BacMap

Definition	Pyrococcus furiosus DSM 3638, complete genome.
Accession	NC_003413
Length	1,908,256

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The map label for this gene is yhcH [H]

Identifier: 18977104

GI number: 18977104

Start: 727207

End: 727956

Strand: Reverse

Name: yhcH [H]

Synonym: PF0732

Alternate gene names: 18977104

Gene position: 727956-727207 (Counterclockwise)

Preceding gene: 33359502

Following gene: 33359501

Centisome position: 38.15

GC content: 51.47

Gene sequence:

>750_bases
ATGGTAGAGCTTGAAAACGTGAGGAAAAGTATAAATAGAAAAGAAGTTCTTCGAGGGATAAGCCTGACTGTGAAGCCCGG
CGAAGTCCACGCCTACCTCGGCCACAACGGGGCAGGCAAGACCACCGCCTTCCGCCCGATCCTCGGCCTCCGCTACCTTC
CGGAGTACGACCTTCTCTATCCGAGCCTTTCAGTGTGGGACAACCTCAAGCGCTATGCTTCGCTGAAGGGGGTTTACGAT
GAGAAAGAGCTTAGAGAACTGTTGGAGTTCTTCGAGCTTTTGGAGTGCGCCAGAAAAAAGGTCTCGGCTCTCTCAAGTGG
AACCCAGAGGAGGGTCGCAATGGCGAGGGCTTTTCTTGGGAGCCCTGAGGTTCTAATCCTCGACGAGCCCACAAGAGAAC
TCGACCCCGAGTGGAGGCTCAAATTCAAGCGGTTTTTGGAGAGATATGTGAAAGAGAGAAACACCGCAGTCTTGTTCTCC
ACACACATTTTGAGCGACGTTGACGAGCTATGCGAGAAGATTACAGTTATCAAAGAGGGCAGAGTGCTGTTCTCAGGAAG
TTTGAAGGAGTTCAAGCGCGGTTTTCCTACAGGAGCTTCAATCTCCCTGAAGGTGGAGAACATCAAGATGGTTGCCGAAG
TGCTTGAGGATAACGGATACTACCCAAATCATGAAAGGGTACATCCTGCTGGAAAATGCCGAGCCGTCGGAAATCAACAC
GCTCCTCGTGAGCGAGAGTATAACCGTTGA

Upstream 100 bases:

>100_bases
GTTGTGCTGGCAGCTTACTTTGCAGTAATCAAGTACTATGGAGAAAGACTCCCGGAAGCTATAATGATAGTATAAGTGGT
AAGAGCCGTAAGGTGGTTTT

Downstream 100 bases:

>100_bases
GGAGATAAAACGAAACGAACCCACATTAGAGGAACTCTACTCTATGCTCCACAGAAAAAATGGATAAAATGAAAGAATGG
GGGCTCAAACCTTCAGGAAC

Product: daunorubicin resistance ATP-binding protein

Products: ADP; phosphate; S2O32- [Cytoplasm]; SO42- [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MVELENVRKSINRKEVLRGISLTVKPGEVHAYLGHNGAGKTTAFRPILGLRYLPEYDLLYPSLSVWDNLKRYASLKGVYD
EKELRELLEFFELLECARKKVSALSSGTQRRVAMARAFLGSPEVLILDEPTRELDPEWRLKFKRFLERYVKERNTAVLFS
THILSDVDELCEKITVIKEGRVLFSGSLKEFKRGFPTGASISLKVENIKMVAEVLEDNGYYPNHERVHPAGKCRAVGNQH
APREREYNR

Sequences:

>Translated_249_residues
MVELENVRKSINRKEVLRGISLTVKPGEVHAYLGHNGAGKTTAFRPILGLRYLPEYDLLYPSLSVWDNLKRYASLKGVYD
EKELRELLEFFELLECARKKVSALSSGTQRRVAMARAFLGSPEVLILDEPTRELDPEWRLKFKRFLERYVKERNTAVLFS
THILSDVDELCEKITVIKEGRVLFSGSLKEFKRGFPTGASISLKVENIKMVAEVLEDNGYYPNHERVHPAGKCRAVGNQH
APREREYNR
>Mature_249_residues
MVELENVRKSINRKEVLRGISLTVKPGEVHAYLGHNGAGKTTAFRPILGLRYLPEYDLLYPSLSVWDNLKRYASLKGVYD
EKELRELLEFFELLECARKKVSALSSGTQRRVAMARAFLGSPEVLILDEPTRELDPEWRLKFKRFLERYVKERNTAVLFS
THILSDVDELCEKITVIKEGRVLFSGSLKEFKRGFPTGASISLKVENIKMVAEVLEDNGYYPNHERVHPAGKCRAVGNQH
APREREYNR

Specific function: Part Of The Abc Transporter Complex Cysawtp Involved In Sulfate/Thiosulfate Import. Responsible For Energy Coupling To The Transport System. [C]

COG id: COG1131

COG function: function code V; ABC-type multidrug transport system, ATPase component

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI153792144, Length=225, Percent_Identity=28.8888888888889, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI6005701, Length=227, Percent_Identity=28.6343612334802, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI27477115, Length=232, Percent_Identity=27.5862068965517, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI45446740, Length=252, Percent_Identity=28.5714285714286, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI47078218, Length=252, Percent_Identity=28.1746031746032, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI27436953, Length=225, Percent_Identity=28.8888888888889, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI105990541, Length=221, Percent_Identity=31.2217194570136, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI27262624, Length=248, Percent_Identity=25, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI27262626, Length=248, Percent_Identity=25, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI21536376, Length=241, Percent_Identity=30.2904564315353, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI27881501, Length=230, Percent_Identity=28.695652173913, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI30795238, Length=230, Percent_Identity=28.695652173913, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI150417984, Length=218, Percent_Identity=32.1100917431193, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI116734710, Length=219, Percent_Identity=27.8538812785388, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI31657092, Length=235, Percent_Identity=28.0851063829787, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI46592978, Length=204, Percent_Identity=25.4901960784314, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI46592956, Length=204, Percent_Identity=25.4901960784314, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI46592915, Length=204, Percent_Identity=25.4901960784314, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI46592971, Length=204, Percent_Identity=25.4901960784314, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI46592964, Length=204, Percent_Identity=25.4901960784314, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI46592898, Length=204, Percent_Identity=25.4901960784314, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788761, Length=213, Percent_Identity=28.6384976525822, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789593, Length=219, Percent_Identity=27.8538812785388, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1790467, Length=213, Percent_Identity=29.5774647887324, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787712, Length=275, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787029, Length=230, Percent_Identity=29.1304347826087, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1787370, Length=219, Percent_Identity=28.310502283105, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788165, Length=192, Percent_Identity=29.6875, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87081709, Length=220, Percent_Identity=27.7272727272727, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081782, Length=221, Percent_Identity=26.6968325791855, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788225, Length=228, Percent_Identity=29.8245614035088, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1787792, Length=216, Percent_Identity=27.3148148148148, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI48994943, Length=206, Percent_Identity=27.6699029126214, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1786319, Length=224, Percent_Identity=29.4642857142857, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48995001, Length=201, Percent_Identity=29.8507462686567, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI87082267, Length=208, Percent_Identity=26.4423076923077, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1790544, Length=238, Percent_Identity=24.3697478991597, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI87081791, Length=219, Percent_Identity=24.6575342465753, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1786398, Length=227, Percent_Identity=26.431718061674, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789864, Length=219, Percent_Identity=26.027397260274, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788506, Length=213, Percent_Identity=29.1079812206573, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789873, Length=216, Percent_Identity=25, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788450, Length=253, Percent_Identity=23.3201581027668, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790190, Length=221, Percent_Identity=25.3393665158371, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787164, Length=201, Percent_Identity=29.3532338308458, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787759, Length=104, Percent_Identity=34.6153846153846, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI48994997, Length=206, Percent_Identity=26.6990291262136, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI48994883, Length=215, Percent_Identity=25.5813953488372, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=248, Percent_Identity=29.4354838709677, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17565586, Length=217, Percent_Identity=29.9539170506912, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17510237, Length=227, Percent_Identity=27.3127753303965, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71983523, Length=227, Percent_Identity=27.7533039647577, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71983510, Length=227, Percent_Identity=27.7533039647577, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71983516, Length=227, Percent_Identity=27.7533039647577, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI133930907, Length=212, Percent_Identity=26.8867924528302, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321121, Length=212, Percent_Identity=27.3584905660377, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324498, Length=145, Percent_Identity=28.9655172413793, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24643674, Length=259, Percent_Identity=27.027027027027, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI116007184, Length=192, Percent_Identity=28.6458333333333, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI221500365, Length=192, Percent_Identity=28.6458333333333, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221512771, Length=227, Percent_Identity=26.431718061674, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24666092, Length=221, Percent_Identity=28.0542986425339, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24650855, Length=205, Percent_Identity=29.7560975609756, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24650853, Length=205, Percent_Identity=29.7560975609756, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28574150, Length=241, Percent_Identity=26.1410788381743, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI116007328, Length=241, Percent_Identity=26.1410788381743, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281362751, Length=205, Percent_Identity=29.7560975609756, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28573571, Length=231, Percent_Identity=25.5411255411255, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI28573573, Length=231, Percent_Identity=25.5411255411255, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24582014, Length=205, Percent_Identity=29.2682926829268, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24582012, Length=205, Percent_Identity=29.2682926829268, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24648314, Length=221, Percent_Identity=23.5294117647059, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI85725262, Length=239, Percent_Identity=27.6150627615063, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24581191, Length=207, Percent_Identity=28.0193236714976, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581189, Length=207, Percent_Identity=28.0193236714976, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581193, Length=207, Percent_Identity=28.0193236714976, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581195, Length=207, Percent_Identity=28.0193236714976, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571209, Length=223, Percent_Identity=25.5605381165919, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17136592, Length=219, Percent_Identity=27.8538812785388, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: 3.6.3.25 [C]

