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The map label for this gene is 18976944

Identifier: 18976944

GI number: 18976944

Start: 592552

End: 594519

Strand: Direct

Name: 18976944

Synonym: PF0572

Alternate gene names: NA

Gene position: 592552-594519 (Clockwise)

Preceding gene: 18976941

Following gene: 18976945

Centisome position: 31.05

GC content: 45.93

Gene sequence:

>1968_bases
ATGAACATAAAGAGCTTCATAAACAGGCTTAAGGAGCTAGTTGAAATCGAGAGGGAAGCTGAAATAGAGGCTATGAGGTT
GGAGATGAAAAGGCTTAGCGGAGTGGAGAGGGAGAGGTTAGGTAGGGCAATTCTCAGCTTAAACGGTAAAATCGTTGGTG
AAGAGCTCGGTTATTTCTTGGTTAAGTACGGAAGGAATAAGGAGATAAAGACCGAGATCAGCGTTGGGGATTTGGTTGTT
ATAAGCAAGAGGGATCCCCTGAAGAGCGACCTCCTGGGAACTGTTGTTGAGAAGGGGAAGAGATTCATCGTCGTTGCCTT
AGAACCAGTCCCAGAGTGGGCCCTTAGAGATGTGAGGATAGACCTCTACGCCAACGATATAACATTCAAGAGGTGGATCG
AAAACCTCGACAGGGTTAGGAAGGCTGGAAAAAAGGCTTTAGAGTTTTACTTAGGTTTAGATGAGCCTTCCCAGGGGGAG
GAAGTGAGCTTTGAACCCTTTGATAAGAGCCTAAACCCCTCTCAAAGGAAAGCGATAGCTAAGGCTTTAGGTAGTGAAGA
CTTCTTCCTTATCCACGGCCCCTTTGGAACTGGAAAGACGAGGACTTTAGTTGAGCTGATTAGGCAGGAGGTAAAGAGGG
GGAACAAAGTTCTAGCTACAGCTGAGAGCAACGTTGCCGTGGACAATTTAGTTGAAAGATTGGCCAAAGATGGAGTTAAG
ATAGTTAGGGTTGGGCACCCAAGTAGGGTTTCGAGGCATTTGCACGAGACAACTTTAGCTTACCTCATTACTCAGCACGA
GCTCTACGGTGAGCTTAGGGAGCTTAGGGTGATAGGGCAGAGTTTGGCAGAGAAGAGGGACACATATACAAAGCCGACTC
CAAAGTTCAGGAGGGGACTGAGTGATGCTGAGATAATTAAGTTGGCCGAGAAGGGAAGAGGGGCTAGAGGACTCTCAGCT
AGACTAATAAAGGAGATGGCCGAGTGGATAAAGCTAAACAGGCAGGTTCAGAAGGCCTTTGAAGATGCTAGAAAGCTTGA
GGAGAGGATTGCGAGGGATATAATTAGGGAAGCCGATGTGGTTTTGACAACTAACTCTTCTGCAGCCCTTGATGTTGTTG
ATGCTACCGATTATGATGTTGCGATAATAGATGAAGCAACTCAGGCAACTATACCGAGCATATTAATACCTCTCAACAAG
GTTGATAGGTTTATACTTGCTGGAGACCACAAGCAACTACCACCAACTATCTTAAGCTTGGAGGCCCAGGAGCTCTCCCA
CACGCTTTTCGAGGGTTTAATTGAGAAGTACCCATGGAAGAGCGAAATGCTGACAATTCAGTATAGGATGAATGAGAGGA
TAATGGAGTTTCCGAGCAGGGAGTTTTACGATGGAAGAATAGTTGCTGATGAAAGTGTAAAAAACATAACTCTGGCCGAC
CTGGGAATTAAAGTTAATGCTAGTGGAATATGGAGGGACATCCTAGATCCAAACAACGTCCTCGTGTTCATAGATACTTG
CATGCTCGAAAATAGGTTCGAGAGGCAGAGAAGGGGAAGCGAAAGCAGGGAGAATCCCTTGGAGGCCAAGATAGTGAGCA
AAATCGTTGAAAAGCTCTTGGAAAGTGGGGTTAAAGCGGAAATGATGGGAGTGATTACACCTTACGATGACCAGAGGGAT
TTGATAAGCTTGAATGTTCCCGAAGAAGTTGAGGTCAAGACTGTGGATGGTTACCAGGGAAGGGAGAAGGAAGTGATAAT
TCTATCATTTGTCCGCTCTAACAAAGCGGGAGAGATCGGCTTTCTCAAGGACTTGAGGAGGCTAAACGTGTCCTTAACTA
GGGCTAAGAGGAAGCTTATCATGATTGGCGATTCCTCAACGCTTTCATCTCACGAAACCTACAGGAGGTTAATCGAGCAC
GTGAGGGAGAAGGGGTTATATGTTGTGCTAACGAAGGATAGCATTTGA

