BacMap

Definition	Pyrococcus furiosus DSM 3638, complete genome.
Accession	NC_003413
Length	1,908,256

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The map label for this gene is natA [H]

Identifier: 18977253

GI number: 18977253

Start: 852173

End: 852880

Strand: Reverse

Name: natA [H]

Synonym: PF0881

Alternate gene names: 18977253

Gene position: 852880-852173 (Counterclockwise)

Preceding gene: 18977254

Following gene: 18977249

Centisome position: 44.69

GC content: 40.25

Gene sequence:

>708_bases
ATGATAGTCGCTAAAAACCTTGTAAAACGCTTTGGAAACATATATGCCCTCAAGGGTATAACCACAGAGATTCCCGAGGG
AACTACTCTTATCCTAGGCCCTAATGGAGGGGGAAAGTCTACCTTTCTAAAGCTCGCTACAGGAATATATAGACCCACCA
AGGGAAAAATAAGGGTTCTTGGAGAGAACCCATGGAAAAGCAAAAAGATAAAAAAGTATATCGGTGCCTCCTATGATCCT
CCCTCTTTTCCTAAGCTGATTACGGGTAGAGAATGGTTGATGTTCTTTGCCTCTGCTAAGGGATACGGAGAGGAAGAAGT
TGAAAGGGTAGCAAAGTTATTTAAAATAGATTTTCTTGATAAGAGGATAGGAGGATACTCCTCTGGAATGCTAAAGAAGT
TAAGTGTGGCACAGGCTTTTATAGGAGAACCAAAACTCATATTCCTAGATGAACCTCTAGCCAACCTTGACTTTAAGAAC
ATCGCTGGATTTATCAAAATTATGAGAAAAATTAAACAGAATAATGAGTCGAATTTCGTGATAATCAGTCACATTTGGGA
GCCTCTGCTTTTCCTCGCTGATTGGATCTTGGTTATTGCTGACGGAGAAATAGTGCTCGAAGGCGATGTACAGGAAGTCC
AGGAAGACGTTAAAAGTCTCTTTAAAGTAGATGTGGATATTAATGAAGAGCAGGATGAACACGCTTAA

Upstream 100 bases:

>100_bases
AAGGAGAATCATCCAACAAGGAGCGTGCAAAATGCTACATACTTTGTAGGAATAGTATCGGCATTCGGTCTCATACTCTA
TCTCTGGAGGGGGTGGAAAA

Downstream 100 bases:

>100_bases
TTCCTGTAATGCTTAGAAACCCATCTTCTAACATTCACAAACTTGCACTCGATAAGTGGAAGGCTACTAGGACATTTGTG
ATCTCCTATACGTGGAATTA

Product: putative ABC transporter

Products: NA

Alternate protein names: Na(+) ABC transporter [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MIVAKNLVKRFGNIYALKGITTEIPEGTTLILGPNGGGKSTFLKLATGIYRPTKGKIRVLGENPWKSKKIKKYIGASYDP
PSFPKLITGREWLMFFASAKGYGEEEVERVAKLFKIDFLDKRIGGYSSGMLKKLSVAQAFIGEPKLIFLDEPLANLDFKN
IAGFIKIMRKIKQNNESNFVIISHIWEPLLFLADWILVIADGEIVLEGDVQEVQEDVKSLFKVDVDINEEQDEHA

Sequences:

>Translated_235_residues
MIVAKNLVKRFGNIYALKGITTEIPEGTTLILGPNGGGKSTFLKLATGIYRPTKGKIRVLGENPWKSKKIKKYIGASYDP
PSFPKLITGREWLMFFASAKGYGEEEVERVAKLFKIDFLDKRIGGYSSGMLKKLSVAQAFIGEPKLIFLDEPLANLDFKN
IAGFIKIMRKIKQNNESNFVIISHIWEPLLFLADWILVIADGEIVLEGDVQEVQEDVKSLFKVDVDINEEQDEHA
>Mature_235_residues
MIVAKNLVKRFGNIYALKGITTEIPEGTTLILGPNGGGKSTFLKLATGIYRPTKGKIRVLGENPWKSKKIKKYIGASYDP
PSFPKLITGREWLMFFASAKGYGEEEVERVAKLFKIDFLDKRIGGYSSGMLKKLSVAQAFIGEPKLIFLDEPLANLDFKN
IAGFIKIMRKIKQNNESNFVIISHIWEPLLFLADWILVIADGEIVLEGDVQEVQEDVKSLFKVDVDINEEQDEHA

Specific function: Involved in ATP-dependent electrogenic sodium extrusion [H]