Molecular weight: Translated: 28624; Mature: 28624

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVELENVRKSINRKEVLRGISLTVKPGEVHAYLGHNGAGKTTAFRPILGLRYLPEYDLLY
CCCHHHHHHHCCHHHHHHCCEEEEECCCEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHC
PSLSVWDNLKRYASLKGVYDEKELRELLEFFELLECARKKVSALSSGTQRRVAMARAFLG
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
SPEVLILDEPTRELDPEWRLKFKRFLERYVKERNTAVLFSTHILSDVDELCEKITVIKEG
CCCEEEEECCHHHCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCC
RVLFSGSLKEFKRGFPTGASISLKVENIKMVAEVLEDNGYYPNHERVHPAGKCRAVGNQH
CEEEECCHHHHHCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCC
APREREYNR
CCCCCCCCC
>Mature Secondary Structure
MVELENVRKSINRKEVLRGISLTVKPGEVHAYLGHNGAGKTTAFRPILGLRYLPEYDLLY
CCCHHHHHHHCCHHHHHHCCEEEEECCCEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHC
PSLSVWDNLKRYASLKGVYDEKELRELLEFFELLECARKKVSALSSGTQRRVAMARAFLG
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
SPEVLILDEPTRELDPEWRLKFKRFLERYVKERNTAVLFSTHILSDVDELCEKITVIKEG
CCCEEEEECCHHHCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCC
RVLFSGSLKEFKRGFPTGASISLKVENIKMVAEVLEDNGYYPNHERVHPAGKCRAVGNQH
CEEEECCHHHHHCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCC
APREREYNR
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S2O32- [Periplasm]; H2O; SO42- [Periplasm]; ATP [C]

Specific reaction: ATP + S2O32- [Periplasm] + H2O = ADP + phosphate + S2O32- [Cytoplasm] SO42- [Periplasm] + H2O + ATP = SO42- [Cytoplasm] + phosphate + ADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969498; 9384377 [H]