Upstream 100 bases:

>100_bases
TTCAATTTAAACCTTTTGTCTAGTAAATTGTTACAGTGTTAAATGAGTACCAACGACCTTATACCAAAACTTTTTGAATT
GACTTTTCGAGCCGATTTTG

Downstream 100 bases:

>100_bases
TTTCTAGGAAAGATTATTTCTTAGGAGAAATATTAATATAGTTGAAATACTAATTTACTAGCAAGGTGAACGTAAAATGC
CCATTACGAAGGTTACTAGA

Product: dna2-nam7 helicase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 655; Mature: 655

Protein sequence:

>655_residues
MNIKSFINRLKELVEIEREAEIEAMRLEMKRLSGVERERLGRAILSLNGKIVGEELGYFLVKYGRNKEIKTEISVGDLVV
ISKRDPLKSDLLGTVVEKGKRFIVVALEPVPEWALRDVRIDLYANDITFKRWIENLDRVRKAGKKALEFYLGLDEPSQGE
EVSFEPFDKSLNPSQRKAIAKALGSEDFFLIHGPFGTGKTRTLVELIRQEVKRGNKVLATAESNVAVDNLVERLAKDGVK
IVRVGHPSRVSRHLHETTLAYLITQHELYGELRELRVIGQSLAEKRDTYTKPTPKFRRGLSDAEIIKLAEKGRGARGLSA
RLIKEMAEWIKLNRQVQKAFEDARKLEERIARDIIREADVVLTTNSSAALDVVDATDYDVAIIDEATQATIPSILIPLNK
VDRFILAGDHKQLPPTILSLEAQELSHTLFEGLIEKYPWKSEMLTIQYRMNERIMEFPSREFYDGRIVADESVKNITLAD
LGIKVNASGIWRDILDPNNVLVFIDTCMLENRFERQRRGSESRENPLEAKIVSKIVEKLLESGVKAEMMGVITPYDDQRD
LISLNVPEEVEVKTVDGYQGREKEVIILSFVRSNKAGEIGFLKDLRRLNVSLTRAKRKLIMIGDSSTLSSHETYRRLIEH
VREKGLYVVLTKDSI

Sequences:

>Translated_655_residues
MNIKSFINRLKELVEIEREAEIEAMRLEMKRLSGVERERLGRAILSLNGKIVGEELGYFLVKYGRNKEIKTEISVGDLVV
ISKRDPLKSDLLGTVVEKGKRFIVVALEPVPEWALRDVRIDLYANDITFKRWIENLDRVRKAGKKALEFYLGLDEPSQGE
EVSFEPFDKSLNPSQRKAIAKALGSEDFFLIHGPFGTGKTRTLVELIRQEVKRGNKVLATAESNVAVDNLVERLAKDGVK
IVRVGHPSRVSRHLHETTLAYLITQHELYGELRELRVIGQSLAEKRDTYTKPTPKFRRGLSDAEIIKLAEKGRGARGLSA
RLIKEMAEWIKLNRQVQKAFEDARKLEERIARDIIREADVVLTTNSSAALDVVDATDYDVAIIDEATQATIPSILIPLNK
VDRFILAGDHKQLPPTILSLEAQELSHTLFEGLIEKYPWKSEMLTIQYRMNERIMEFPSREFYDGRIVADESVKNITLAD
LGIKVNASGIWRDILDPNNVLVFIDTCMLENRFERQRRGSESRENPLEAKIVSKIVEKLLESGVKAEMMGVITPYDDQRD
LISLNVPEEVEVKTVDGYQGREKEVIILSFVRSNKAGEIGFLKDLRRLNVSLTRAKRKLIMIGDSSTLSSHETYRRLIEH
VREKGLYVVLTKDSI
>Mature_655_residues
MNIKSFINRLKELVEIEREAEIEAMRLEMKRLSGVERERLGRAILSLNGKIVGEELGYFLVKYGRNKEIKTEISVGDLVV
ISKRDPLKSDLLGTVVEKGKRFIVVALEPVPEWALRDVRIDLYANDITFKRWIENLDRVRKAGKKALEFYLGLDEPSQGE
EVSFEPFDKSLNPSQRKAIAKALGSEDFFLIHGPFGTGKTRTLVELIRQEVKRGNKVLATAESNVAVDNLVERLAKDGVK
IVRVGHPSRVSRHLHETTLAYLITQHELYGELRELRVIGQSLAEKRDTYTKPTPKFRRGLSDAEIIKLAEKGRGARGLSA
RLIKEMAEWIKLNRQVQKAFEDARKLEERIARDIIREADVVLTTNSSAALDVVDATDYDVAIIDEATQATIPSILIPLNK
VDRFILAGDHKQLPPTILSLEAQELSHTLFEGLIEKYPWKSEMLTIQYRMNERIMEFPSREFYDGRIVADESVKNITLAD
LGIKVNASGIWRDILDPNNVLVFIDTCMLENRFERQRRGSESRENPLEAKIVSKIVEKLLESGVKAEMMGVITPYDDQRD
LISLNVPEEVEVKTVDGYQGREKEVIILSFVRSNKAGEIGFLKDLRRLNVSLTRAKRKLIMIGDSSTLSSHETYRRLIEH
VREKGLYVVLTKDSI

Specific function: Unknown

COG id: COG1112

COG function: function code L; Superfamily I DNA and RNA helicases and helicase subunits

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA2/NAM7 helicase family [H]

Homologues:

Organism=Homo sapiens, GI119392094, Length=681, Percent_Identity=33.7738619676946, Blast_Score=302, Evalue=5e-82,
Organism=Homo sapiens, GI18375673, Length=493, Percent_Identity=32.4543610547667, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI122937299, Length=310, Percent_Identity=34.8387096774194, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI113722133, Length=557, Percent_Identity=27.1095152603232, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI254826809, Length=311, Percent_Identity=32.1543408360129, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI156105693, Length=529, Percent_Identity=27.0321361058601, Blast_Score=109, Evalue=1e-23,
Organism=Homo sapiens, GI156105695, Length=529, Percent_Identity=27.0321361058601, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI14251207, Length=440, Percent_Identity=27.9545454545455, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI255759908, Length=420, Percent_Identity=28.3333333333333, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI255759910, Length=311, Percent_Identity=29.903536977492, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI28626521, Length=318, Percent_Identity=27.3584905660377, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI194272168, Length=416, Percent_Identity=26.2019230769231, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI14211540, Length=416, Percent_Identity=26.2019230769231, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI54792138, Length=322, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI255759906, Length=375, Percent_Identity=27.2, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510163, Length=494, Percent_Identity=34.6153846153846, Blast_Score=208, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI71981659, Length=500, Percent_Identity=28, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17533987, Length=259, Percent_Identity=36.2934362934363, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17533985, Length=259, Percent_Identity=36.2934362934363, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17538027, Length=337, Percent_Identity=27.0029673590504, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17531515, Length=307, Percent_Identity=28.3387622149837, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17531513, Length=307, Percent_Identity=28.3387622149837, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17541326, Length=330, Percent_Identity=26.969696969697, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17535407, Length=255, Percent_Identity=27.4509803921569, Blast_Score=66, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322835, Length=515, Percent_Identity=34.9514563106796, Blast_Score=226, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6323726, Length=508, Percent_Identity=33.8582677165354, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6323462, Length=539, Percent_Identity=28.7569573283859, Blast_Score=163, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6321024, Length=519, Percent_Identity=28.7090558766859, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321958, Length=320, Percent_Identity=32.8125, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI18859757, Length=500, Percent_Identity=31.4, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24660647, Length=503, Percent_Identity=27.4353876739563, Blast_Score=152, Evalue=1e-36,
Organism=Drosophila melanogaster, GI221330969, Length=503, Percent_Identity=27.6341948310139, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI281363531, Length=505, Percent_Identity=27.7227722772277, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI281363529, Length=505, Percent_Identity=27.7227722772277, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI161077698, Length=355, Percent_Identity=29.5774647887324, Blast_Score=130, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24640932, Length=355, Percent_Identity=29.5774647887324, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24649577, Length=492, Percent_Identity=28.4552845528455, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24656854, Length=307, Percent_Identity=27.3615635179153, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI62471854, Length=307, Percent_Identity=27.3615635179153, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45550425, Length=312, Percent_Identity=29.4871794871795, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR004483 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 74583; Mature: 74583

