: 54.71

GC content: 46.55

Gene sequence:

>3201_bases
ATGATAAAGGAGCCAGAGTTTAGAGACTACACTCCGGGAAAGCTTGAAGAAAAAATAGAGCAATTCTGGAAGGAGAGCAA
CATATACCAGAAGGTTAAGGAGCTAAGAAAGAACGGACCAAAGTACTACTTCTTGGATGGGCCTCCGTATGTAAGTGGAG
CAATTCACTTAGGCACTGCTTGGAACAAGATAATCAAAGATATGATAATAAGATTCAGAACAATGCAGGGCTATAACGTT
TGGAGGCAGCCCGGTTACGACATGCACGGGCTTCCAATTGAGGTAAAGGTTGAACAGGCTTTGGGGTTAAAGACGAAGAA
GGAGATAGAAGAAAAGATCGGAGTTGAGAACTTCATCCAGAAGTGTAAGGAATTCGCATTAAACAATCTCAGGATAATGA
CAGAACAATTCAAGATGCTGGGCGTTTGGATGGACTGGGATAATCCCTACATGACCATAAAGAATGAGTACATTGAATCA
GCATGGTTCACGCTAAAGAGGGCTTGGGAAAAGGGTTTGCTGGAGAAGGACAAGCGCGTCCTTCACTGGTGTCCCAGATG
TGAGACGGCTTTAGCTGAGCACGAGGTAAGGGGAGAGTACAAGCTGAGAAAGGATCCAAGCATCTACGTGAAGTTCCCAG
TTGAGGGGAAGGAAAATGAGTACTTGCTAATTTGGACAACCACCCCATGGACCCTCCCAGCGAACTTAGCTGTTTCCGCC
CACCCAGATTACGATTATGTAAAGGTGAGGGTTGATCTTAACGGTAGGGAGGAGTACTGGATATTGGCTAAGGCATTAGT
AGAGAAGGTTCTGGGAGATATTGGTGTCAAAGGTGAAGTTGTGGAGGAGTTCAAGGGTAAAGAGCTTGAAGGTTTGAGAT
ACGTCCATATCTTAATGGACGAGTACCCAAGGCAGAAGGAGTTCAGGGAGAAGTACGAGTGGGTCCATAGAGTAATACTA
GCTGACTTCGTGACGTTGGAGGAAGGTACTGGGCTTGTCCACACAGCTCCTGGGCATGGTGAGGAAGACTTTGAAGTTGG
GCAGAAGTATGGACTACCAGTTTACAGTCCGGTAGATGACCAAGGAAAGTACGTGGAGGGCAAGTGGAAGGGAGTATATG
TTAAGGAGGCAGATCCTCAAATAATAGAGCATCTCAAAGAGAAGGGCTACCTAGTTAAGGCTGGAGAAATAGAGCACAAG
TACCCCCACTGTTGGCGTTGTAAGACGCCACTAATCTTTAGGGCCACAGACCAGTGGTTCCTCAAAGTTAGCAAAGTTAA
GGAGAAGATAATCAAGGAGAACGACGAAAAAGTAACTTGGTATCCTGAGTGGGTTAAGATAAGGTTCGACAATGGAGTAA
GGGACAGCGGTGACTGGGTGATAAGCAGGCAACGTTACTGGGGAATCCCACTTCCAATATGGCAGAGCGAGGACGGAGAA
ATATATGTAGTCGGCTCCTGGAAGGAGTTGGTTGAGCTGGCTGTTGCAATAGAGGTCAACGGTGAAAGAATAGACTTGCC
AGAGAGCTATGAGGAGAAGCTCAAGGTTATAGAAGAGAAGCTGGGCCCAGAAGACCTCCACAGGCCCTACGTTGATGCAT
TCATAATAAAGGTCAACGGAAAAGAGATGAGAAGGGTAAAGGATGTGGTTGACGTTTGGTTCGACAGTGGAATAGCGAGC
TGGGCCTCCCTGGGATATCCCAGGAACAAGGAGCTGTTCGAAAAGCTTTGGCCTGCTGATTTCATAGTTGAGGGTGAAGA
TCAAGTTACAAAGTGGTTCTATTCTCAACAAGCTGCCTCAGTGATAGCCTTCGACACAGTCCCATATAGGGCAGTTGCAA
TGCACGGTTACGTTCTTGACGAGAAAGGAGATAAGATGAGTAAGAGCCTTGGGAACATAATAAGGCCTGAAGAGGTAGTT
GAAAAGGCTGGAAGAGATACATTTAGATTTTACATGCTCTGGGCAACCAACCCCTGGGAGAACCTCAAGTTCAGCTGGAA
GGGTGTTGAGCAGGTAAGGAGGATGCTCAACATACTCTGGAACGTTTACGTTCTCTCAGCAACTTACATGAGCCTAGACA
ACTTTGATCCAAGAAATGTTAAGGTAGAGGAACTGGAATTCAGAGAAGAGGATAAGTGGATACTGAGTAGGGTCAACAAC
TTGATAAAGGAAGTAGAGAACGGAATAGAGACGTTCTACCTAACGAAGGCTACAAGGGCATTATACAACTTCGTGGTTGA
GGATTTGAGCAGGTGGTACGTGAGGCTGATAAGGAAGAGGCTCTGGGTTGAGGGTGATGATCCAGATAAGCTGGCAGCGT
ACTACACTCTCTGGAAGGTCTTTGATGTTCTGCTAAGGCTTATGGCACCGTTCACTCCCTACATAACCGAGGAGATCTAC
CAGAATATAATGAGGCCATTCACCGGCATCGAGAGCGTTCACATGCTTGACTGGCCAAAGCCAGATGAGAGTGCAGTAGA
TGAAGAGCTTGAGAGGGAGATGGAATTCATAAGGAGAATCGTTGAGGCGGGCTCAGCCGCAAGGCAGAAGGCCAAGATAA
AGTTAAGGTACCCCGTCAGGAAGATAATAATTGAGACCCAGGACGATACTGTAAAGAAGGCAGTGGAGAGGTTAAACTAC
ATACTTAGGGATCAGCTCAATGCCAAGGAAGTCGTCGTTGGAAATGTTGAGAGAGAAATTACCGTTAAACCGAACTTTGC
CAAGGTTGGTCCAGAGTTCAAGGGAGATGCAAGGTTGGTGGCTAAGTGGATAAGCGAGCACGGTCTTGAGCTCTACGAGA
AGGGAGAAGTCGATGTTGAGATAGAGGGCAAGAAGTTCCACTTAACAAGGGAGCATATAATTGTGGAAGAGAACATCCCA
GACTTCCTCGTTGCAGAGGACTTCGAGGGAGGAAGGGTCTACGTCGACAAGACCCTTACAAGAGAATTGCTCGCTGAAGG
ATTGGCTAGGGAGTTCGTTAGAAGAATTCAAGAGATGAGAAAGAGGCTCGACCTTGACGTCAATGATAGAATTGTTGTCA
CAATAGAGACCACAGAGGAGAACCGCGAACTCTTGCAAGAGAATCTAGAGTATATAATGCGTGAGACTAGAGCTATCGAG
GTTCGCTTTGAAGAGGCCAAGGGTTACGTTGTGGAGTGGCCAGAGGTTCAGGCAAAGATAGGAATTGAGAAGATTGAATG
A

Upstream 100 bases:

>100_bases
GATGAGGGGGGATTTATTTATCTCCAGCTCAAATGTTGCCTGAGCTTTCTACACGCTGTTCTAGGTTATTCTTCAATATA
AATCCCAGGAGGGTTCTGAG

Downstream 100 bases:

>100_bases
TTTTTTCCTCTTTTCTTTCCTCTAAAAATATTTTAACATCAGCCCGAATTGAAAGAGAAAAAGCTTGAATTAATTGAGTT
GAATCTCAAGGATATTTGCT

Product: isoleucyl-tRNA synthetase

Products: NA

Alternate protein names: Isoleucine--tRNA ligase; IleRS [H]

Number of amino acids: Translated: 1066; Mature: 1066

Protein sequence:

>1066_residues
MIKEPEFRDYTPGKLEEKIEQFWKESNIYQKVKELRKNGPKYYFLDGPPYVSGAIHLGTAWNKIIKDMIIRFRTMQGYNV
WRQPGYDMHGLPIEVKVEQALGLKTKKEIEEKIGVENFIQKCKEFALNNLRIMTEQFKMLGVWMDWDNPYMTIKNEYIES
AWFTLKRAWEKGLLEKDKRVLHWCPRCETALAEHEVRGEYKLRKDPSIYVKFPVEGKENEYLLIWTTTPWTLPANLAVSA
HPDYDYVKVRVDLNGREEYWILAKALVEKVLGDIGVKGEVVEEFKGKELEGLRYVHILMDEYPRQKEFREKYEWVHRVIL
ADFVTLEEGTGLVHTAPGHGEEDFEVGQKYGLPVYSPVDDQGKYVEGKWKGVYVKEADPQIIEHLKEKGYLVKAGEIEHK
YPHCWRCKTPLIFRATDQWFLKVSKVKEKIIKENDEKVTWYPEWVKIRFDNGVRDSGDWVISRQRYWGIPLPIWQSEDGE
IYVVGSWKELVELAVAIEVNGERIDLPESYEEKLKVIEEKLGPEDLHRPYVDAFIIKVNGKEMRRVKDVVDVWFDSGIAS
WASLGYPRNKELFEKLWPADFIVEGEDQVTKWFYSQQAASVIAFDTVPYRAVAMHGYVLDEKGDKMSKSLGNIIRPEEVV
EKAGRDTFRFYMLWATNPWENLKFSWKGVEQVRRMLNILWNVYVLSATYMSLDNFDPRNVKVEELEFREEDKWILSRVNN
LIKEVENGIETFYLTKATRALYNFVVEDLSRWYVRLIRKRLWVEGDDPDKLAAYYTLWKVFDVLLRLMAPFTPYITEEIY
QNIMRPFTGIESVHMLDWPKPDESAVDEELEREMEFIRRIVEAGSAARQKAKIKLRYPVRKIIIETQDDTVKKAVERLNY
ILRDQLNAKEVVVGNVEREITVKPNFAKVGPEFKGDARLVAKWISEHGLELYEKGEVDVEIEGKKFHLTREHIIVEENIP
DFLVAEDFEGGRVYVDKTLTRELLAEGLAREFVRRIQEMRKRLDLDVNDRIVVTIETTEENRELLQENLEYIMRETRAIE
VRFEEAKGYVVEWPEVQAKIGIEKIE

Sequences:

>Translated_1066_residues
MIKEPEFRDYTPGKLEEKIEQFWKESNIYQKVKELRKNGPKYYFLDGPPYVSGAIHLGTAWNKIIKDMIIRFRTMQGYNV
WRQPGYDMHGLPIEVKVEQALGLKTKKEIEEKIGVENFIQKCKEFALNNLRIMTEQFKMLGVWMDWDNPYMTIKNEYIES
AWFTLKRAWEKGLLEKDKRVLHWCPRCETALAEHEVRGEYKLRKDPSIYVKFPVEGKENEYLLIWTTTPWTLPANLAVSA
HPDYDYVKVRVDLNGREEYWILAKALVEKVLGDIGVKGEVVEEFKGKELEGLRYVHILMDEYPRQKEFREKYEWVHRVIL
ADFVTLEEGTGLVHTAPGHGEEDFEVGQKYGLPVYSPVDDQGKYVEGKWKGVYVKEADPQIIEHLKEKGYLVKAGEIEHK
YPHCWRCKTPLIFRATDQWFLKVSKVKEKIIKENDEKVTWYPEWVKIRFDNGVRDSGDWVISRQRYWGIPLPIWQSEDGE
IYVVGSWKELVELAVAIEVNGERIDLPESYEEKLKVIEEKLGPEDLHRPYVDAFIIKVNGKEMRRVKDVVDVWFDSGIAS
WASLGYPRNKELFEKLWPADFIVEGEDQVTKWFYSQQAASVIAFDTVPYRAVAMHGYVLDEKGDKMSKSLGNIIRPEEVV
EKAGRDTFRFYMLWATNPWENLKFSWKGVEQVRRMLNILWNVYVLSATYMSLDNFDPRNVKVEELEFREEDKWILSRVNN
LIKEVENGIETFYLTKATRALYNFVVEDLSRWYVRLIRKRLWVEGDDPDKLAAYYTLWKVFDVLLRLMAPFTPYITEEIY
QNIMRPFTGIESVHMLDWPKPDESAVDEELEREMEFIRRIVEAGSAARQKAKIKLRYPVRKIIIETQDDTVKKAVERLNY
ILRDQLNAKEVVVGNVEREITVKPNFAKVGPEFKGDARLVAKWISEHGLELYEKGEVDVEIEGKKFHLTREHIIVEENIP
DFLVAEDFEGGRVYVDKTLTRELLAEGLAREFVRRIQEMRKRLDLDVNDRIVVTIETTEENRELLQENLEYIMRETRAIE
VRFEEAKGYVVEWPEVQAKIGIEKIE
>Mature_1066_residues
MIKEPEFRDYTPGKLEEKIEQFWKESNIYQKVKELRKNGPKYYFLDGPPYVSGAIHLGTAWNKIIKDMIIRFRTMQGYNV
WRQPGYDMHGLPIEVKVEQALGLKTKKEIEEKIGVENFIQKCKEFALNNLRIMTEQFKMLGVWMDWDNPYMTIKNEYIES
AWFTLKRAWEKGLLEKDKRVLHWCPRCETALAEHEVRGEYKLRKDPSIYVKFPVEGKENEYLLIWTTTPWTLPANLAVSA
HPDYDYVKVRVDLNGREEYWILAKALVEKVLGDIGVKGEVVEEFKGKELEGLRYVHILMDEYPRQKEFREKYEWVHRVIL
ADFVTLEEGTGLVHTAPGHGEEDFEVGQKYGLPVYSPVDDQGKYVEGKWKGVYVKEADPQIIEHLKEKGYLVKAGEIEHK
YPHCWRCKTPLIFRATDQWFLKVSKVKEKIIKENDEKVTWYPEWVKIRFDNGVRDSGDWVISRQRYWGIPLPIWQSEDGE
IYVVGSWKELVELAVAIEVNGERIDLPESYEEKLKVIEEKLGPEDLHRPYVDAFIIKVNGKEMRRVKDVVDVWFDSGIAS
WASLGYPRNKELFEKLWPADFIVEGEDQVTKWFYSQQAASVIAFDTVPYRAVAMHGYVLDEKGDKMSKSLGNIIRPEEVV
EKAGRDTFRFYMLWATNPWENLKFSWKGVEQVRRMLNILWNVYVLSATYMSLDNFDPRNVKVEELEFREEDKWILSRVNN
LIKEVENGIETFYLTKATRALYNFVVEDLSRWYVRLIRKRLWVEGDDPDKLAAYYTLWKVFDVLLRLMAPFTPYITEEIY
QNIMRPFTGIESVHMLDWPKPDESAVDEELEREMEFIRRIVEAGSAARQKAKIKLRYPVRKIIIETQDDTVKKAVERLNY
ILRDQLNAKEVVVGNVEREITVKPNFAKVGPEFKGDARLVAKWISEHGLELYEKGEVDVEIEGKKFHLTREHIIVEENIP
DFLVAEDFEGGRVYVDKTLTRELLAEGLAREFVRRIQEMRKRLDLDVNDRIVVTIETTEENRELLQENLEYIMRETRAIE
VRFEEAKGYVVEWPEVQAKIGIEKIE

Specific function: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activi

COG id: COG0060

COG function: function code J; Isoleucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI94721239, Length=1084, Percent_Identity=33.210332103321, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI94721241, Length=1084, Percent_Identity=33.210332103321, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI46852147, Length=930, Percent_Identity=29.5698924731183, Blast_Score=358, Evalue=1e-98,
Organism=Homo sapiens, GI268370293, Length=935, Percent_Identity=22.3529411764706, Blast_Score=210, Evalue=5e-54,
Organism=Homo sapiens, GI268370297, Length=935, Percent_Identity=22.3529411764706, Blast_Score=210, Evalue=6e-54,
Organism=Homo sapiens, GI268370295, Length=886, Percent_Identity=22.7990970654628, Blast_Score=209, Evalue=1e-53,
Organism=Homo sapiens, GI5454158, Length=896, Percent_Identity=22.65625, Blast_Score=201, Evalue=4e-51,
Organism=Homo sapiens, GI7661872, Length=180, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI2367096, Length=805, Percent_Identity=33.7888198757764, Blast_Score=418, Evalue=1e-118,
Organism=Escherichia coli, GI1790708, Length=950, Percent_Identity=23.2631578947368, Blast_Score=229, Evalue=9e-61,
Organism=Escherichia coli, GI1786861, Length=941, Percent_Identity=23.8044633368757, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17541896, Length=1049, Percent_Identity=33.9370829361296, Blast_Score=533, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI71980946, Length=811, Percent_Identity=27.8668310727497, Blast_Score=287, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17510661, Length=914, Percent_Identity=23.9606126914661, Blast_Score=229, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI72001587, Length=903, Percent_Identity=23.0343300110742, Blast_Score=188, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6319395, Length=1098, Percent_Identity=32.2404371584699, Blast_Score=525, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6325217, Length=848, Percent_Identity=30.6603773584906, Blast_Score=323, Evalue=8e-89,
Organism=Saccharomyces cerevisiae, GI6321531, Length=862, Percent_Identity=24.3619489559165, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI28574730, Length=1062, Percent_Identity=31.4500941619586, Blast_Score=514, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24668547, Length=1062, Percent_Identity=31.4500941619586, Blast_Score=514, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24668543, Length=1062, Percent_Identity=31.4500941619586, Blast_Score=514, Evalue=1e-145,
Organism=Drosophila melanogaster, GI281366294, Length=796, Percent_Identity=32.286432160804, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI17864482, Length=907, Percent_Identity=25.3583241455347, Blast_Score=226, Evalue=5e-59,
Organism=Drosophila melanogaster, GI24653289, Length=907, Percent_Identity=25.3583241455347, Blast_Score=226, Evalue=5e-59,
Organism=Drosophila melanogaster, GI21355675, Length=854, Percent_Identity=22.248243559719, Blast_Score=187, Evalue=4e-47,
Organism=Drosophila melanogaster, GI21355409, Length=182, Percent_Identity=28.021978021978, Blast_Score=68, Evalue=4e-11,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002300
- InterPro:   IPR002301
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008 [H]

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.5 [H]

Molecular weight: Translated: 125754; Mature: 125754

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKEPEFRDYTPGKLEEKIEQFWKESNIYQKVKELRKNGPKYYFLDGPPYVSGAIHLGTA
CCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEECHH
WNKIIKDMIIRFRTMQGYNVWRQPGYDMHGLPIEVKVEQALGLKTKKEIEEKIGVENFIQ
HHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCEEEEEHHHHCCCHHHHHHHHCCHHHHHH
KCKEFALNNLRIMTEQFKMLGVWMDWDNPYMTIKNEYIESAWFTLKRAWEKGLLEKDKRV
HHHHHHHCCHHHHHHHEEEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHWCPRCETALAEHEVRGEYKLRKDPSIYVKFPVEGKENEYLLIWTTTPWTLPANLAVSA
HHHCCCHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEC
HPDYDYVKVRVDLNGREEYWILAKALVEKVLGDIGVKGEVVEEFKGKELEGLRYVHILMD
CCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEEEEEEEHH
EYPRQKEFREKYEWVHRVILADFVTLEEGTGLVHTAPGHGEEDFEVGQKYGLPVYSPVDD
CCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEECCCCCCCCHHHHHHHCCCCCCCCCCC
QGKYVEGKWKGVYVKEADPQIIEHLKEKGYLVKAGEIEHKYPHCWRCKTPLIFRATDQWF
CCCEEECEEEEEEEECCCHHHHHHHHHCCEEEEECCCCCCCCCCEECCCCEEEEECHHHH
LKVSKVKEKIIKENDEKVTWYPEWVKIRFDNGVRDSGDWVISRQRYWGIPLPIWQSEDGE
HHHHHHHHHHHCCCCCEEEEECEEEEEEECCCCCCCCCEEEECCCCCCCCCCCEECCCCC
IYVVGSWKELVELAVAIEVNGERIDLPESYEEKLKVIEEKLGPEDLHRPYVDAFIIKVNG
EEEEECHHHHHHEEEEEEECCCEECCCHHHHHHHHHHHHHCCHHHHCCCCEEEEEEEECC
KEMRRVKDVVDVWFDSGIASWASLGYPRNKELFEKLWPADFIVEGEDQVTKWFYSQQAAS
HHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHCCCCEEECCCHHHHHHHHHHHHCC
VIAFDTVPYRAVAMHGYVLDEKGDKMSKSLGNIIRPEEVVEKAGRDTFRFYMLWATNPWE
EEEECCCCCEEEEEECEEECCCCCHHHHHHCCCCCHHHHHHHCCCCEEEEEEEEECCCCC
NLKFSWKGVEQVRRMLNILWNVYVLSATYMSLDNFDPRNVKVEELEFREEDKWILSRVNN
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCCHHHHHHHHHHH
LIKEVENGIETFYLTKATRALYNFVVEDLSRWYVRLIRKRLWVEGDDPDKLAAYYTLWKV
HHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
FDVLLRLMAPFTPYITEEIYQNIMRPFTGIESVHMLDWPKPDESAVDEELEREMEFIRRI
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHH
VEAGSAARQKAKIKLRYPVRKIIIETQDDTVKKAVERLNYILRDQLNAKEVVVGNVEREI
HHCCHHHHHCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEE
TVKPNFAKVGPEFKGDARLVAKWISEHGLELYEKGEVDVEIEGKKFHLTREHIIVEENIP
EECCCHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCEEEEECCCEEEEEEEEEEEECCCC
DFLVAEDFEGGRVYVDKTLTRELLAEGLAREFVRRIQEMRKRLDLDVNDRIVVTIETTEE
CCEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHH
NRELLQENLEYIMRETRAIEVRFEEAKGYVVEWPEVQAKIGIEKIE
