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The map label for this gene is xapA [C]

Identifier: 18977225

GI number: 18977225

Start: 826577

End: 827374

Strand: Reverse

Name: xapA [C]

Synonym: PF0853

Alternate gene names: 18977225

Gene position: 827374-826577 (Counterclockwise)

Preceding gene: 18977226

Following gene: 18977224

Centisome position: 43.36

GC content: 46.12

Gene sequence:

>798_bases
ATGCCCAGGATAGCCATAGTTGGGGGTTCTGGAGTTTATGATTTCCCAGCAGAGAACAAGAGAGAAGAGACCGTCAAGAC
TCCCTATGGAGAAGTCAAAATTACCGTTGGAGTTGTGGGAGATGAGGAAGTAGCTTTCTTGGCTAGACATGGGAAAGGAC
ATTCAATTCCACCCCATAAAATAAACTACAGGGCAAACATTTGGGCTTTATATGAGCTTGGAGTTGAGAGGATAATAGCT
ACTTCAGCCGTTGGCTCAATGAATCCAGAGATGAAGCCGGGAGATTTTGTAATACTAGATCAGATTATTGACTTCACAGT
GTCAAGACCAAGAACATTCTATGATGGAGAGGAAAGCCCACATGAAAGGAAATTCGTTGCCCATGTAGACTTTACTGAAC
CCTACTGCCCAGAGATAAGGAAGGCATTAATCACGGCGGCCAGAAACCTTGGATTGCCTTATCACCCAAGAGGGACCTAT
GTATGTACGGAAGGGCCGAGATTTGAGACTGCAGCTGAGATTAGAGCCTACAGAATCCTCGGAGGGGACGTTGTTGGAAT
GACCCAATGTCCCGAGGCTATATTGGCGAGAGAGCTGGAAATGTGCTACGCCACAGTTGCTATTGTAACGAACTATGCAG
CGGGAATGAGTGGGAAAAAGCTCACTCACTCTGAAGTTGTTGAGTTAATGCAAAAGAAGAGCGAAGATATCGTAAAGCTA
ATTCTCGCAGCTATTCCTCTAATACCAAAGGAGAGGAGGTGTGGGTGCAAAGATGCTCTGAAGGGTGCCACTGGCTAG

Upstream 100 bases:

>100_bases
CGGAGGGCGGCGTTCTCTCCTGGCTAAACTACCGGCCCACCCAACTCTCATATTCCAGACACCTTAAAAAGGATTACCTC
CTATTATAGCTGGTGGTATA

Downstream 100 bases:

>100_bases
CCCTCCCTTTTTATTATTATGACGAATTTCAAACGGATTAACAACCCAAAGAGTTACATCCGAGAAGTTTTATACACATT
CATGTCTAAAAAAGCTTAAA

Product: 5'-methylthioadenosine phosphorylase

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MPRIAIVGGSGVYDFPAENKREETVKTPYGEVKITVGVVGDEEVAFLARHGKGHSIPPHKINYRANIWALYELGVERIIA
TSAVGSMNPEMKPGDFVILDQIIDFTVSRPRTFYDGEESPHERKFVAHVDFTEPYCPEIRKALITAARNLGLPYHPRGTY
VCTEGPRFETAAEIRAYRILGGDVVGMTQCPEAILARELEMCYATVAIVTNYAAGMSGKKLTHSEVVELMQKKSEDIVKL
ILAAIPLIPKERRCGCKDALKGATG

Sequences:

>Translated_265_residues
MPRIAIVGGSGVYDFPAENKREETVKTPYGEVKITVGVVGDEEVAFLARHGKGHSIPPHKINYRANIWALYELGVERIIA
TSAVGSMNPEMKPGDFVILDQIIDFTVSRPRTFYDGEESPHERKFVAHVDFTEPYCPEIRKALITAARNLGLPYHPRGTY
VCTEGPRFETAAEIRAYRILGGDVVGMTQCPEAILARELEMCYATVAIVTNYAAGMSGKKLTHSEVVELMQKKSEDIVKL
ILAAIPLIPKERRCGCKDALKGATG
>Mature_264_residues
PRIAIVGGSGVYDFPAENKREETVKTPYGEVKITVGVVGDEEVAFLARHGKGHSIPPHKINYRANIWALYELGVERIIAT
SAVGSMNPEMKPGDFVILDQIIDFTVSRPRTFYDGEESPHERKFVAHVDFTEPYCPEIRKALITAARNLGLPYHPRGTYV
CTEGPRFETAAEIRAYRILGGDVVGMTQCPEAILARELEMCYATVAIVTNYAAGMSGKKLTHSEVVELMQKKSEDIVKLI
LAAIPLIPKERRCGCKDALKGATG

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=250, Percent_Identity=40.8, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI157168362, Length=273, Percent_Identity=28.2051282051282, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1788746, Length=250, Percent_Identity=30.4, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71980569, Length=253, Percent_Identity=37.9446640316205, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17541190, Length=171, Percent_Identity=23.9766081871345, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323045, Length=228, Percent_Identity=35.0877192982456, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323238, Length=199, Percent_Identity=31.6582914572864, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI20130079, Length=277, Percent_Identity=36.4620938628159, Blast_Score=180, Evalue=8e-46,
Organism=Drosophila melanogaster, GI221459247, Length=249, Percent_Identity=36.5461847389558, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45552885, Length=258, Percent_Identity=29.0697674418605, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45552887, Length=258, Percent_Identity=29.0697674418605, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656090, Length=258, Percent_Identity=29.0697674418605, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656093, Length=258, Percent_Identity=29.0697674418605, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 29208; Mature: 29077

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRIAIVGGSGVYDFPAENKREETVKTPYGEVKITVGVVGDEEVAFLARHGKGHSIPPHK
CCEEEEEECCCEECCCCCCCCHHHHCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCE
INYRANIWALYELGVERIIATSAVGSMNPEMKPGDFVILDQIIDFTVSRPRTFYDGEESP
ECCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHCCCCCEECCCCCCC
HERKFVAHVDFTEPYCPEIRKALITAARNLGLPYHPRGTYVCTEGPRFETAAEIRAYRIL
CCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHEEEEEE
GGDVVGMTQCPEAILARELEMCYATVAIVTNYAAGMSGKKLTHSEVVELMQKKSEDIVKL
CCCEECHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
ILAAIPLIPKERRCGCKDALKGATG
HHHHHCCCCCHHCCCCHHHHCCCCC
>Mature Secondary Structure 
PRIAIVGGSGVYDFPAENKREETVKTPYGEVKITVGVVGDEEVAFLARHGKGHSIPPHK
CEEEEEECCCEECCCCCCCCHHHHCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCE
INYRANIWALYELGVERIIATSAVGSMNPEMKPGDFVILDQIIDFTVSRPRTFYDGEESP
ECCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHCCCCCEECCCCCCC
HERKFVAHVDFTEPYCPEIRKALITAARNLGLPYHPRGTYVCTEGPRFETAAEIRAYRIL
CCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHEEEEEE
GGDVVGMTQCPEAILARELEMCYATVAIVTNYAAGMSGKKLTHSEVVELMQKKSEDIVKL
CCCEECHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
ILAAIPLIPKERRCGCKDALKGATG
HHHHHCCCCCHHCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]