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The map label for this gene is lhr [C]

Identifier: 18976964

GI number: 18976964

Start: 611563

End: 614166

Strand: Reverse

Name: lhr [C]

Synonym: PF0592

Alternate gene names: 18976964

Gene position: 614166-611563 (Counterclockwise)

Preceding gene: 18976965

Following gene: 18976963

Centisome position: 32.18

GC content: 41.94

Gene sequence:

>2604_bases
ATGATTGAGGAGCTGTTCAAGGGATTAGAGAGTGAAATCGTTGGACTTCACGAGATTCCCCCAAAGAGGGGAGAGTATGG
GGAGTTCAAATTCAGGAATGAAGAAGTTAATGAGTTAGTTAAGAGGCTCGGATTTAGACTTTATTCTCACCAAGTTAAAG
CCCTAGAAAAGCTGTATTCAGGGAAAAACGTAGTTGTTTCAACGCCCACAGCTAGTGGGAAAAGCGAGATATTTAGGTTG
TTTATCTTTGACGAAATACTGTCAAGCCCGTCCTCAACTTTTCTCTTAATCTACCCAACAAGAGCCTTAATAAACAACCA
AATGGAAAAATTCGAAAAAGAAAACACTATCTTTGAGGAGATTTGTGGAAAAAGAGTTCGAGCAGAAGTCTTAACTGGAG
ATACGGAATGGGAAAAGAGAAGAGAAATCATTAGGAGCAAACCAAACGTAATCTTCACGACACCCGATATGCTTCATCAT
CACATTCTTCCCAGGTGGAGGGATTATTTCTGGCTTTTAAAGGGGCTTAGACTTCTTGTCGTGGACGAATTGCACGTTTA
TAGGGGGATCTTTGGAACAAATGTTGCTTATGTTTTCAAGAGACTCTTTCTCAGGCTTAAGAGATTAAGTTCAAGCCCCC
AAATACTTGCCCTTTCAGCAACTTTGAGAAACCCCAAAGAATTTGCTGAACAATTTTTTGAGACTGAATTTGAGGAGGTC
AAGGAAGCTGGAAGTCCAAGCCCGAGAAGAATTATAGTCATGTTTGAGCCAAGAAGGTTTACTGGAGAACAACTAATCAA
GCAAATTGTTGAGAGACTAACTAGAAAGAACATAAAGACCTTGGTATTTTTTGACTCCAGAAAGGGGACAGAAAGAATCA
TGAGGCTTTTCCTGTTCTCAGATGCTTTTGATAGGATCACAACATACAAAGGGACGCTAACTAAGAGGGAAAGGTTTCTA
ATAGAGAGAGACTTTAGGGAGGGCAACCTCACAGTTCTCCTAACGACAAATGCACTCGAGTTGGGAATTGACATTGGAGA
TTTAGATGCAGTAATAAACTATGGGATTCCTTCAGATGGATTGTTTTCACTAATTCAAAGATTTGGTAGGGCCGGAAGGG
ATCCAAATAGAATTGCAATAAACGGGATAATTTTGAGAAGAAATGGATTGGACTACTATTACAAAGAACATTTCGATGAG
CTCGTTGAGGGAATAGAAAAGGGCCTAGTGGAGAAAATCCCCGTTAACTTGGACAATGAAAAGATAGCGAAAAAGCACCT
CCACTATGCCATAGCTGAACTTGGAGTTGTCTCAATTAAAGAAATTGAGGGGAGATGGAAGAGATTCATAAAGACCCTCG
TAGAGGAGGGATACGTGGAAGTTACAAGAAATCCAATAACTGGAGAGGAAGAAATAAGACTCAGAAGACCTCCTGTCTAT
TCTTCAATTAGAACGGCGAGCGATGAAAGCTACTTCTTAGTCGTGGATGAACCCTGGATAAGGGGAGCTTTGCAGAGGAA
GAGGGGAGCCGAACTTCTCCGTTTTGTAAACTACCTCAAAGTTAGAGGAATGGTAGTTGAGGAAGTTGATGAGATAGAAT
TCCACAGAAGTCTACTCCCTGGAATGGTCTACCTTTCAAGGGGAAGGCCCTACATGGCAGTTGATAAGATAAAGATTGAG
AAGTTCCACTTCGTTTTTGCGAGGCCTCTTCCAATCGAAGAAGAAATAGATACTAGTTCAAGTAAAATTGAAAACATTGA
GATACTTGAGGTTAAAGACGAGAAAACTGTTGGCCCAATAAAAGTGAAGTTCGGAAGACTTAGAGTAAGGCACGAATACA
CTGGATACGCCGTGAGGGGAAGAGACGTTGAAAGGCACGTTAAGAGATTAGAAGAGCTAAAAGATGAGGGGATACTAAGG
GGAGAGATTGACATCGTCCCATACATTTGGGAATCCTGGAAGTTTGCGAGGGTACTCTTTGACACCCCCTACATTAGAGA
GTTTGAAACTGAAGGTTTCTGGCTTGAGTTTCCAAACGATATTAGGATAGTTCCCGAAGAGGAGTTTAGGGAATTCTTTG
CAGTGGCCTCTGAGATAGATCCAGAGCTCGCGATGTTCCTCTACAACAGAATTAGTAGAAAATCTCTATTCCCCACGCTT
CTGGGAGCAACCACACACTACATAAGGAGTTTCATCCTTCACCACGCCAAAGATAAGGGAGAAGAATTCGCATTTGCCGT
AAAAAAGATGATCGACAGCAAGGATGGGATAGGCTCAGGGCTTCATGCAATTGAGCCCAATATAATAAAGCTTGCTCCAG
TTGTGACTCATGTGGATTCGAGAGAAATAGGCGGCTACAGCTACGATGACTTCCATGGAAAGCCAGTGATCTTCATCTAT
GATGGGAATGAAGGCGGAAGCGGAATAATTAGGCAGGTGTATGAGAACGTAGAAAAGCTGATGTACAGGAGTTTGGAGCA
TATAAAGAAGTGTCCATGCAAAGACGGCTGTCCTGCCTGCATATATTCTCCCAAGTGCGGAACTTTCAATGAATTCCTCG
ACAAGTGGATGGCAATAAGAATATGGGAAAAAGTCCTTCCTTAA

Upstream 100 bases:

>100_bases
TAGAAGCTTATAGAAAAGAGCTCCACGAGTTTGAAAAGGGAAAAGATGTTGAATTACCAAAAGGGATAGTCAAATTCCTA
AAAGAGCTGGGAGAGCAAAA

Downstream 100 bases:

>100_bases
CAGTTATATACTCCCTCTTGTATATTCTTTTTGGTGGTTAAATGCTTCTCGAGGCACCTGTATATAAGGAGATATTTGGA
GCTGTGAAGATTTATGAGCT

Product: ATP-dependent RNA helicase, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 867; Mature: 867

Protein sequence:

>867_residues
MIEELFKGLESEIVGLHEIPPKRGEYGEFKFRNEEVNELVKRLGFRLYSHQVKALEKLYSGKNVVVSTPTASGKSEIFRL
FIFDEILSSPSSTFLLIYPTRALINNQMEKFEKENTIFEEICGKRVRAEVLTGDTEWEKRREIIRSKPNVIFTTPDMLHH
HILPRWRDYFWLLKGLRLLVVDELHVYRGIFGTNVAYVFKRLFLRLKRLSSSPQILALSATLRNPKEFAEQFFETEFEEV
KEAGSPSPRRIIVMFEPRRFTGEQLIKQIVERLTRKNIKTLVFFDSRKGTERIMRLFLFSDAFDRITTYKGTLTKRERFL
IERDFREGNLTVLLTTNALELGIDIGDLDAVINYGIPSDGLFSLIQRFGRAGRDPNRIAINGIILRRNGLDYYYKEHFDE
LVEGIEKGLVEKIPVNLDNEKIAKKHLHYAIAELGVVSIKEIEGRWKRFIKTLVEEGYVEVTRNPITGEEEIRLRRPPVY
SSIRTASDESYFLVVDEPWIRGALQRKRGAELLRFVNYLKVRGMVVEEVDEIEFHRSLLPGMVYLSRGRPYMAVDKIKIE
KFHFVFARPLPIEEEIDTSSSKIENIEILEVKDEKTVGPIKVKFGRLRVRHEYTGYAVRGRDVERHVKRLEELKDEGILR
GEIDIVPYIWESWKFARVLFDTPYIREFETEGFWLEFPNDIRIVPEEEFREFFAVASEIDPELAMFLYNRISRKSLFPTL
LGATTHYIRSFILHHAKDKGEEFAFAVKKMIDSKDGIGSGLHAIEPNIIKLAPVVTHVDSREIGGYSYDDFHGKPVIFIY
DGNEGGSGIIRQVYENVEKLMYRSLEHIKKCPCKDGCPACIYSPKCGTFNEFLDKWMAIRIWEKVLP

Sequences:

>Translated_867_residues
MIEELFKGLESEIVGLHEIPPKRGEYGEFKFRNEEVNELVKRLGFRLYSHQVKALEKLYSGKNVVVSTPTASGKSEIFRL
FIFDEILSSPSSTFLLIYPTRALINNQMEKFEKENTIFEEICGKRVRAEVLTGDTEWEKRREIIRSKPNVIFTTPDMLHH
HILPRWRDYFWLLKGLRLLVVDELHVYRGIFGTNVAYVFKRLFLRLKRLSSSPQILALSATLRNPKEFAEQFFETEFEEV