HHHHHHHHHHHHHHHHHEEEEEEECCCCEEEECCCHHHHCCCEECC
>Mature Secondary Structure
MIKEPEFRDYTPGKLEEKIEQFWKESNIYQKVKELRKNGPKYYFLDGPPYVSGAIHLGTA
CCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEECHH
WNKIIKDMIIRFRTMQGYNVWRQPGYDMHGLPIEVKVEQALGLKTKKEIEEKIGVENFIQ
HHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCEEEEEHHHHCCCHHHHHHHHCCHHHHHH
KCKEFALNNLRIMTEQFKMLGVWMDWDNPYMTIKNEYIESAWFTLKRAWEKGLLEKDKRV
HHHHHHHCCHHHHHHHEEEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHWCPRCETALAEHEVRGEYKLRKDPSIYVKFPVEGKENEYLLIWTTTPWTLPANLAVSA
HHHCCCHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEC
HPDYDYVKVRVDLNGREEYWILAKALVEKVLGDIGVKGEVVEEFKGKELEGLRYVHILMD
CCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEEEEEEEHH
EYPRQKEFREKYEWVHRVILADFVTLEEGTGLVHTAPGHGEEDFEVGQKYGLPVYSPVDD
CCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEECCCCCCCCHHHHHHHCCCCCCCCCCC
QGKYVEGKWKGVYVKEADPQIIEHLKEKGYLVKAGEIEHKYPHCWRCKTPLIFRATDQWF
CCCEEECEEEEEEEECCCHHHHHHHHHCCEEEEECCCCCCCCCCEECCCCEEEEECHHHH
LKVSKVKEKIIKENDEKVTWYPEWVKIRFDNGVRDSGDWVISRQRYWGIPLPIWQSEDGE
HHHHHHHHHHHCCCCCEEEEECEEEEEEECCCCCCCCCEEEECCCCCCCCCCCEECCCCC
IYVVGSWKELVELAVAIEVNGERIDLPESYEEKLKVIEEKLGPEDLHRPYVDAFIIKVNG
EEEEECHHHHHHEEEEEEECCCEECCCHHHHHHHHHHHHHCCHHHHCCCCEEEEEEEECC
KEMRRVKDVVDVWFDSGIASWASLGYPRNKELFEKLWPADFIVEGEDQVTKWFYSQQAAS
HHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHCCCCEEECCCHHHHHHHHHHHHCC
VIAFDTVPYRAVAMHGYVLDEKGDKMSKSLGNIIRPEEVVEKAGRDTFRFYMLWATNPWE
EEEECCCCCEEEEEECEEECCCCCHHHHHHCCCCCHHHHHHHCCCCEEEEEEEEECCCCC
NLKFSWKGVEQVRRMLNILWNVYVLSATYMSLDNFDPRNVKVEELEFREEDKWILSRVNN
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCCHHHHHHHHHHH
LIKEVENGIETFYLTKATRALYNFVVEDLSRWYVRLIRKRLWVEGDDPDKLAAYYTLWKV
HHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
FDVLLRLMAPFTPYITEEIYQNIMRPFTGIESVHMLDWPKPDESAVDEELEREMEFIRRI
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHH
VEAGSAARQKAKIKLRYPVRKIIIETQDDTVKKAVERLNYILRDQLNAKEVVVGNVEREI
HHCCHHHHHCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEE
TVKPNFAKVGPEFKGDARLVAKWISEHGLELYEKGEVDVEIEGKKFHLTREHIIVEENIP
EECCCHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCEEEEECCCEEEEEEEEEEEECCCC
DFLVAEDFEGGRVYVDKTLTRELLAEGLAREFVRRIQEMRKRLDLDVNDRIVVTIETTEE
CCEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHH
NRELLQENLEYIMRETRAIEVRFEEAKGYVVEWPEVQAKIGIEKIE
HHHHHHHHHHHHHHHHHEEEEEEECCCCEEEECCCHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]