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKSFINRLKELVEIEREAEIEAMRLEMKRLSGVERERLGRAILSLNGKIVGEELGYFL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEHHHHHHHH
VKYGRNKEIKTEISVGDLVVISKRDPLKSDLLGTVVEKGKRFIVVALEPVPEWALRDVRI
EEECCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHEEE
DLYANDITFKRWIENLDRVRKAGKKALEFYLGLDEPSQGEEVSFEPFDKSLNPSQRKAIA
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
KALGSEDFFLIHGPFGTGKTRTLVELIRQEVKRGNKVLATAESNVAVDNLVERLAKDGVK
HHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCEE
IVRVGHPSRVSRHLHETTLAYLITQHELYGELRELRVIGQSLAEKRDTYTKPTPKFRRGL
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCC
SDAEIIKLAEKGRGARGLSARLIKEMAEWIKLNRQVQKAFEDARKLEERIARDIIREADV
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VLTTNSSAALDVVDATDYDVAIIDEATQATIPSILIPLNKVDRFILAGDHKQLPPTILSL
EEEECCCCEEEEEECCCCCEEEECCCHHHCCCHHEEEHHHHCEEEEECCCCCCCCHHHHC
EAQELSHTLFEGLIEKYPWKSEMLTIQYRMNERIMEFPSREFYDGRIVADESVKNITLAD
CHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHCCCCCCCCCEEEECCCCCEEEEEE
LGIKVNASGIWRDILDPNNVLVFIDTCMLENRFERQRRGSESRENPLEAKIVSKIVEKLL
CCEEEECCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
ESGVKAEMMGVITPYDDQRDLISLNVPEEVEVKTVDGYQGREKEVIILSFVRSNKAGEIG
HCCCCEEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCH
FLKDLRRLNVSLTRAKRKLIMIGDSSTLSSHETYRRLIEHVREKGLYVVLTKDSI
HHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEECCCC
>Mature Secondary Structure
MNIKSFINRLKELVEIEREAEIEAMRLEMKRLSGVERERLGRAILSLNGKIVGEELGYFL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEHHHHHHHH
VKYGRNKEIKTEISVGDLVVISKRDPLKSDLLGTVVEKGKRFIVVALEPVPEWALRDVRI
EEECCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHEEE
DLYANDITFKRWIENLDRVRKAGKKALEFYLGLDEPSQGEEVSFEPFDKSLNPSQRKAIA
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
KALGSEDFFLIHGPFGTGKTRTLVELIRQEVKRGNKVLATAESNVAVDNLVERLAKDGVK
HHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCEE
IVRVGHPSRVSRHLHETTLAYLITQHELYGELRELRVIGQSLAEKRDTYTKPTPKFRRGL
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCC
SDAEIIKLAEKGRGARGLSARLIKEMAEWIKLNRQVQKAFEDARKLEERIARDIIREADV
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VLTTNSSAALDVVDATDYDVAIIDEATQATIPSILIPLNKVDRFILAGDHKQLPPTILSL
EEEECCCCEEEEEECCCCCEEEECCCHHHCCCHHEEEHHHHCEEEEECCCCCCCCHHHHC
EAQELSHTLFEGLIEKYPWKSEMLTIQYRMNERIMEFPSREFYDGRIVADESVKNITLAD
CHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHCCCCCCCCCEEEECCCCCEEEEEE
LGIKVNASGIWRDILDPNNVLVFIDTCMLENRFERQRRGSESRENPLEAKIVSKIVEKLL
CCEEEECCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
ESGVKAEMMGVITPYDDQRDLISLNVPEEVEVKTVDGYQGREKEVIILSFVRSNKAGEIG
HCCCCEEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCH
FLKDLRRLNVSLTRAKRKLIMIGDSSTLSSHETYRRLIEHVREKGLYVVLTKDSI
HHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]