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The map label for this gene is moeA [C]

Identifier: 18976914

GI number: 18976914

Start: 561410

End: 562615

Strand: Direct

Name: moeA [C]

Synonym: PF0542

Alternate gene names: 18976914

Gene position: 561410-562615 (Clockwise)

Preceding gene: 18976913

Following gene: 18976915

Centisome position: 29.42

GC content: 41.79

Gene sequence:

>1206_bases
ATGGCATTTCTAAAGGTAGTGTCATTGGAAGAAGCAATTTCAATAATTAATAGCTTTAGACTTGAAATAGGATTTGAGGA
AGTTACTTTAGATAAAGCTCTGGGGAGGATAGTTGCAGAGGATATTTATTCCCCCTTGGATATTCCTCCCTTTGATAGAT
CGACCGTTGATGGGTATGCTGTTAGGGCGGAGGATACTTTTATGGCCAGTGAAGCTAATCCAGTGGAACTCAAAGTAATT
GGAGAAGTTCATGCCGGAGAACAACCTTCAGTAAAGTTAAGCAAGGGAGAGGCGGTCTACATTACAACGGGGTCAATGAT
GCCAGAGAACGCAAATGCTGTGATTCCTTTTGAGGATGTTGAGAGAGAAGGAGATATTATAAGAATTTATAAGCCTGCAT
ACCCAGGTTTAGGAGTCATGAAGAAAGGAACTGACATAAAAAAGGGCCAACTCTTAATTAGAAGAGGAACTAAGCTAACG
TTTAAAGAAACTGCCCTGCTTTCTGCTGCGGGATTTTTAAAAGTAAAGGTCTTTAAAAAGCCTAAAGTTGCGGTCATAAG
TACGGGGAATGAAATTGTTCTCCCAGGTGAAGAGCTTAGGCCTGGCCAAATATATGACATCAATGGTAGAGCAATAGTTG
ATGCCGTTAATGAATTGGGTGGAGAGGGAATATTCGTTGGGATTGCCAGGGATGACAGAGAAAGTCTCAAAAAATTAATA
CTTCAAGCCTTAGAAGTTGGAGATATTATCGTTATTAGTGGGGGGGCAAGTGGGGGAATAAAAGACTTAACAGCCTCGGT
AATAGAGGAACTTGGAGAGGTTAAAGTTCATGGAATTGCAATTCAGCCAGGTAAACCCACAATAATAGGGGTTATAAACG
GTAAGCCTGTCTTTGGCCTACCTGGGTATCCGACAAGTTGCCTAACAAACTTCACCCTCTTAGTTGCTCCCCTGCTTTTG
AGGCTACTTGGAAGGGAAGGAAAAATTAAGAAGGTTAAGGCGAAAATTAAGCATAAAGTATTTTCGGTAAAGGGAAGAAG
ACAATTCCTCCCAGTTAAACTTGAGGGAGATGTAGCGGTTCCTATCTTGAAGGGAAGCGGAGCAGTCACAAGCTTTGTGG
AGGCAGATGGTTTTGTGGAAATTCCCGAGAATGTAGAAAGCCTTGATGAGGGAGAAGAAGTAACGGTAACGTTGTTCTCG
TTTTAG

Upstream 100 bases:

>100_bases
TCAGGGAAGGCGCGGGACTCGAGATCCCGTGGGCGTTCGCCCGCCGGGGTTCAAATCCCCGCCCCGGCGCCATTTGTTAA
GCACTTGGAGGTTTGATAAT

Downstream 100 bases:

>100_bases
GAGGTGATAGTATGGTCAAGGTTAAGGTTAAGTACTTTGCTAGATTTAGGCAACTTGCAGGAGTTGATGAAGAGGAGATT
GAGCTTCCAGAGGGAGCTAG

Product: molybdenum cofactor biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MAFLKVVSLEEAISIINSFRLEIGFEEVTLDKALGRIVAEDIYSPLDIPPFDRSTVDGYAVRAEDTFMASEANPVELKVI
GEVHAGEQPSVKLSKGEAVYITTGSMMPENANAVIPFEDVEREGDIIRIYKPAYPGLGVMKKGTDIKKGQLLIRRGTKLT
FKETALLSAAGFLKVKVFKKPKVAVISTGNEIVLPGEELRPGQIYDINGRAIVDAVNELGGEGIFVGIARDDRESLKKLI
LQALEVGDIIVISGGASGGIKDLTASVIEELGEVKVHGIAIQPGKPTIIGVINGKPVFGLPGYPTSCLTNFTLLVAPLLL
RLLGREGKIKKVKAKIKHKVFSVKGRRQFLPVKLEGDVAVPILKGSGAVTSFVEADGFVEIPENVESLDEGEEVTVTLFS
F

Sequences:

>Translated_401_residues
MAFLKVVSLEEAISIINSFRLEIGFEEVTLDKALGRIVAEDIYSPLDIPPFDRSTVDGYAVRAEDTFMASEANPVELKVI
GEVHAGEQPSVKLSKGEAVYITTGSMMPENANAVIPFEDVEREGDIIRIYKPAYPGLGVMKKGTDIKKGQLLIRRGTKLT
FKETALLSAAGFLKVKVFKKPKVAVISTGNEIVLPGEELRPGQIYDINGRAIVDAVNELGGEGIFVGIARDDRESLKKLI
LQALEVGDIIVISGGASGGIKDLTASVIEELGEVKVHGIAIQPGKPTIIGVINGKPVFGLPGYPTSCLTNFTLLVAPLLL
RLLGREGKIKKVKAKIKHKVFSVKGRRQFLPVKLEGDVAVPILKGSGAVTSFVEADGFVEIPENVESLDEGEEVTVTLFS
F
>Mature_400_residues
AFLKVVSLEEAISIINSFRLEIGFEEVTLDKALGRIVAEDIYSPLDIPPFDRSTVDGYAVRAEDTFMASEANPVELKVIG
EVHAGEQPSVKLSKGEAVYITTGSMMPENANAVIPFEDVEREGDIIRIYKPAYPGLGVMKKGTDIKKGQLLIRRGTKLTF
KETALLSAAGFLKVKVFKKPKVAVISTGNEIVLPGEELRPGQIYDINGRAIVDAVNELGGEGIFVGIARDDRESLKKLIL
QALEVGDIIVISGGASGGIKDLTASVIEELGEVKVHGIAIQPGKPTIIGVINGKPVFGLPGYPTSCLTNFTLLVAPLLLR
LLGREGKIKKVKAKIKHKVFSVKGRRQFLPVKLEGDVAVPILKGSGAVTSFVEADGFVEIPENVESLDEGEEVTVTLFSF

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=429, Percent_Identity=31.002331002331, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI66932975, Length=429, Percent_Identity=31.002331002331, Blast_Score=182, Evalue=7e-46,
Organism=Escherichia coli, GI1787049, Length=381, Percent_Identity=34.1207349081365, Blast_Score=203, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI25147659, Length=328, Percent_Identity=32.0121951219512, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17562606, Length=333, Percent_Identity=26.1261261261261, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136978, Length=343, Percent_Identity=29.7376093294461, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24638841, Length=343, Percent_Identity=29.7376093294461, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43135; Mature: 43004

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFLKVVSLEEAISIINSFRLEIGFEEVTLDKALGRIVAEDIYSPLDIPPFDRSTVDGYA
CCEEEEECHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
VRAEDTFMASEANPVELKVIGEVHAGEQPSVKLSKGEAVYITTGSMMPENANAVIPFEDV
EEECCEEEECCCCCEEEEEEEEECCCCCCCEEEECCCEEEEEECCCCCCCCCEEEEHHHC
EREGDIIRIYKPAYPGLGVMKKGTDIKKGQLLIRRGTKLTFKETALLSAAGFLKVKVFKK
CCCCCEEEEECCCCCCCCEEECCCCCCCCEEEEECCCEEEEHHHHHHHHCCEEEEEEECC
PKVAVISTGNEIVLPGEELRPGQIYDINGRAIVDAVNELGGEGIFVGIARDDRESLKKLI
CCEEEEECCCEEEECCCCCCCCEEEECCCCCHHHHHHHCCCCEEEEEEECCCHHHHHHHH
LQALEVGDIIVISGGASGGIKDLTASVIEELGEVKVHGIAIQPGKPTIIGVINGKPVFGL
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCEEEEEECCCEEECC
PGYPTSCLTNFTLLVAPLLLRLLGREGKIKKVKAKIKHKVFSVKGRRQFLPVKLEGDVAV
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCEEEEEEECCCEEE
PILKGSGAVTSFVEADGFVEIPENVESLDEGEEVTVTLFSF
EEEECCCCEEEEECCCCEEECCCCHHHHCCCCEEEEEEEEC
>Mature Secondary Structure 
AFLKVVSLEEAISIINSFRLEIGFEEVTLDKALGRIVAEDIYSPLDIPPFDRSTVDGYA
CEEEEECHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
VRAEDTFMASEANPVELKVIGEVHAGEQPSVKLSKGEAVYITTGSMMPENANAVIPFEDV
EEECCEEEECCCCCEEEEEEEEECCCCCCCEEEECCCEEEEEECCCCCCCCCEEEEHHHC
EREGDIIRIYKPAYPGLGVMKKGTDIKKGQLLIRRGTKLTFKETALLSAAGFLKVKVFKK
CCCCCEEEEECCCCCCCCEEECCCCCCCCEEEEECCCEEEEHHHHHHHHCCEEEEEEECC
PKVAVISTGNEIVLPGEELRPGQIYDINGRAIVDAVNELGGEGIFVGIARDDRESLKKLI
CCEEEEECCCEEEECCCCCCCCEEEECCCCCHHHHHHHCCCCEEEEEEECCCHHHHHHHH
LQALEVGDIIVISGGASGGIKDLTASVIEELGEVKVHGIAIQPGKPTIIGVINGKPVFGL
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCEEEEEECCCEEECC
PGYPTSCLTNFTLLVAPLLLRLLGREGKIKKVKAKIKHKVFSVKGRRQFLPVKLEGDVAV
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCEEEEEEECCCEEE
PILKGSGAVTSFVEADGFVEIPENVESLDEGEEVTVTLFSF
EEEECCCCEEEEECCCCEEECCCCHHHHCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]