COG id: COG1131

COG function: function code V; ABC-type multidrug transport system, ATPase component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI21536376, Length=214, Percent_Identity=30.3738317757009, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI30795238, Length=230, Percent_Identity=29.1304347826087, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI27881501, Length=230, Percent_Identity=29.1304347826087, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI105990541, Length=209, Percent_Identity=28.7081339712919, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI116734710, Length=206, Percent_Identity=29.6116504854369, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI31657092, Length=244, Percent_Identity=27.8688524590164, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI153792144, Length=223, Percent_Identity=23.3183856502242, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI45446740, Length=243, Percent_Identity=27.1604938271605, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI47078218, Length=243, Percent_Identity=27.1604938271605, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI27436953, Length=220, Percent_Identity=22.2727272727273, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI150417984, Length=212, Percent_Identity=26.8867924528302, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI46592915, Length=215, Percent_Identity=28.3720930232558, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI46592978, Length=215, Percent_Identity=28.3720930232558, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI46592956, Length=215, Percent_Identity=28.3720930232558, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI46592898, Length=215, Percent_Identity=28.3720930232558, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI46592964, Length=215, Percent_Identity=28.3720930232558, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI46592971, Length=215, Percent_Identity=28.3720930232558, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI27477115, Length=174, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI27262624, Length=208, Percent_Identity=25, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI27262626, Length=208, Percent_Identity=25, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI6005701, Length=208, Percent_Identity=25, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1787758, Length=215, Percent_Identity=28.3720930232558, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI87081709, Length=223, Percent_Identity=25.5605381165919, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787370, Length=196, Percent_Identity=26.0204081632653, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1789891, Length=207, Percent_Identity=28.9855072463768, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI48994943, Length=226, Percent_Identity=28.7610619469027, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787089, Length=227, Percent_Identity=25.5506607929515, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1790525, Length=224, Percent_Identity=28.125, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787500, Length=221, Percent_Identity=28.0542986425339, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1786803, Length=215, Percent_Identity=24.6511627906977, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788761, Length=209, Percent_Identity=24.4019138755981, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87081782, Length=165, Percent_Identity=30.9090909090909, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787712, Length=210, Percent_Identity=26.1904761904762, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790467, Length=211, Percent_Identity=25.1184834123223, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786319, Length=220, Percent_Identity=28.6363636363636, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790544, Length=236, Percent_Identity=22.4576271186441, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI87082267, Length=216, Percent_Identity=24.0740740740741, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786398, Length=231, Percent_Identity=24.2424242424242, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788472, Length=209, Percent_Identity=28.7081339712919, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787547, Length=219, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787029, Length=224, Percent_Identity=29.4642857142857, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789962, Length=232, Percent_Identity=25, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1789890, Length=218, Percent_Identity=27.0642201834862, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1787792, Length=223, Percent_Identity=24.2152466367713, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1790190, Length=225, Percent_Identity=28.4444444444444, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI48995001, Length=247, Percent_Identity=24.6963562753036, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87081791, Length=226, Percent_Identity=22.5663716814159, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786253, Length=188, Percent_Identity=23.936170212766, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789873, Length=179, Percent_Identity=29.608938547486, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71983523, Length=245, Percent_Identity=27.3469387755102, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71983516, Length=245, Percent_Identity=27.3469387755102, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71983510, Length=245, Percent_Identity=27.3469387755102, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17510237, Length=238, Percent_Identity=26.4705882352941, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17565586, Length=240, Percent_Identity=25, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115533608, Length=225, Percent_Identity=27.1111111111111, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17558664, Length=213, Percent_Identity=25.8215962441315, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24643674, Length=251, Percent_Identity=30.2788844621514, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI221512771, Length=215, Percent_Identity=28.8372093023256, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24666092, Length=239, Percent_Identity=28.4518828451883, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573573, Length=241, Percent_Identity=26.1410788381743, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28573571, Length=241, Percent_Identity=26.1410788381743, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28574150, Length=206, Percent_Identity=28.6407766990291, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI116007328, Length=206, Percent_Identity=28.6407766990291, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI221500365, Length=229, Percent_Identity=25.3275109170306, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI116007184, Length=229, Percent_Identity=25.3275109170306, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19920532, Length=221, Percent_Identity=25.7918552036199, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24580930, Length=221, Percent_Identity=25.7918552036199, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24648314, Length=215, Percent_Identity=26.9767441860465, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 26394; Mature: 26394

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVAKNLVKRFGNIYALKGITTEIPEGTTLILGPNGGGKSTFLKLATGIYRPTKGKIRVL
CCCHHHHHHHHCCEEEECCCCEECCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEE
GENPWKSKKIKKYIGASYDPPSFPKLITGREWLMFFASAKGYGEEEVERVAKLFKIDFLD
CCCCCCHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
KRIGGYSSGMLKKLSVAQAFIGEPKLIFLDEPLANLDFKNIAGFIKIMRKIKQNNESNFV
HHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEE
IISHIWEPLLFLADWILVIADGEIVLEGDVQEVQEDVKSLFKVDVDINEEQDEHA
EHHHHHHHHHHHHHHHEEEECCCEEEECCHHHHHHHHHHHHEECCCCCCCCCCCC
>Mature Secondary Structure
MIVAKNLVKRFGNIYALKGITTEIPEGTTLILGPNGGGKSTFLKLATGIYRPTKGKIRVL
CCCHHHHHHHHCCEEEECCCCEECCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEE
GENPWKSKKIKKYIGASYDPPSFPKLITGREWLMFFASAKGYGEEEVERVAKLFKIDFLD
CCCCCCHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
KRIGGYSSGMLKKLSVAQAFIGEPKLIFLDEPLANLDFKNIAGFIKIMRKIKQNNESNFV
HHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEE
IISHIWEPLLFLADWILVIADGEIVLEGDVQEVQEDVKSLFKVDVDINEEQDEHA
EHHHHHHHHHHHHHHHEEEECCCEEEECCHHHHHHHHHHHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9106203; 9274031; 9384377 [H]