KEAGSPSPRRIIVMFEPRRFTGEQLIKQIVERLTRKNIKTLVFFDSRKGTERIMRLFLFSDAFDRITTYKGTLTKRERFL
IERDFREGNLTVLLTTNALELGIDIGDLDAVINYGIPSDGLFSLIQRFGRAGRDPNRIAINGIILRRNGLDYYYKEHFDE
LVEGIEKGLVEKIPVNLDNEKIAKKHLHYAIAELGVVSIKEIEGRWKRFIKTLVEEGYVEVTRNPITGEEEIRLRRPPVY
SSIRTASDESYFLVVDEPWIRGALQRKRGAELLRFVNYLKVRGMVVEEVDEIEFHRSLLPGMVYLSRGRPYMAVDKIKIE
KFHFVFARPLPIEEEIDTSSSKIENIEILEVKDEKTVGPIKVKFGRLRVRHEYTGYAVRGRDVERHVKRLEELKDEGILR
GEIDIVPYIWESWKFARVLFDTPYIREFETEGFWLEFPNDIRIVPEEEFREFFAVASEIDPELAMFLYNRISRKSLFPTL
LGATTHYIRSFILHHAKDKGEEFAFAVKKMIDSKDGIGSGLHAIEPNIIKLAPVVTHVDSREIGGYSYDDFHGKPVIFIY
DGNEGGSGIIRQVYENVEKLMYRSLEHIKKCPCKDGCPACIYSPKCGTFNEFLDKWMAIRIWEKVLP
>Mature_867_residues
MIEELFKGLESEIVGLHEIPPKRGEYGEFKFRNEEVNELVKRLGFRLYSHQVKALEKLYSGKNVVVSTPTASGKSEIFRL
FIFDEILSSPSSTFLLIYPTRALINNQMEKFEKENTIFEEICGKRVRAEVLTGDTEWEKRREIIRSKPNVIFTTPDMLHH
HILPRWRDYFWLLKGLRLLVVDELHVYRGIFGTNVAYVFKRLFLRLKRLSSSPQILALSATLRNPKEFAEQFFETEFEEV
KEAGSPSPRRIIVMFEPRRFTGEQLIKQIVERLTRKNIKTLVFFDSRKGTERIMRLFLFSDAFDRITTYKGTLTKRERFL
IERDFREGNLTVLLTTNALELGIDIGDLDAVINYGIPSDGLFSLIQRFGRAGRDPNRIAINGIILRRNGLDYYYKEHFDE
LVEGIEKGLVEKIPVNLDNEKIAKKHLHYAIAELGVVSIKEIEGRWKRFIKTLVEEGYVEVTRNPITGEEEIRLRRPPVY
SSIRTASDESYFLVVDEPWIRGALQRKRGAELLRFVNYLKVRGMVVEEVDEIEFHRSLLPGMVYLSRGRPYMAVDKIKIE
KFHFVFARPLPIEEEIDTSSSKIENIEILEVKDEKTVGPIKVKFGRLRVRHEYTGYAVRGRDVERHVKRLEELKDEGILR
GEIDIVPYIWESWKFARVLFDTPYIREFETEGFWLEFPNDIRIVPEEEFREFFAVASEIDPELAMFLYNRISRKSLFPTL
LGATTHYIRSFILHHAKDKGEEFAFAVKKMIDSKDGIGSGLHAIEPNIIKLAPVVTHVDSREIGGYSYDDFHGKPVIFIY
DGNEGGSGIIRQVYENVEKLMYRSLEHIKKCPCKDGCPACIYSPKCGTFNEFLDKWMAIRIWEKVLP

Specific function: Unknown

COG id: COG1205

COG function: function code R; Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI83700235, Length=332, Percent_Identity=23.4939759036145, Blast_Score=71, Evalue=5e-12,
Organism=Homo sapiens, GI4503529, Length=335, Percent_Identity=24.7761194029851, Blast_Score=70, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508543, Length=346, Percent_Identity=26.878612716763, Blast_Score=74, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI115532548, Length=403, Percent_Identity=22.0843672456576, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320497, Length=576, Percent_Identity=31.4236111111111, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6321963, Length=334, Percent_Identity=25.1497005988024, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24584399, Length=354, Percent_Identity=24.0112994350282, Blast_Score=76, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24582080, Length=334, Percent_Identity=24.5508982035928, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24582078, Length=334, Percent_Identity=24.5508982035928, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17136248, Length=334, Percent_Identity=24.5508982035928, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24582075, Length=334, Percent_Identity=24.5508982035928, Blast_Score=68, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 101124; Mature: 101124

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEELFKGLESEIVGLHEIPPKRGEYGEFKFRNEEVNELVKRLGFRLYSHQVKALEKLYS
CHHHHHHHHHHHCCCHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKNVVVSTPTASGKSEIFRLFIFDEILSSPSSTFLLIYPTRALINNQMEKFEKENTIFEE
CCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCHHHHH
ICGKRVRAEVLTGDTEWEKRREIIRSKPNVIFTTPDMLHHHILPRWRDYFWLLKGLRLLV
HCCHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECHHHHHHHHCHHHHHHHHHHHCCHHHH
VDELHVYRGIFGTNVAYVFKRLFLRLKRLSSSPQILALSATLRNPKEFAEQFFETEFEEV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHH
KEAGSPSPRRIIVMFEPRRFTGEQLIKQIVERLTRKNIKTLVFFDSRKGTERIMRLFLFS
HHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHH
DAFDRITTYKGTLTKRERFLIERDFREGNLTVLLTTNALELGIDIGDLDAVINYGIPSDG
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEECCEEECCCCCCHHHHHCCCCCCHH
LFSLIQRFGRAGRDPNRIAINGIILRRNGLDYYYKEHFDELVEGIEKGLVEKIPVNLDNE
HHHHHHHHHHCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCHH
KIAKKHLHYAIAELGVVSIKEIEGRWKRFIKTLVEEGYVEVTRNPITGEEEIRLRRPPVY
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHEEEECCCCH
SSIRTASDESYFLVVDEPWIRGALQRKRGAELLRFVNYLKVRGMVVEEVDEIEFHRSLLP
HHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GMVYLSRGRPYMAVDKIKIEKFHFVFARPLPIEEEIDTSSSKIENIEILEVKDEKTVGPI
HHHEEECCCCEEEEEEEEEEEEEEEEECCCCCHHHCCCCCCCCCCEEEEEECCCCCCCCE
KVKFGRLRVRHEYTGYAVRGRDVERHVKRLEELKDEGILRGEIDIVPYIWESWKFARVLF
EEEECEEEEEEECCCEEEECCCHHHHHHHHHHHHHCCCEECCEEEEHHHHCCCHHHHHHH
DTPYIREFETEGFWLEFPNDIRIVPEEEFREFFAVASEIDPELAMFLYNRISRKSLFPTL
CCCCCEEECCCCEEEECCCCCEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LGATTHYIRSFILHHAKDKGEEFAFAVKKMIDSKDGIGSGLHAIEPNIIKLAPVVTHVDS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEHHHHCCCC
REIGGYSYDDFHGKPVIFIYDGNEGGSGIIRQVYENVEKLMYRSLEHIKKCPCKDGCPAC
CCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
IYSPKCGTFNEFLDKWMAIRIWEKVLP
EECCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIEELFKGLESEIVGLHEIPPKRGEYGEFKFRNEEVNELVKRLGFRLYSHQVKALEKLYS
CHHHHHHHHHHHCCCHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKNVVVSTPTASGKSEIFRLFIFDEILSSPSSTFLLIYPTRALINNQMEKFEKENTIFEE
CCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCHHHHH
ICGKRVRAEVLTGDTEWEKRREIIRSKPNVIFTTPDMLHHHILPRWRDYFWLLKGLRLLV
HCCHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECHHHHHHHHCHHHHHHHHHHHCCHHHH
VDELHVYRGIFGTNVAYVFKRLFLRLKRLSSSPQILALSATLRNPKEFAEQFFETEFEEV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHH
KEAGSPSPRRIIVMFEPRRFTGEQLIKQIVERLTRKNIKTLVFFDSRKGTERIMRLFLFS
HHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHH
DAFDRITTYKGTLTKRERFLIERDFREGNLTVLLTTNALELGIDIGDLDAVINYGIPSDG
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEECCEEECCCCCCHHHHHCCCCCCHH
LFSLIQRFGRAGRDPNRIAINGIILRRNGLDYYYKEHFDELVEGIEKGLVEKIPVNLDNE
HHHHHHHHHHCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCHH
KIAKKHLHYAIAELGVVSIKEIEGRWKRFIKTLVEEGYVEVTRNPITGEEEIRLRRPPVY
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHEEEECCCCH
SSIRTASDESYFLVVDEPWIRGALQRKRGAELLRFVNYLKVRGMVVEEVDEIEFHRSLLP
HHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GMVYLSRGRPYMAVDKIKIEKFHFVFARPLPIEEEIDTSSSKIENIEILEVKDEKTVGPI
HHHEEECCCCEEEEEEEEEEEEEEEEECCCCCHHHCCCCCCCCCCEEEEEECCCCCCCCE
KVKFGRLRVRHEYTGYAVRGRDVERHVKRLEELKDEGILRGEIDIVPYIWESWKFARVLF
EEEECEEEEEEECCCEEEECCCHHHHHHHHHHHHHCCCEECCEEEEHHHHCCCHHHHHHH
DTPYIREFETEGFWLEFPNDIRIVPEEEFREFFAVASEIDPELAMFLYNRISRKSLFPTL
CCCCCEEECCCCEEEECCCCCEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LGATTHYIRSFILHHAKDKGEEFAFAVKKMIDSKDGIGSGLHAIEPNIIKLAPVVTHVDS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEHHHHCCCC
REIGGYSYDDFHGKPVIFIYDGNEGGSGIIRQVYENVEKLMYRSLEHIKKCPCKDGCPAC
CCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
IYSPKCGTFNEFLDKWMAIRIWEKVLP
EECCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]