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The map label for this gene is cobS [H]

Identifier: 18977208

GI number: 18977208

Start: 812605

End: 813072

Strand: Direct

Name: cobS [H]

Synonym: PF0836

Alternate gene names: 18977208

Gene position: 812605-813072 (Clockwise)

Preceding gene: 18977205

Following gene: 18977209

Centisome position: 42.58

GC content: 40.17

Gene sequence:

>468_bases
ATGAGAAACATCATCCCCTTCATGACAAGAGTCCCAATAAGGGGAAACTTCGAAAAAGCTAGGAATGAAATATGGGCCTT
TCCTCTGCTTGCTACCCTTACCTCCTCTCTGCCCACTTTGATTTTATACCTTGACCTTCCTATGAAAAACATCTTAGCAA
TTCTCTCGCTTTACTCCATAATAGGCCTGCTCCACTTGGATGGACTAGCCGACTGGGCCGATGGAGTTATGGCTAAAGGA
GACAGAAAAAAGAAGATTAAAACCATGAAAGATCTGAACACGTGTATAGCTGGAATTTTTGCTGTTGTAATGGTACTTTT
TGTTCAGATATACTCTCTAAACTATCTCCCATTTTATGCAATATTTCTAGCTGAGCTGAACTCAAAGTATGCAATGCTCC
TTGCTTTAGCCACCAAAAAACCACTTGGATCAGGATTAGGATGGTACTTTATGGAAAAGATGAACTAA

Upstream 100 bases:

>100_bases
AGTGATTTAAATCGCCCCTACTGCTTATCCTGGCAGTATTCGTACATGGGGCAGACTTTTTAAGCTTTCTTGCAATTGGA
TTAATTAGCCAGGTGGTTGC

Downstream 100 bases:

>100_bases
AGGCAATTAACTGTTGGCACCTTGTTATGTTCAGTCCTCATCTTCCCTATAGGATTTTATAACCCAGAGGCCATTTTCAG
TTGTTGGACTTTTGGTTAGT

Product: cobalamin synthase

Products: GMP; adenosylcobalamin

Alternate protein names: NA

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MRNIIPFMTRVPIRGNFEKARNEIWAFPLLATLTSSLPTLILYLDLPMKNILAILSLYSIIGLLHLDGLADWADGVMAKG
DRKKKIKTMKDLNTCIAGIFAVVMVLFVQIYSLNYLPFYAIFLAELNSKYAMLLALATKKPLGSGLGWYFMEKMN

Sequences:

>Translated_155_residues
MRNIIPFMTRVPIRGNFEKARNEIWAFPLLATLTSSLPTLILYLDLPMKNILAILSLYSIIGLLHLDGLADWADGVMAKG
DRKKKIKTMKDLNTCIAGIFAVVMVLFVQIYSLNYLPFYAIFLAELNSKYAMLLALATKKPLGSGLGWYFMEKMN
>Mature_155_residues
MRNIIPFMTRVPIRGNFEKARNEIWAFPLLATLTSSLPTLILYLDLPMKNILAILSLYSIIGLLHLDGLADWADGVMAKG
DRKKKIKTMKDLNTCIAGIFAVVMVLFVQIYSLNYLPFYAIFLAELNSKYAMLLALATKKPLGSGLGWYFMEKMN

Specific function: Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) [H]

COG id: COG0368

COG function: function code H; Cobalamin-5-phosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobS family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003805 [H]

Pfam domain/function: PF02654 CobS [H]

EC number: 2.7.8.26

Molecular weight: Translated: 17511; Mature: 17511

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNIIPFMTRVPIRGNFEKARNEIWAFPLLATLTSSLPTLILYLDLPMKNILAILSLYSI
CCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEHHCCCCHHHHHHHHHHHHH
IGLLHLDGLADWADGVMAKGDRKKKIKTMKDLNTCIAGIFAVVMVLFVQIYSLNYLPFYA
HHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
IFLAELNSKYAMLLALATKKPLGSGLGWYFMEKMN
HHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MRNIIPFMTRVPIRGNFEKARNEIWAFPLLATLTSSLPTLILYLDLPMKNILAILSLYSI
CCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEHHCCCCHHHHHHHHHHHHH
IGLLHLDGLADWADGVMAKGDRKKKIKTMKDLNTCIAGIFAVVMVLFVQIYSLNYLPFYA
HHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
IFLAELNSKYAMLLALATKKPLGSGLGWYFMEKMN
HHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: adenosylcobinamide-GDP; alpha-ribazole

Specific reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA